CUR-N399, a PI4KB inhibitor, for the treatment of Enterovirus A71 infection

In this study, we investigate the antiviral efficacy of a novel PI4KB inhibitor, CUR-N399. We found that CUR-N399 displayed broad-spectrum antiviral activity against picornaviruses in cell culture models. Using a suckling mouse model of lethal EV-A71 infection, CUR-N399 was found to be well-tolerated, promote survival and reduce viral titre mice organs. Together, these support the discovery of CUR-N399 as an antiviral against EV-A71 and potentially other closely related viruses.PMID:37657668 | DOI:10.1016/j.antiviral.2023.105713

Source: Antiviral Research - September 1, 2023 Category: Virology Authors: Dorothy Hui Juan Cheong Thinesshwary Yogarajah Yi Hao Wong Gustav Arbrandt Jacob Westman Justin Jang Hann Chu Source Type: research