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Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017
In this study, we characterized the DENV-2 cosmopolitan genotype from patients during this epidemic. Also, we identified host factors that contributed to the severity of dengue infection in patients infected with this particular virus. Ninety-one acute serum samples from patients at the National Hospital in Kandy were randomly selected. Of these, 40.2% and 48.9% were positive for dengue IgM and IgG, respectively. NS1 antigen levels were significantly higher in primary infections. The severe dengue (SD) and dengue with warning signs (DWWS) groups exhibited significantly higher viral genome and infectivity titers than the de...
Source: The American Journal of Tropical Medicine and Hygiene - September 11, 2023 Category: Tropical Medicine Authors: Khine Mya Nwe Mya Myat Ngwe Tun Rohitha Muthugala Takeshi Nabeshima Jean Claude Balingit Lakmali Rajamanthri Dulani Jayawardana Shanthi Attanayake Shingo Inoue Yuki Takamatsu Takeshi Urano Kouichi Morita Source Type: research
Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research
Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017
In this study, we characterized the DENV-2 cosmopolitan genotype from patients during this epidemic. Also, we identified host factors that contributed to the severity of dengue infection in patients infected with this particular virus. Ninety-one acute serum samples from patients at the National Hospital in Kandy were randomly selected. Of these, 40.2% and 48.9% were positive for dengue IgM and IgG, respectively. NS1 antigen levels were significantly higher in primary infections. The severe dengue (SD) and dengue with warning signs (DWWS) groups exhibited significantly higher viral genome and infectivity titers than the de...
Source: The American Journal of Tropical Medicine and Hygiene - September 11, 2023 Category: Tropical Medicine Authors: Khine Mya Nwe Mya Myat Ngwe Tun Rohitha Muthugala Takeshi Nabeshima Jean Claude Balingit Lakmali Rajamanthri Dulani Jayawardana Shanthi Attanayake Shingo Inoue Yuki Takamatsu Takeshi Urano Kouichi Morita Source Type: research
PEDV promotes the differentiation of CD4 < sup > + < /sup > T cells towards Th1, Tfh, and Treg cells via CD103 < sup > + < /sup > DCs
In this study, CD103+DCs were differentiated successfully with retinoic acid (RA) treatment in vitro. PEDV could not replicate efficiently in differentiated CD103+DCs but could promote maturation of CD103+DCs by up-regulating the expression of SLA-DR, CD1a, CD86, and cytokines of IL-1β and IL-10. In addition, PEDV-infected CD103+DCs and CD4+T cells were co-cultured, and the results showed that the differentiation of CD4+T cells toward Th1, Tfh, and Treg, but not Th2. These results demonstrate that PEDV-infected CD103+DCs could promote the differentiation of CD4+T cells, which provided the basis for further study of mucosa...
Source: Virology - September 11, 2023 Category: Virology Authors: Haoyuan Yu Guohui Chen Tao Zhang Xin Huang YaBin Lu Maolin Li Shuxian Li Caiying Wang Baoyu Li Yunhang Zhang Guangliang Liu Yuguang Fu Source Type: research
Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017
In this study, we characterized the DENV-2 cosmopolitan genotype from patients during this epidemic. Also, we identified host factors that contributed to the severity of dengue infection in patients infected with this particular virus. Ninety-one acute serum samples from patients at the National Hospital in Kandy were randomly selected. Of these, 40.2% and 48.9% were positive for dengue IgM and IgG, respectively. NS1 antigen levels were significantly higher in primary infections. The severe dengue (SD) and dengue with warning signs (DWWS) groups exhibited significantly higher viral genome and infectivity titers than the de...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Khine Mya Nwe Mya Myat Ngwe Tun Rohitha Muthugala Takeshi Nabeshima Jean Claude Balingit Lakmali Rajamanthri Dulani Jayawardana Shanthi Attanayake Shingo Inoue Yuki Takamatsu Takeshi Urano Kouichi Morita Source Type: research
Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research
Promoting societal resilience during the COVID-19 pandemic: a multi-country analysis of public health strategies
CONCLUSIONS: The COVID-19 pandemic highlighted the importance of Public Health in developing proper strategies and utilizing digitals tools to counteract infodemic and spread relevant information. Healthcare workers should improve their communication skills to face future epidemics and be trusted by the population. Social media and digital platforms should be studied and used effectively in times of emergency.PMID:37695174 | DOI:10.23750/abm.v94iS3.14562
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Anna Carole D'Amelio Sarah Cataldi Giulia Dallagiacoma Leandro Gentile Anna Odone Carlo Signorelli Source Type: research
Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017
In this study, we characterized the DENV-2 cosmopolitan genotype from patients during this epidemic. Also, we identified host factors that contributed to the severity of dengue infection in patients infected with this particular virus. Ninety-one acute serum samples from patients at the National Hospital in Kandy were randomly selected. Of these, 40.2% and 48.9% were positive for dengue IgM and IgG, respectively. NS1 antigen levels were significantly higher in primary infections. The severe dengue (SD) and dengue with warning signs (DWWS) groups exhibited significantly higher viral genome and infectivity titers than the de...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Khine Mya Nwe Mya Myat Ngwe Tun Rohitha Muthugala Takeshi Nabeshima Jean Claude Balingit Lakmali Rajamanthri Dulani Jayawardana Shanthi Attanayake Shingo Inoue Yuki Takamatsu Takeshi Urano Kouichi Morita Source Type: research
Promoting societal resilience during the COVID-19 pandemic: a multi-country analysis of public health strategies
CONCLUSIONS: The COVID-19 pandemic highlighted the importance of Public Health in developing proper strategies and utilizing digitals tools to counteract infodemic and spread relevant information. Healthcare workers should improve their communication skills to face future epidemics and be trusted by the population. Social media and digital platforms should be studied and used effectively in times of emergency.PMID:37695174 | DOI:10.23750/abm.v94iS3.14562
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Anna Carole D'Amelio Sarah Cataldi Giulia Dallagiacoma Leandro Gentile Anna Odone Carlo Signorelli Source Type: research
Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017
In this study, we characterized the DENV-2 cosmopolitan genotype from patients during this epidemic. Also, we identified host factors that contributed to the severity of dengue infection in patients infected with this particular virus. Ninety-one acute serum samples from patients at the National Hospital in Kandy were randomly selected. Of these, 40.2% and 48.9% were positive for dengue IgM and IgG, respectively. NS1 antigen levels were significantly higher in primary infections. The severe dengue (SD) and dengue with warning signs (DWWS) groups exhibited significantly higher viral genome and infectivity titers than the de...
Source: The American Journal of Tropical Medicine and Hygiene - September 11, 2023 Category: Tropical Medicine Authors: Khine Mya Nwe Mya Myat Ngwe Tun Rohitha Muthugala Takeshi Nabeshima Jean Claude Balingit Lakmali Rajamanthri Dulani Jayawardana Shanthi Attanayake Shingo Inoue Yuki Takamatsu Takeshi Urano Kouichi Morita Source Type: research
Antiviral Compounds to Address Influenza Pandemics: An Update from 2016-2022
Curr Med Chem. 2023 Sep 7. doi: 10.2174/0929867331666230907093501. Online ahead of print.ABSTRACTIn recent decades, the world has gained experience of the dangerous effects of pandemic events caused by emerging respiratory viruses. In particular, annual epidemics of influenza are responsible for severe illness and deaths. Even if conventional influenza vaccines represent the most effective tool for preventing virus infections, they are not completely effective in patients with severe chronic disease and immunocompromised and new small molecules have emerged to prevent and control the influenza viruses. Thus, the attention ...
Source: Current Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Roberto Romeo Laura Legnani Maria Assunta Chiacchio Salvatore V Giofr è Daniela Iannazzo Source Type: research
Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 2017
In this study, we characterized the DENV-2 cosmopolitan genotype from patients during this epidemic. Also, we identified host factors that contributed to the severity of dengue infection in patients infected with this particular virus. Ninety-one acute serum samples from patients at the National Hospital in Kandy were randomly selected. Of these, 40.2% and 48.9% were positive for dengue IgM and IgG, respectively. NS1 antigen levels were significantly higher in primary infections. The severe dengue (SD) and dengue with warning signs (DWWS) groups exhibited significantly higher viral genome and infectivity titers than the de...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Khine Mya Nwe Mya Myat Ngwe Tun Rohitha Muthugala Takeshi Nabeshima Jean Claude Balingit Lakmali Rajamanthri Dulani Jayawardana Shanthi Attanayake Shingo Inoue Yuki Takamatsu Takeshi Urano Kouichi Morita Source Type: research
PEDV promotes the differentiation of CD4 < sup > + < /sup > T cells towards Th1, Tfh, and Treg cells via CD103 < sup > + < /sup > DCs
In this study, CD103+DCs were differentiated successfully with retinoic acid (RA) treatment in vitro. PEDV could not replicate efficiently in differentiated CD103+DCs but could promote maturation of CD103+DCs by up-regulating the expression of SLA-DR, CD1a, CD86, and cytokines of IL-1β and IL-10. In addition, PEDV-infected CD103+DCs and CD4+T cells were co-cultured, and the results showed that the differentiation of CD4+T cells toward Th1, Tfh, and Treg, but not Th2. These results demonstrate that PEDV-infected CD103+DCs could promote the differentiation of CD4+T cells, which provided the basis for further study of mucosa...
Source: Virology - September 11, 2023 Category: Virology Authors: Haoyuan Yu Guohui Chen Tao Zhang Xin Huang YaBin Lu Maolin Li Shuxian Li Caiying Wang Baoyu Li Yunhang Zhang Guangliang Liu Yuguang Fu Source Type: research
Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research
