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Total 447 results found since Jan 2013.

The effect of Candida albicans systemic infection on matrix metalloproteinases in breast cancer bearing BALB/c mice.
Abstract Breast cancer patients are susceptible to infections such as candidiasis. Due to the importance and the role of matrix metalloproteinases (MMP) in breast cancer progression and its correlation with tumor metastasis, we analyzed the serum level of MMPs -2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in breast cancer bearing mice in the presence of systemic Candida albicans infection. Female BALB/c mice were divided into 4 groups: group I had tumor + candidiasis; group II, tumor only; group III, candidiasis only and group IV as negative control. Tumor tissue was separated from stock b...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 1, 2013 Category: Allergy & Immunology Authors: Hajari Taheri F, Seyedolmohadesin M, Bayat M, Mahdavi M, Yazdi MH, Eslamifar A, Abolhasani M Tags: Iran J Allergy Asthma Immunol Source Type: research

A Case of Anaphylaxis to Patent Blue in a Patient with Sentinel Lymph Node Excision.
This article supports the necessity of an increased awareness of the possibility of anaphylactic reactions to PBV during SLN surgery, even if the patient never had contact to PBV before. PMID: 28129687 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - November 30, 2016 Category: Allergy & Immunology Authors: Aurich S, Seitz AT, Tomm J, Simon JC, Treudler R Tags: Iran J Allergy Asthma Immunol Source Type: research

Assessment of the Inhibitory Effects of Ficin-hydrolyzed Gelatin Derived from Squid (Uroteuthis duvauceli) on Breast Cancer Cell Lines and Animal Model.
Abstract Marine novel natural products have been applied for cancer therapy. Enzyme-digested gelatin hydrolysates have proven to serve as promising sources of potent biologically active peptides. Potential anti-breast cancer properties of the extracted Ficin-digesterd gelatin hydrolysate from Indian squid (Uroteuthis duvauceli) was extensively characterized by cellular and animal models. Gelatin was extracted from squid skin, hydrolyzed by Ficin, and characterized by standard physico-chemical methods. Ficin-digested gelatin hydrolysate was used at various doses of 0-0.1 mg/mL for assessment of MCF-7 and MDA-MB-231...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 14, 2018 Category: Allergy & Immunology Authors: Shahidi S, Jamili S, Ghavam Mostafavi P, Rezaie S, Khorramizadeh M Tags: Iran J Allergy Asthma Immunol Source Type: research

The Anti-tumoral Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID on Treg Cells Frequency and MMP-2, MMP-9, CCL22 and TGFβ1 Gene Expression in Pre-surgical Breast Cancer Patients.
Abstract With respect to the role of chronic inflammation in the induction and progression of breast cancer (BC). The relationship between tumor and tumor microenvironment may be a hopeful strategy for BC therapy. According to the effect of β-D-Mannuronic acid (M2000) as a novel non-steroidal anti-inflammatory drug (NSAID) on BC murine model and 4T1 cell line, we started to study that was a phase II, randomized, controlled clinical trial. 24 women with BC were included in this study and were followed by fixed oral doses of M2000, 500 mg two times a day (6-8 weeks). Blood samples were collected at baseline and wee...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 31, 2019 Category: Allergy & Immunology Authors: Kashefi S, Ahmadi H, Omranipour R, Mahmoodzadeh H, Jafarnezhad-Ansariha F, Tofighi Zavareh F, Mirshafiey A Tags: Iran J Allergy Asthma Immunol Source Type: research

High Glucose-reduced Apoptosis in Human Breast Cancer Cells Is Mediated by Activation of NF- κB.
In this study, MCF-7 derived from human breast adenocarcinoma, were cultured in DMEM with two different concentrations of glucose for 48 h (5.5 mM as normal glucose (NG) condition and 25 mM as HG condition). We used Zingiber officinale extraction for the inhibition of NF-κB. Cell proliferation assay was done by direct counting, cell viability by MTT method, bcl-2 by Immunocytochemistry, apoptosis by Hoechst/PI double staining and vascular endothelium growth factor (VEGF) by ELISA. Results showed that HG increased lactate production, significantly. HG increased cell proliferation, cell viability, VEGF secretion, and bcl-2 ...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 31, 2019 Category: Allergy & Immunology Authors: Nasir Kansestani A, Mansouri K, Hemmati S, Zare ME, Moatafaei A Tags: Iran J Allergy Asthma Immunol Source Type: research

Association of rs1946518 C/A Polymorphism in Promoter Region of Interleukin 18 Gene and Breast Cancer Risk in Iranian Women: A Case-control Study.
In conclusion, our study indicated that IL-18 rs1946518 C/A polymorphism was not associated with BC in the Iranian women population. However, more studies on different races and geographic areas are required to determine the exact role of rs1946518 C/A polymorphism in prognosis, diagnosis, and risk of BC. PMID: 32245311 [PubMed - as supplied by publisher]
Source: Iranian Journal of Allergy, Asthma and Immunology - November 9, 2019 Category: Allergy & Immunology Authors: Fathi Maroufi N, Aghayi E, Garshasbi H, Gholampour Matin M, Babazadeh Bedoustani A, Firouzi Amoudizaj F, Hajazimian S, Isazadeh A, Taefehshokr S, Taefehshokr N, Baradaran B Tags: Iran J Allergy Asthma Immunol Source Type: research

Immunogenicity Evaluation of Recombinant Edible Vaccine Candidate Containing HER2-MUC1 against Breast Cancer.
In this study, Her2, MUC1, and a novel fusion structure were expressed in the seeds and hairy roots of transgenic plants appropriately. The mice groups were immunized either by feeding of transgenic seeds or hairy roots. All immunized groups showed a considerable rise in anti-glycoprotein serum IgG and IgA, and IFNɣ cytokine. However, the animals received chimeric protein showed significant higher immune responses in comparison to ones received one of these immunogen. The results indicated that the oral immunization of an animal model with transgenic plants could effectively elicit immune responses against two major tumo...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 22, 2019 Category: Allergy & Immunology Authors: Mehrab Mohseni M, Amani J, Fasihi Ramandi M, Mahjoubi F, Jafaria M, Salmanian AH Tags: Iran J Allergy Asthma Immunol Source Type: research

Combination of 5-fluorouracil and Lipopolysaccharide Synergistically Induces Cytotoxicity and Apoptosis in MCF-7 Human Breast Cancer Cells.
Abstract Several studies have been conducted to find suitable combinations of drugs to increase the efficacy of chemotherapy and reduce the resistance of tumor cells to treatment. Lipopolysaccharide (LPS), as a ligand for Toll-like receptor 4 (TLR-4), can modify immune responses in different cancers. Although multiple studies have been performed in this area, the effect of LPS on tumor cells remains controversial. In the present study, the cytotoxic effects of 5-fluorouracil (5-FU), with or without LPS, were evaluated in human breast cancer cell line (MCF-7) on apoptosis and gene expression in downstream signaling...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 25, 2020 Category: Allergy & Immunology Authors: Nokhandani N, Naghavi Alhosseini M, Memarian A, Davoodi H Tags: Iran J Allergy Asthma Immunol Source Type: research

Objective allergy markers and risk of cancer mortality and hospitalization in a large population-based cohort
Conclusions We found no associations between objective allergy markers and cancer in the total population. However, skin test positivity and a high number of eosinophils were associated with a reduced risk to die of cancer in specific subgroups. Hence, it seems important to study specific subgroups defined by gender and smoking habits in order to identify allergy markers of predictive value for cancer mortality.
Source: Cancer Causes and Control - November 12, 2014 Category: Cancer & Oncology Source Type: research

Specific Immunotherapy in Hymenoptera Venom Allergy and concomitant Malignancies. A retrospective follow-up focusing on efficacy and safety.
CONCLUSIONS: Efficacy and side effects of VIT in patients with Hymenoptera venom allergy and cancer are comparable to those without malignancy if cancer is in remission. This study shows that these patients are also eligible for VIT. PMID: 28675375 [PubMed - as supplied by publisher]
Source: Journal of Investigational Allergology and Clinical Immunology - July 4, 2017 Category: Allergy & Immunology Authors: Aeberhard J, Haeberli G, Müller UR, Helbling A Tags: J Investig Allergol Clin Immunol Source Type: research

Atopy and cause-specific mortality.
CONCLUSIONS & CLINICAL RELEVANCE: We found no statistically significant association between atopy and all-cause mortality. However, atopy was associated with a significantly higher risk of dying from mental and behavioural disorders and gastrointestinal diseases, particularly liver diseases, and a lower risk of dying from breast cancer, but these associations were not statistically significant when applying the Bonferroni adjusted significance level. Further studies are needed to confirm our findings. This article is protected by copyright. All rights reserved. PMID: 25220375 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - September 14, 2014 Category: Cancer & Oncology Authors: Skaaby T, Husemoen LL, Thuesen BH, Hammer-Helmich L, Linneberg A Tags: Clin Exp Allergy Source Type: research

Younger pubertal age is associated with allergy and other atopic conditions in girls
ConclusionsAtopic conditions during childhood are associated with younger age at pubarche, independent of obesity, and these relationships may vary by racial/ethnic groups.This article is protected by copyright. All rights reserved.
Source: Pediatric Allergy and Immunology - November 11, 2014 Category: Allergy & Immunology Authors: Chi‐Chen Hong, Ashley Pajak, Susan L. Teitelbaum, Nita Vangeepuram, Maida Galvez, Susan M. Pinney, Gayle Windham, Lawrence H. Kushi, Frank M. Biro, Mary S. Wolff, Tags: Original Source Type: research

Atopy and Development of Cancer: A Population-Based Prospective Study
Conclusion Our data did not support the hypothesis that atopy is associated with an altered risk of total cancer development, although effects of atopy on specific types of cancer cannot be excluded.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 18, 2014 Category: Allergy & Immunology Source Type: research

P384 Expanding the role of tryptase from allergy to cancer?
Elevated serum tryptase values may be found in several conditions, including mastocytosis, myeloproliferative neoplasms, hypereosinophilic disorders, and myelodysplastic syndromes. Increased density of tissue mast cells is correlated with poor prognosis in lung adenocarcinoma as well as melanoma, gastric carcinoma, and breast cancer. While an elevated tryptase has been proposed as a biomarker in several hematologic malignancies including chronic myeloid leukemia, an elevated tryptase has not been previously reported in association with lung adenocarcinoma.
Source: Annals of Allergy, Asthma and Immunology - October 27, 2017 Category: Allergy & Immunology Authors: J. Hagan, T. Pongdee Source Type: research

Peanut Allergy Patch; FIT for Colon Cancer: It ' s PodMed Double T! (with audio)
(MedPage Today) -- This week ' s topics also include testing for breast cancer mutations and daily aspirin ' s bleeding risks
Source: MedPage Today Allergy - March 10, 2019 Category: Allergy & Immunology Source Type: news