circ_PPAPDC1A promotes Osimertinib resistance by sponging the miR-30a-3p/ IGF1R pathway in non-small cell lung cancer (NSCLC)
Recent evidence has demonstrated that abnormal expression and regulation of circular RNA (circRNAs) are involved in the occurrence and development of a variety of tumors. The aim of this study was to investiga... (Source: Molecular Cancer)
Source: Molecular Cancer - May 7, 2024 Category: Cancer & Oncology Authors: Yi-fang Tang, Zheng-hua Liu, Lei-yi Zhang, Sheng-hao Shi, Shun Xu, Jin-An Ma, Chun-Hong Hu and Fang-wen Zou Tags: Research Source Type: research
Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer
Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is more challenging and may be unresponsive to conventional thera... (Source: Molecular Cancer)
Source: Molecular Cancer - May 7, 2024 Category: Cancer & Oncology Authors: Moumita Kundu, Ramesh Butti, Venketesh K. Panda, Diksha Malhotra, Sumit Das, Tandrima Mitra, Prachi Kapse, Suresh W. Gosavi and Gopal C. Kundu Tags: Review Source Type: research
Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma
Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type of histone mark, which links... (Source: Molecular Cancer)
Source: Molecular Cancer - May 6, 2024 Category: Cancer & Oncology Authors: Fei Li, Wenzhe Si, Li Xia, Deshan Yin, Tianjiao Wei, Ming Tao, Xiaona Cui, Jin Yang, Tianpei Hong and Rui Wei Tags: Research Source Type: research
Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications
Intratumoral heterogeneity (ITH) and tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) play important roles in tumor evolution and patient outcomes. However, the precise characterization ... (Source: Molecular Cancer)
Source: Molecular Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Joo Kyung Park, Hyoung-oh Jeong, Hyemin Kim, Jin Ho Choi, Eun Mi Lee, Seunghoon Kim, Jinho Jang, David Whee-Young Choi, Se-Hoon Lee, Kyoung Mee Kim, Kee-Taek Jang, Kwang Hyuck Lee, Kyu Taek Lee, Min Woo Lee, Jong Kyun Lee and Semin Lee Tags: Correspondence Source Type: research
Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options
Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating ... (Source: Molecular Cancer)
Source: Molecular Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Hongli Gao, Zhuo Xi, Jingwei Dai, Jinqi Xue, Xin Guan, Liang Zhao, Zhiguang Chen and Fei Xing Tags: Review Source Type: research
Ferroptotic therapy in cancer: benefits, side effects, and risks
Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigat... (Source: Molecular Cancer)
Source: Molecular Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Jiandong Diao, Yuanyuan Jia, Enyong Dai, Jiao Liu, Rui Kang, Daolin Tang, Leng Han, Yingjie Zhong and Lingjun Meng Tags: Review Source Type: research
Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance
CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the ... (Source: Molecular Cancer)
Source: Molecular Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Jianfeng Cui, Xiaochen Liu, Qinghong Shang, Shuna Sun, Shouzhen Chen, Jianping Dong, Yaofeng Zhu, Lei Liu, Yangyang Xia, Yong Wang, Lu Xiang, Bowen Fan, Jiafeng Zhan, Yadi Zhou, Pengxiang Chen, Renchang Zhao & hellip; Tags: Research Source Type: research
R-loop and diseases: the cell cycle matters
The cell cycle is a crucial biological process that is involved in cell growth, development, and reproduction. It can be divided into G1, S, G2, and M phases, and each period is closely regulated to ensure the... (Source: Molecular Cancer)
Source: Molecular Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Yuqin Xu, Yue Jiao, Chengbin Liu, Rui Miao, Chunyan Liu, Yilong Wang, Chunming Ma and Jiao Liu Tags: Review Source Type: research
Exclusion of HDAC1/2 complexes by oncogenic nuclear condensates
Nuclear condensates have been shown to regulate cell fate control, but its role in oncogenic transformation remains largely unknown. Here we show acquisition of oncogenic potential by nuclear condensate remode... (Source: Molecular Cancer)
Source: Molecular Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Junqi Kuang, Pengli Li, Ziwei Zhai, Yixin Fan, HuaiYuan Xu, Chengchen Zhao, Wei Li, Xiaoxi Li, Zechuan Liang, Tao Huang, Yue Qin, Huiru Gao, Zhaoyi Ma, Dong Liu, Guifa Zhong, Bo Wang & hellip; Tags: Research Source Type: research
Mutation of neurotrophic tyrosine receptor kinase can promote pan-cancer immunity and the efficacy of immunotherapy
The Neurotrophic tyrosine receptor kinase (NTRK) family plays important roles in tumor progression and is involved in tumor immunogenicity. Here, we conducted a comprehensive bioinformatic and clinical analysis t... (Source: Molecular Cancer)
Source: Molecular Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Congren Wang, Yingying Li, Jinyuan Huang, Huimeng Yan and Bin Zhao Tags: Correspondence Source Type: research
The incorporation of acetylated LAP-TGF- β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis
Triple-negative breast cancer (TNBC) stands as the breast cancer subtype with the highest recurrence and mortality rates, with the lungs being the common site of metastasis. The pulmonary microenvironment play... (Source: Molecular Cancer)
Source: Molecular Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Pei Yu, Yubao Han, Lulu Meng, Zengying Tang, Zhiwei Jin, Zhenzhen Zhang, Yunjiang Zhou, Jun Luo, Jianguang Luo, Chao Han, Chao Zhang and Lingyi Kong Tags: Research Source Type: research
Co-transcriptional R-loops-mediated epigenetic regulation drives growth retardation and docetaxel chemosensitivity enhancement in advanced prostate cancer
R-loops are prevalent three-stranded nucleic acid structures, comprising a DNA-RNA hybrid and a displaced single-stranded DNA, that frequently form during transcription and may be attributed to genomic stabili... (Source: Molecular Cancer)
Source: Molecular Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Yufan Ying, Yuqing Wu, Fenghao Zhang, Yijie Tang, Jiahe Yi, Xueyou Ma, Jiangfeng Li, Danni Chen, Xiao Wang, Xiaoyan Liu, Ben Liu, Jindan Luo, Xiangyi Zheng and Liping Xie Tags: Research Source Type: research
Evolving insights into the improvement of adoptive T-cell immunotherapy through PD-1/PD-L1 blockade in the clinical spectrum of lung cancer
Undeniably, cancer immunotherapies have expanded the spectrum of cancer treatment, however, some patients do not respond to immunotherapies. This scenario is no different for lung cancer, whose two main types,... (Source: Molecular Cancer)
Source: Molecular Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Yutao Li, Amit Sharma and Ingo G.H. Schmidt-Wolf Tags: Review Source Type: research
Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
This study analyzes the effects of trametinib on... (Source: Molecular Cancer)
Source: Molecular Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Ander Puyalto, Mar ía Rodríguez-Remírez, Inés López, Irati Macaya, Elizabeth Guruceaga, María Olmedo, Anna Vilalta-Lacarra, Connor Welch, Sergio Sandiego, Silvestre Vicent, Karmele Valencia, Alfonso Calvo, Ruben Pio, Luis E. Raez, Christian Rolfo, D Tags: Research Source Type: research
Efficacy and safety of bispecific antibodies vs. immune checkpoint blockade combination therapy in cancer: a real-world comparison
Emerging tumor immunotherapy methods encompass bispecific antibodies (BSABs), immune checkpoint inhibitors (ICIs), and adoptive cell immunotherapy. BSABs belong to the antibody family that can specifically rec... (Source: Molecular Cancer)
Source: Molecular Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Linyan Cheng, Lujun Chen, Yuan Shi, Weiying Gu, Weidong Ding, Xiao Zheng, Yan Liu, Jingting Jiang and Zhuojun Zheng Tags: Review Source Type: research
