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Total 34 results found since Jan 2013.

Allergic‐like reactions to asparaginase: Atypical allergies without asparaginase inactivation
ConclusionsIn conclusion, allergic‐like reactions occur relatively late after the start of infusion and without antibodies. Despite these clinical differences, allergic‐like reactions can only be distinguished from real allergies by continually measuring asparaginase activity levels. If clinically tolerated, formulations should not be switched in case of allergic‐like reactions. Moreover, failure to recognize these reactions may lead to a less favorable prognosis if asparaginase therapy is terminated unnecessarily.
Source: Pediatric Blood and Cancer - July 4, 2016 Category: Cancer & Oncology Authors: Robin Q. H. Kloos, Rob Pieters, Gabriele Escherich, Inge M. der Sluis Tags: Research Article Source Type: research

Allergic ‐like reactions to asparaginase: Atypical allergies without asparaginase inactivation
ConclusionsIn conclusion, allergic‐like reactions occur relatively late after the start of infusion and without antibodies. Despite these clinical differences, allergic‐like reactions can only be distinguished from real allergies by continually measuring asparaginase activity levels. If clinically tolerated, formulations should not be switched in case of allergic‐like reactions. Moreover, failure to recognize these reactions may lead to a less favorable prognosis if asparaginase therapy is terminated unnecessarily.
Source: Pediatric Blood and Cancer - July 3, 2016 Category: Cancer & Oncology Authors: Robin Q. H. Kloos, Rob Pieters, Gabriele Escherich, Inge M. der Sluis Tags: Research Article Source Type: research

Allergies, atopy, immune‐related factors and childhood rhabdomyosarcoma: A report from the children's oncology group
Abstract Rhabdomyosarcoma (RMS) is a highly malignant tumor of developing muscle that can occur anywhere in the body. Due to its rarity, relatively little is known about the epidemiology of RMS. Atopic disease is hypothesized to be protective against several malignancies; however, to our knowledge, there have been no assessments of atopy and childhood RMS. Therefore, we explored this association in a case‐control study of 322 childhood RMS cases and 322 pair‐matched controls. Cases were enrolled in a trial run by the Intergroup Rhabdomyosarcoma Study Group. Controls were matched to cases on race, sex, and age. The foll...
Source: International Journal of Cancer - July 3, 2013 Category: Cancer & Oncology Authors: Philip J. Lupo, Renke Zhou, Stephen X. Skapek, Douglas S. Hawkins, Logan G. Spector, Michael E. Scheurer, M. Fatih Okcu, Beatrice Melin, Karin Papworth, Erik B. Erhardt, Seymour Grufferman Tags: Epidemiology Source Type: research

Reply: Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter-Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – A reality or myth or two viewpoints about the association between allergies and acute leukaemia in Down syndrome children
Reply: Comment on ‘Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican Inter-Institutional Group for the Identification of the Causes of Childhood Leukaemia (MIGICCL)’ – A reality or myth or two viewpoints about the association between allergies and acute leukaemia in Down syndrome children British Journal of Cancer advance online publication, August 1 2013. doi:10.1038/bjc.2013.436 Authors: J C Núñez-Enríquez, A Fajardo-Gutiérrez, E P Buchán-Durán, E Jiménez-Hernández & J M Mejía-Aranguré
Source: British Journal of Cancer AOP - August 1, 2013 Category: Cancer & Oncology Authors: J C Núñez-EnríquezA Fajardo-GutiérrezE P Buchán-DuránE Jiménez-HernándezJ M Mejía-Aranguré Source Type: research

The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids
Conclusion In Table 1, an overview is presented of the complex roles of AAs described in this review regarding the microbiome-gut-immune-brain axis in ASD. Besides behavioral deficits, people with ASD are characterized by systemic inflammation, gastrointestinal immune-related disturbances and changes in the gut microbiota composition. Moreover, differences in levels of specific AAs in various body compartments, including the intestinal tract, blood, urine and brain have been reported in patients with ASD, as well as in rodent models for ASD. This review described that specific AAs can modulate the intestinal epithelial im...
Source: Frontiers in Endocrinology - April 15, 2019 Category: Endocrinology Source Type: research

Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia.
Conclusions:This finding might have implication for treatment individualization in ALL and other cancers employing asparagine depletion strategies. PMID: 24907114 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - June 6, 2014 Category: Cancer & Oncology Authors: Ben Tanfous M, Sharif-Askari B, Ceppi F, Laaribi H, Gagné V, Rousseau J, Labuda M, Silverman LB, Sallan SE, Neuberg D, Kutok JL, Sinnett D, Laverdière C, Krajinovic M Tags: Clin Cancer Res Source Type: research

Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children
Conclusion: Our results indicate alterations in systemic inflammatory markers in 8-y-old children in relation to early-life exposure to traffic-related air pollution. https://doi.org/10.1289/EHP460 Received: 04 May 2016 Revised: 20 October 2016 Accepted: 07 November 2016 Published: 16 June 2017 Address correspondence to O. Gruzieva, Karolinska Institutet, Institute of Environmental Medicine, Nobels väg 13 Box 210, SE-17177, Stockholm, Sweden. Telephone: 46 8 524 80022. Fax: 46 8 304571. E-mail: olena.gruzieva@ki.se Supplemental Material is available online (https://doi.org/10.1289/EHP460). The authors declare they h...
Source: EHP Research - June 16, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

The Conspirituality of Robert F. Kennedy Jr.
This article has been adapted from Chapter 23 of Conspirituality: How New Age Conspiracy Theories Became a Health Threat by Derek Beres, Matthew Remski, and Julian Walker. Copyright © 2023. Available from PublicAffairs, an imprint of Hachette Book Group, Inc.
Source: TIME: Health - July 5, 2023 Category: Consumer Health News Authors: Derek Beres, Matthew Remski, and Julian Walker Tags: Uncategorized freelance politics Source Type: news

Elemental Sulfur Use and Associations with Pediatric Lung Function and Respiratory Symptoms in an Agricultural Community (California, USA)
Conclusions: This study suggests that elemental sulfur use, allowed in both organic and conventional farming, in close proximity to residential areas, may adversely affect children’s respiratory health. https://doi.org/10.1289/EHP528 Received: 19 May 2016 Revised: 05 May 2017 Accepted: 09 May 2017 Published: 14 August 2017 Address correspondence to R. Raanan, Center for Environmental Research and Children’s Health (CERCH), University of California, Berkeley, School of Public Health, 1995 University Ave., Suite 265, Berkeley, CA 94704 USA. Telephone: (510) 642-9431. Email: rachelraananrr@gmail.com Supplemental Ma...
Source: EHP Research - August 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Cochrane Skin Group celebrate 20 years of improving treatment of skin diseases
World-leading dermatologists and their patients are celebrating huge improvements in the treatment of skin diseases like skin cancer, psoriasis, and acne as theCochrane Skin Group marks its 20th anniversary this week.   The effects of the 120 plus published Cochrane Skin Reviews have been far-reaching and have had real impacts on patient care. These include skin cancer, skin allergies, and acne, blistering diseases, hair disorders like alopecia, fungal infections and psoriasis as well as tropical parasitic disea ses.The group is coordinated by the University of Nottingham ’s Centre of Evidence Based Dermatology and is p...
Source: Cochrane News and Events - September 12, 2017 Category: Information Technology Authors: Muriah Umoquit Source Type: news

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

This Type of Non-Dairy Milk is the Healthiest, Study Says
That almond milk latte may be delicious, but a study just published in the Journal of Food Science and Technology suggests that the trendy beverage also has some drawbacks. When researchers compared the nutritional profiles of four popular “alternative” milks, they found that soy milk came out on top—and that almond, rice and coconut “milks” all lacked essential nutrients important for overall health. Plant-based “milks” are often marketed as wholesome and appropriate substitutes for the real thing. To find out if these claims measured up, scientists at McGill University in Canada ...
Source: TIME: Health - January 30, 2018 Category: Consumer Health News Authors: Amanda MacMillan Tags: Uncategorized almond milk almond milk calories almond milk nutrition coconut milk Diet/Nutrition healthytime is soy milk fattening Lactose Intolerance onetime soy milk calories soy milk nutrition soy milk vs milk Source Type: news

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

Why Would I Be Low in Vitamin D?
My doctors and I test blood levels of vitamin D on everyone we see in our clinic. When the results come in, two things happen: 1. Pretty much everyone is low in vitamin D. 2. Pretty much everyone is shocked that they are low in vitamin D. Why worry about vitamin D? It's important. Multiple studies have shown that people with low levels of Vitamin D have the following: • Weaker bones [1] • Higher mortality rate [2] • More allergies and asthma [3] • Greater risk of cancer [4] • Higher risk of diabetes [5] • Greater risk of heart attacks [6] • Higher rates of MS [7] • Higher risk of infections [8] • More me...
Source: Healthy Living - The Huffington Post - November 20, 2015 Category: Consumer Health News Source Type: news