Diagnostic Efficacy and Clinical Impact of Image-guided Core Needle Biopsy of Suspected Vertebral Osteomyelitis
Vertebral osteomyelitis diagnosis and etiologic identification is best accomplished by surgical sampling or by image-guided core needle biopsy and/or aspiration to obtain tissue for histopathologic examination and microbiological cultures [1,2]. The identification and antimicrobial susceptibility data of a causative microorganism is crucial, as the current standard of care is to treat patients with at least 6 weeks of antimicrobials, along with surgical therapy whenever possible [3,4]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 24, 2024 Category: Infectious Diseases Authors: Winston L. Winkler, Ige A. Geroge, Sumanth Gandra, Jonathan C. Baker, Anderanik Tomasian, Benjamin Northrup, Theodore L. Vander Velde, Travis J. Hillen, Chongliang Luo, Resten Imaoka, Gino M. Dettorre, Jack W. Jennings Source Type: research

The contributions of vaccination and natural infection to the production of neutralizing antibodies against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) prototype strain and variants
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel coronavirus responsible for the coronavirus disease 2019 (COVID-19) global pandemic [1-3]. As the pandemic progressed, new, more transmissible but less virulent variants, like the Omicron variant, emerged and became more dominant, further reducing the mortality rate [4-8]. The World Health Organization (WHO) eventually declared that the COVID-19 pandemic no longer constitutes a public health emergency of international concern on May 2023 [9]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 24, 2024 Category: Infectious Diseases Authors: Hui Xie, Junnan Zhang, Shuang Bai, Min Lv, Juan Li, Weixin Chen, Luodan Suo, Meng Chen, Wei Zhao, Shanshan Zhou, Jian Wang, Ao Zhang, Jianxin Ma, Fengshuang Wang, Le Yan, Dongmei Li, Jiang Wu Source Type: research

Time to care and factors influencing appropriate Sudan Virus Disease care among case patients in Uganda, September to November 2022
Both the case-fatality and the transmission of Ebola Disease (EBOD) can be reduced with early isolation of and appropriate care and treatment for EBOD patients at Ebola Treatment Units (ETUs) [1]. This requires active case finding, monitoring of contacts, and rapid isolation of contacts who become ill, [2,3] as well as strong health-seeking behavior of persons with EBOD symptoms [2,4]. As such, communities must be aware of EBOD-related symptoms, both the early non-specific symptoms as well as the late EBOD-related symptoms. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 24, 2024 Category: Infectious Diseases Authors: Rebecca Akunzirwe, Simone Carter, Brenda N. Simbwa, Mercy W. Wanyana, Sherry R. Ahirirwe, Saudah K. Namubiru, Mackline Ninsiima, Allan Komakech, Alex R. Ario, Daniel Kadobera, Benon Kwesiga, Richard Migisha, Lilian Bulage, Helen N. Naiga, Jane F. Zalwango Source Type: research

Safety and effectiveness of isavuconazole in real-life non-neutropenic patients
There is a notable change in the profile of patients with invasive fungal infections (IFI): there has been a progressive rise of such infections in non-neutropenic population (i.e., COVID-19, influenza, biologic agents, corticosteroids, cancer, chronic obstructive pulmonary disorder [COPD] or cirrhosis) [1 –3]. However, information concerning the management of non-neutropenic patients with IFI remains limited. Caution should be exercised before these patients are treated like those who are neutropenic, given a considerable variability in pathogenesis and clinical manifestations of IFI [4]. (Source: International Journal ...
Source: International Journal of Infectious Diseases - April 23, 2024 Category: Infectious Diseases Authors: Patricia Monz ó-Gallo, Carlos Lopera, Ana M Badía-Tejero, Marina Machado, Julio García-Rodríguez, Pablo Vidal-Cortés, Esperanza Merino, Jorge Calderón, Jesús Fortún, Zaira R. Palacios-Baena, Javier Pemán, Joan Roig Sanchis, Manuela Aguilar-Guisad Source Type: research

Why is sharing knowledge about hand hygiene and infection prevention and control still so important?
The global health care workforce is estimated to exceed 65 million. [1] Broken down by cadre, this “stock” comprises 29.1 million nurses, 12.7 million medical doctors, 3.7 million pharmacists, 2.5 million dentists, 2.2 million midwives and 14.9 million in additional occupations, including cleaners and healthcare waste workers. These numbers have not accounted for external contractors. Each of these numbers represents a person requiring training and education in infection prevention and control (IPC), to support the overall safety and quality of health care delivery. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 22, 2024 Category: Infectious Diseases Authors: Claire Kilpatrick, Ermira Tartari, Julie Storr, Didier Pittet, Benedetta Allegranzi Source Type: research

Death after cure: mortality among pulmonary tuberculosis survivors in rural Uganda
This study aimed to determine the incidence and predictors of mortality among TB survivors at a rural tertiary hospital in Uganda. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 20, 2024 Category: Infectious Diseases Authors: Joseph Baruch Baluku, Brenda Namanda, Sharon Namiiro, Diana Karungi Rwabwera, Gloria Mwesigwa, Catherine Namaara, Bright Twinomugisha, Isabella Nyirazihawe, Edwin Nuwagira, Grace Kansiime, Enock Kizito, Mary G. Nabukenya-Mudiope, Moorine Penninah Sekadde, Tags: Short Communication Source Type: research

Long-term remission of candidiasis with fermented lingonberry mouth rinse in an adult patient with APECED.
APECED, or autoimmune polyendocrine syndrome type 1 (APS-1), is a disease caused by mutations in the autoimmune regulator (AIRE) gene [1]. The consequent impaired immune responses formation of organ-specific autoantibodies (AABs). Disorder manifestations are broad, including organ-specific autoimmunity and chronic mucocutaneous candidiasis (CMC) [2]. Patients need lifelong follow-up and hormone replacement therapy. T helper 17 (Th17)-type adaptive immune response is crucial in the mucosal defense against Candida infections [3]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 20, 2024 Category: Infectious Diseases Authors: Pirjo P ärnänen, Juho Suojanen, Mikael Laine, Timo Sorsa, Annamari Ranki Tags: Case Report Source Type: research

SARS-CoV-2 mRNA vaccination and short-term changes in viral load and CD4/CD8 T cell counts in people living with HIV
A great body of evidence reassures on the safety of SARS-CoV-2 vaccination in people with HIV (PWH), who can mount a satisfactory immune response [1] comparable to those of the general population, except for cases with a low CD4+T cell (CD4) count recovery [1]. Notwithstanding, some concerns emerged because of the possible detrimental effects of SARS-CoV-2 vaccination on HIV viral load (VL) and CD4 and CD8 T cells, although most of the evidence is anecdotal or comes from limited case series with conflicting results [2-5]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 18, 2024 Category: Infectious Diseases Authors: Alessandra Vergori, Alessandro Cozzi-Lepri, Alessandro Tavelli, Valentina Mazzotta, Anna Maria Azzini, Roberta Gagliardini, Ilaria Mastrorosa, Alessandra Latini, Giovanni Pellican ò, Lucia Taramasso, Francesca Ceccherini-Silberstein, Maddalena Giannella, Tags: Short Communication Source Type: research

Age-specific prevalence of IgG against measles/rubella and the impact of routine and supplementary immunization activities – a multistage random cluster sampling study with mathematical modelling
Measles and rubella continue to be global public health priorities as vaccine-preventable causes of morbidity and mortality. Measles only vaccine was introduced in the 1960s, and, globally, there were an estimated 2 million measles deaths annually before vaccination coverage increased during the 1980s. In 2019, measles still caused more than 207,500 deaths globally due to repeated epidemics, and most were among children aged (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 17, 2024 Category: Infectious Diseases Authors: Masahiko Hachiya, Emilia Vynnycky, Yoshio Mori, Hung Thai Do, Mai Kim Huynh, Long Hoang Trinh, Duy Duc Nguyen, Nhu Anh Thi Tran, Thanh Tien Hoang, Hai Hang Thi Hoang, Ngoc Dieu Thi Vo, Thieu Hoang Le, Yasunori Ichimura, Shinsuke Miyano, Sumiyo Okawa, Moe Source Type: research

Incidence of SARS-CoV-2 Seropositivity in Pediatric Healthcare Workers Prior to Widespread Vaccination: A Five-month Longitudinal Cohort Study
Understanding the prevalence and incidence of SARS-CoV-2 infection among frontline healthcare workers is important to inform health policy and strategy. In the early stages of the COVID-19 pandemic, children were thought to be at low risk for infection, suggesting minimal risk of work-acquired SARS-CoV-2 infection in pediatric healthcare workers (pHCWs). This is due to early hypotheses that children were not affected by and did not spread SARS-CoV-2 to the degree that was seen among adult patients and their caregivers [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 17, 2024 Category: Infectious Diseases Authors: Mark Griffiths, Dunia Hatabah, Patrick Sullivan, Grace Mantus, Travis Sanchez, Maria Zlotorzynska, Stacy Heilman, Andres Camacho-Gonzalez, Deborah Leake, Rawan Korman, Mimi Le, Mehul Suthara, Jens Wrammert, Miriam B. Vos, Claudia R. Morris Source Type: research

Global analysis of respiratory viral circulation and timing of epidemics in the pre-COVID-19 and COVID-19 pandemic eras, based on data from the Global Influenza Surveillance and Response System (GISRS)
The emergence of the COVID-19 pandemic, caused by SARS-CoV-2, has undeniably reshaped life on a global scale. As infection rates and fatalities surged to historic proportions, initial strategies to combat the crisis revolved around non-pharmaceutical interventions (NPIs) such as the use of facemasks, physical distancing, travel bans, and lockdowns, considering the absence of available vaccines or targeted therapeutics. Characterized by a spectrum of actions spanning individual precautions to broader societal measures, NPIs aimed to curtail the rapid dissemination of the virus [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 16, 2024 Category: Infectious Diseases Authors: Marco Del Riccio, Saverio Caini, Guglielmo Bonaccorsi, Chiara Lorini, John Paget, Koos van der Velden, Adam Meijer, Mendel Haag, Ian McGovern, Patrizio Zanobini Source Type: research

The contribution of SARS-CoV-2 to the burden of acute respiratory infections in winter season 2022/2023: Results from the DigiHero study
At the beginning of September 2022, three years after the detection of the first SARS-CoV-2 case, the World Health Organization (WHO) globally had registered over 600 million confirmed cases and over 6.4 million deaths due to an infection with the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) [1]. By the end of the winter season in March 2023 those numbers had risen to over 761 million confirmed cases and over 6.8 million deaths [2]. Our World in Data reported an even higher number of deaths of 8.6 million [3]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: Nadine Glaser, Sophie Diexer, Bianca Klee, Dr. Oliver Purschke, Prof. Dr. med. Mascha Binder, Prof. Dr. med. Thomas Frese, Prof. Dr. med. Matthias Girndt, PD Dr. med. Jessica H öll, Dr. Irene Moor, Prof. Dr. med. Jonas Rosendahl, Prof. Dr. med. Michael G Source Type: research

Comparison of prevalence estimates of pfhrp2 and pfhrp3 deletions in Plasmodium falciparum determined by conventional PCR and multiplex qPCR and implications for surveillance and monitoring
The emergence of mutant Plasmodium falciparum parasites with pfhrp2 and pfhrp3 deletions poses a major threat to the utility of histidine rich protein-2 (HRP2)-based malaria rapid diagnostic tests (RDTs), the mainstay diagnostic tool for detecting falciparum malaria in resource-limited settings. These gene-deleted parasites do not express HRP2/3 and are therefore undetectable by HRP2-based RDTs leading to false-negative results. Mutant parasites have now been reported from 40 of the 47 countries where investigations have been conducted [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: Michelle L. Gatton, David Smith, Cielo Pasay, Karen Anderson, Selam Mihreteab, Hugo O. Valdivia, Juan F. Sanchez, Khalid B. Beshir, Jane Cunningham, Qin Cheng Source Type: research

Avian ‘Bird’ Flu – undue media panic or genuine concern for pandemic potential requiring global preparedness action?
epidemics, avian influenza, H5N1, highly pathogenic avian influenza, HPAI (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: Eskild Petersen, Ziad A Memish, David S Hui, Alessandra Scagliarini, Lone Simonsen, Edgar Simulundu, Jennifer Bloodgood, Lucille Blumberg, Shui- Shan Lee, Alimuddin Zumla Tags: Editorial Source Type: research

Editorial Board
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 13, 2024 Category: Infectious Diseases Source Type: research