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Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing < em > Escherichia coli < /em >
Antimicrob Agents Chemother. 2023 Sep 13:e0051023. doi: 10.1128/aac.00510-23. Online ahead of print.ABSTRACTCefmetazole is active against extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC) and is a potential candidate for carbapenem-sparing therapy. This multicenter, observational study included patients hospitalized for invasive urinary tract infection due to ESBLEC between March 2020 and November 2021 at 10 facilities in Japan, for whom either cefmetazole or meropenem was initiated as a definitive therapy within 96 h of culture collection and continued for at least 3 d. Outcomes included clinical and micr...
Source: Antimicrobial Agents and Chemotherapy - September 13, 2023 Category: Microbiology Authors: Kayoko Hayakawa Yasufumi Matsumura Kohei Uemura Shinya Tsuzuki Aki Sakurai Ryutaro Tanizaki Koh Shinohara Takehiro Hashimoto Ryota Hase Takashi Matono Hideaki Kato Momoko Mawatari Hiroshi Hara Yukihiro Hamada Sho Saito Norio Ohmagari Yohei Doi Source Type: research
Oxidative stress in breast cancer after chemotherapy
Bioinformation. 2022 Dec 31;18(12):1141-1145. doi: 10.6026/973206300181141. eCollection 2022.ABSTRACTIt is of interest to evaluate the influence of breast cancer on oxidative stress, liver function tests, renal biomarkers, action of doxorubicin, cyclophosphamide and paclitaxel (AC-T) in the treatment and mechanism over altering the measured markers in breast cancer. Sixty histopathological confirmed cases of female patients suffering with breast carcinoma from the Department of Oncology at Omega Cancer Hospital, Visakhapatnam were included in the study. The investigation was performed in 3 groups: a control group containin...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Tejaswi Pullakanam Sri Phani Murugan Mannangatti Ramakrishna Nekkala Venkata Madhavi Bellala Ravi Shankar Bellala Vijayalakshmi Payala Source Type: research
Linkage of blood cell division cycle 42 with T helper cells, and their correlation with anxiety, depression, and cognitive impairment in stroke patients
This study aimed to assess the correlation between blood CDC42 and Th cells, and their association with mental issues in stroke patients. Peripheral blood samples were obtained from 264 stroke patients and 50 controls. Then, serum CDC42 was measured by enzyme-linked immunosorbent assay, and Th1, Th2, and Th17 cells were detected by flow cytometry. Hospital Anxiety and Depression Scale (HADS) and Mini Mental State Examination (MMSE) were applied to patients. CDC42 was decreased (P<0.001), Th1 (P=0.013) and Th17 (P<0.001) cells were elevated, while Th2 cells (P=0.108) showed no difference in stroke patients compared to...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: Haifeng Ma Qing Chang Jujuan Jia Yaoyuan Zhang Gang Wang Yuanyuan Li Source Type: research
Effectiveness of cefmetazole versus meropenem for invasive urinary tract infections caused by extended-spectrum β-lactamase-producing < em > Escherichia coli < /em >
Antimicrob Agents Chemother. 2023 Sep 13:e0051023. doi: 10.1128/aac.00510-23. Online ahead of print.ABSTRACTCefmetazole is active against extended-spectrum β-lactamase-producing Escherichia coli (ESBLEC) and is a potential candidate for carbapenem-sparing therapy. This multicenter, observational study included patients hospitalized for invasive urinary tract infection due to ESBLEC between March 2020 and November 2021 at 10 facilities in Japan, for whom either cefmetazole or meropenem was initiated as a definitive therapy within 96 h of culture collection and continued for at least 3 d. Outcomes included clinical and micr...
Source: Antimicrobial Agents and Chemotherapy - September 13, 2023 Category: Microbiology Authors: Kayoko Hayakawa Yasufumi Matsumura Kohei Uemura Shinya Tsuzuki Aki Sakurai Ryutaro Tanizaki Koh Shinohara Takehiro Hashimoto Ryota Hase Takashi Matono Hideaki Kato Momoko Mawatari Hiroshi Hara Yukihiro Hamada Sho Saito Norio Ohmagari Yohei Doi Source Type: research
An Estimation Formula for Resonance Frequency Using Sex and Height for Healthy Individuals and Patients with Incurable Cancers
Appl Psychophysiol Biofeedback. 2023 Sep 13. doi: 10.1007/s10484-023-09602-5. Online ahead of print.ABSTRACTResonance frequency breathing is a technique that involves breathing that maximizes heart rate variability. It is specific to individuals and is determined through a procedure taking approximately 30 min, using a procedure that is often best carried out at specialized medical institutions. This is a physical and time-consuming burden because of hospital visits and measurements, particularly for patients with cancer. Therefore it would be beneficial if a procedure can be found to determine resonance frequency from the...
Source: Applied Psychophysiology and Biofeedback - September 13, 2023 Category: Psychiatry & Psychology Authors: Hideaki Hasuo Keita Mori Hiromichi Matsuoka Hiroko Sakuma Hideki Ishikawa Source Type: research
Linkage of blood cell division cycle 42 with T helper cells, and their correlation with anxiety, depression, and cognitive impairment in stroke patients
This study aimed to assess the correlation between blood CDC42 and Th cells, and their association with mental issues in stroke patients. Peripheral blood samples were obtained from 264 stroke patients and 50 controls. Then, serum CDC42 was measured by enzyme-linked immunosorbent assay, and Th1, Th2, and Th17 cells were detected by flow cytometry. Hospital Anxiety and Depression Scale (HADS) and Mini Mental State Examination (MMSE) were applied to patients. CDC42 was decreased (P<0.001), Th1 (P=0.013) and Th17 (P<0.001) cells were elevated, while Th2 cells (P=0.108) showed no difference in stroke patients compared to...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: Haifeng Ma Qing Chang Jujuan Jia Yaoyuan Zhang Gang Wang Yuanyuan Li Source Type: research
An Estimation Formula for Resonance Frequency Using Sex and Height for Healthy Individuals and Patients with Incurable Cancers
Appl Psychophysiol Biofeedback. 2023 Sep 13. doi: 10.1007/s10484-023-09602-5. Online ahead of print.ABSTRACTResonance frequency breathing is a technique that involves breathing that maximizes heart rate variability. It is specific to individuals and is determined through a procedure taking approximately 30 min, using a procedure that is often best carried out at specialized medical institutions. This is a physical and time-consuming burden because of hospital visits and measurements, particularly for patients with cancer. Therefore it would be beneficial if a procedure can be found to determine resonance frequency from the...
Source: Applied Psychophysiology and Biofeedback - September 13, 2023 Category: Psychiatry & Psychology Authors: Hideaki Hasuo Keita Mori Hiromichi Matsuoka Hiroko Sakuma Hideki Ishikawa Source Type: research
Finding Power in My Panic Attacks
Trouble started in the form of rivulets of sweat dampening the waistband of my underwear. It was a bluebird afternoon in Phoenix in December of 2020, mid 60s, desert dry, and my heart was jackhammering against my ribcage. Breathing felt like I was sucking air through a stir straw. A small ABC News crew was arrayed before me, ready to broadcast the report I’d written that day, but with my vision narrowed to a needle’s eye, I could barely see them. I tried to swallow away the sandiness in my mouth but realized I’d forgotten how.
[time-brightcove not-tgx=”true”]
“I can’t swallow!...
Source: TIME: Health - September 12, 2023 Category: Consumer Health News Authors: Matt Gutman Tags: Uncategorized freelance Source Type: news
Leukemic-phase mucosa-associated lymphoid tissue lymphoma
Int J Hematol. 2023 Sep 12. doi: 10.1007/s12185-023-03654-3. Online ahead of print.ABSTRACTA 78-year-old man presenting with leukocytosis was admitted to our hospital. The patient was asymptomatic and showed no lymphadenopathy. Peripheral blood flow cytometry revealed a leukemic-phase B-cell lymphoma with medium-to-large abnormal cells with reticulum. Positron emission tomography/computed tomography revealed abnormal uptake in the right orbit, bone marrow, and spleen. We performed immunological staining and fluorescence in situ hybridization on tissues extracted from the right orbit and bone marrow, which led to the diagno...
Source: International Journal of Hematology - September 12, 2023 Category: Hematology Authors: Takayuki Yotsuyanagi Naoto Tomita Yusuke Saiki Akiko Uchida Yu Uemura Yoshinori Suzuki Tsuneaki Hirakawa Masayuki Kato Naoya Nakamura Ayako Arai Source Type: research
Long-course chemoradiation plus concurrent/sequential PD-1 blockade as neoadjuvant treatment for MMR-status-unscreened locally advanced rectal cancer: protocol of a multicentre, phase 2, randomised controlled trial (the POLAR-STAR trial)
BMJ Open. 2023 Sep 12;13(9):e069499. doi: 10.1136/bmjopen-2022-069499.ABSTRACTINTRODUCTION: Recent preclinical studies have discovered unique synergism between radiotherapy and immune checkpoint inhibitors, which has already brought significant survival benefit in lung cancer. In locally advanced rectal cancer (LARC), neoadjuvant radiotherapy plus immune checkpoint inhibitors have also achieved surprisingly high pathological complete response (pCR) rates even in proficient mismatch-repair patients. As existing researches are all phase 2, single-cohort trials, we aim to conduct a randomised, controlled trial to further clar...
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Kai Pang Yun Yang Dan Tian Na Zeng Shun Cao Shen Ling Jiale Gao Pengfei Zhao Hao Wang Yuanyuan Kong Jie Zhang Guangyong Chen Wei Deng Zhigang Bai Lan Jin Guoju Wu Danyang Zhu Yue Wang Jiaolin Zhou Bin Wu Guole Lin Yi Xiao Zhidong Gao Yingjiang Ye Xin Wang Source Type: research
Early mortality in German patients with lung cancer: risk factors associated with 30-and 60-day mortality
In this study, we aimed to assess risk factors for 30- and 60-day mortality in German lung cancer patients. In this retrospective cross-sectional analysis, we used data of lung cancer patients treated at LMU Hospital Munich between 2015 and 2019. We categorized patients into 30-day mortality, 60 day-mortality, and longer survival. We used Student's t-test and ANOVA to compare means and Chi2-test to compare frequencies. We used logistic regression analysis to identify factors associated with a risk for early mortality. Of the 2454 lung cancer patients, 2.0% (n = 50) died within 30 and 1.7% (n = 41) within 30 to 60 days of d...
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Amanda Tufman Sophie Schneiderbauer Julia Walter Blerina Resuli Diego Kauffmann-Guerrero Carlo M ümmler Pontus Mertsch Jeremias G ötschke Julia Kov ács Farkhad Manapov Christian Schneider Laura Sellmer Paola Arnold Volker Heinemann J ürgen Behr Daniel Source Type: research
Waldenstrom's macroglobulinemia-like B cell lymphoma with MYD88 L265P mutation and t(14;18)(q32;q21) involving IGH < em > - < /em > MALT1
Leuk Res Rep. 2023 Aug 28;20:100389. doi: 10.1016/j.lrr.2023.100389. eCollection 2023.ABSTRACTA 65-year-old woman was referred to the hospital for further investigation of weight loss, hyperproteinemia, and anemia. Serum immunofixation electrophoresis revealed IgM-κ M protein. Bone marrow examination revealed an increase in the number of B -cells with immunoglobulin kappa light-chain restriction. Although the MYD88 L265P mutation was identified in bone marrow mononuclear cells, which suggested the diagnosis of Waldenstrom's macroglobulinemia (WM), a fusion signal of IgH-MALT1, which is commonly observed in extranodal marg...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Rie Furuta Hiro Tatetsu Jun-Ichirou Yasunaga Mitsunori Ueno Kento Oshiro Satoshi Kumanomido Yawara Kawano Yusuke Higuchi Yumi Honda Yoshiki Mikami Kisato Nosaka Masao Matsuoka Source Type: research
Antiretroviral treatment is less effective at reducing gut microbiome-associated inflammation and T cell activation in people living with HIV in rural versus urban Zimbabwe
Res Sq. 2023 Aug 31:rs.3.rs-3300723. doi: 10.21203/rs.3.rs-3300723/v1. Preprint.ABSTRACTThe widespread availability of antiretroviral therapy (ART) for people living with HIV (PLWH) has dramatically reduced mortality and improved life expectancy. However, even with suppression of HIV-1 replication, chronic immune activation and elevated inflammation persist. Chronic immune activation has been linked to a pro-inflammatory gut microbiome composition, exacerbated by compromised intestinal barrier integrity that occurs after HIV infection. Individuals living in urban versus rural areas of sub-Saharan Africa have differences in...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Alessandro Lazzaro Angela Sofia Burkhart Colorado Charles Preston Neff Nichole Nusbacher Kathryn Boyd Suzanne Fiorillo Casey Martin Janet Siebert Thomas Campbell Margaret Borok Brent Palmer Catherine Lozupone Source Type: research
