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Total 84379 results found since Jan 2013.
NECAB2 is an endosomal protein important for striatal function
Free Radic Biol Med. 2023 Sep 16:S0891-5849(23)00615-9. doi: 10.1016/j.freeradbiomed.2023.09.003. Online ahead of print.ABSTRACTSynaptic signaling depends on ATP generated by mitochondria. Dysfunctional mitochondria shift the redox balance towards a more oxidative environment. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction. We found that neuronal calcium-binding protein 2 (NECAB2) plays a role in striatal function and mitochondrial homeostasis. NECAB2 is a predominantly endosomal striatal protein which partially colocalizes with mitochondria. This colocalization is enhance...
Source: Free Radical Biology and Medicine - September 18, 2023 Category: Biology Authors: Diones Bueno Partha Narayan Dey Teresa Schacht Christina Wolf Verena W üllner Elena Morpurgo Liliana Rojas-Charry Lena Sessinghaus Petra Leukel Clemens Sommer Konstantin Radyushkin Luise Florin Jan Baumgart Paul Stamm Andreas Daiber Guilherme Horta Leona Source Type: research
Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
Free Radic Biol Med. 2023 Sep 16:S0891-5849(23)00640-8. doi: 10.1016/j.freeradbiomed.2023.09.016. Online ahead of print.ABSTRACTIn the tumor microenvironment (TME), communication between cancer cells and tumor-associated macrophages (TAMs) through secreted extracellular proteins promotes cancer progression. Here, we observed that co-culturing cancer cells (4T1) and macrophage cells (Raw264.7) significantly enhanced superoxide production in both cell types. Using MALDI-TOF, we identified PKM2 as a highly secreted protein by Raw264.7 cells and bone marrow-derived monocytes. The extracellular recombinant PKM2 protein not only...
Source: Free Radical Biology and Medicine - September 18, 2023 Category: Biology Authors: Amir Hamza Jung Yoon Cho Kim Cuong Cap Abu Jubayer Hossain Jae-Gyu Kim Jae-Bong Park Source Type: research
Association between circadian clock gene expressions and meal timing in young and older adults
In this study, we investigated the relationship between clock gene expression and meal timing in young and older adults. In this cross-sectional study, we enrolled 51 healthy young men and 35 healthy older men (age, mean±standard deviation: 24 ± 4 and 70 ± 4 y, respectively). Under daily living conditions, beard follicle cells were collected at 4-h intervals over a 24-h period to evaluate clock gene expression. Participants were asked to record the timing of habitual sleep and wake-up, breakfast, lunch, and dinner. From these data, we calculated "From bedtime to breakfast time," "From wake up to first meal time," and "F...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Masaki Takahashi Mayuko Fukazawa Yu Tahara Hyeon-Ki Kim Kumpei Tanisawa Tomoko Ito Takashi Nakaoka Mitsuru Higuchi Shigenobu Shibata Source Type: research
Early-to-mid pregnancy sleep and circadian markers in relation to birth outcomes: An epigenetics pilot study
Chronobiol Int. 2023 Sep 18:1-11. doi: 10.1080/07420528.2023.2256854. Online ahead of print.ABSTRACTMaternal sleep and circadian health during pregnancy are emerging as important predictors of pregnancy outcomes, but examination of potential epigenetic mechanisms is rare. We investigated links between maternal leukocyte DNA methylation of circadian genes and birth outcomes within a pregnancy cohort. Women (n = 96) completed a questionnaire and provided a blood sample at least once during early-to-mid pregnancy (average gestation weeks = 14.2). Leukocyte DNA was isolated and DNA methylation (average percent of methylation) ...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Erica C Jansen Kelvin Pengyuan Zhang Dana C Dolinoy Helen J Burgess Louise M O'Brien Elizabeth Langen Naquia Unwala Jessa Ehlinger Molly C Mulcahy Jaclyn M Goodrich Source Type: research
Intraindividual variability in sleep duration and college degree attainment
The objective of the current study was to examine the relationship between sleep characteristics and college degree attainment. Participants were 968 college students (72% female; mean age 19.7 [1.7]). Participants completed a psychosocial and sleep questionnaire battery followed by one week of daily sleep diaries. Academic degree completion data was obtained from the university registrar 10 years later. Logistic regression examined whether mean and variability in sleep duration and sleep efficiency and insomnia symptoms predicted degree attainment, adjusting for age, gender, semester, grade point average (GPA), and percei...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Jessica R Dietch Alisa Huskey Ian O Dadeboe Danica C Slavish Daniel J Taylor Source Type: research
Sensation seeking, drinking motives, and going out mediate the link between eveningness and alcohol use and problems in adolescence
Chronobiol Int. 2023 Sep 18:1-11. doi: 10.1080/07420528.2023.2256396. Online ahead of print.ABSTRACTThe present study was aimed at obtaining a more comprehensive understanding of the possible mediating factors in the morningness-eveningness → alcohol consumption relation. We explored the role of mediators such as sensation seeking, the frequency of going out in the evenings, and drinking motives. We tested the proposed mediation model via structural equation modeling based on cross-sectional research conducted among Hungarian adolescents and young adults (N = 1695, 42.5% male, Mage = 18.98, SDage = 1.89). The outcomes in...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Adrien Rig ó Istv án Tóth-Király Anna Magi Andrea Eisinger Zsolt Demetrovics R óbert Urbán Source Type: research
Is implementing a post-lunch nap beneficial on evening performance, following two nights partial sleep restriction?
Chronobiol Int. 2023 Sep 18:1-18. doi: 10.1080/07420528.2023.2253908. Online ahead of print.ABSTRACTWe have investigated the effects that partial-sleep-restriction (PSR0, 4-h sleep retiring at 02:30 and waking at 06:30 h for two consecutive nights) have on 07:30 and 17:00 h cognitive and submaximal weightlifting; and whether this performance improves at 17:00 h following a 13:00 h powernap (0, 30 or 60-min). Fifteen resistance-trained males participated in this study. Prior to the experimental protocol, one repetition max (1RM) bench press and back squat, normative habitual sleep and food intake were recorded. Participants...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Chloe Gallagher Chloe E Green Michael L Kenny Jessie R Evans Glenn D W McCullagh Samuel A Pullinger Ben J Edwards Source Type: research
The histone demethylase KdmB is part of a trimeric protein complex and mediates virulence and mycotoxin production in Penicillium expansum
Fungal Genet Biol. 2023 Sep 16:103837. doi: 10.1016/j.fgb.2023.103837. Online ahead of print.ABSTRACTEpigenetic modification of chromosome structure has increasingly been associated with alterations in secondary metabolism and sporulation defects in filamentous fungal pathogens. Recently, the epigenetic reader protein SntB was shown to govern virulence, spore production and mycotoxin synthesis in the fruit pathogen Penicillium expansum. Through immunoprecipitation-coupled mass spectrometry, we found that SntB is a member of a protein complex with KdmB, a histone demethylase and the essential protein RpdA, a histone deacety...
Source: Fungal Genetics and Biology - September 18, 2023 Category: Biology Authors: Dianiris Luciano-Rosario Omer Barda Joanna Tannous Dean Frawley Özgür Bayram Dov Prusky Edward Sionov Nancy P Keller Source Type: research
Valuing mortality attributable to present and future temperature extremes in Argentina
This study analyzes the weather-related health damage of present and future extreme temperatures in Argentina. Focusing on mortality, short-term impacts of temperature are obtained by regressing monthly mortality rates on inter-annual monthly weather variability. For this purpose, a countrywide panel dataset at the municipal level was constructed from the universe of deaths between 2010 and 2019, and daily meteorological records from the ERA5 weather dataset. Then, NASA Earth Exchange Global Daily Downscaled Projections (NEX-GDDP) are used to project future mortality by 2085 under two climate scenarios. Finally, present an...
Source: Economics and Human Biology - September 18, 2023 Category: Biology Authors: Christian Garc ía-Witulski Mariano Javier Rabassa Mariana Conte Grand Julie Rozenberg Source Type: research
Multiomic analysis implicates FOXO4 in genetic regulation of chick lens fiber cell differentiation
Dev Biol. 2023 Sep 16:S0012-1606(23)00159-8. doi: 10.1016/j.ydbio.2023.09.005. Online ahead of print.ABSTRACTA classic model for identification of novel differentiation mechanisms and pathways is the eye lens that consists of a monolayer of quiescent epithelial cells that are the progenitors of a core of mature fully differentiated fiber cells. The differentiation of lens epithelial cells into fiber cells follows a coordinated program involving cell cycle exit, expression of key structural proteins and the hallmark elimination of organelles to achieve transparency. Although multiple mechanisms and pathways have been identi...
Source: Developmental Biology - September 18, 2023 Category: Biology Authors: Lisa Brennan Joshua Disatham A Sue Menko Marc Kantorow Source Type: research
Valuing mortality attributable to present and future temperature extremes in Argentina
This study analyzes the weather-related health damage of present and future extreme temperatures in Argentina. Focusing on mortality, short-term impacts of temperature are obtained by regressing monthly mortality rates on inter-annual monthly weather variability. For this purpose, a countrywide panel dataset at the municipal level was constructed from the universe of deaths between 2010 and 2019, and daily meteorological records from the ERA5 weather dataset. Then, NASA Earth Exchange Global Daily Downscaled Projections (NEX-GDDP) are used to project future mortality by 2085 under two climate scenarios. Finally, present an...
Source: Economics and Human Biology - September 18, 2023 Category: Biology Authors: Christian Garc ía-Witulski Mariano Javier Rabassa Mariana Conte Grand Julie Rozenberg Source Type: research
Equilibrium vitrification of oocytes using low concentrations of cryoprotectants
In this study, we investigated whether mouse oocytes are vitrifiable with EDFS10/10a in a highly dehydrated/concentrated state, and whether they can remain fertilizable and developing into embryos after vitrification. When mature mouse oocytes were vitrified in liquid nitrogen and after 4-28 days of storage at -80 °C, high survival rates were observed (88-99%). Vitrified and warmed oocytes were subjected to partial zona dissection and in vitro fertilized. The rate of 2-cell stage was 80-82%. Blastocyst formation rate was 55-70% which was similar to that of embryos derived from fresh oocytes. After the 2-cell embryos were ...
Source: Cryobiology - September 18, 2023 Category: Biology Authors: Juan Qiu Kazutsugu Matsukawa Keisuke Edashige Source Type: research
The histone demethylase KdmB is part of a trimeric protein complex and mediates virulence and mycotoxin production in Penicillium expansum
Fungal Genet Biol. 2023 Sep 16:103837. doi: 10.1016/j.fgb.2023.103837. Online ahead of print.ABSTRACTEpigenetic modification of chromosome structure has increasingly been associated with alterations in secondary metabolism and sporulation defects in filamentous fungal pathogens. Recently, the epigenetic reader protein SntB was shown to govern virulence, spore production and mycotoxin synthesis in the fruit pathogen Penicillium expansum. Through immunoprecipitation-coupled mass spectrometry, we found that SntB is a member of a protein complex with KdmB, a histone demethylase and the essential protein RpdA, a histone deacety...
Source: Fungal Genetics and Biology - September 18, 2023 Category: Biology Authors: Dianiris Luciano-Rosario Omer Barda Joanna Tannous Dean Frawley Özgür Bayram Dov Prusky Edward Sionov Nancy P Keller Source Type: research
Approaches to characterize chromatin subcompartment organization in the cell nucleus
Curr Opin Struct Biol. 2023 Sep 16;83:102695. doi: 10.1016/j.sbi.2023.102695. Online ahead of print.ABSTRACTThe mechanism of self-organization of chromatin subcompartments on the 0.1-1 μm scale and their impact on genome-associated activities has long been a key aspect of research on nuclear organization. Understanding the underlying structure-function relationship, however, remains challenging due to the complex hierarchical structure of chromatin and the polymorphic organization of subcompartments that assemble around it. Towards this goal, approaches to measure local properties and compositional dynamics of chromatin i...
Source: Current Opinion in Structural Biology - September 18, 2023 Category: Biology Authors: Robin Weinmann Lukas Frank Karsten Rippe Source Type: research
