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Infectious Disease: Epidemics
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CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection
In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713
Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research
Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil
This study illustrates that genomics linked with eco-epidemiology can provide new insights into the landscape of YFV transmission, augmenting traditional approaches to infectious disease surveillance and control.PMID:37656782 | DOI:10.1126/sciadv.adg9204
Source: Adv Data - September 1, 2023 Category: Epidemiology Authors: Marta Giovanetti Francesco Pinotti Camila Zanluca Vagner Fonseca Taishi Nakase Andrea C Koishi Marcel Tscha Guilherme Soares Gisiane Gruber Dorl Ant ônio Ernesto M L Marques Renato Sousa Talita Emile Ribeiro Adelino Joilson Xavier Carla de Oliveira Sandr Source Type: research
CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection
In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre in mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713
Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research
Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis
CONCLUSIONS: This review identifies many of the factors that influence a person's decision to take part in a vaccine trial, and these reflect findings from reviews that examine trials more broadly. However, we also recognise some factors that become more important in connection with a vaccine trial in the context of a pandemic or epidemic. These factors include the potential stigma of taking part, the possible adverse effects of a vaccine, the added motivation for helping society, the role of community leaders in trial dissemination, and the level of trust placed in governments and companies developing vaccines. These spec...
Source: Cochrane Database of Systematic Reviews - September 1, 2023 Category: General Medicine Authors: Pauline Meskell Linda M Biesty Maura Dowling Kevin Roche Elaine Meehan Claire Glenton Declan Devane Sasha Shepperd Andrew Booth Rebecca Cox Xin Hui S Chan Catherine Houghton Source Type: research
CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection
In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre in mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713
Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research
Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis
CONCLUSIONS: This review identifies many of the factors that influence a person's decision to take part in a vaccine trial, and these reflect findings from reviews that examine trials more broadly. However, we also recognise some factors that become more important in connection with a vaccine trial in the context of a pandemic or epidemic. These factors include the potential stigma of taking part, the possible adverse effects of a vaccine, the added motivation for helping society, the role of community leaders in trial dissemination, and the level of trust placed in governments and companies developing vaccines. These spec...
Source: Cochrane Database of Systematic Reviews - September 1, 2023 Category: General Medicine Authors: Pauline Meskell Linda M Biesty Maura Dowling Kevin Roche Elaine Meehan Claire Glenton Declan Devane Sasha Shepperd Andrew Booth Rebecca Cox Xin Hui S Chan Catherine Houghton Source Type: research
CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection
In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre in mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713
Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research
Silences and Omissions in Reporting Epidemics in Russian and Soviet Prisons, 1890-2021
J Hist Med Allied Sci. 2023 Aug 31:jrad047. doi: 10.1093/jhmas/jrad047. Online ahead of print.ABSTRACTPenitentiary systems serve as breeding grounds for all kinds of diseases. Drawing upon new archival materials, this article examines the history of the management and reporting of epidemics in the Russian prison system from the late Imperial period to the present day. We use the case studies of cholera (1892-1893), typhus (1932-1933), and pulmonary tuberculosis (the 1990s) to examine how the general political and social conjuncture at different times affected the response of prison authorities to epidemics to show that, no...
Source: Medical History - August 31, 2023 Category: History of Medicine Authors: Mikhail Nakonechnyi Judith Pallot Source Type: research
Integrating Big Data and Assistive Technology to Improve College Students' Public Mental Health Quality During the COVID-19 Pandemic
J Autism Dev Disord. 2023 Aug 31. doi: 10.1007/s10803-023-06095-3. Online ahead of print.ABSTRACTThe Corona Virus Disease 2019 (COVID-19) suddenly broke out in a large area in December 2019, and now it has become a "global pandemic". The World Health Organization (WHO) defines COVID-19 as a serious global public health emergency of high international concern. In the context of epidemic prevention and control, some universities adopt the method of students staying at home and online teaching by teachers. Faced with changes in the learning environment, interpersonal environment, and social environment, some university studen...
Source: Journal of Autism and Developmental Disorders - August 31, 2023 Category: Psychiatry Authors: Fangling Yang Meiying Ni Xiaoying Bian Mei Liu Source Type: research
Silences and Omissions in Reporting Epidemics in Russian and Soviet Prisons, 1890-2021
J Hist Med Allied Sci. 2023 Aug 31:jrad047. doi: 10.1093/jhmas/jrad047. Online ahead of print.ABSTRACTPenitentiary systems serve as breeding grounds for all kinds of diseases. Drawing upon new archival materials, this article examines the history of the management and reporting of epidemics in the Russian prison system from the late Imperial period to the present day. We use the case studies of cholera (1892-1893), typhus (1932-1933), and pulmonary tuberculosis (the 1990s) to examine how the general political and social conjuncture at different times affected the response of prison authorities to epidemics to show that, no...
Source: Medical History - August 31, 2023 Category: History of Medicine Authors: Mikhail Nakonechnyi Judith Pallot Source Type: research
Integrating Big Data and Assistive Technology to Improve College Students' Public Mental Health Quality During the COVID-19 Pandemic
J Autism Dev Disord. 2023 Aug 31. doi: 10.1007/s10803-023-06095-3. Online ahead of print.ABSTRACTThe Corona Virus Disease 2019 (COVID-19) suddenly broke out in a large area in December 2019, and now it has become a "global pandemic". The World Health Organization (WHO) defines COVID-19 as a serious global public health emergency of high international concern. In the context of epidemic prevention and control, some universities adopt the method of students staying at home and online teaching by teachers. Faced with changes in the learning environment, interpersonal environment, and social environment, some university studen...
Source: Journal of Autism and Developmental Disorders - August 31, 2023 Category: Psychiatry Authors: Fangling Yang Meiying Ni Xiaoying Bian Mei Liu Source Type: research
Silences and Omissions in Reporting Epidemics in Russian and Soviet Prisons, 1890-2021
J Hist Med Allied Sci. 2023 Aug 31:jrad047. doi: 10.1093/jhmas/jrad047. Online ahead of print.ABSTRACTPenitentiary systems serve as breeding grounds for all kinds of diseases. Drawing upon new archival materials, this article examines the history of the management and reporting of epidemics in the Russian prison system from the late Imperial period to the present day. We use the case studies of cholera (1892-1893), typhus (1932-1933), and pulmonary tuberculosis (the 1990s) to examine how the general political and social conjuncture at different times affected the response of prison authorities to epidemics to show that, no...
Source: Medical History - August 31, 2023 Category: History of Medicine Authors: Mikhail Nakonechnyi Judith Pallot Source Type: research
