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Drug: Metformin
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Total 6410 results found since Jan 2013.
Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway
In conclusion, metformin combined with rapamycin decreased proteinuria, improved renal fibrosis and podocyte autophagy via AMPK/mTOR pathway in IMN rats. The metformin and rapamycin decreased proteinuria and inproved renal fibrosis in IMN model rats.PMID:37702819 | DOI:10.1007/s12079-023-00781-8
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Meichen Ma Yue Pan Yue Zhang Mei Yang Ying Xi Baoxu Lin Wudi Hao Jianhua Liu Lina Wu Yong Liu Xiaosong Qin Source Type: research
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes
In conclusion, the findings suggest that metformin-induced inhibition of pyruvate oxidation combined with altered cellular redox state, shifts the equilibrium of the lactate dehydrogenase (LDH) reaction leading to a dose-dependent lactate production in primary human myotubes.PMID:37694284 | DOI:10.1152/ajpcell.00186.2023
Source: Am J Physiol Cell Ph... - September 11, 2023 Category: Cytology Authors: Jennifer Maurer Xinjie Zhao Martin Irmler Anders Gudiksen Nanna S Pilmark Qi Li Thomas Goj Johannes Beckers Martin Hrab ě de Angelis Andreas Birkenfeld Andreas Peter Rainer Lehmann Henriette Pilegaard Kristian Karstoft Guowang Xu Cora Weigert Source Type: research
Metformin and Covid-19: a systematic review of systematic reviews with meta-analysis
Conclusions More in-depth studies on the use of metformin, compared to other molecules, may be required to understand the real protective potential of the drug against negative outcomes caused by COVID-19 infection in DM2 patients.PMID:37695186 | DOI:10.23750/abm.v94iS3.14405
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Fabio Petrelli Iolanda Grappasonni Cuc Thi Thu Nguyen Marina Tesauro Paola Pantanetti Sonila Xhafa Giovanni Cangelosi Source Type: research
Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer
J Clin Oncol. 2023 Sep 11:JCO2300296. doi: 10.1200/JCO.23.00296. Online ahead of print.ABSTRACTClinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available. Clinical trial updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.Metformin has been associated with lower cancer risk in epidemiologic and preclinical research. In the MA.32 rando...
Source: Clinical Breast Cancer - September 11, 2023 Category: Cancer & Oncology Authors: Pamela J Goodwin Bingshu E Chen Karen A Gelmon Timothy J Whelan Marguerite Ennis Julie Lemieux Jennifer A Ligibel Dawn L Hershman Ingrid A Mayer Timothy J Hobday Judith M Bliss Priya Rastogi Manuela Rabaglio-Poretti Alastair M Thompson Daniel W Rea Paul M Source Type: research
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes
In conclusion, the findings suggest that metformin-induced inhibition of pyruvate oxidation combined with altered cellular redox state, shifts the equilibrium of the lactate dehydrogenase (LDH) reaction leading to a dose-dependent lactate production in primary human myotubes.PMID:37694284 | DOI:10.1152/ajpcell.00186.2023
Source: American Journal of Physiology. Cell Physiology - September 11, 2023 Category: Cytology Authors: Jennifer Maurer Xinjie Zhao Martin Irmler Anders Gudiksen Nanna S Pilmark Qi Li Thomas Goj Johannes Beckers Martin Hrab ě de Angelis Andreas Birkenfeld Andreas Peter Rainer Lehmann Henriette Pilegaard Kristian Karstoft Guowang Xu Cora Weigert Source Type: research
Metformin and Covid-19: a systematic review of systematic reviews with meta-analysis
Conclusions More in-depth studies on the use of metformin, compared to other molecules, may be required to understand the real protective potential of the drug against negative outcomes caused by COVID-19 infection in DM2 patients.PMID:37695186 | DOI:10.23750/abm.v94iS3.14405
Source: Acta Bio-Medica : Atenei Parmensis - September 11, 2023 Category: General Medicine Authors: Fabio Petrelli Iolanda Grappasonni Cuc Thi Thu Nguyen Marina Tesauro Paola Pantanetti Sonila Xhafa Giovanni Cangelosi Source Type: research
Redox state and altered pyruvate metabolism contribute to a dose-dependent metformin-induced lactate production of human myotubes
In conclusion, the findings suggest that metformin-induced inhibition of pyruvate oxidation combined with altered cellular redox state, shifts the equilibrium of the lactate dehydrogenase (LDH) reaction leading to a dose-dependent lactate production in primary human myotubes.PMID:37694284 | DOI:10.1152/ajpcell.00186.2023
Source: Am J Physiol Cell Ph... - September 11, 2023 Category: Cytology Authors: Jennifer Maurer Xinjie Zhao Martin Irmler Anders Gudiksen Nanna S Pilmark Qi Li Thomas Goj Johannes Beckers Martin Hrab ě de Angelis Andreas Birkenfeld Andreas Peter Rainer Lehmann Henriette Pilegaard Kristian Karstoft Guowang Xu Cora Weigert Source Type: research
Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer
J Clin Oncol. 2023 Sep 11:JCO2300296. doi: 10.1200/JCO.23.00296. Online ahead of print.ABSTRACTClinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available. Clinical trial updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.Metformin has been associated with lower cancer risk in epidemiologic and preclinical research. In the MA.32 rando...
Source: Clinical Genitourinary Cancer - September 11, 2023 Category: Cancer & Oncology Authors: Pamela J Goodwin Bingshu E Chen Karen A Gelmon Timothy J Whelan Marguerite Ennis Julie Lemieux Jennifer A Ligibel Dawn L Hershman Ingrid A Mayer Timothy J Hobday Judith M Bliss Priya Rastogi Manuela Rabaglio-Poretti Alastair M Thompson Daniel W Rea Paul M Source Type: research
