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Therapy: Statin Therapy
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Total 11873 results found since Jan 2013.
A cardiovascular polypill for secondary stroke prevention in a tertiary centre in Ghana (SMAART): a phase 2 randomised clinical trial
Lancet Glob Health. 2023 Oct;11(10):e1619-e1628. doi: 10.1016/S2214-109X(23)00347-9.ABSTRACTBACKGROUND: A cardiovascular polypill containing generic drugs might facilitate sustained implementation of and adherence to evidence-based treatments, especially in resource-limited settings. However, the impact of a cardiovascular polypill in mitigating atherosclerotic risk among stroke survivors has not been assessed. We aimed to compare a polypill regimen with usual care on carotid intima-media thickness (CIMT) regression after ischaemic stroke.METHODS: In SMAART, a phase 2 parallel, open-label, assessor-masked, randomised clini...
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Fred Stephen Sarfo Jenifer Voeks Sheila Adamu Benedict Apaw Agyei Manolo Agbenorku Nyantakyi Adu-Darko Mercy Adomah Oteng Vida Obese Rexford Adu Gyamfi Nathaniel Adusei Mensah Raelle Tagge Michael Ampofo Samuel Amoabeng Kontoh Samuel Blay Nguah Bruce Ovbi Source Type: research
Sex differences in lipids: A life course approach
Atherosclerosis. 2023 Sep 1:117270. doi: 10.1016/j.atherosclerosis.2023.117270. Online ahead of print.ABSTRACTDifferences between men and women in lipids and lipoproteins are observed in distribution and trajectory from infancy to adulthood in the general population. However, these differences are more pronounced in hereditary lipid disorders such as familial hypercholesterolemia (FH) when absolute cholesterol levels are higher from birth onwards. In the early life course, girls compared to boys have higher low-density lipoprotein cholesterol (LDL-C) levels and total cholesterol, while high-density lipoprotein cholesterol ...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Kirsten B Holven Jeanine Roeters van Lennep Source Type: research
Statins and portal hypertension: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: Treatment with statins did not decrease significantly portal hypertension.PMID:37723637 | DOI:10.2174/0929867331666230918114451
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Tannaz Jamialahmadi Željko Reiner Maryam Matbou Riahi Seyed Ahmad Emami Zahra Tayarani-Najaran Sepideh Salehabadi Prashant Kesharwani Khalid Al-Rasadi Amirhossein Sahebkar Source Type: research
Transient left bundle branch block associated with very high coronary artery calcium: a case report
We present a case of very high CAC in a 64-year-old woman with hypertension, type 2 diabetes, and hyperlipidemia presenting with dyspnea. Initial electrocardiogram (ECG) demonstrated normal conduction with a heart rate of 76 beats/min, but new T-wave inversions in V1-V4 and a high-sensitivity troponin-I (hsTnI) value of 6 ng/L (normal < 6 ng/L). Repeat ECG in the emergency department showed normal sinus rhythm (heart rate of 80 beats/min); however, it subsequently demonstrated a left bundle branch block (LBBB) with a repeat hsTnI of 7 ng/L. Stress testing with pharmacologic single-photon emission computerized tomography...
Source: Atherosclerosis - September 19, 2023 Category: Cardiology Authors: Alexander C Razavi Sindhu Prabakaran Mariem Sawan Lakshmi Tummala Ifeoma Onuorah Sagar B Amin Marly van Assen Carlo N De Cecco Arshed A Quyyumi Seamus P Whelton Laurence S Sperling Francois G Rollin Source Type: research
Evaluating the prevalence of lipid assessments in children in Alberta, Canada
CMAJ Open. 2023 Sep 19;11(5):E820-E825. doi: 10.9778/cmajo.20220163. Print 2023 Sep-Oct.ABSTRACTBACKGROUND: Familial hypercholesterolemia is a common, inherited, life-threatening and treatable condition that is characterized by marked elevations of low-density lipoprotein cholesterol (LDL-C), resulting in a high risk of cardiovascular disease, but treatment starting in childhood dramatically reduces this risk. We sought to evaluate the prevalence of pediatric lipid assessments among children in Alberta.METHODS: We reviewed laboratory and administrative data from Alberta Health between Apr. 1, 2012, and Dec. 31, 2021. We ev...
Source: cmaj - September 19, 2023 Category: General Medicine Authors: Susan Christian Ross Ridsdale Mu Lin Michael Khoury Source Type: research
Treat-to-Target LDL Strategy of Statin Dosing Is Noninferior to High-Intensity Dosing
Am Fam Physician. 2023 Sep;108(3):Online.NO ABSTRACTPMID:37725472
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: David C Slawson Source Type: research
Evaluating the prevalence of lipid assessments in children in Alberta, Canada
CMAJ Open. 2023 Sep 19;11(5):E820-E825. doi: 10.9778/cmajo.20220163. Print 2023 Sep-Oct.ABSTRACTBACKGROUND: Familial hypercholesterolemia is a common, inherited, life-threatening and treatable condition that is characterized by marked elevations of low-density lipoprotein cholesterol (LDL-C), resulting in a high risk of cardiovascular disease, but treatment starting in childhood dramatically reduces this risk. We sought to evaluate the prevalence of pediatric lipid assessments among children in Alberta.METHODS: We reviewed laboratory and administrative data from Alberta Health between Apr. 1, 2012, and Dec. 31, 2021. We ev...
Source: cmaj - September 19, 2023 Category: General Medicine Authors: Susan Christian Ross Ridsdale Mu Lin Michael Khoury Source Type: research
Treat-to-Target LDL Strategy of Statin Dosing Is Noninferior to High-Intensity Dosing
Am Fam Physician. 2023 Sep;108(3):Online.NO ABSTRACTPMID:37725472
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: David C Slawson Source Type: research
Statins and portal hypertension: a systematic review and meta-analysis of randomized controlled trials
CONCLUSION: Treatment with statins did not decrease significantly portal hypertension.PMID:37723637 | DOI:10.2174/0929867331666230918114451
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Tannaz Jamialahmadi Željko Reiner Maryam Matbou Riahi Seyed Ahmad Emami Zahra Tayarani-Najaran Sepideh Salehabadi Prashant Kesharwani Khalid Al-Rasadi Amirhossein Sahebkar Source Type: research
Pravastatin for lowering lipids
CONCLUSIONS: Pravastatin lowers blood total cholesterol, LDL cholesterol and triglyceride in a dose-dependent linear fashion. This review did not provide a good estimate of the incidence of harms associated with pravastatin because of the lack of reporting of adverse effects in 48.4% of the randomized placebo-controlled trials.PMID:37721222 | DOI:10.1002/14651858.CD013673.pub2
Source: Cochrane Database of Systematic Reviews - September 18, 2023 Category: General Medicine Authors: Stephen P Adams Nima Alaeiilkhchi Sara Tasnim James M Wright Source Type: research
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
Nurse Practitioner Care Compared to Primary Care or Nephrologist Care in Early CKD
CONCLUSIONS: Nurse practitioner care for patients with CKD was associated with better guideline-concordant care than primary care alone or nephrologist care, with clinical outcomes that were better than or equivalent to primary care alone, and similar to those with care by nephrologists.PMID:37721865 | DOI:10.2215/CJN.0000000000000305
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 18, 2023 Category: Urology & Nephrology Authors: Matthew T James Tayler D Scory Ellen Novak Braden J Manns Brenda R Hemmelgarn Aminu K Bello Pietro Ravani Bhavneet Kahlon Jennifer M MacRae Paul E Ronksley Source Type: research
Atherosclerosis as a Risk Factor for IBD: A Population-Based Case-Control Study
CONCLUSIONS: A history of an atherosclerotic-related condition is associated with increased odds of developing IBD, particularly among older adults. Future studies should investigate whether drugs targeting atherosclerotic-related inflammation may prevent IBD in higher-risk individuals.PMID:37721310 | DOI:10.14309/ajg.0000000000002502
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Adam S Faye Jordan Axelrad Jiangwei Sun Jonas Halfvarson Jonas S öderling Ola Ol én Jonas F Ludvigsson Source Type: research
