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Total 13533 results found since Jan 2013.
The Warburg effect on radioresistance: Survival beyond growth
Biochim Biophys Acta Rev Cancer. 2023 Sep 17:188988. doi: 10.1016/j.bbcan.2023.188988. Online ahead of print.ABSTRACTThe Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its involvement in cell proliferation has been discovered, the advantages of the Warburg effect in cancer cell survival under treatment have not been fully elucidated. In recent years, the metabolic characteristics of radioresistant cancer cells have been evaluated, enabling an extension of the original concept of the Warburg effect....
Source: Biochimica et Biophysica Acta - September 19, 2023 Category: Biochemistry Authors: Hyunkoo Kang Byeongsoo Kim Junhyeong Park HyeSook Youn BuHyun Youn Source Type: research
Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models
We present a comprehensive therapeutic and biomarker analysis of a B7H3-ADC with pyrrolobenzodiazepine(PBD) payload in 26 treatment-resistant, metastatic prostate cancer(mPC) models. B7H3 is a tumor-specific surface protein widely expressed in mPC, and PBD is a DNA cross-linking agent. B7H3 expression was necessary but not sufficient for B7H3-PBD-ADC responsiveness. RB1 deficiency and/or replication stress, characteristics of poor prognosis, conferred sensitivity and were associated with complete tumor regression in both neuroendocrine (NEPC) and androgen receptor positive(ARPC) prostate cancer models, even with low B7H3 l...
Source: Clinical Prostate Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Supreet Agarwal Lei Fang Kerry McGowen JuanJuan Yin Joel Bowman Anson T Ku Aian Neil Alilin Eva Corey Martine P Roudier Lawrence D True Ruth F Dumpit Ilsa Coleman John K Lee Peter S Nelson Brian J Capaldo Aida Mariani Clare E Hoover Ilya S Senatorov Micha Source Type: research
Gd/hafnium oxide@gold@chitosan core –shell nanoparticles as a platform for multimodal theranostics in oncology research
Chem. Commun., 2023, Advance Article DOI: 10.1039/D3CC02971A, CommunicationAastha Gupta, Ritu Singhmar, Ankur Sood, Dimpy Bhardwaj, S. Senthil Kumaran, Shubhra Chaturvedi, Garima Agrawal Fabrication of a multimodal theranostic platform with capabilities of performing multiple actions together for cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 18, 2023 Category: Chemistry Authors: Aastha Gupta Source Type: research
Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies
Chromosome Res. 2023 Sep 18;31(4):28. doi: 10.1007/s10577-023-09737-5.ABSTRACTAneuploidy is defined as the cellular state of having a number of chromosomes that deviates from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy can be present in a static state: Down syndrome individuals stably maintain an extra copy of chromosome 21 in their cells. In cancer cells, however, aneuploidy is usually present in combination with chromosomal instability (CIN) which leads to a continual generation of new chromosomal alterations and the development of intratumour heterogeneity (ITH). The prevalence of ...
Source: Chromosome Research - September 18, 2023 Category: Genetics & Stem Cells Authors: Joana Reis Andrade Annie Dinky Gallagher Jovanna Maharaj Sarah Elizabeth McClelland Source Type: research
The role of ubiquitination and deubiquitination in PI3K/AKT/mTOR pathway: a potential target for cancer therapy
Gene. 2023 Sep 16:147807. doi: 10.1016/j.gene.2023.147807. Online ahead of print.ABSTRACTThe PI3K/AKT/mTOR pathway controls key cellular processes, including proliferation and tumor progression, and abnormally high activation of this pathway is a hallmark in human cancers. The post-translational modification, such as Ubiquitination and deubiquitination, fine-tuning the protein level and the activity of members in this pathway play a pivotal role in maintaining normal physiological process. Emerging evidence show that the unbalanced ubiquitination/deubiquitination modification leads to human diseases via PI3K/AKT/mTOR pathw...
Source: Gene - September 18, 2023 Category: Genetics & Stem Cells Authors: Jiabei Jin Jian He Xinming Li Xiaoqi Ni Xiaofeng Jin Source Type: research
Cell-nanocarrier drug delivery system: a promising strategy for cancer therapy
Drug Deliv Transl Res. 2023 Sep 18. doi: 10.1007/s13346-023-01429-1. Online ahead of print.ABSTRACTTumor targeting has been a great challenge for drug delivery systems. A number of nanotechnology-derived drug carriers have been developed for cancer treatment to improve efficacy and biocompatibility. Among them, the emergence of cell-nanocarriers has attracted great attention, which simulates cell function and has good biocompatibility. They can also escape the clearance of reticuloendothelial system, showing a long-cycle effect. The inherent tumor migration and tumor homing ability of cells increase their significance as t...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Jiefen Yang Xiongxi Shi Yanting Kuang Ruting Wei Lanni Feng Jianming Chen Xin Wu Source Type: research
The role of ubiquitination and deubiquitination in PI3K/AKT/mTOR pathway: a potential target for cancer therapy
Gene. 2023 Sep 16:147807. doi: 10.1016/j.gene.2023.147807. Online ahead of print.ABSTRACTThe PI3K/AKT/mTOR pathway controls key cellular processes, including proliferation and tumor progression, and abnormally high activation of this pathway is a hallmark in human cancers. The post-translational modification, such as Ubiquitination and deubiquitination, fine-tuning the protein level and the activity of members in this pathway play a pivotal role in maintaining normal physiological process. Emerging evidence show that the unbalanced ubiquitination/deubiquitination modification leads to human diseases via PI3K/AKT/mTOR pathw...
Source: Gene - September 18, 2023 Category: Genetics & Stem Cells Authors: Jiabei Jin Jian He Xinming Li Xiaoqi Ni Xiaofeng Jin Source Type: research
Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies
Chromosome Res. 2023 Sep 18;31(4):28. doi: 10.1007/s10577-023-09737-5.ABSTRACTAneuploidy is defined as the cellular state of having a number of chromosomes that deviates from a multiple of the normal haploid chromosome number of a given organism. Aneuploidy can be present in a static state: Down syndrome individuals stably maintain an extra copy of chromosome 21 in their cells. In cancer cells, however, aneuploidy is usually present in combination with chromosomal instability (CIN) which leads to a continual generation of new chromosomal alterations and the development of intratumour heterogeneity (ITH). The prevalence of ...
Source: Chromosome Research - September 18, 2023 Category: Genetics & Stem Cells Authors: Joana Reis Andrade Annie Dinky Gallagher Jovanna Maharaj Sarah Elizabeth McClelland Source Type: research
Stimuli-Responsive and Multifunctional Nanogels
Chem Biodivers. 2023 Sep 17:e202301009. doi: 10.1002/cbdv.202301009. Online ahead of print.ABSTRACTNanogels represent promising drug delivery systems in the biomedical field, designed to overcome challenges associated with standard treatment approaches. Stimuli-responsive nanogels, often referred to as intelligent materials, have garnered significant attention for their potential to enhance control over properties such as drug release and targeting. Furthermore, researchers have recently explored the application of nanogels in diverse sectors beyond biomedicine including sensing materials, catalysts, or adsorbents for envi...
Source: Chemistry and Biodiversity - September 17, 2023 Category: Biochemistry Authors: Ashwani P V Gopika G Josena Jose Arun Krishna K V Franklin John Jinu George Source Type: research
Extracellular vimentin as a versatile immune suppressive protein in cancer
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188985. doi: 10.1016/j.bbcan.2023.188985. Online ahead of print.ABSTRACTThe interest in finding new targets in the tumor microenvironment for anti-cancer therapy has increased rapidly over the years. More specifically, the tumor-associated blood vessels are a promising target. We recently found that the intermediate filament protein vimentin is externalized by endothelial cells of the tumor vasculature. Extracellular vimentin was shown to sustain angiogenesis by mimicking VEGF and supporting cell migration, as well as endothelial cell anergy, the unresponsiveness of the endothel...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Karlijn van Loon Mathilda E van Breest Smallenburg Elisabeth J M Huijbers Arjan W Griffioen Judy R van Beijnum Source Type: research
Targeting STING in cancer: Challenges and emerging opportunities
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188983. doi: 10.1016/j.bbcan.2023.188983. Online ahead of print.ABSTRACTThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a key pathway through which the host regulates immune responses by recognizing cytoplasmic double-stranded DNA of abnormal origin, and it plays an important role in tumor growth as well as metastasis, with relevant molecular details constantly being explored and updated. The significant immunomodulatory effects make STING an attractive target for cancer immunotherapy, and STING agonists have been receiving great at...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Kexin Zhao Jiaojiao Huang Yue Zhao Shengjun Wang Juan Xu Kai Yin Source Type: research
Extracellular vimentin as a versatile immune suppressive protein in cancer
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188985. doi: 10.1016/j.bbcan.2023.188985. Online ahead of print.ABSTRACTThe interest in finding new targets in the tumor microenvironment for anti-cancer therapy has increased rapidly over the years. More specifically, the tumor-associated blood vessels are a promising target. We recently found that the intermediate filament protein vimentin is externalized by endothelial cells of the tumor vasculature. Extracellular vimentin was shown to sustain angiogenesis by mimicking VEGF and supporting cell migration, as well as endothelial cell anergy, the unresponsiveness of the endothel...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Karlijn van Loon Mathilda E van Breest Smallenburg Elisabeth J M Huijbers Arjan W Griffioen Judy R van Beijnum Source Type: research
Targeting STING in cancer: Challenges and emerging opportunities
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188983. doi: 10.1016/j.bbcan.2023.188983. Online ahead of print.ABSTRACTThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a key pathway through which the host regulates immune responses by recognizing cytoplasmic double-stranded DNA of abnormal origin, and it plays an important role in tumor growth as well as metastasis, with relevant molecular details constantly being explored and updated. The significant immunomodulatory effects make STING an attractive target for cancer immunotherapy, and STING agonists have been receiving great at...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Kexin Zhao Jiaojiao Huang Yue Zhao Shengjun Wang Juan Xu Kai Yin Source Type: research
