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A comprehensive review on the global efforts on vaccines and repurposed drugs for combating COVID-19
Eur J Med Chem. 2023 Aug 10;260:115719. doi: 10.1016/j.ejmech.2023.115719. Online ahead of print.ABSTRACTThe recently discovered coronavirus, known as SARS-CoV-2, is a highly contagious and potentially lethal viral infection that was declared a pandemic by the World Health Organization on March 11, 2020. Since the beginning of the pandemic, an unprecedented number of COVID-19 vaccine candidates have been investigated for their potential to manage the pandemic. Herein, we reviewed vaccine development and the associated research effort, both traditional and forward-looking, to demonstrate the advantages and disadvantages of ...
Source: European Journal of Medicinal Chemistry - August 19, 2023 Category: Chemistry Authors: Narva Deshwar Kushwaha Jivanka Mohan Babita Kushwaha Terisha Ghazi Joshua C Nwabuife Neil Koorbanally Anil A Chuturgoon Source Type: research
Baricitinib versus Tocilizumab in Critically Ill COVID ‐19 Patients: A Retrospective Cohort Study
ConclusionsBaricitinib use was associated with better WHO-CPS scores at day 14 and day 7 compared with tocilizumab in a cohort of critically ill patients with COVID-19. The odds of having a one unit increase in WHO-CPS score at day 14 was 71% higher with tocilizumab than baricitinib. No difference in mortality or adverse effects was noted.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - August 19, 2023 Category: Drugs & Pharmacology Authors: Grace M. Conroy,
Seth R. Bauer,
Andrea M. Pallotta,
Abhijit Duggal,
Lu Wang,
Gretchen L. Sacha Tags: RESEARCH ARTICLE Source Type: research
Monday briefing: The new variant that ’s a reminder the pandemic never fully ended
In today ’s newsletter: The ‘Eris’ strain of Covid is a reminder that the virus has never fully gone away – but what will it mean for Britain?•Sign up here for our daily newsletter, First EditionGood morning. Covid has become a polarising topic that many people just want to forget about. Earlier this year, the World Health Organization officially declared the pandemic over. Cases, hospitalisations and deaths are at their lowest levels, though infections have undoubtedly become more difficult to track as monitoring systems are dismantled. But even so, experts have made it clear that Covid will be with us for many ...
Source: Guardian Unlimited Science - August 14, 2023 Category: Science Authors: Nimo Omer Tags: Coronavirus Science World news UK news Health World Health Organization Source Type: news
SARS-CoV-2 seroprevalence in pregnant women during the first three COVID-19 waves in The Gambia
SARS-CoV-2, the causative agent of the coronavirus disease 2019 (COVID-19), was first identified in December 2019 in Wuhan, China [1]. SARS-CoV-2 was rapidly transmitted globally, disrupting structures and systems; and causing millions of deaths. Globally, there were 278.7M COVID-19 cases and 5.39M attributable deaths by December 2021 [2], 21 months after the World Health Organization (WHO) declared COVID-19 a pandemic [3]. Nigeria reported the first case in Sub-Saharan Africa (SSA) on 28 January 2020 [4].
Source: International Journal of Infectious Diseases - August 14, 2023 Category: Infectious Diseases Authors: Ramatoulie E. Janha, Alasana Bah, Hawanatu Jah, Fatima Touray, Yahaya Idris, Saikou Keita, Yassin Gaye, Samba Jallow, Tisbeh Faye-Joof, Baboucarr Njie, Rachel Craik, Nuredin I. Mohammed, Peter von Dadelszen, Umberto D'Alessandro, Anna Roca, the PRECISE Ne Source Type: research
News at a glance: A win for obesity drugs, NIH unionization roadblocks, and Mexican fireflies under threat
CONSERVATION
Researchers raise alarm over threat to Mexican fireflies
Scientists from the International Union for Conservation of Nature (IUCN) last week delivered a letter to the Mexican government requesting it regulate tourism centered on the threatened firefly species
Photinus palaciosi
. Endemic to Mexico’s Tlaxcala forests,
P. palaciosi
is one of the few species that glow in synchrony, offering an annual spectacle that attracts thousands of visitors during summer mating season. The letter describes how littering, artificial light, and noise interfere with the insects’ courtship and eg...
Source: ScienceNOW - August 10, 2023 Category: Science Source Type: news
News at a glance: A win for obesity drugs, a new infectious disease institute head, and Mexican fireflies under threat
CONSERVATION
Researchers raise alarm over threat to Mexican fireflies
Scientists from the International Union for Conservation of Nature (IUCN) last week delivered a letter to the Mexican government requesting it regulate tourism centered on the threatened firefly species
Photinus palaciosi
. Endemic to Mexico’s Tlaxcala forests,
P. palaciosi
is one of the few species that glow in synchrony, offering an annual spectacle that attracts thousands of visitors during summer mating season. The letter describes how littering, artificial light, and noise interfere with the insects’ courtship and eg...
Source: Science of Aging Knowledge Environment - August 10, 2023 Category: Geriatrics Source Type: research
WHO Classifies EG.5 as COVID-19 ' Variant of Interest ' WHO Classifies EG.5 as COVID-19 ' Variant of Interest '
The World Health Organization on Wednesday classified the EG.5 coronavirus strain circulating in the US and China as a"variant of interest."Reuters Health Information
Source: Medscape Medical News Headlines - August 10, 2023 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
Can a WHO pandemic treaty help poorer nations in future outbreaks?
Global accord aims to avoid the damage caused during Covid-19 and ensure vaccines and medical equipment are distributed equally to allCovid-19 caught the world unprepared; the scramble it prompted for treatments, tests, protective equipment and vaccines favoured the world ’s richest nations. To avoid the same thing happening in future pandemics, a group of world leaders has proposed a pandemic treaty, which is being negotiated in a series of international meetings hosted by the World Health Organization (WHO).The draft treaty is aimed at ensuring equity in distributing all that is needed to handle a future pandemic, inst...
Source: Guardian Unlimited Science - August 10, 2023 Category: Science Authors: Kaamil Ahmed Tags: Global health Global development Coronavirus Infectious diseases Science World news World Health Organization Society Pharmaceuticals industry Business Source Type: news
WHO declares ‘Eris’ Covid strain a variant of interest as UK cases rise
Health risk of EG.5, which is related to Omicron subvariant, judged to be low but may drive larger wave of infectionsA new strain of Covid-19 that is circulating in the UK has been designated as a variant of interest by the World Health Organization, although the public health risk has been judged as low.The variant, known as EG.5 or “Eris”, is related to an Omicron subvariant called XBB.1.9.2, and is growing in prevalence globally, with countries including the UK, China, and US among those affected.Continue reading...
Source: Guardian Unlimited Science - August 9, 2023 Category: Science Authors: Nicola Davis Science correspondent Tags: Coronavirus World Health Organization Infectious diseases Science World news Microbiology UK news Source Type: news
WHO declares ‘Eris’ Covid strain a variant of interest as cases rise globally
Health risk of EG.5, which is related to Omicron subvariant, judged to be low but may drive larger wave of infectionsA new strain of Covid-19 has been designated as a variant of interest by the World Health Organization, although the public health risk has been judged as low.The variant, known as EG.5 or “Eris”, is related to an Omicron subvariant called XBB.1.9.2, and is growing in prevalence globally, with countries including the UK, China and US among those affected.Continue reading...
Source: Guardian Unlimited Science - August 9, 2023 Category: Science Authors: Nicola Davis Science correspondent Tags: Coronavirus World Health Organization Infectious diseases Science World news Microbiology UK news Source Type: news
Incidence of Coronavirus Disease 2019 (COVID-19) among healthcare workers during the first and second wave in the Democratic Republic of the Congo: a descriptive study
Healthcare workers (HCWs) are at the frontline of response to the COVID-19 pandemic. Protecting HCWs is of paramount importance to the World Health Organization (WHO). Outbreak investigation which is based on ...
Source: BMC Infectious Diseases - August 8, 2023 Category: Infectious Diseases Authors: Jean Paul Muambangu Milambo, James Ndirangu, Samuel Mangala, Hannah Simba and Landry Kabego Tags: Research Source Type: research
IJERPH, Vol. 20, Pages 6526: The Relationship between Socio-Demographic Factors, Preventive Health Behaviors and Acceptance of COVID-19 Vaccine among Israeli Pregnant Women during the Coronavirus Pandemic
Conclusions: These findings can be helpful as a preliminary evidence base for policy-making at present and for future epidemics regarding guidelines on PHB adjusted for pregnant women.
Source: International Journal of Environmental Research and Public Health - August 4, 2023 Category: Environmental Health Authors: Shir Nahum Talma Kushnir Tags: Article Source Type: research
The impact of the Covid 19 pandemic in colorectal cancer
CONCLUSIONS: In this study, it was seen that the COVID-19 pandemic did not affect morbidity and mortality in CRC surgery, but it prolonged admission waiting and operation waiting times. Since there is very little data in the literature regarding the effect of COVID-19 on CRC surgery, our study will guide future studies on this subject.KEY WORDS: Colorectal Cancer, Coronavirus disease 2019, COVID-19, Surgery.PMID:37530050
Source: Annali Italiani di Chirurgia - August 2, 2023 Category: Surgery Authors: Afig Gojayev Cemil Yuksel Ogun Ersen Umit Mercan Haydar Celasin Ali Ekrem Unal Salim Demirci Source Type: research
