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Cefazolin versus cloxacillin in methicillin-susceptible Staphylococcus aureus endocarditis: Too good to be true? Authors ’ reply
We sincerely appreciate the comments of Buis and his interest in our work, and we would like to respond to his justified concerns [1,2]: (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 21, 2024 Category: Infectious Diseases Authors: Laura Herrera-Hidalgo, Ar ístides de Alarcón Tags: Letter to the Editor Source Type: research

Cefazolin vs. cloxacillin in MSSA endocarditis: too good to be true? Authors ’ reply
We sincerely appreciate the comments of DTP Buis and his interest for our work, and we would like to response to his justified concerns [1,2]: (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 21, 2024 Category: Infectious Diseases Authors: Laura Herrera-Hidalgo, Ar ístides de Alarcón Tags: Letter to the Editor Source Type: research

Getting to the heart of the matter - Are two agents really better than one for the treatment of staphylococcal infective endocarditis?
The recently published 2023 update from the European Society of Cardiology (ESC) regarding the management of infective endocarditis introduces many welcome changes. Commendable are the transition towards outpatient care and the adoption of oral therapeutic regimens for carefully selected and clinically stable patients [1]. However, the management of these patients still presents numerous challenges, particularly in the context of selecting the most appropriate antimicrobial regimen. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 21, 2024 Category: Infectious Diseases Authors: James Donnelly, Helene McDermott, Sadhbh Gash, Ciara O'Connor, Karina O'Connell, Sinead O'Donnell, Binu Dinesh, Karen Burns, Fidelma Fitzpatrick Tags: Perspective Source Type: research

Editorial Board
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 20, 2024 Category: Infectious Diseases Source Type: research

Doxycycline post-exposure prophylaxis could theoretically select for resistance to various antimicrobials in 19 pathobionts: an in silico analysis
Three randomized controlled trials have found that doxycycline post exposure prophylaxis (doxy-PEP) can reduce the incidence of gonorrhoea, chlamydia and syphilis in men who have sex with men (MSM) [1]. As a result, a number of international organizations suggest that doxy-PEP should be considered for use by MSM at risk [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 20, 2024 Category: Infectious Diseases Authors: Chris Kenyon Tags: Short Communication Source Type: research

Cerebrospinal fluid inflammatory markers to differentiate between neonatal bacterial meningitis and sepsis: a prospective study of diagnostic accuracy
Neonatal and infant meningitis and sepsis are associated with substantial mortality and long-term morbidity.[1] Early detection of meningitis in suspected sepsis patients is important because of the difference in empiric antibiotic regimen, dosage and duration of antibiotic treatment. Also, it influences the need for monitoring of complications during hospitalization, as well as the risk of long-term neurodevelopmental impairment.[2] The interpretation of CSF parameters in neonates can be difficult due to considerable overlap of CSF characteristics between sepsis and meningitis. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 20, 2024 Category: Infectious Diseases Authors: Nina S. Groeneveld, Sabine E. Olie, Douwe H. Visser, Linde Snoek, Diederik van de Beek, Matthijs C. Brouwer, Merijn W. Bijlsma, NOGBS study group Tags: Short Communication Source Type: research

Recurrent and persistent fever after SARS-CoV-2 infection in patients with follicular lymphoma: a case series
We reported 6 follicular lymphoma developed recurrent symptomatic COVID-19 infection. They tested persistently negative for SARS-CoV-2 on pharyngeal swabs and ultimately confirmed by BALF metagenomics next generation sequencing. All 6 patients presented with lymphopenia and B-cell depletion, and 5 of them received the anti-CD 20 treatment in the last year. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 20, 2024 Category: Infectious Diseases Authors: Lixue Huang, Xunliang Tong, Jia Cui, Xiaoman Du, Yixuan Liao, Xiaoming Tan, Yang Ju, Xuefeng Zhong, Wei Zhou, Xiaomao Xu, Yanming Li Source Type: research

Doxycycline post exposure prophylaxis could theoretically select for resistance to various antimicrobials in 19 pathobionts: an in silico analysis
Three randomized controlled trials have found that doxycycline post exposure prophylaxis (doxy-PEP) can reduce the incidence of gonorrhoea, chlamydia and syphilis in men who have sex with men (MSM) [1]. As a result, a number of international organizations suggest that doxy-PEP should be considered for use by MSM at risk [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 20, 2024 Category: Infectious Diseases Authors: Chris Kenyon Tags: Short Communication Source Type: research

The associations between invasive group A streptococcal disease and infection with influenza, varicella or hepatitis C viruses: A data linkage study, Victoria, Australia
Invasive group A streptococcal disease (iGAS) is a rare and life-threatening infection. It occurs when group A Streptococcus bacteria (GAS, Streptococcus pyogenes) invade otherwise sterile sites of the body, such as the blood and cerebrospinal fluid.[1] Globally, it is estimated that 15 –25% of iGAS cases are fatal.[1] Severe manifestations such as sepsis, streptococcal toxic shock syndrome (STSS) and necrotising fasciitis have higher case fatality rates, even in well-resourced settings.[1, 2] iGAS is managed with antibiotics, and often requires surgery and supportive care for or gan dysfunction.[2] However, patients fre...
Source: International Journal of Infectious Diseases - February 20, 2024 Category: Infectious Diseases Authors: Jessie J. Goldsmith, Christy Vu, Ziheng Zhu, Jennifer MacLachlan, Tilda N. Thomson, Patricia Therese Campbell, Katherine B. Gibney Source Type: research

Analytical performances of a point-of-care loop-mediated isothermal amplification assay to detect Group B Streptococcus in intrapartum pregnant women living in the Democratic Republic of the Congo
Infection is an important cause of maternal, fetal, and infant mortality in resource-constrained settings [1]. Children living in sub-Saharan Africa are ten-fold more likely to die at and/or around birth compared to high-income countries [2]. Worldwide, Streptococcus agalactiae, commonly referred to as Group B Streptococcus (GBS), is the leading infectious cause of stillbirth, and neonatal morbidity and mortality [3,4]. GBS colonizes the gastrointestinal and/or genital tract of 15% to 40% of healthy adults, the rectum being the reservoir [5]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 19, 2024 Category: Infectious Diseases Authors: Serge Tonen-Wolyec, Noel Labana Otuli, Monde Otsatre-Okuti, Raelle Atenyi-Kasemire, Raphael Dupont, Laurent B élec Source Type: research

Analytical performances of a point-of-care loop-mediated isothermal amplification (LAMP) assay to detect Group B Streptococcus in intrapartum pregnant women living in the Democratic Republic of the Congo
Infection is an important cause of maternal, foetal, and infant mortality in resource-constrained settings [1]. Children living in sub-Saharan Africa are ten-fold more likely to die at and/or around birth compared to high-income countries [2]. Worldwide, Streptococcus agalactiae, commonly referred to as Group B Streptococcus (GBS), is the leading infectious cause of stillbirth, and neonatal morbidity and mortality [3,4]. GBS colonizes the gastrointestinal and/or genital tract of 15% to 40% of healthy adults, the rectum being the reservoir [5]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 19, 2024 Category: Infectious Diseases Authors: Serge Tonen-Wolyec, Noel Labana Otuli, Monde Otsatre-Okuti, Raelle Atenyi-Kasemire, Raphael Dupont, Laurent B élec Source Type: research

Epidemiological shifts in and impact of COVID-19 on streptococcal toxic shock syndrome in Japan: A genotypic analysis of Group A Streptococcus isolates
Group A Streptococcus (GAS, Streptococcus pyogenes) strains cause pharyngitis, tonsillitis, skin and soft tissue infections, bacteremia, and scarlet fever. Since the late 1980s, streptococcal toxic shock syndrome (STSS) caused by GAS infection has been a major health problem in several countries [1 –5]. The characteristic symptoms progress rapidly and are fulminant from disease onset. Patients can develop necrotizing fasciitis, acute kidney failure, acute respiratory distress syndrome, disseminated intravascular coagulopathy, and multi-organ failure within a few hours of disease onset, leadi ng to shock and even death. (...
Source: International Journal of Infectious Diseases - February 19, 2024 Category: Infectious Diseases Authors: Tadayoshi Ikebe, Rumi Okuno, Yumi Uchitani, Takahiro Yamaguchi, Junko Isobe, Emi Maenishi, Yoshimi Date, Hitoshi Otsuka, Yu Kazawa, Shohei Fujita, Ayaka Kobayashi, Mami Takano, Shinya Tsukamoto, Yoshiko Kanda, Makoto Ohnishi, Yukihiro Akeda, The Working G Source Type: research

A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors
Hepatitis B virus (HBV) infection remains a serious health problem globally with 3.5% (296 million) of the adult population estimated to have chronic infection. Of 1.5 million new infections in 2019, most have been acquired in Africa [1]. Furthermore, HBV continues to be endemic in Africa and the Western Pacific countries which carry the highest global burden with an HBsAg prevalence of 6% each [2-4]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 17, 2024 Category: Infectious Diseases Authors: Ute Jentsch, Marion Vermeulen, Karin van den Berg, Ronel Swanevelder, Darryl Creel, Genevieve Jacobs, Jennifer Jay Hemingway-Foday, Cynthia Nyoni, Edward L. Murphy, Brian Custer Source Type: research

Real-Time Genomic Epidemiologic Investigation of a Multispecies Plasmid-Associated Hospital Outbreak of NDM-5-Producing Enterobacterales Infections
Bacteria that cause healthcare-associated infections (HAIs) can harbor plasmids encoding genes conferring antibiotic resistance to commonly prescribed antimicrobial agents, leading to pathogens that are well adapted to the hospital environment. Infections with antimicrobial-resistant pathogens are associated with poor patient outcomes and have limited options for therapy [1]. Horizontal plasmid transfer represents the primary mechanism by which antibiotic resistance genes can be shared between different bacterial species [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 17, 2024 Category: Infectious Diseases Authors: Nathan J. Raabe, Abby L. Valek, Marissa P. Griffith, Emma Mills, Kady Waggle, Vatsala Rangachar Srinivasa, Ashley M. Ayres, Claire Bradford, Hannah M. Creager, Lora L. Pless, Alexander J. Sundermann, Daria Van Tyne, Graham M. Snyder, Lee H. Harrison Source Type: research

Estimating excess mortality and economic burden of Clostridioides difficile infections and recurrences during 2015 –2019: The RECUR England study
Clostridioides difficile is a common source of healthcare-associated infection, with symptoms ranging from mild diarrhoea to life-threatening colon damage [1,2]. While most C. difficile infection (CDI) cases are acquired in healthcare facilities, the incidence of community-associated CDIs has been increasing [1,3]. Nearly a quarter of patients experience a recurrent CDI (rCDI) episode. The recurrence rate increases with each subsequent episode, and 40% –65% of patients with one recurrence experience ≥2 recurrences [4]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 15, 2024 Category: Infectious Diseases Authors: Subrata Ghosh, Ana Antunes, Hanna Rinta-Kokko, Elena Chaparova, Sarah Lay-Flurrie, Aurore Tricotel, Fredrik L Andersson Source Type: research