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Epilepsy and recommendations for breastfeeding
Conclusion Most AEDs are considered safe or moderately safe during breastfeeding. Mothers with epilepsy should be encouraged to breastfeed, provided careful monitoring of the infant.
Source: Seizure - March 27, 2015 Category: Neurology Source Type: research

The Potential Preventive Effect of Pregnancy and Breastfeeding on Multiple Sclerosis
Background: Multiple sclerosis (MS) is an inflammatory demyelinating chronic neurological disease that affects the central nervous system of young adults and their quality of life. Several studies have investigated the effects of pregnancy and breastfeeding on MS. However, the evidence regarding the influence of pregnancy and breastfeeding on MS is still accumulating. This review aimed to summarize the current evidence regarding the effects of pregnancy and breastfeeding on MS.Summary: A systematic electronic literature search of the PubMed and Embase databases was conducted to determine relevant published articles. The el...
Source: European Neurology - March 19, 2021 Category: Neurology Source Type: research

Psychopharmacotherapy during pregnancy and breastfeeding-Part II: focus on breastfeeding : Support options by using therapeutic drug monitoring
Nervenarzt. 2023 Jul 14. doi: 10.1007/s00115-023-01526-z. Online ahead of print.ABSTRACTThe drug treatment of mental disorders during lactation requires special knowledge about the possible effects on the breastfed infant. The first part of this 2‑part article is devoted to the use of psychotropic drugs during pregnancy. This second part addresses the use of psychotropic drugs during breastfeeding.The uncertainty about whether maternal breastfeeding can be recommended during drug treatment is high and the clinical management of psychopharmacotherapy during breastfeeding is a major challenge. Due to sparse scientific evid...
Source: Der Nervenarzt - July 14, 2023 Category: Neurology Authors: Michael Paulzen Georgios Schoretsanitis Source Type: research

Breastfeeding is associated with lower risk for multiple sclerosis
Conclusion: The results of this case-control study support the hypothesis that breastfeeding is associated with a lower risk of MS. These results are in line with findings of previous studies on other autoimmune diseases, in which breastfeeding was shown to have protective effects.
Source: Multiple Sclerosis - April 18, 2013 Category: Neurology Authors: Conradi, S., Malzahn, U., Paul, F., Quill, S., Harms, L., Then Bergh, F., Ditzenbach, A., Georgi, T., Heuschmann, P., Rosche, B. Tags: Research Papers Source Type: research

Use of antiepileptic drugs during breastfeeding : What do we tell the mother?
CONCLUSION: Phenobarbital, primidone, carbamazepine, valproate and levetiracetam are probably compatible with breastfeeding. Treatment with phenytoin, ethosuximide, clonazepam, oxcarbazepine, vigabatrin, topiramate, gabapentin, pregabalin, lamotrigine and zonisamide can be authorized during breastfeeding, provided breastfed infants are carefully monitored for side effects. Since data on the use of mesuximide, clobazam, rufinamide, felbamate, lacosamide, sultiame, perampanel and retigabine are insufficient to adequately assess the risk for breastfed infants, use in breastfeeding women is in principle not recommended and sho...
Source: Der Nervenarzt - February 27, 2018 Category: Neurology Authors: Crettenand M, Rossetti AO, Buclin T, Winterfeld U Tags: Nervenarzt Source Type: research

Breastfeeding recommendations for women taking anti-seizure medications
Epilepsy Behav. 2022 Jun 8:108769. doi: 10.1016/j.yebeh.2022.108769. Online ahead of print.ABSTRACTThe literature regarding breastfeeding and effects of anti-seizure medication (ASM) exposure on the breastfed infant has been evolving rapidly over the last decade as new studies advance our understanding of the extent of medication exposure via breastfeeding and the long-term developmental outcomes of breastfed infants. Currently, strong evidence supports the safety of breastfeeding for women with epilepsy (WWE) taking most prescribed ASMs. In this review, we present a comprehensive overview of the data regarding ASM exposur...
Source: Epilepsy and Behaviour - June 11, 2022 Category: Neurology Authors: Abrar O Al-Faraj Trudy D Pang Source Type: research

Reduced duration of breastfeeding is associated with a higher risk of multiple sclerosis in both Italian and Norwegian adult males: the EnvIMS study
Abstract Breastfeeding for at least 4 months has been found to be associated with a reduced risk of immune-mediated diseases including multiple sclerosis (MS). Using data from a large multinational case–control study (EnvIMS), the association between MS and breastfeeding was investigated in two distinct populations. A questionnaire (EnvIMS-Q) which included a section on feeding during the first year of life was administered to MS cases and to age and sex frequency-matched controls from Italy and Norway. Logistic regression was used to estimate the odds ratio (ORs) and 95 % confidence intervals (95 % CIs) as a...
Source: Journal of Neurology - March 20, 2015 Category: Neurology Source Type: research

Prolonged Breastfeeding as an Infant Reduces Future Risk of Pediatric-Onset Multiple Sclerosis: A Case-Control Study (P1.377)
Conclusions: Preliminary analysis of our data demonstrates that infant breastfeeding for less than 4 months’ duration is associated with a two-fold increase in odds of future POMS diagnosis. Disclosure: Dr. Brenton has nothing to disclose. Dr. Goldman has received personal compensation for activities with Evidera, Genyzme, Novartis, Biogen, and Acorda. Dr. Goldman has received research support from Biogen Idec and Novartis.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Brenton, J., Goldman, M. Tags: MS and CNS Inflammatory Disease: Risk Factors for Disease Progression and Treatment Response Source Type: research

Epilepsy and breastfeeding: from myth to reality.
CONCLUSIONS: Very few AEDs are incompatible with breastfeeding. The decision to breastfeed should take into account not only the AED, but also its number, dose, serum levels, transmission and elimination rates in the infant, and the conditions of the newborn infant. Ethosuximide and felbamate are probably high risk and incompatible with breastfeeding. Lamotrigine, phenobarbital, pregabalin, primidone, tiagabine, eslicarbazepine, brivaracetam, perampanel, zonisamide, lacosamide or the sporadic use of benzodiazepines in low doses are considered quite safe, with a low risk for breastfeeding. The other AEDs present a very low ...
Source: Revista de Neurologia - July 11, 2019 Category: Neurology Authors: Cabo-Lopez I, Canneti B, Puy-Nunez A Tags: Rev Neurol Source Type: research

Disease-Modifying Drugs and Breastfeeding in Multiple Sclerosis: A Narrative Literature Review
Pregnancy-related issues in women with multiple sclerosis (MS) have been receiving increasing attention, with particular interest for the use of disease-modifying therapies (DMTs) before conception, during pregnancy, and postpartum, including breastfeeding. The risk of relapse is higher in the early postpartum period, especially in cases of significant disease activity prior to pregnancy, and thus treatment resumption and/or switching strategies might be necessary. Moreover, breastfeeding provides unmatched health benefits for babies and mothers, and is recommended as the best source of nutrition for infants. Furthermore, ...
Source: Frontiers in Neurology - April 15, 2022 Category: Neurology Source Type: research

Psychopharmacotherapy during pregnancy and breastfeeding-Part I: focus on pregnancy : Support options by using therapeutic drug monitoring
Nervenarzt. 2023 Jul 17. doi: 10.1007/s00115-023-01528-x. Online ahead of print.ABSTRACTThe medicinal treatment of mental disorders during pregnancy and lactation requires special knowledge about possible effects of the psychopharmacotherapy on the intrauterine exposure of the embryo/fetus. Therefore, the first part of this 2‑part article focuses on the use of psychotropic drugs during pregnancy. In the second part, the use of psychotropic drugs during breastfeeding is addressed. Possible substance-specific risks as a consequence of the administration have to be assessed compared to the natural risk of pregnancy complica...
Source: Der Nervenarzt - July 17, 2023 Category: Neurology Authors: Michael Paulzen Georgios Schoretsanitis Source Type: research