Filtered By:
Therapy: Cancer Therapy
This page shows you your search results in order of date. This is page number 16.
Order by Relevance | Date
Total 13533 results found since Jan 2013.
A practical approach to the ESC 2022 cardio-oncology guidelines. Comments by a team of experts: cardiologists and oncologists
Kardiol Pol. 2023 Sep 3. doi: 10.33963/v.kp.96840. Online ahead of print.ABSTRACTThe 2022 European Society of Cardiology (ESC) guidelines [1] are a comprehensive document, prepared jointly by experts in cardiology and oncology. In the case of an oncological patient, it is necessary to individualize care in relation to the cardiological condition, the stage of the cancer and the type of potential anti-cancer therapy. Cardiac care optimisation should be undertaken before the start of oncological therapy, and continued during oncological therapy, as well as long-term after its completion [2]. The published ESC Guidelines were...
Source: Kardiologia Polska - September 3, 2023 Category: Cardiology Authors: Przemys ław Leszek Aneta Klotzka Stanis ław Bartuś Pawe ł Burchardt Anna M Czarnecka Monika D ługosz-Danecka Marek Gierlotka Hanna Kose ła-Paterczyk Agata Krawczyk-O żóg Tomasz Kubiatowski Marcin Kurzyna Adam Maciejczyk Przemys ław Mitkowski Alek Source Type: research
Novel ProTide prodrugs of 5-fluoro-2'-deoxyuridine for the treatment of liver cancer
Eur J Med Chem. 2023 Aug 25;260:115763. doi: 10.1016/j.ejmech.2023.115763. Online ahead of print.ABSTRACTProTide prodrug technology has emerged as a promising way for the development of anti-viral and anti-tumor drugs, whereas, there are fewer applications for the treatment of liver cancer. Herein, a series of distinct 3'-ester ProTide prodrugs of 5-fluoro-2'-deoxyuridine (FdUR) were synthesized and evaluated for their anti-liver cancer activity. The most efficient prodrug 11b reached a sub-micromolar activity (IC50 = 0.42 ± 0.13 μM) against HepG2 and over 100-fold and 200-fold improvements compared to 5-FU, respectively...
Source: European Journal of Medicinal Chemistry - September 2, 2023 Category: Chemistry Authors: Leilei Jiang Ting Pan Qin Lv Wenmin Yuan Xiaochun Liu Xianjun Qu Dongdong Luo Shengbiao Wan Shuxiang Cui Source Type: research
Graphene oxide nanoarchitectures in cancer therapy: Drug and gene delivery, phototherapy, immunotherapy, and vaccine development
Environ Res. 2023 Aug 31:117027. doi: 10.1016/j.envres.2023.117027. Online ahead of print.ABSTRACTThe latest advancements in oncology involves the creation of multifunctional nanostructures. The integration of nanoparticles into the realm of cancer therapy has brought about a transformative shift, revolutionizing the approach to addressing existing challenges and limitations in tumor elimination. This is particularly crucial in combating the emergence of resistance, which has significantly undermined the effectiveness of treatments like chemotherapy and radiotherapy. GO stands as a carbon-derived nanoparticle that is incre...
Source: Environmental Research - September 2, 2023 Category: Environmental Health Authors: Mohammad Saleh Sadeghi Faezeh Hosseini Sangrizeh Negar Jahani Mahdi Sadegh Abedin Soheila Chaleshgari Alireza Khodaei Ardakan Reza Baeelashaki Golnaz Ranjbarpazuki Parham Rahmanian Mohammad Arad Zandieh Noushin Nabavi Amir Reza Aref Shokooh Salimimoghadam Source Type: research
Targeted protein modification as a paradigm shift in drug discovery
Eur J Med Chem. 2023 Aug 29;260:115765. doi: 10.1016/j.ejmech.2023.115765. Online ahead of print.ABSTRACTTargeted Protein Modification (TPM) is an umbrella term encompassing numerous tools and approaches that use bifunctional agents to induce a desired modification over the POI. The most well-known TPM mechanism is PROTAC-directed protein ubiquitination. PROTAC-based targeted degradation offers several advantages over conventional small-molecule inhibitors, has shifted the drug discovery paradigm, and is acquiring increasing interest as over ten PROTACs have entered clinical trials in the past few years. Targeting the prot...
Source: European Journal of Medicinal Chemistry - September 2, 2023 Category: Chemistry Authors: Roshanak Amirian Mehdi Azadi Badrbani Zhila Izadi Hadi Samadian Gholamreza Bahrami Sajad Sarvari Sara Abdolmaleki Seyed Mohammad Nabavi Hossein Derakhshankhah Mehdi Jaymand Source Type: research
Graphene oxide nanoarchitectures in cancer therapy: Drug and gene delivery, phototherapy, immunotherapy, and vaccine development
Environ Res. 2023 Aug 31:117027. doi: 10.1016/j.envres.2023.117027. Online ahead of print.ABSTRACTThe latest advancements in oncology involves the creation of multifunctional nanostructures. The integration of nanoparticles into the realm of cancer therapy has brought about a transformative shift, revolutionizing the approach to addressing existing challenges and limitations in tumor elimination. This is particularly crucial in combating the emergence of resistance, which has significantly undermined the effectiveness of treatments like chemotherapy and radiotherapy. GO stands as a carbon-derived nanoparticle that is incre...
Source: Environmental Research - September 2, 2023 Category: Environmental Health Authors: Mohammad Saleh Sadeghi Faezeh Hosseini Sangrizeh Negar Jahani Mahdi Sadegh Abedin Soheila Chaleshgari Alireza Khodaei Ardakan Reza Baeelashaki Golnaz Ranjbarpazuki Parham Rahmanian Mohammad Arad Zandieh Noushin Nabavi Amir Reza Aref Shokooh Salimimoghadam Source Type: research
HDAC11: A novel target for improved cancer therapy
Biomed Pharmacother. 2023 Aug 31;166:115418. doi: 10.1016/j.biopha.2023.115418. Online ahead of print.ABSTRACTHistone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family that plays an important role in the regulation of gene expression and protein function. In recent years, research on the role of HDAC11 in tumors has attracted increasing attention. This review summarizes the current knowledge on the subcellular localization, structure, expression, and functions of HDAC11 in tumors, as well as the regulatory mechanisms involved in its network, including ncRNA and substrates. Moreover, we focus on t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 2, 2023 Category: Drugs & Pharmacology Authors: Yan Liu Xuechao Tong Weina Hu Da Chen Source Type: research
Graphene oxide nanoarchitectures in cancer therapy: Drug and gene delivery, phototherapy, immunotherapy, and vaccine development
Environ Res. 2023 Aug 31:117027. doi: 10.1016/j.envres.2023.117027. Online ahead of print.ABSTRACTThe latest advancements in oncology involves the creation of multifunctional nanostructures. The integration of nanoparticles into the realm of cancer therapy has brought about a transformative shift, revolutionizing the approach to addressing existing challenges and limitations in tumor elimination. This is particularly crucial in combating the emergence of resistance, which has significantly undermined the effectiveness of treatments like chemotherapy and radiotherapy. GO stands as a carbon-derived nanoparticle that is incre...
Source: Cancer Control - September 2, 2023 Category: Cancer & Oncology Authors: Mohammad Saleh Sadeghi Faezeh Hosseini Sangrizeh Negar Jahani Mahdi Sadegh Abedin Soheila Chaleshgari Alireza Khodaei Ardakan Reza Baeelashaki Golnaz Ranjbarpazuki Parham Rahmanian Mohammad Arad Zandieh Noushin Nabavi Amir Reza Aref Shokooh Salimimoghadam Source Type: research
Radiopharmaceuticals used for diagnosis and therapy of NETs
Hell J Nucl Med. 2023 May-Aug;26 Suppl:19-20.ABSTRACTThe first description of the in vivo visualization of somatostatin receptor-positive tumors in patients was based on the use of a radioiodine (123I) labelled somatostatin analogue (Krenning et al. 1989). In the years that followed an Indium-111 (111In) labelled somatostatin analogue, chelated with diethylenetriaminepentaacetic acid (DTPA), was successfully developed. Subsequently, 111In-OctreoScan was introduced worldwide. In the years to come 99mTc-Tektrotyde became commercially available with easy access. In the last decade, with the increasing use of positron emission...
Source: Cancer Control - September 2, 2023 Category: Cancer & Oncology Authors: Maria Papachristou Source Type: research
HDAC11: A novel target for improved cancer therapy
Biomed Pharmacother. 2023 Aug 31;166:115418. doi: 10.1016/j.biopha.2023.115418. Online ahead of print.ABSTRACTHistone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family that plays an important role in the regulation of gene expression and protein function. In recent years, research on the role of HDAC11 in tumors has attracted increasing attention. This review summarizes the current knowledge on the subcellular localization, structure, expression, and functions of HDAC11 in tumors, as well as the regulatory mechanisms involved in its network, including ncRNA and substrates. Moreover, we focus on t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 2, 2023 Category: Drugs & Pharmacology Authors: Yan Liu Xuechao Tong Weina Hu Da Chen Source Type: research
Novel ProTide prodrugs of 5-fluoro-2'-deoxyuridine for the treatment of liver cancer
Eur J Med Chem. 2023 Aug 25;260:115763. doi: 10.1016/j.ejmech.2023.115763. Online ahead of print.ABSTRACTProTide prodrug technology has emerged as a promising way for the development of anti-viral and anti-tumor drugs, whereas, there are fewer applications for the treatment of liver cancer. Herein, a series of distinct 3'-ester ProTide prodrugs of 5-fluoro-2'-deoxyuridine (FdUR) were synthesized and evaluated for their anti-liver cancer activity. The most efficient prodrug 11b reached a sub-micromolar activity (IC50 = 0.42 ± 0.13 μM) against HepG2 and over 100-fold and 200-fold improvements compared to 5-FU, respectively...
Source: European Journal of Medicinal Chemistry - September 2, 2023 Category: Chemistry Authors: Leilei Jiang Ting Pan Qin Lv Wenmin Yuan Xiaochun Liu Xianjun Qu Dongdong Luo Shengbiao Wan Shuxiang Cui Source Type: research
Targeted protein modification as a paradigm shift in drug discovery
Eur J Med Chem. 2023 Aug 29;260:115765. doi: 10.1016/j.ejmech.2023.115765. Online ahead of print.ABSTRACTTargeted Protein Modification (TPM) is an umbrella term encompassing numerous tools and approaches that use bifunctional agents to induce a desired modification over the POI. The most well-known TPM mechanism is PROTAC-directed protein ubiquitination. PROTAC-based targeted degradation offers several advantages over conventional small-molecule inhibitors, has shifted the drug discovery paradigm, and is acquiring increasing interest as over ten PROTACs have entered clinical trials in the past few years. Targeting the prot...
Source: European Journal of Medicinal Chemistry - September 2, 2023 Category: Chemistry Authors: Roshanak Amirian Mehdi Azadi Badrbani Zhila Izadi Hadi Samadian Gholamreza Bahrami Sajad Sarvari Sara Abdolmaleki Seyed Mohammad Nabavi Hossein Derakhshankhah Mehdi Jaymand Source Type: research
Sulfur dioxide-releasing polymeric micelles based on modified hyaluronic acid for combined cancer therapy
In this study, an amphiphilic polymer mPEG-HA(SA)-DNs was designed and synthesized to fabricate a multifunctional micellar system to enhance the therapeutic efficacy and reduce the toxic effect of paclitaxel (PTX). The polymer was prepared by introducing mPEG, stearic acid (SA) and 2,4-dinitrobenzenesulfonic acid (DNs) to the backbone of hyaluronic acid (HA). With above modifications, the fabricated micelles could encapsulate PTX in the core with high drug loading. The optimized PTX-loaded micelles had a mean size of 158.3 nm. Upon the effect of mPEG, the mPEG-HA(SA)-DNs micelles reduced the non-specific protein adsorption...
Source: International Journal of Biological Macromolecules - September 1, 2023 Category: Biochemistry Authors: Sheng Wang Shupeng Li Na Liang Siyi Li Xiaoxin Li Pengfei Yan Shaoping Sun Source Type: research
Biomacromolecule-based nanocarrier strategies to deliver plant-derived bioactive components for cancer treatment: A recent review
Int J Biol Macromol. 2023 Aug 30:126623. doi: 10.1016/j.ijbiomac.2023.126623. Online ahead of print.ABSTRACTThe quest for safe chemotherapy has attracted researchers to explore anticancer potential of herbal medicines. Owing to upsurging evidence of herbal drug's beneficial effects, hopes are restored for augmenting survival rates in cancer patients. However, phytoconstituents confronted severe limitations in terms of poor absorption, low-stability, and low bioavailability. Along with toxicity issues associated with phytoconstituents, quality control and limited regulatory guidance also hinder the prevalence of herbal medi...
Source: International Journal of Biological Macromolecules - September 1, 2023 Category: Biochemistry Authors: Bapi Gorain Varnita Karmakar Biswatrish Sarkar Monika Dwivedi Janelle Tsui Lyn Leong Jing Hen Toh Even Seah Kang Yi Ling Kah Yee Chen Hira Choudhury Manisha Pandey Source Type: research
Roles of salt ‑inducible kinases in cancer (Review)
Int J Oncol. 2023 Nov;63(5):118. doi: 10.3892/ijo.2023.5566. Epub 2023 Sep 1.ABSTRACTSalt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP‑activated protein kinase family. They are expressed ubiquitously in humans. Under normal circumstances, SIK1 regulates adrenocortical function in response to high salt or adrenocorticotropic hormone stimulation, SIK2 is involved in cell metabolism, controlling insulin signaling and gluconeogenesis and SIK3 coordinates with the mTOR complex, promoting cancer. The dysregulation of SIKs has been widely detected in various types of cancers. Based on most...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Shenghui Feng Fangyi Wei Haoran Shi Shen Chen Bangqi Wang Deqiang Huang Lingyu Luo Source Type: research
Single-cell dissection of tumor microenvironmental response and resistance to cancer therapy
Trends Genet. 2023 Aug 30:S0168-9525(23)00163-4. doi: 10.1016/j.tig.2023.07.005. Online ahead of print.ABSTRACTCancer treatment strategies have evolved significantly over the years, with chemotherapy, targeted therapy, and immunotherapy as major pillars. Each modality leads to unique treatment outcomes by interacting with the tumor microenvironment (TME), which imposes a fundamental selective pressure on cancer progression. The advent of single-cell profiling technologies has revolutionized our understanding of the intricate and heterogeneous nature of the TME at an unprecedented resolution. This review delves into the com...
Source: Trends in Genetics : TIG - September 1, 2023 Category: Genetics & Stem Cells Authors: Yikai Luo Han Liang Source Type: research
