Filtered By:
Education: Study

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 1880766 results found since Jan 2013.

The SEARCH for Diabetes in Youth Study: Rationale, Findings, and Future Directions.
Abstract The SEARCH for Diabetes in Youth (SEARCH) study was initiated in 2000, with funding from the Centers for Disease Control and Prevention and support from the National Institute of Diabetes and Digestive and Kidney Diseases, to address major knowledge gaps in the understanding of childhood diabetes. SEARCH is being conducted at five sites across the U.S. and represents the largest, most diverse study of diabetes among U.S. youth. An active registry of youth diagnosed with diabetes at age <20 years allows the assessment of prevalence (in 2001 and 2009), annual incidence (since 2002), and trends by age, ra...
Source: Diabetes Care - November 25, 2014 Category: Endocrinology Authors: Hamman RF, Bell RA, Dabelea D, D'Agostino RB, Dolan L, Imperatore G, Lawrence JM, Linder B, Marcovina SM, Mayer-Davis EJ, Pihoker C, Rodriguez BL, Saydah S, for the SEARCH for Diabetes in Youth Study Group Tags: Diabetes Care Source Type: research

Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for Diabetes in Youth.
Conclusions/Interpretation:In this systematic study of MODY in a large pediatric US diabetes cohort, unselected by referral pattern or family history, MODY was usually misdiagnosed and incorrectly treated with insulin. While many type 2 diabetes-like metabolic features were less common in the mutation-positive group, no single characteristic identified all patients with mutations. Clinicians should be alert to the possibility of MODY diagnosis, particularly in antibody negative youth with diabetes. PMID: 23771925 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 14, 2013 Category: Endocrinology Authors: Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, for the SEARCH for Diabetes in Youth Study Group Tags: J Clin Endocrinol Metab Source Type: research

A novel fast Fourier transform accelerated off-grid exhaustive search method for cryo-electron microscopy fitting
This paper presents a novel fast Fourier transform (FFT)-based exhaustive search method extended to off-grid translational and rotational degrees of freedom. The method combines the advantages of the FFT-based exhaustive search, which samples all the conformations of a system under study on a grid, with a local optimization technique that guarantees to find the nearest optimal off-grid conformation. The method is demonstrated on a fitting problem and can be readily applied to a docking problem. The algorithm first samples a scoring function on a six-dimensional grid of size N6 using the FFT. This operation has an asymptoti...
Source: Journal of Applied Crystallography - June 26, 2017 Category: Physics Authors: Hoffmann, A. Perrier, V. Grudinin, S. Tags: cryo-EM fitting fast Fourier transform FFT exhaustive search off-grid search trust-region problem research papers Source Type: research

Prevalence of Diabetes Mellitus in U.S. Youth in 2009: The SEARCH for Diabetes in Youth Study.
ConclusionDiabetes mellitus, one of the leading chronic diseases in childhood, affects over 190,000 (1 out of 433) youth less than age 20 years in the US, with racial and ethnic disparities seen in diabetes prevalence, overall and by diabetes type. PMID: 24041677 [PubMed - as supplied by publisher]
Source: Diabetes Care - September 16, 2013 Category: Endocrinology Authors: Pettitt DJ, Talton J, Dabelea D, Divers J, Imperatore G, Lawrence JM, Liese AD, Linder B, Mayer-Davis EJ, Pihoker C, Saydah SH, Standiford DA, Hamman RF, for the SEARCH for Diabetes in Youth Study Group Tags: Diabetes Care Source Type: research

Peripheral Neuropathy in Adolescents and Young Adults With Type 1 and Type 2 Diabetes From the SEARCH for Diabetes in Youth Follow-Up Cohort: A pilot study.
CONCLUSIONSDPN prevalence among youth with type 2 diabetes approached rates reported in adult populations with diabetes. Our findings suggest not only that youth with diabetes are at risk for DPN but also that many already show measurable signs of DPN. PMID: 24144652 [PubMed - as supplied by publisher]
Source: Diabetes Care - October 21, 2013 Category: Endocrinology Authors: Jaiswal M, Lauer A, Martin CL, Bell RA, Divers J, Dabelea D, Pettitt DJ, Saydah S, Pihoker C, Standiford DA, Rodriguez BL, Pop-Busui R, Feldman EL, for The SEARCH For Diabetes In Youth Study Group Tags: Diabetes Care Source Type: research

Complementary, Alternative, and Other Noncomplete Decongestive Therapy Treatment Methods in the Management of Lymphedema: A Systematic Search and Review
Conclusions: No interventions were ranked as “recommended for practice” based on the Putting Evidence into Practice guidelines. Two treatment modalities in 3 studies were ranked as “likely to be effective” in reducing LE or in managing secondary LE complications. Consideration should be given that many of the PAMs demonstrate long-standing support within the literature, with broad parameters for therapeutic application and benefit for secondary conditions associated with LE. However, further investigation as to their individual contributory value and the factors that contribute to their efficacy, specific to LE, h...
Source: PM and R - September 20, 2013 Category: Rehabilitation Authors: Julia R. Rodrick, Ellen Poage, Ausanee Wanchai, Bob R. Stewart, Janice N. Cormier, Jane M. Armer Tags: Analytical Review: Systematic Search Source Type: research

Factors influencing time to case registration for youth with type 1  and type 2 diabetes: SEARCH for Diabetes in Youth Study.
CONCLUSIONS: These findings highlight the need for continued childhood diabetes surveillance to identify future trends and influences on changes in prevalence and incidence. PMID: 27664849 [PubMed - as supplied by publisher]
Source: Annals of Epidemiology - August 31, 2016 Category: Epidemiology Authors: Crume TL, Hamman RF, Isom S, Talton J, Divers J, Mayer-Davis EJ, Zhong VW, Liese AD, Saydah S, Standiford DA, Lawrence JM, Pihoker C, Dabelea D, SEARCH for Diabetes in Youth Study Group Tags: Ann Epidemiol Source Type: research

Obesity, risk of biochemical recurrence, and prostate ‐specific antigen doubling time after radical prostatectomy: results from the SEARCH database
ConclusionWhile we confirmed that higher BMI was associated with BCR, we found no link between BMI and PSADT at the time of recurrence. Our data suggest obese men do not have more aggressive recurrences. Future studies are needed to test whether obesity predicts response to salvage therapies.
Source: BJU International - November 16, 2018 Category: Urology & Nephrology Authors: Stephen J. Freedland, Brandee L. Branche, Lauren E. Howard, Robert J. Hamilton, William J. Aronson, Martha K. Terris, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane, On behalf of the SEARCH Database Study Group Tags: Original Article Source Type: research

Authorship Order in Medical Education Publications: In Search of Practical Guidance for the Community.
This study describes principles commonly applied to authorship order decisions within the medical education community and educators' opinions about the significance of authorship order. Approach: A questionnaire was developed to ascertain current practices related to authorship decisions. Sixteen items were rated in terms of frequency of actual use and the desirability of the practice using a 4-point rating scale: 1 (never), 2 (sometimes), 3 (often), and 4 (always). Additional questions addressed the perceived significance of authorship order. The last set of questions provided information about respondents' personal and c...
Source: Teaching and Learning in Medicine - December 15, 2018 Category: Universities & Medical Training Authors: Authorship Order in Medical Education Publications: In Search of Practical Guidance for the Community. Tags: Teach Learn Med Source Type: research

Characterizing White Matter Tract Organization in Polymicrogyria and Lissencephaly: A Multifiber Diffusion MRI Modeling and Tractography Study FUNCTIONAL
CONCLUSIONS: We demonstrated a range of white matter tract structural abnormalities in patients with polymicrogyria and lissencephaly. The patterns of white matter tract involvement are related to polymicrogyria and lissencephaly subgroups, distribution, and, possibly, their underlying etiologies.
Source: American Journal of Neuroradiology - August 11, 2020 Category: Radiology Authors: Arrigoni, F., Peruzzo, D., Mandelstam, S., Amorosino, G., Redaelli, D., Romaniello, R., Leventer, R., Borgatti, R., Seal, M., Yang, J. Y.- M. Tags: FUNCTIONAL Source Type: research

Ultra-High-Field MR Imaging in Polymicrogyria and Epilepsy BRAIN
CONCLUSIONS: 7T imaging reveals more anatomic details of polymicrogyria compared with 3T conventional sequences, with potential implications for diagnosis, genetic studies, and surgical treatment of associated epilepsy. Abnormalities of cortical veins may suggest a role for vascular dysgenesis in pathogenesis.
Source: American Journal of Neuroradiology - February 11, 2015 Category: Radiology Authors: De Ciantis, A., Barkovich, A. J., Cosottini, M., Barba, C., Montanaro, D., Costagli, M., Tosetti, M., Biagi, L., Dobyns, W. B., Guerrini, R. Tags: BRAIN Source Type: research

Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study
Publication date: Available online 29 October 2015 Source:The Lancet Neurology Author(s): Ghayda M Mirzaa, Valerio Conti, Andrew E Timms, Christopher D Smyser, Sarah Ahmed, Melissa Carter, Sarah Barnett, Robert B Hufnagel, Amy Goldstein, Yoko Narumi-Kishimoto, Carissa Olds, Sarah Collins, Kathreen Johnston, Jean-François Deleuze, Patrick Nitschké, Kathryn Friend, Catharine Harris, Allison Goetsch, Beth Martin, Evan August Boyle, Elena Parrini, Davide Mei, Lorenzo Tattini, Anne Slavotinek, Ed Blair, Christopher Barnett, Jay Shendure, Jamel Chelly, William B Dobyns, Renzo Guerrini Background...
Source: The Lancet Neurology - October 30, 2015 Category: Neurology Source Type: research

Assessing Corticospinal Tract Asymmetry in Unilateral Polymicrogyria PEDIATRICS
CONCLUSIONS: Visual assessment of corticospinal tract asymmetry in unilateral polymicrogyria involving the motor cortex is most reliable with T1WI and color-coded DTI maps at the level of the midbrain. Pronounced asymmetry predicts preserved motor function after hemispherectomy. DTI-based tractography can be used as a guidance tool to the motor cortex within polymicrogyria.
Source: American Journal of Neuroradiology - August 14, 2018 Category: Radiology Authors: Foesleitner, O., Nenning, K.- H., Traub-Weidinger, T., Feucht, M., Bonelli, S., Czech, T., Dorfer, C., Prayer, D., Kasprian, G. Tags: PEDIATRICS Source Type: research

Polymicrogyria associated with 17p13.3p13.2 duplication: Case report and review of the literature.
We present the case of a male infant with bilateral perisylvian polymicrogyria associated with a de novo duplication of chromosome region 17p13.3p13.2. To our knowledge, this is the first report of polymicrogyria associated with the 17p13.3 contiguous gene duplication syndrome. Testing for known monogenic causes of polymicrogyria was negative and there was no clinical evidence of an acquired prenatal cause. Given the critical, dose-sensitive role that the 17p13.3 region plays in brain development we suggest that the chromosome duplication is the most likely explanation for the polymicrogyria. Clinical and functional studie...
Source: European Journal of Medical Genetics - September 30, 2019 Category: Genetics & Stem Cells Authors: Stutterd CA, Francis D, McGillivray G, Lockhart PJ, Leventer RJ Tags: Eur J Med Genet Source Type: research

ATP1A2- and ATP1A3-associated early profound epileptic encephalopathy and polymicrogyria
AbstractConstitutional heterozygous mutations ofATP1A2 andATP1A3, encoding for two distinct isoforms of the Na+/K+-ATPase (NKA) alpha-subunit, have been associated with familial hemiplegic migraine (ATP1A2), alternating hemiplegia of childhood (ATP1A2/A3), rapid-onset dystonia-parkinsonism, cerebellar ataxia-areflexia-progressive optic atrophy, and relapsing encephalopathy with cerebellar ataxia (allATP1A3). A few reports have described single individuals with heterozygous mutations ofATP1A2/A3 associated with severe childhood epilepsies. Early lethal hydrops fetalis, arthrogryposis, microcephaly, and polymicrogyria have b...
Source: Brain - May 10, 2021 Category: Neurology Source Type: research