Molecules, Vol. 29, Pages 1985: Design and Synthesis of Dimethylaminomethyl-Substituted Curcumin Derivatives: Potent Anti-Inflammatory, Anti-Oxidant, and Radioprotection Activity, Improved Aqueous Solubility Compared with Curcumin
Shuchen Liu
Although the wide variety of bioactivities of curcumin has been reported by researchers, the clinical application of curcumin is still limited due to its poor aqueous solubility. In view of this, a series of dimethylaminomethyl-substituted curcumin derivatives were designed and synthesized (compounds 1–15). Acetate of these derivatives were prepared (compounds 1a–15a). The Mannich reaction and aldol condensation reaction are the main reactions involved in this study. Compounds 6, 10, 12, 3a, 5a, 6a, 7a, 8a, 10a, 11a, 12a, 13a, 14a, and 15a exhibited better in vitro anti-inflamm...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Huiling Gu Sifan Liu Kai Liang Ziming Xia Guangjie Zhang Bin Li Shuchen Liu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1987: Co/SiO2 Catalyst for Methoxycarbonylation of Acetylene: On Catalytic Performance and Active Species
in Wang
Reppe carbonylation of acetylene is an atom-economic and non-petroleum approach to synthesize acrylic acid and acrylate esters, which are key intermediates in the textile, leather finishing, and polymer industries. In the present work, a noble metal-free Co@SiO2 catalyst was prepared and evaluated in the methoxycarbonylation reaction of acetylene. It was discovered that pretreatment of the catalyst by different reductants (i.e., C2H2, CO, H2, and syngas) greatly improved the catalytic activity, of which Co/SiO2-H2 demonstrated the best performance under conditions of 160 °C, 0.05 MPa C2H2, 4 MPa CO,...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: An Wang Hongchen Cao Leilei Zhang Aiqin Wang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1986: Unveiling the Untapped Potential of Bertagnini & rsquo;s Salts in Microwave-Assisted Synthesis of Quinazolinones
Molecules, Vol. 29, Pages 1986: Unveiling the Untapped Potential of Bertagnini’s Salts in Microwave-Assisted Synthesis of Quinazolinones
Molecules doi: 10.3390/molecules29091986
Authors:
Shyamal Kanti Bera
Sourav Behera
Lidia De Luca
Francesco Basoccu
Rita Mocci
Andrea Porcheddu
Microwave-assisted organic synthesis (MAOS) has emerged as a transformative technique in organic chemistry, significantly enhancing the speed, efficiency, and selectivity of chemical reactions. In our research, we have employed microwave irradiation to expedite the synthesis of quinazolinones, using water as an eco-frien...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Shyamal Kanti Bera Sourav Behera Lidia De Luca Francesco Basoccu Rita Mocci Andrea Porcheddu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1988: Uniform P-Doped MnMoO4 Nanosheets for Enhanced Asymmetric Supercapacitors Performance
In this study, MnMoO4·H2O nanosheets were synthesized on nickel foam via a hydrothermal route, and the MnMoO4·H2O nanosheet structure was successfully doped with a phosphorus element using a gas–solid reaction method. Phosphorus element doping forms phosphorus–metal bonds and oxygen vacancies, thereby increasing the charge storage and conductivity of the electrode material. The specific capacitance value is as high as 2.112 F cm−2 (1760 F g−1) at 1 mA cm−2, which is 3.2 times higher than that of the MnMoO4·H2O...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Yu Liu Yan Li Zhuohao Liu Tao Feng Huichuan Lin Gang Li Kaiying Wang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1989: Comprehensive Two-Dimensional Gas Chromatography with a TOF MS Detector & mdash;An Effective Tool to Trace the Signature of Grape Varieties
Molecules, Vol. 29, Pages 1989: Comprehensive Two-Dimensional Gas Chromatography with a TOF MS Detector—An Effective Tool to Trace the Signature of Grape Varieties
Molecules doi: 10.3390/molecules29091989
Authors:
Daniela Fonseca
Nuno Martins
Raquel Garcia
Maria João Cabrita
Varietal volatile compounds are characteristic of each variety of grapes and come from the skins of the grapes. This work focuses on the development of a methodology for the analysis of free compounds in grapes from Trincadeira, Cabernet Sauvignon, Syrah, Castelão and Tinta Barroca from the 2021 and 2022 harvests...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Daniela Fonseca Nuno Martins Raquel Garcia Maria Jo ão Cabrita Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1990: Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N,N & prime;-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus
Molecules, Vol. 29, Pages 1990: Synthesis, Structure and Antibacterial Activity of Two Novel Coordination Polymers Based on N,N′-bis(4-carbozvlbenzvl)-4-aminotoluene and Heterocyclic Ligand against S. aureus
Molecules doi: 10.3390/molecules29091990
Authors:
Ziyun Wang
Lun Zhao
Hongwei Jing
Guanying Song
Jiayu Li
As the use of antibiotics increases, the increasing resistance of bacteria is the main reason for the reduced efficiency of antibacterial drugs, making the research of new antibacterial materials become new hot spot. In this article, two novel coordination polymers (CPs), namely, [Cd2(L)2(...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Ziyun Wang Lun Zhao Hongwei Jing Guanying Song Jiayu Li Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1991: Palladium-Catalyzed Esterification of Aryl Fluorosulfates with Aryl Formates
Zhi-Liang Shen
An efficient palladium-catalyzed carbonylation of aryl fluorosulfates with aryl formates for the facile synthesis of esters was developed. The cross-coupling reactions proceeded effectively in the presence of a palladium catalyst, phosphine ligand, and triethylamine in DMF to produce the corresponding esters in moderate to good yields. Of note, functionalities or substituents, such as nitro, cyano, methoxycarbonyl, trifluoromethyl, methylsulfonyl, trifluoromethoxy, fluoro, chloro, bromo, methyl, methoxy, N,N-dimethyl, and [1,3]dioxolyl, were well-tolerated in the reactions, which could be kept for lat...
Source: Molecules - April 26, 2024 Category: Chemistry Authors: Xue Chen Yuan Liang Wen-Wen Wang Chengping Miao Xue-Qiang Chu Weidong Rao Hao Xu Xiaocong Zhou Zhi-Liang Shen Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1984: A Review of Ultrasonic Treatment in Mineral Flotation: Mechanism and Recent Development
ng
Song
Ultrasonic treatment has been widely used in the mineral flotation process due to its advantages in terms of operational simplicity, no secondary pollutant formation, and safety. Currently, many studies have reported the effect of ultrasonic treatment on mineral flotation and shown excellent flotation performance. In this review, the ultrasonic mechanisms are classified into three types: the transient cavitation effect, stable cavitation effect, and acoustic radiation force effect. The effect of the main ultrasonic parameters, including ultrasonic power and ultrasonic frequency, on mineral flotation are disc...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Zhang Du Hu Zhang Song Tags: Review Source Type: research
Molecules, Vol. 29, Pages 1962: Conformation Analysis and Stereodynamics of Symmetrically ortho-Disubstituted Carvacrol Derivatives
ssilev
The design and synthesis of analogs of natural products can be a valuable source of medicinal preparations for the pharmaceutical industry. In the present study, the structural elucidation of eleven derivatives of 2,4-dihalogeno substituted synthetic analogues of the natural compound carvacrol was carried out by means of NMR experiments, and of another thirteen by DFT calculations. By selective NOE experiments and the irradiation of CH signals of the isopropyl group, individual conformers were assigned as syn and anti. By comparing GIAO/B3LYP/6-311++G(d,p)-calculated and experimentally measured vicinal 3JCH spin...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Miljana R. Đorđević Zlatković Niko S. Radulovi ć Miroslav Dangalov Nikolay G. Vassilev Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1963: Y(OTf)3-Salazin-Catalyzed Asymmetric Aldol Condensation
iaxi Xu
The chiral aziridine-containing vicinal iminophenol tridentate ligands (named salazins) are a class of readily prepared chiral ligands from enantiopure aziridines and salicylaldehydes. Their scandium and yttrium triflate complexes show excellent reactivity and enantioselectivities in the catalytic asymmetric aldol condensation of electron-deficient aromatic aldehydes and ketones, including acetone and cycloalkanones. The stereoselectivity is rationalized to the strong π–stacking interaction between aromatic aldehydes and the vicinal iminophenol group in the chiral ligands. (Source: Molecules)
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Chengzhuo Wang Ning Chen Zhanhui Yang Jiaxi Xu Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1965: The Effects of Antofine on the Morphological and Physiological Characteristics of Phytophthora capsici
This study revealed that antofine is likely to affect the pathways related to the energy metabolism of P. capsici and thus affect the activity of respiratory chain complexes. These results increase our understanding of the action mechanism of antofine against P. capsici. (Source: Molecules)
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Mei Wang Weirong Zhang Jiaojiao Lu Yanbo Huo Jing Wang Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1964: Self-Assembly Behavior, Aggregation Structure, and the Charge Carrier Transport Properties of S-Heterocyclic Annulated Perylene Diimide Derivatives
Ye
Haifeng Ji
Liang Lv
The construction of high-performance n-type semiconductors is crucial for the advancement of organic electronics. As an attractive n-type semiconductor, molecular systems based on perylene diimide derivatives (PDIs) have been extensively investigated over recent years. Owing to the fascinating aggregated structure and high performance, S-heterocyclic annulated PDIs (SPDIs) are receiving increasing attention. However, the relationship between the structure and the electrical properties of SPDIs has not been deeply revealed, restricting the progress of PDI-based organic electronics. Here, we d...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Haijie Ben Gaojie Yan Yulin Wang Huiming Zeng Yuechao Wu Feng Lin Junhua Zhao Wanglong Du Shaojie Zhang Shijia Zhou Jingyu Pu Milan Ye Haifeng Ji Liang Lv Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1967: 3-Ethynyltriimidazo[1,2-a:1 & prime;,2 & prime;-c:1 & Prime;,2 & Prime;-e][1,3,5]triazine Dual Short- and Long-Lived Emissions with Crystallization-Enhanced Feature: Role of Hydrogen Bonds and & pi;- & pi; Interactions
Molecules, Vol. 29, Pages 1967: 3-Ethynyltriimidazo[1,2-a:1′,2′-c:1″,2″-e][1,3,5]triazine Dual Short- and Long-Lived Emissions with Crystallization-Enhanced Feature: Role of Hydrogen Bonds and π-π Interactions
Molecules doi: 10.3390/molecules29091967
Authors:
Daniele Malpicci
Daniele Maver
Elisabetta Rosadoni
Alessia Colombo
Elena Lucenti
Daniele Marinotto
Chiara Botta
Fabio Bellina
Elena Cariati
Alessandra Forni
Organic room temperature phosphorescent (ORTP) materials with stimuli-responsive, multicomponent emissive behaviour are extremely des...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Daniele Malpicci Daniele Maver Elisabetta Rosadoni Alessia Colombo Elena Lucenti Daniele Marinotto Chiara Botta Fabio Bellina Elena Cariati Alessandra Forni Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1966: Sc-Modified C3N4 Nanotubes for High-Capacity Hydrogen Storage: A Theoretical Prediction
In this study, the stability and capacity for hydrogen storage in the Sc-modified C3N4 nanotube are thoroughly examined through the application of density functional theory (DFT). Our finding indicates that a strong coupling between the Sc-3d orbitals and N-2p orbitals stabilizes the Sc-modified C3N4 nanotube at a high temperature (500 K), and the high migration barrier (5.10 eV) between adjacent Sc atoms prevents the creation of metal clusters. Particularly, it has been found that each Sc-modified C3N4 nanotube is capable of adsorbing up to nine H2 molecules, and the gravimetric hydrogen storage density is calculated to b...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Shuli Liu Xiao Tang Chang He Tingting Wang Liying Shang Mengyuan Wang Shenbo Yang Zhenjie Tang Lin Ju Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1968: Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities
Niu
Sheng Liu
Terpenoid alkaloids are recognized as a class of compounds with limited numbers but potent biological activities, primarily derived from plants, with a minor proportion originating from animals and microorganisms. These alkaloids are synthesized from the same prenyl unit that forms the terpene skeleton, with the nitrogen atom introduced through β-aminoethanol, ethylamine, or methylamine, leading to a range of complex and diverse structures. Based on their skeleton type, they can be categorized into monoterpenes, sesquiterpenes, diterpenes, and triterpene alkaloids. To date, 289 natural terp...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Xuyan Wang Jianzeng Xin Lili Sun Yupei Sun Yaxi Xu Feng Zhao Changshan Niu Sheng Liu Tags: Review Source Type: research
