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Infectious Disease: Endemics
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Total 16411 results found since Jan 2013.
Fluoride Binding Potential of Selected Phytochemicals: A Pilot Study
Environ Sci Pollut Res Int. 2023 Aug 23. doi: 10.1007/s11356-023-29216-y. Online ahead of print.ABSTRACTFluoride (F-) contamination in drinking water is a major global concern. According to several studies, India and China are the most affected by the presence of excess F-. Long-time exposure to F- concentrations above 1.5 ppm can lead to hard and soft tissue fluorosis (F- toxicity). There are no effective cure or treatment for fluorosis and the condition is almost irreversible. Considering water to be the prime media through which F- reaches humans, maintaining optimal F- levels in water remains the only possible remedy. ...
Source: Environmental Science and Pollution Research International - August 23, 2023 Category: Environmental Health Authors: Harsheema Ottappilakkil Anitha Ottoor Suryaa Manoharan Murugesapandian Balasubramanian Ekambaram Perumal Source Type: research
Effects of chloride, sulfate, and bicarbonate stress on mortality rate, gill tissue morphology, and gene expression in mandarin fish (Siniperca chuatsi)
Environ Sci Pollut Res Int. 2023 Aug 23. doi: 10.1007/s11356-023-29411-x. Online ahead of print.ABSTRACTThe mandarin fish Siniperca chuatsi is a freshwater fish that is endemic to East Asia. To study the different damages and molecular mechanisms caused by different salt (NaCl, Na2SO4, and NaHCO3) on Siniperca chuatsi, the fish were subjected to NaCl, Na2SO4, and NaHCO3 stresses with different concentration for 96 h for mortality assessment, moreover, the fish were exposed to these salt stresses with equal sodium ion concentration (Na+ = 210 mmol/L), then gill morphological changes were observed and gene expression was ana...
Source: Environmental Science and Pollution Research International - August 23, 2023 Category: Environmental Health Authors: Yan Zhao Shuaishuai Li Shoujie Tang Yanling Wang Xiaoli Yao Jinyang Xie Jinliang Zhao Source Type: research
Genomic Characteristics of Emerging Intraerythrocytic Anaplasma capra and High Prevalence in Goats, China
We describe whole-genome sequences of 2 A. capra strains from metagenomic sequencing of purified erythrocytes from infected goats in China. The genome of A. capra was the smallest among members of the genus Anaplasma. The genomes of the 2 A. capra strains contained comparable G+C content and numbers of pseudogenes with intraerythrocytic Anaplasma species. The 2 A. capra strains had 54 unique genes. The prevalence of A. capra was high among goats in the 2 endemic areas. Phylogenetic analyses revealed that the A. capra strains detected in this study were basically classified into 2 subclusters with those previously detected ...
Source: Emerging Infectious Diseases - August 23, 2023 Category: Infectious Diseases Authors: Zhe-Tao Lin Li-Feng Du Ming-Zhu Zhang Xiao-Yu Han Bai-Hui Wang Jiao Meng Fu-Xun Yu Xiao-Quan Zhou Ning Wang Cheng Li Xiao-Yang Wang Jing Liu Wan-Ying Gao Run-Ze Ye Luo-Yuan Xia Yi Sun Na Jia Jia-Fu Jiang Lin Zhao Xiao-Ming Cui Lin Zhan Wu-Chun Cao Source Type: research
Integrating core subtractive proteomics and reverse vaccinology for multi-epitope vaccine design against Rickettsia prowazekii endemic typhus
Immunol Res. 2023 Aug 22. doi: 10.1007/s12026-023-09415-y. Online ahead of print.ABSTRACTRickettsia prowazekii is an intracellular, obligate, gram-negative coccobacillus responsible for epidemic typhus. Usually, the infected body louse or its excrement when rubbed into the skin abrasions transmits the disease. The infection with R. prowazekii causes the highest death rate (> 20% without antibiotic treatment and now 1-7%), followed by epidemic typhus, which often manifests in unsanitary conditions (up to 15-30%). Conventionally, vaccine design has required pathogen growth and both assays (in vivo and in vitro), which are...
Source: Genomics Proteomics ... - August 22, 2023 Category: Genetics & Stem Cells Authors: Ariba Khan Muhammad Hassan Khanzada Kanwal Khan Khurshid Jalal Reaz Uddin Source Type: research
Preferences of Patients and Providers in High-Burden Malaria Settings for Long-Acting Malaria Chemoprevention
Am J Trop Med Hyg. 2023 Aug 21:tpmd230245. doi: 10.4269/ajtmh.23-0245. Online ahead of print.ABSTRACTAntimalarial medications are recommended for chemoprevention as part of malaria control programs to decrease the morbidity and mortality related to more than 200 million infections each year. We sought to evaluate patient and provider acceptability of malaria chemoprevention in a long-acting formulation. We administered questionnaires to patients and providers in malaria endemic districts in Kenya and Zambia. Questions explored preferences and concerns around long-acting antimalarial formulations compared with oral formulat...
Source: The American Journal of Tropical Medicine and Hygiene - August 21, 2023 Category: Tropical Medicine Authors: Kimberly K Scarsi Harlan Sayles Kelvin Kapungu Peter Sifuna Matthew M Ippolito Renae Furl Matthew J Anderson Joelle Dountio Ofimboudem Gershom Chongwe Jack Hutter Steven P Rannard Andrew Owen Susan Swindells Source Type: research
Clinical Presentation of American Tegumentary Leishmaniasis in a Leishmania (Viannia) braziliensis Endemic Hotspot: A 35-Year History
Am J Trop Med Hyg. 2023 Aug 21:tpmd230234. doi: 10.4269/ajtmh.23-0234. Online ahead of print.ABSTRACTAmerican tegumentary leishmaniasis (ATL) is a neglected tropical disease affecting the skin and mucosa. American tegumentary leishmaniasis due to Leishmania (Viannia) braziliensis is endemic in Argentina, where the Department of Oran is a hyperendemic focus. All cases of ATL with laboratory confirmation evaluated at a referral center in Oran city between 1985 and 2019 were analyzed retrospectively. Information from cases included clinical form, lesion size and number, time of evolution, and anatomical location; sex, age, an...
Source: The American Journal of Tropical Medicine and Hygiene - August 21, 2023 Category: Tropical Medicine Authors: Mar ía Cristina Almazán Silvana Pamela Cajal Melisa D íaz-Fernández Marisa Ju árez Marcelo Quipildor Guillermo Portal Valeria Tejerina Carlos Vargas Griselda Noem í Copa Jos é Fernando Gil Rub én Oscar Cimino Alejandro Javier Krolewiecki Source Type: research
Preferences of Patients and Providers in High-Burden Malaria Settings for Long-Acting Malaria Chemoprevention
Am J Trop Med Hyg. 2023 Aug 21:tpmd230245. doi: 10.4269/ajtmh.23-0245. Online ahead of print.ABSTRACTAntimalarial medications are recommended for chemoprevention as part of malaria control programs to decrease the morbidity and mortality related to more than 200 million infections each year. We sought to evaluate patient and provider acceptability of malaria chemoprevention in a long-acting formulation. We administered questionnaires to patients and providers in malaria endemic districts in Kenya and Zambia. Questions explored preferences and concerns around long-acting antimalarial formulations compared with oral formulat...
Source: Am J Trop Med Hyg - August 21, 2023 Category: Infectious Diseases Authors: Kimberly K Scarsi Harlan Sayles Kelvin Kapungu Peter Sifuna Matthew M Ippolito Renae Furl Matthew J Anderson Joelle Dountio Ofimboudem Gershom Chongwe Jack Hutter Steven P Rannard Andrew Owen Susan Swindells Source Type: research
Clinical Presentation of American Tegumentary Leishmaniasis in a Leishmania (Viannia) braziliensis Endemic Hotspot: A 35-Year History
Am J Trop Med Hyg. 2023 Aug 21:tpmd230234. doi: 10.4269/ajtmh.23-0234. Online ahead of print.ABSTRACTAmerican tegumentary leishmaniasis (ATL) is a neglected tropical disease affecting the skin and mucosa. American tegumentary leishmaniasis due to Leishmania (Viannia) braziliensis is endemic in Argentina, where the Department of Oran is a hyperendemic focus. All cases of ATL with laboratory confirmation evaluated at a referral center in Oran city between 1985 and 2019 were analyzed retrospectively. Information from cases included clinical form, lesion size and number, time of evolution, and anatomical location; sex, age, an...
Source: Am J Trop Med Hyg - August 21, 2023 Category: Infectious Diseases Authors: Mar ía Cristina Almazán Silvana Pamela Cajal Melisa D íaz-Fernández Marisa Ju árez Marcelo Quipildor Guillermo Portal Valeria Tejerina Carlos Vargas Griselda Noem í Copa Jos é Fernando Gil Rub én Oscar Cimino Alejandro Javier Krolewiecki Source Type: research
Topical repellents for malaria prevention
CONCLUSIONS: There is insufficient evidence to conclude that topical repellents can prevent malaria in settings where other vector control interventions are in place. We found the certainty of evidence for all outcomes to be low, primarily due to the risk of bias. A protective effect was suggested among high-risk populations, specially refugees, who might not have access to other standard vector control measures. More adequately powered clinical trials carried out in refugee camps could provide further information on the potential benefit of topical repellents in this setting. Individually randomized studies are also likel...
Source: Cochrane Database of Systematic Reviews - August 21, 2023 Category: General Medicine Authors: Juan Carlos Gabald ón Figueira Martin G Wagah Lawrence Babu Adipo Caroline Wanjiku Marta F Maia Source Type: research
Functionally distinct regions of the locus < em > Leishmania major response 15 < /em > control IgE or IFN γ level in addition to skin lesions
In this study, we analyzed the L. major response locus Lmr15 originally mapped in the strain CcS-9 which carries 12.5% of the genome of the resistant strain STS on the genetic background of the susceptible strain BALB/c. For this analysis, we used the advanced intercross line K3FV between the strains BALB/c and STS. We confirmed the previously detected loci Lmr15, Lmr18, Lmr24, and Lmr27 and performed genetic dissection of the effects of Lmr15 on chromosome 11. We prepared the interval-specific recombinant strains 6232HS1 and 6229FUD, carrying two STS-derived segments comprising the peak linkage of Lmr15 whose lengths were...
Source: Cancer Control - August 21, 2023 Category: Cancer & Oncology Authors: Imtissal Krayem Yahya Sohrabi Helena Havelkov á Elena S Gusareva Hynek Strnad Marie Čepičková Valeryia Volkova Iryna Kurey Jarmila Vojt íšková Milena Svobodov á Peter Demant Marie Lipoldov á Source Type: research
