Analytical performances of a point-of-care loop-mediated isothermal amplification (LAMP) assay to detect Group B Streptococcus in intrapartum pregnant women living in the Democratic Republic of the Congo
Infection is an important cause of maternal, foetal, and infant mortality in resource-constrained settings [1]. Children living in sub-Saharan Africa are ten-fold more likely to die at and/or around birth compared to high-income countries [2]. Worldwide, Streptococcus agalactiae, commonly referred to as Group B Streptococcus (GBS), is the leading infectious cause of stillbirth, and neonatal morbidity and mortality [3,4]. GBS colonizes the gastrointestinal and/or genital tract of 15% to 40% of healthy adults, the rectum being the reservoir [5]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 19, 2024 Category: Infectious Diseases Authors: Serge Tonen-Wolyec, Noel Labana Otuli, Monde Otsatre-Okuti, Raelle Atenyi-Kasemire, Raphael Dupont, Laurent B élec Source Type: research

Epidemiological shifts in and impact of COVID-19 on streptococcal toxic shock syndrome in Japan: A genotypic analysis of Group A Streptococcus isolates
Group A Streptococcus (GAS, Streptococcus pyogenes) strains cause pharyngitis, tonsillitis, skin and soft tissue infections, bacteremia, and scarlet fever. Since the late 1980s, streptococcal toxic shock syndrome (STSS) caused by GAS infection has been a major health problem in several countries [1 –5]. The characteristic symptoms progress rapidly and are fulminant from disease onset. Patients can develop necrotizing fasciitis, acute kidney failure, acute respiratory distress syndrome, disseminated intravascular coagulopathy, and multi-organ failure within a few hours of disease onset, leadi ng to shock and even death. (...
Source: International Journal of Infectious Diseases - February 19, 2024 Category: Infectious Diseases Authors: Tadayoshi Ikebe, Rumi Okuno, Yumi Uchitani, Takahiro Yamaguchi, Junko Isobe, Emi Maenishi, Yoshimi Date, Hitoshi Otsuka, Yu Kazawa, Shohei Fujita, Ayaka Kobayashi, Mami Takano, Shinya Tsukamoto, Yoshiko Kanda, Makoto Ohnishi, Yukihiro Akeda, The Working G Source Type: research

A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors
Hepatitis B virus (HBV) infection remains a serious health problem globally with 3.5% (296 million) of the adult population estimated to have chronic infection. Of 1.5 million new infections in 2019, most have been acquired in Africa [1]. Furthermore, HBV continues to be endemic in Africa and the Western Pacific countries which carry the highest global burden with an HBsAg prevalence of 6% each [2-4]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 17, 2024 Category: Infectious Diseases Authors: Ute Jentsch, Marion Vermeulen, Karin van den Berg, Ronel Swanevelder, Darryl Creel, Genevieve Jacobs, Jennifer Jay Hemingway-Foday, Cynthia Nyoni, Edward L. Murphy, Brian Custer Source Type: research

Real-Time Genomic Epidemiologic Investigation of a Multispecies Plasmid-Associated Hospital Outbreak of NDM-5-Producing Enterobacterales Infections
Bacteria that cause healthcare-associated infections (HAIs) can harbor plasmids encoding genes conferring antibiotic resistance to commonly prescribed antimicrobial agents, leading to pathogens that are well adapted to the hospital environment. Infections with antimicrobial-resistant pathogens are associated with poor patient outcomes and have limited options for therapy [1]. Horizontal plasmid transfer represents the primary mechanism by which antibiotic resistance genes can be shared between different bacterial species [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 17, 2024 Category: Infectious Diseases Authors: Nathan J. Raabe, Abby L. Valek, Marissa P. Griffith, Emma Mills, Kady Waggle, Vatsala Rangachar Srinivasa, Ashley M. Ayres, Claire Bradford, Hannah M. Creager, Lora L. Pless, Alexander J. Sundermann, Daria Van Tyne, Graham M. Snyder, Lee H. Harrison Source Type: research

Estimating excess mortality and economic burden of Clostridioides difficile infections and recurrences during 2015 –2019: The RECUR England study
Clostridioides difficile is a common source of healthcare-associated infection, with symptoms ranging from mild diarrhoea to life-threatening colon damage [1,2]. While most C. difficile infection (CDI) cases are acquired in healthcare facilities, the incidence of community-associated CDIs has been increasing [1,3]. Nearly a quarter of patients experience a recurrent CDI (rCDI) episode. The recurrence rate increases with each subsequent episode, and 40% –65% of patients with one recurrence experience ≥2 recurrences [4]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 15, 2024 Category: Infectious Diseases Authors: Subrata Ghosh, Ana Antunes, Hanna Rinta-Kokko, Elena Chaparova, Sarah Lay-Flurrie, Aurore Tricotel, Fredrik L Andersson Source Type: research

Influenza-like illness surveillance may underestimate the incidence of respiratory syncytial virus in adult outpatients
In adults, respiratory syncytial virus (RSV) is a common cause of acute respiratory infections (ARIs) and is associated with a significant burden [1]. Two adult RSV vaccines have recently been authorized [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 15, 2024 Category: Infectious Diseases Authors: Alexander Domnich, Andrea Orsi, Matilde Ogliastro, Allegra Ferrari, Bianca Bruzzone, Donatella Panatto, Giancarlo Icardi Tags: Short Communication Source Type: research

Analysis of the effectiveness of combination antimicrobial therapy for Legionnaires' Disease: A nationwide inpatient database study
Legionnaires ’ Disease is a type of pneumonia caused by Legionella spp. such as L. pneumophila, L. longbeachae and L. anisa., and accounts for 1–10% of community-acquired pneumonia cases 1. It is a severe form of pneumonia with a reported fatality rate of 6.4%4. Multiple reports have shown that a delay in th e administration of appropriate antimicrobials is associated with worse prognosis in Legionnaires’ Disease 2. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 14, 2024 Category: Infectious Diseases Authors: Satoshi Kutsuna, Hiroyuki Ohbe, Hiroki Matsui, Hideo Yasunaga Source Type: research

Acute COVID-19 treatment is not associated with health problems 2 years after hospitalization
COVID-19, caused by SARS-CoV-2, has resulted in a worldwide pandemic, requiring hospitalization for respiratory insufficiency in numerous patients. Many of these patients suffer lingering and debilitating health problems that can persist for months or years,[1] commonly referred to as ‘long COVID’ or ‘post-COVID syndrome’. Long COVID comprises a wide range of symptoms, with dyspnea, fatigue, and neurocognitive symptoms among the most frequently reported, may negatively affect health-related quality of life, and more commonly affects patients after severe COVID-19.[1,2] (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 14, 2024 Category: Infectious Diseases Authors: Julia C. Berentschot, L. Martine Bek, Majanka H. Heijenbrok-Kal, Rita J.G. van den Berg-Emons, Gerard M. Ribbers, Joachim G.J.V. Aerts, Merel E. Hellemons Tags: Short Communication Source Type: research

Assessing the temporal and cause-effect relationship between myocarditis and mRNA COVID-19 vaccines. A retrospective observational study.
Myocarditis is an inflammation of the heart muscle, and if it is accompanied by pericarditis, it is referred to as myopericarditis; in both cases, the body's immune system is causing inflammation in response to an infection or some other trigger. According to the US Centers for Disease Control and Prevention (CDC), the term “myocarditis” refers to myocarditis, pericarditis, or myopericarditis [1]. Myocarditis typically occurs more commonly in males than females, and the incidence is highest among infants, adolescents, and young adults [2–4]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 13, 2024 Category: Infectious Diseases Authors: Francesco Paolo Bianchi, Donato Rizzi, Antonio Daleno, Pasquale Stefanizzi, Giovanni Migliore, Silvio Tafuri Source Type: research

Preexisting renal graft dysfunction as a major risk factor for SARS-CoV-2 Omicron variant pneumonia: A postinfection cross-sectional study of 312 immunosuppressed renal transplant recipients
SARS-CoV-2 pneumonia poses significant challenges to health systems worldwide, particularly, in severe and critical cases [1]. Patients with COVID-19 are at risk of diffuse alveolar damage, acute respiratory distress syndrome, and multi-organ failure, which are the main causes of death [2,3]. Renal transplant recipients are particularly vulnerable to severe or critical COVID-19 illness, and the mortality rates are high in this patient group [4 –7]. SARS-CoV-2 pneumonia in renal transplant recipients often presents with an unfavorable disease course and poor outcome [8]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 12, 2024 Category: Infectious Diseases Authors: Qi Tang, Xubiao Xie, Longkai Peng, Linxin Yang, Yubin Chen, Shaojie Yu Source Type: research

Pre-existing Renal Graft Dysfunction As A Major Risk Factor for SARS-CoV-2 Omicron Variant Pneumonia: a Post-Infection Cross-Sectional Study of 312 Immunosuppressed Renal Transplant Recipients
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia poses significant challenges to global health systems, particularly in severe and critical cases [1]. Coronavirus disease 2019 (COVID-19) patients are at risk of diffuse alveolar damage (DAD), acute respiratory distress syndrome (ARDS), and multi-organ failure, which are the main causes of death [2, 3]. Renal transplant recipients are particularly vulnerable to severe or critical COVID-19 illness, and mortality rates are high in this patient group [4-7]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 12, 2024 Category: Infectious Diseases Authors: Qi Tang, Xubiao Xie, Longkai Peng, Linxin Yang, Yubin Chen, Shaojie Yu Source Type: research

Sustaining the momentum for adult vaccination post-COVID-19 to leverage the global uptake of life-course immunisation: a scoping review.
The coronavirus disease 2019 (COVID-19) pandemic has altered the vaccination landscape globally and possibly permanently. More adults have died due to a single infectious cause than in the living memory of most individuals, challenging mindsets of complacency and denial around the idea of vulnerability to infectious disease. The extreme vulnerability of the frail, elderly, and those with chronic medical conditions to severe disease and death due to infection has been highlighted. The global response to the COVID-19 pandemic has been unprecedented in terms of funding to support research and rapid vaccine development, regula...
Source: International Journal of Infectious Diseases - February 12, 2024 Category: Infectious Diseases Authors: T.Mark Doherty, Alberta Di Pasquale, Gary Finnegan, Jayesh Lele, Roy K Philip Tags: Review Source Type: research

Performance and impact of contact tracing in the Sudan virus outbreak in Uganda, September 2022-January 2023
Sudan virus disease (SVD) is a severe viral hemorrhagic fever caused by the Sudan Virus (SUDV). Bats are assumed to be the virus reservoir, and after zoonotic introduction into primates or humans (either through presumed bat-human or bat-primate contact), the virus can pass through direct contact or contact with infected body fluids or contaminated fomites [1]. Zoonotic transmission is rare; in a given outbreak once the virus passes into the human population, most or all subsequent cases result from human-to-human transmission [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 8, 2024 Category: Infectious Diseases Authors: Mercy Wendy Wanyana, Rebecca Akunzirwe, Patrick King, Immaculate Atuhaire, Robert Zavuga, Bernard Lubwama, Zainah Kabami, Sherry Rita Ahirirwe, Mackline Ninsiima, Hellen Nelly Naiga, Jane Frances Zalwango, Marie Gorreti Zalwango, Peter Chris Kawungezi, Br Source Type: research

Incidence of tuberculosis disease in individuals diagnosed with tuberculosis infection after screening: A population-based cohort study in South Korea
The eradication of tuberculosis (TB), a significant global public health concern, requires an ambitious target and a well-defined implementation plan [1]. In South Korea, the incidence rate of TB was 45 cases per 100,000 population in 2021, reflecting a 50% decrease over the past decade [2]. Efforts to reduce rates further to (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 8, 2024 Category: Infectious Diseases Authors: Jaehee Lee, Dohyang Kim, Jinseub Hwang, Jin-Won Kwon Source Type: research

Performance and impact of contact tracing in the Sudan Virus Outbreak in Uganda, September 2022 –January 2023
Sudan Virus Disease (SVD) is a severe viral haemorrhagic fever caused by the Sudan Virus (SUDV). Bats are assumed to be the virus reservoir, and after zoonotic introduction into primates or humans (either through presumed bat-human or bat-primate contact), the virus can pass through direct contact or contact with infected body fluids or contaminated fomites [1]. Zoonotic transmission is rare; in a given outbreak once the virus passes into the human population, most or all subsequent cases result from human-to-human transmission [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 8, 2024 Category: Infectious Diseases Authors: Mercy Wendy Wanyana, Rebecca Akunzirwe, Patrick King, Immaculate Atuhaire, Robert Zavuga, Bernard Lubwama, Zainah Kabami, Sherry Rita Ahirirwe, Mackline Ninsiima, Hellen Nelly Naiga, Jane Frances Zalwango, Marie Gorreti Zalwango, Peter Chris Kawungezi, Br Source Type: research