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Protocatechuic acid boosts continual efferocytosis in macrophages by derepressing KLF4 to transcriptionally activate MerTK | Science Signaling
A pathway by which an anthocyanin metabolite enhances efferocytosis in macrophages is revealed. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 23, 2023 Category: Science Source Type: news

JMJD8 reduces cancer ’s STING | Science Signaling
JMJD8 inhibits STING signaling and reduces antitumor responses. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 23, 2023 Category: Science Source Type: news

The Bacillus cereus toxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100 | Science Signaling
A Bacillus cereus toxin compromises epithelial cell junctions by perturbing microtubule dynamics. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 16, 2023 Category: Science Source Type: news

Neuronal-glioma cross-talk | Science Signaling
Remodeling of neural circuits by glioma cells decreases patient survival. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 16, 2023 Category: Science Source Type: news

THEMIS increases TCR signaling in CD4+CD8+ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1 | Science Signaling
THEMIS inhibits the phosphatase SHP1 to enhance thymocyte sensitivity to TCR stimulation by self-peptides. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 9, 2023 Category: Science Source Type: news

SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model | Science Signaling
Long Covid pain may arise from a targetable antiviral response to SARS-CoV-2 particles in dorsal root ganglia. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 9, 2023 Category: Science Source Type: news

In lonely mice, astrocytes turn inhibitory | Science Signaling
Social deprivation in mice switches the role of astrocytes from supporting to inhibiting cognition. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 9, 2023 Category: Science Source Type: news

The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING | Science Signaling
A SARS-CoV-2 protease deubiquitinates STING to block antiviral signaling. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 2, 2023 Category: Science Source Type: news

The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression | Science Signaling
The preference of a protease for ubiquitin or ISG15 is associated with coronavirus pathogenicity. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 2, 2023 Category: Science Source Type: news

Mechanosensation to inflammation: Roles for YAP/TAZ in innate immune cells | Science Signaling
The contributions of the transcriptional coactivators YAP and TAZ to inflammation and innate immune responses are discussed. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 2, 2023 Category: Science Source Type: news

Stressing the gut-brain axis | Science Signaling
Stress-induced changes in gut microbiota cause γδ T cell migration to the meninges, where they affect behavior in mice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 2, 2023 Category: Science Source Type: news

MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca2+ uniporter channel | Science Signaling
MICU1 plays distinct roles in regulating mitochondrial architecture and Ca2+ influx into mitochondria. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 25, 2023 Category: Science Source Type: news

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release | Science Signaling
ACE2 in macrophages promotes infection that enables an intrinsic antiviral response to SARS-CoV-2. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 25, 2023 Category: Science Source Type: news

DEAD box RNA helicases act as nucleotide exchange factors for casein kinase 2 | Science Signaling
RNA helicases link RNA processing to signaling mediated by the kinase activity of CK2. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 25, 2023 Category: Science Source Type: news

Metabolically fitter with fibronectin | Science Signaling
Activation of hepatic autophagy by skeletal muscle –secreted fibronectin underlies the metabolic benefits of exercise. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 25, 2023 Category: Science Source Type: news