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Total 84379 results found since Jan 2013.
Early-to-mid pregnancy sleep and circadian markers in relation to birth outcomes: An epigenetics pilot study
Chronobiol Int. 2023 Sep 18:1-11. doi: 10.1080/07420528.2023.2256854. Online ahead of print.ABSTRACTMaternal sleep and circadian health during pregnancy are emerging as important predictors of pregnancy outcomes, but examination of potential epigenetic mechanisms is rare. We investigated links between maternal leukocyte DNA methylation of circadian genes and birth outcomes within a pregnancy cohort. Women (n = 96) completed a questionnaire and provided a blood sample at least once during early-to-mid pregnancy (average gestation weeks = 14.2). Leukocyte DNA was isolated and DNA methylation (average percent of methylation) ...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Erica C Jansen Kelvin Pengyuan Zhang Dana C Dolinoy Helen J Burgess Louise M O'Brien Elizabeth Langen Naquia Unwala Jessa Ehlinger Molly C Mulcahy Jaclyn M Goodrich Source Type: research
Intraindividual variability in sleep duration and college degree attainment
The objective of the current study was to examine the relationship between sleep characteristics and college degree attainment. Participants were 968 college students (72% female; mean age 19.7 [1.7]). Participants completed a psychosocial and sleep questionnaire battery followed by one week of daily sleep diaries. Academic degree completion data was obtained from the university registrar 10 years later. Logistic regression examined whether mean and variability in sleep duration and sleep efficiency and insomnia symptoms predicted degree attainment, adjusting for age, gender, semester, grade point average (GPA), and percei...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Jessica R Dietch Alisa Huskey Ian O Dadeboe Danica C Slavish Daniel J Taylor Source Type: research
Sensation seeking, drinking motives, and going out mediate the link between eveningness and alcohol use and problems in adolescence
Chronobiol Int. 2023 Sep 18:1-11. doi: 10.1080/07420528.2023.2256396. Online ahead of print.ABSTRACTThe present study was aimed at obtaining a more comprehensive understanding of the possible mediating factors in the morningness-eveningness → alcohol consumption relation. We explored the role of mediators such as sensation seeking, the frequency of going out in the evenings, and drinking motives. We tested the proposed mediation model via structural equation modeling based on cross-sectional research conducted among Hungarian adolescents and young adults (N = 1695, 42.5% male, Mage = 18.98, SDage = 1.89). The outcomes in...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Adrien Rig ó Istv án Tóth-Király Anna Magi Andrea Eisinger Zsolt Demetrovics R óbert Urbán Source Type: research
Is implementing a post-lunch nap beneficial on evening performance, following two nights partial sleep restriction?
Chronobiol Int. 2023 Sep 18:1-18. doi: 10.1080/07420528.2023.2253908. Online ahead of print.ABSTRACTWe have investigated the effects that partial-sleep-restriction (PSR0, 4-h sleep retiring at 02:30 and waking at 06:30 h for two consecutive nights) have on 07:30 and 17:00 h cognitive and submaximal weightlifting; and whether this performance improves at 17:00 h following a 13:00 h powernap (0, 30 or 60-min). Fifteen resistance-trained males participated in this study. Prior to the experimental protocol, one repetition max (1RM) bench press and back squat, normative habitual sleep and food intake were recorded. Participants...
Source: Chronobiology International - September 18, 2023 Category: Biology Authors: Chloe Gallagher Chloe E Green Michael L Kenny Jessie R Evans Glenn D W McCullagh Samuel A Pullinger Ben J Edwards Source Type: research
Equilibrium vitrification of oocytes using low concentrations of cryoprotectants
In this study, we investigated whether mouse oocytes are vitrifiable with EDFS10/10a in a highly dehydrated/concentrated state, and whether they can remain fertilizable and developing into embryos after vitrification. When mature mouse oocytes were vitrified in liquid nitrogen and after 4-28 days of storage at -80 °C, high survival rates were observed (88-99%). Vitrified and warmed oocytes were subjected to partial zona dissection and in vitro fertilized. The rate of 2-cell stage was 80-82%. Blastocyst formation rate was 55-70% which was similar to that of embryos derived from fresh oocytes. After the 2-cell embryos were ...
Source: Cryobiology - September 18, 2023 Category: Biology Authors: Juan Qiu Kazutsugu Matsukawa Keisuke Edashige Source Type: research
Multiomic analysis implicates FOXO4 in genetic regulation of chick lens fiber cell differentiation
Dev Biol. 2023 Sep 16:S0012-1606(23)00159-8. doi: 10.1016/j.ydbio.2023.09.005. Online ahead of print.ABSTRACTA classic model for identification of novel differentiation mechanisms and pathways is the eye lens that consists of a monolayer of quiescent epithelial cells that are the progenitors of a core of mature fully differentiated fiber cells. The differentiation of lens epithelial cells into fiber cells follows a coordinated program involving cell cycle exit, expression of key structural proteins and the hallmark elimination of organelles to achieve transparency. Although multiple mechanisms and pathways have been identi...
Source: Developmental Biology - September 18, 2023 Category: Biology Authors: Lisa Brennan Joshua Disatham A Sue Menko Marc Kantorow Source Type: research
Approaches to characterize chromatin subcompartment organization in the cell nucleus
Curr Opin Struct Biol. 2023 Sep 16;83:102695. doi: 10.1016/j.sbi.2023.102695. Online ahead of print.ABSTRACTThe mechanism of self-organization of chromatin subcompartments on the 0.1-1 μm scale and their impact on genome-associated activities has long been a key aspect of research on nuclear organization. Understanding the underlying structure-function relationship, however, remains challenging due to the complex hierarchical structure of chromatin and the polymorphic organization of subcompartments that assemble around it. Towards this goal, approaches to measure local properties and compositional dynamics of chromatin i...
Source: Current Opinion in Structural Biology - September 18, 2023 Category: Biology Authors: Robin Weinmann Lukas Frank Karsten Rippe Source Type: research
Height and political activism in rural Arag ón (Spain) during the 20th century. A new perspective using individual-level data
This article explores the relationship between the political leanings of more than 1000 men born in the 1870-1970 s in 11 rural Aragonese villages and their biological well-being during childhood and adolescence, proxied by height. The aim is to test whether an individual was more likely to be left-wing if his level of biological well-being was lower and, therefore, with more incentives to fight against the social inequality that had negatively affected his family. Our results confirm that, for most of the study period, there was a strong relationship between shorter height and political activism1 in left-wing parties and ...
Source: Economics and Human Biology - September 17, 2023 Category: Biology Authors: Francisco J Marco-Gracia Margarita L ópez-Antón Source Type: research
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00636-6. doi: 10.1016/j.freeradbiomed.2023.09.012. Online ahead of print.ABSTRACTFerroptosis is a novel form of cell death that plays a critical role in the pathological and physiological processes of early brain injury following subarachnoid hemorrhage. Melatonin, as the most potent endogenous antioxidant, has shown strong protective effects against pathological changes following subarachnoid hemorrhage, but its impact on ferroptosis induced by subarachnoid hemorrhage remains unexplored. In our study, we established a subarachnoid hemorrhage model in male SD rats. We found th...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Sheng-Ji Ma Chen Li Cong Yan Nan Liu Guang-You Jiang Hong-Rui Yang Hao-Chen Yan Ji-Yi Li Huai-Lei Liu Cheng Gao Source Type: research
Asiatic acid protects against pressure overload-induced heart failure in mice by inhibiting mitochondria-dependent apoptosis
CONCLUSIONS: Our findings suggest that AA effectively combats chronic TAC-induced and hydrogen peroxide-induced cardiomyocyte apoptosis through a mitochondria-dependent mechanism. AA reduces cellular levels of oxidative stress and inhibits the activation of the JNK pathway, highlighting its potential therapeutic value in the treatment of HF.PMID:37717794 | DOI:10.1016/j.freeradbiomed.2023.09.015
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Junjie Du Dongmin Yu Jinghang Li Linjie Si Dawei Zhu Ben Li Yizhou Gao Lifu Sun Xufeng Wang Xiaowei Wang Source Type: research
Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression
This study aimed to examine the synergistic therapeutic impact of combining erastin with a bioactive flavonoid compound luteolin on the ferroptosis-mediated suppression of colon cancer. Human colon cancer HCT116 and SW480 cells were used for the in vitro studies and a xenograft of colon cancer model in BALB/c nude mice was established for the in vivo experiments. The results showed that combinative treatment of luteolin and erastin effectively inhibited the viability and proliferation of colon cancer cells. Luteolin and erastin cotreatment synergistically induced ferroptosis, concomitant with a reduction in glutathione and...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Yinli Zheng Leyan Li Haipeng Chen Yuting Zheng Xuanjing Tan Guiyu Zhang Ruidi Jiang Hong Yu Senyi Lin Yijie Wei Ying Wang Rong Zhang Zhongqiu Liu Jinjun Wu Source Type: research
Hydroxyl radical generations form the physiologically relevant Fenton-like reactions
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00637-8. doi: 10.1016/j.freeradbiomed.2023.09.013. Online ahead of print.ABSTRACTIron(II) species can participate in the Fenton and Fenton-like reactions to generate the hydroxyl radical that can oxidatively damage biomolecules and induce oxidative stress in biological systems. Many diseases, including neurodegeneration, cardiovascular disease and cancer, are associated with oxidative stress. However, it is proposed recently that hydroxyl radical would not be generated from the Fenton reaction under physiological conditions and thus would not cause oxidative stress in biologic...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Zhongwei Zhao Source Type: research
Conformational inhibitors of protein aggregation
Curr Opin Struct Biol. 2023 Sep 15;83:102700. doi: 10.1016/j.sbi.2023.102700. Online ahead of print.ABSTRACTAmyloidoses are fatal conditions associated with the aggregation of proteins into amyloid fibrils that deposit systemically and/or locally. Possibly because the causal mechanism of protein aggregation and deposition is not fully understood, this group of diseases remains uncurable. Advances in structural biology, such as the use of nuclear magnetic resonance and cryo-electron microscopy, have enabled the study of the structures and the conformational nature of the proteins whose aggregation is associated with the und...
Source: Current Opinion in Structural Biology - September 17, 2023 Category: Biology Authors: Mar ía Del Carmen Fernández Ramírez Shumaila Afrin Lorena Saelices Source Type: research
Height and political activism in rural Arag ón (Spain) during the 20th century. A new perspective using individual-level data
This article explores the relationship between the political leanings of more than 1000 men born in the 1870-1970 s in 11 rural Aragonese villages and their biological well-being during childhood and adolescence, proxied by height. The aim is to test whether an individual was more likely to be left-wing if his level of biological well-being was lower and, therefore, with more incentives to fight against the social inequality that had negatively affected his family. Our results confirm that, for most of the study period, there was a strong relationship between shorter height and political activism1 in left-wing parties and ...
Source: Economics and Human Biology - September 17, 2023 Category: Biology Authors: Francisco J Marco-Gracia Margarita L ópez-Antón Source Type: research
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00636-6. doi: 10.1016/j.freeradbiomed.2023.09.012. Online ahead of print.ABSTRACTFerroptosis is a novel form of cell death that plays a critical role in the pathological and physiological processes of early brain injury following subarachnoid hemorrhage. Melatonin, as the most potent endogenous antioxidant, has shown strong protective effects against pathological changes following subarachnoid hemorrhage, but its impact on ferroptosis induced by subarachnoid hemorrhage remains unexplored. In our study, we established a subarachnoid hemorrhage model in male SD rats. We found th...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Sheng-Ji Ma Chen Li Cong Yan Nan Liu Guang-You Jiang Hong-Rui Yang Hao-Chen Yan Ji-Yi Li Huai-Lei Liu Cheng Gao Source Type: research
