Waldenstrom's macroglobulinemia-like B cell lymphoma with MYD88 L265P mutation and t(14;18)(q32;q21) involving IGH < em > - < /em > MALT1

Leuk Res Rep. 2023 Aug 28;20:100389. doi: 10.1016/j.lrr.2023.100389. eCollection 2023.ABSTRACTA 65-year-old woman was referred to the hospital for further investigation of weight loss, hyperproteinemia, and anemia. Serum immunofixation electrophoresis revealed IgM-κ M protein. Bone marrow examination revealed an increase in the number of B -cells with immunoglobulin kappa light-chain restriction. Although the MYD88 L265P mutation was identified in bone marrow mononuclear cells, which suggested the diagnosis of Waldenstrom's macroglobulinemia (WM), a fusion signal of IgH-MALT1, which is commonly observed in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma, was also identified. Here, we describe a rare case of low-grade B-cell lymphoma with MYD88 L265P mutations accompanying IgH-MALT1.PMID:37693842 | PMC:PMC10485152 | DOI:10.1016/j.lrr.2023.100389

Source: Cell Research - September 11, 2023 Category: Cytology Authors: Rie Furuta Hiro Tatetsu Jun-Ichirou Yasunaga Mitsunori Ueno Kento Oshiro Satoshi Kumanomido Yawara Kawano Yusuke Higuchi Yumi Honda Yoshiki Mikami Kisato Nosaka Masao Matsuoka Source Type: research