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Total 21786 results found since Jan 2013.

Lessons from the Titan submersible: A wake-up call for radiation oncology
J Appl Clin Med Phys. 2023 Aug 10:e14121. doi: 10.1002/acm2.14121. Online ahead of print.NO ABSTRACTPMID:37561911 | DOI:10.1002/acm2.14121
Source: Journal of Applied Clinical Medical Physics - August 10, 2023 Category: Physics Authors: Mohammad Bakhtiari Source Type: research

Epithelial inflammasomes, gasdermins, and mucosal inflammation - Lessons from Salmonella and Shigella infected mice
Semin Immunol. 2023 Aug 8;70:101812. doi: 10.1016/j.smim.2023.101812. Online ahead of print.ABSTRACTBesides its crucial function in nutrient absorbance and as barrier against the microbiota, the gut epithelium is essential for sensing pathogenic insults and mounting of an appropriate early immune response. In mice, the activation of the canonical NAIP/NLRC4 inflammasome is critical for the defense against enterobacterial infections. Activation of the NAIP/NLRC4 inflammasome triggers the extrusion of infected intestinal epithelial cells (IEC) into the gut lumen, concomitant with inflammasome-mediated lytic cell death. The m...
Source: Seminars in Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Ersin G ül Stefan A Fattinger Mikael E Sellin Wolf-Dietrich Hardt Source Type: research

Five years of caplacizumab - Lessons learned and remaining controversies in immune-mediated thrombotic thrombocytopenic purpura
J Thromb Haemost. 2023 Aug 8:S1538-7836(23)00591-3. doi: 10.1016/j.jtha.2023.07.027. Online ahead of print.ABSTRACTImmune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare hematologic disease caused by autoantibodies against ADAMTS13 that trigger a microangiopathic hemolytic anemia. Therapeutic plasma exchange and glucocorticoids have been the mainstay of treatment for the past 30 years. In 2019, caplacizumab was approved as an addition to this regimen for the acute treatment of iTTP. Randomized controlled trials and real-world evidence have shown that caplacizumab reduces the time to platelet count normalizati...
Source: Thrombosis and Haemostasis - August 10, 2023 Category: Hematology Authors: Linus Alexander Volker Paul Thomas Brinkkoetter Spero R Cataland Camila Masias Source Type: research

Lessons from the Titan submersible: A wake-up call for radiation oncology
J Appl Clin Med Phys. 2023 Aug 10:e14121. doi: 10.1002/acm2.14121. Online ahead of print.NO ABSTRACTPMID:37561911 | DOI:10.1002/acm2.14121
Source: Health Physics - August 10, 2023 Category: Physics Authors: Mohammad Bakhtiari Source Type: research

When Development of the Alveolar Gas Exchange Unit Fails: Universal Single Cell Lessons from Rare Monogenic Disorders
Am J Respir Crit Care Med. 2023 Aug 9. doi: 10.1164/rccm.202307-1271ED. Online ahead of print.NO ABSTRACTPMID:37555730 | DOI:10.1164/rccm.202307-1271ED
Source: Respiratory Care - August 9, 2023 Category: Respiratory Medicine Authors: Jonas C Schupp Naftali Kaminski Source Type: research

Aspects of Program Engagement in an Online Physical Activity Intervention and Baseline Predictors of Engagement
CONCLUSION: Examining multiple aspects of engagement and a large number of potential predictors of engagement is likely needed to determine facilitators and barriers for high engagement in multi-faceted online intervention programs.PMID:37550892 | DOI:10.1177/08901171231194176
Source: American Journal of Health Promotion : AJHP - August 8, 2023 Category: International Medicine & Public Health Authors: Reagan Moffit Kathleen McTigue Molly B Conroy Andrea Kriska Gary Fischer Edmund Ricci David Dunstan Sarah Deperrior Neel Rao Lora E Burke Bonny Rockette-Wagner Source Type: research

Learning from history of natural disasters in the Sahel: a comprehensive analysis and lessons for future resilience
This study investigates the extent of damage caused by natural disasters from one of the most widely used databases-EM-DAT-with a sample size of 16 Sahelian countries over the period 1960-2020. These countries have been divided into three regions: Western Africa Sahel (WAS), Central Africa Sahel (CAS), and Eastern Africa Sahel (EAS). The analyses encompass four categories of natural hazards, namely, biological, climatological, hydrological, and meteorological. We used descriptive and test statistics to summarize the natural disaster records. Through this approach, we explore tendencies to identify the most frequently repor...
Source: Environmental Science and Pollution Research International - August 7, 2023 Category: Environmental Health Authors: Serigne Mback é Coly Malicki Zorom Babacar Leye Harouna Karambiri Aboudramane Guiro Source Type: research