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Drug: Metformin
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Total 6410 results found since Jan 2013.
The Effect of Metformin on Triple-Negative Breast Cancer Cells and Nude Mice
This study delves deeper into the impact of metformin on TNBC by examining changes in proliferation, apoptosis, invasion, migration, and adhesion of TNBC cells, specifically MDA-MB-231, post-metformin exposure. The treatment of MDA-MB-231 with metformin in immunodeficient nude mice led to discernible changes in tumor metrics such as size, weight, lymph node engagement, and angiogenesis. Post-treatment, MDA-MB-231 cells exhibited a marked decline in proliferation, invasion, migration, and adhesion, alongside a significant rise in apoptosis. In the in vivo model with nude mice, tumors displayed notable reductions in size and...
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Jin Song Junfeng Du Lili Han Xue Lin Cibo Fan Gang Chen Source Type: research
Metformin Impedes Oxidation of LDL In Vitro
Pharmaceutics. 2023 Aug 9;15(8):2111. doi: 10.3390/pharmaceutics15082111.ABSTRACTMetformin is the most commonly prescribed glucose-lowering drug for the treatment of type 2 diabetes. The aim of this study was to investigate whether metformin is capable of impeding the oxidation of LDL, a crucial step in the development of endothelial dysfunction and atherosclerosis. LDL was oxidized by addition of CuCl2 in the presence of increasing concentrations of metformin. The extent of LDL oxidation was assessed by measuring lipid hydroperoxide and malondialdehyde concentrations, relative electrophoretic mobilities, and oxidation-spe...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Christine Rossmann Cornelia Ranz Gerd Kager Gerhard Ledinski Martin Koestenberger Willibald Wonisch Thomas Wagner Sebastian P Schwaminger Bruno Di Geronimo Andelko Hrzenjak Seth Hallst öm Gilbert Reibnegger Gerhard Cvirn Margret Paar Source Type: research
The Effect of Metformin on Triple-Negative Breast Cancer Cells and Nude Mice
This study delves deeper into the impact of metformin on TNBC by examining changes in proliferation, apoptosis, invasion, migration, and adhesion of TNBC cells, specifically MDA-MB-231, post-metformin exposure. The treatment of MDA-MB-231 with metformin in immunodeficient nude mice led to discernible changes in tumor metrics such as size, weight, lymph node engagement, and angiogenesis. Post-treatment, MDA-MB-231 cells exhibited a marked decline in proliferation, invasion, migration, and adhesion, alongside a significant rise in apoptosis. In the in vivo model with nude mice, tumors displayed notable reductions in size and...
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Jin Song Junfeng Du Lili Han Xue Lin Cibo Fan Gang Chen Source Type: research
Reevaluating First-Line Therapies in Youth-onset Type 2 Diabetes
J Clin Endocrinol Metab. 2023 Aug 25:dgad508. doi: 10.1210/clinem/dgad508. Online ahead of print.ABSTRACTThe prevalence of youth-onset type 2 diabetes is growing worldwide and current first-line treatment with metformin and intensive behavior and lifestyle changes are suboptimal in over 50% of youth within two years of diagnosis. This perspective article is a call-to-action for reevaluation of existing strategies and critical appraisal of metformin as first-line therapy in youth-onset type 2 diabetes. Increased attention should be given to novel therapeutics approved in youth, including glucagon-like 1 receptor agonists, s...
Source: The Journal of Clinical Endocrinology and Metabolism - August 25, 2023 Category: Endocrinology Authors: Stephanie T Chung Faith Davis Tejal Patel Lilian Mabundo Doris E Estrada Source Type: research
Non-coding RNA genes modulate PI3K/AKT signaling pathway in polycystic ovary syndrome
CONCLUSIONS: miRNA486 and miRNA483 downregulation may contribute to the etiology of PCOS, influence glucose metabolism, and result in IR in PCOS. Metformin's upregulation of those miRNAs affects glucose metabolism by controlling the expression of GLUT4, ameliorates PCOS-related insulin resistance, and improves PCOS-related hormonal imbalance by controlling the PI3K/AKT signaling pathway.PMID:37620736 | DOI:10.1007/s11033-023-08604-0
Source: Molecular Biology Reports - August 24, 2023 Category: Molecular Biology Authors: Heba S Omar Osama Ahmed Ibrahim Maha Gomaa Sayed Eman Mohammed Faruk Hanan Fouad Miriam Safwat Source Type: research
Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance
Eur J Pharmacol. 2023 Aug 22:175991. doi: 10.1016/j.ejphar.2023.175991. Online ahead of print.ABSTRACTThe use of repurposing drugs that may have neoplastic and anticancer effects increases the efficiency and decrease resistance to chemotherapy drugs through a biochemical and mechanical transduction mechanisms through modulation of fibroblast/fibrosis remodeling in tumor microenvironment (TME). Interestingly, fibroblast/fibrosis remodeling plays a vital role in mediating cancer metastasis and drug resistance after immune chemotherapy. The most essential hypothesis for induction of chemo-immunotherapy resistance is via activ...
Source: European Journal of Pharmacology - August 24, 2023 Category: Drugs & Pharmacology Authors: Mahboubeh Tajaldini Amirhoushang Poorkhani Taghi Amiriani Amirhossein Amiriani Hossein Javid Parham Aref Farahnazsadat Ahmadi Somayeh Sadani Vahid Khori Source Type: research
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia
EMBO Mol Med. 2023 Aug 23:e16908. doi: 10.15252/emmm.202216908. Online ahead of print.ABSTRACTPeriventricular neuronal heterotopia (PH) is one of the most common forms of cortical malformation in the human cortex. We show that human neuronal progenitor cells (hNPCs) derived from PH patients with a DCHS1 or FAT4 mutation as well as isogenic lines had altered migratory dynamics when grafted in the mouse brain. The affected migration was linked to altered autophagy as observed in vivo with an electron microscopic analysis of grafted hNPCs, a Western blot analysis of cortical organoids, and time-lapse imaging of hNPCs in the p...
Source: Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Cedric Bressan Marta Snapyan Marina Snapyan Johannes Klaus Francesco di Matteo Stephen P Robertson Barbara Treutlein Martin Parent Silvia Cappello Armen Saghatelyan Source Type: research
Adding empagliflozin to sitagliptin plus metformin vs. adding sitagliptin to empagliflozin plus metformin as triple therapy in Egyptian patients with type 2 diabetes: a 12-week open trial
CONCLUSIONS: Empagliflozin was superior to sitagliptin in relation to glycemic control, weight, and systolic/diastolic blood pressure reduction.PMID:37606137 | DOI:10.26355/eurrev_202308_33300
Source: Pharmacological Reviews - August 22, 2023 Category: Drugs & Pharmacology Authors: H G Zakaraia H F Salem M A A Mostafa A M Ali H Rabea Source Type: research
