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Total 11873 results found since Jan 2013.
Current Therapeutics in Primary Sclerosing Cholangitis
J Clin Transl Hepatol. 2023 Oct 28;11(5):1267-1281. doi: 10.14218/JCTH.2022.00068S. Epub 2023 Apr 17.ABSTRACTPrimary sclerosing cholangitis (PSC) is an orphan, cholestatic liver disease that is characterized by inflammatory biliary strictures with variable progression to end-stage liver disease. Its pathophysiology is poorly understood. Chronic biliary inflammation is likely driven by immune dysregulation, gut dysbiosis, and environmental exposures resulting in gut-liver crosstalk and bile acid metabolism disturbances. There is no proven medical therapy that alters disease progression in PSC, with the commonly prescribed u...
Source: Clinical Colorectal Cancer - August 14, 2023 Category: Cancer & Oncology Authors: Natassia Tan John Lubel William Kemp Stuart Roberts Ammar Majeed Source Type: research
A meta-analysis of randomized controlled trials of statin-based therapy in patients with COVID-19
CONCLUSION: A critical appraisal of published randomized controlled trials on statin therapy in COVID-19 did not show any significant effect on mortality, the risk of transfer to intensive care, or mechanical ventilation.PMID:37578125 | DOI:10.5414/CP204446
Source: International Journal of Clinical Pharmacology and Therapeutics - August 14, 2023 Category: Drugs & Pharmacology Authors: Guoying Kao Yunlin Chen Jun Xiao Jinqi Fan Source Type: research
Current Therapeutics in Primary Sclerosing Cholangitis
J Clin Transl Hepatol. 2023 Oct 28;11(5):1267-1281. doi: 10.14218/JCTH.2022.00068S. Epub 2023 Apr 17.ABSTRACTPrimary sclerosing cholangitis (PSC) is an orphan, cholestatic liver disease that is characterized by inflammatory biliary strictures with variable progression to end-stage liver disease. Its pathophysiology is poorly understood. Chronic biliary inflammation is likely driven by immune dysregulation, gut dysbiosis, and environmental exposures resulting in gut-liver crosstalk and bile acid metabolism disturbances. There is no proven medical therapy that alters disease progression in PSC, with the commonly prescribed u...
Source: Clinical Colorectal Cancer - August 14, 2023 Category: Cancer & Oncology Authors: Natassia Tan John Lubel William Kemp Stuart Roberts Ammar Majeed Source Type: research
HDL abnormalities in type 2 diabetes: Clinical implications
Atherosclerosis. 2023 Aug 3:117213. doi: 10.1016/j.atherosclerosis.2023.117213. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) represents the primary cause of mortality among patients with Type 2 Diabetes Mellitus (T2DM). In this population, High-Density Lipoprotein (HDL) particles exhibit abnormalities in number, composition, and function, culminating in diminished anti-atherosclerotic capabilities despite normal HDL cholesterol (HDL-C) concentrations. Hyperglycemic conditions contribute to these alterations in HDL kinetics, composition, and function, causing T2DM patients' HDL particles to e...
Source: Atherosclerosis - August 14, 2023 Category: Cardiology Authors: Alexandro J Martagon Rafael Zubir án Rogelio Gonz ález-Arellanes Samantha Praget-Bracamontes J Adri án Rivera-Alcántara Carlos A Aguilar-Salinas Source Type: research
A meta-analysis of randomized controlled trials of statin-based therapy in patients with COVID-19
CONCLUSION: A critical appraisal of published randomized controlled trials on statin therapy in COVID-19 did not show any significant effect on mortality, the risk of transfer to intensive care, or mechanical ventilation.PMID:37578125 | DOI:10.5414/CP204446
Source: International Journal of Clinical Pharmacology and Therapeutics - August 14, 2023 Category: Drugs & Pharmacology Authors: Guoying Kao Yunlin Chen Jun Xiao Jinqi Fan Source Type: research
Development and validation of a sensitive LC-MS/MS method for simultaneous analysis of clopidogrel and simvastatin and their main metabolites in beagles: Application to pharmacokinetic drug interactions
This study developed and validated an LC-MS/MS method for the simultaneous determination of CLP, clopidogrel carboxylic acid (CLPCA), 2-oxo-clopidogrel (2-O-CLP), SV, and simvastatin hydroxy acid (SVA) in beagle plasma. Chromatographic separation was achieved on an InfinityLab Poroshell 120 SB-C8 column (2.1 × 100 mm, 2.7 μm) using methanol and 0.1% formic acid in water as the mobile phase at a flow rate of 0.3 mL/min in gradient mode. The lower limits of quantification are 0.1, 0.8, 0.05, 0.05, and 0.05 ng/mL for CLP, CLPCA, 2-O-CLP, SV, and SVA, respectively. The selectivity, linearity, accuracy, precision, extraction ...
Source: Biomedical Chromatography : BMC - August 14, 2023 Category: Biomedical Science Authors: Xiao Tang Yu Zhang Yue Yi Zhang Zunjian Zhang Yuan Tian Source Type: research
A meta-analysis of randomized controlled trials of statin-based therapy in patients with COVID-19
CONCLUSION: A critical appraisal of published randomized controlled trials on statin therapy in COVID-19 did not show any significant effect on mortality, the risk of transfer to intensive care, or mechanical ventilation.PMID:37578125 | DOI:10.5414/CP204446
Source: International Journal of Clinical Pharmacology and Therapeutics - August 14, 2023 Category: Drugs & Pharmacology Authors: Guoying Kao Yunlin Chen Jun Xiao Jinqi Fan Source Type: research
