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Gender-Based Research Underscores Sex Differences in Biological Processes, Clinical Disorders and Pharmacological Interventions
Biochem Pharmacol. 2023 Aug 5:115737. doi: 10.1016/j.bcp.2023.115737. Online ahead of print.ABSTRACTEarlier research has presumed that the male and female biology is similar in most organs except the reproductive system, leading to major misconceptions in research interpretations and clinical implications, with serious disorders being overlooked or misdiagnosed. Careful research has now identified sex differences in the cardiovascular, renal, endocrine, gastrointestinal, immune, nervous, and musculoskeletal systems. Also, several cardiovascular, immunological, and neurological disorders have shown differences in prevalence...
Source: Biochemical Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Sofia R Bernstein Caroline Kelleher Raouf A Khalil Source Type: research
Protection against COVID-19 hospitalisation conferred by primary-series vaccination with AZD1222 in non-boosted individuals: first vaccine effectiveness results of the European COVIDRIVE study and meta-regression analysis
We report a prespecified interim analysis of primary-series AZD1222 (ChAdOx1 nCoV-19) VE.METHODS: Seven Study Contributors in Europe collected data on individuals aged ≥18 years who were hospitalised with severe acute respiratory infection (June 1st, 2021-September 5th, 2022) and eligible for COVID-19 vaccination prior to hospitalisation. In this test-negative case-control study, individuals were defined as test-positive cases or test-negative controls (SARS-CoV-2 RT-PCR) and were either fully vaccinated (two AZD1222 doses, 4-12 weeks apart, completed ≥14 days prior to symptom onset; no booster doses) or unvaccinated (...
Source: Herpes - August 7, 2023 Category: Infectious Diseases Authors: Wilhelmine Meeraus Leonie de Munter Christen M Gray Akshat Dwivedi Chlo é Wyndham-Thomas Mario Ouwens Wendy Hartig-Merkel Laura Drikite Griet Rebry Antonio Carmona Anke L Stuurman Thi Yen Chi Nguyen Guillermo Mena Ainara Mira-Iglesias Giancarlo Icardi Su Source Type: research
Gender-Based Research Underscores Sex Differences in Biological Processes, Clinical Disorders and Pharmacological Interventions
Biochem Pharmacol. 2023 Aug 5:115737. doi: 10.1016/j.bcp.2023.115737. Online ahead of print.ABSTRACTEarlier research has presumed that the male and female biology is similar in most organs except the reproductive system, leading to major misconceptions in research interpretations and clinical implications, with serious disorders being overlooked or misdiagnosed. Careful research has now identified sex differences in the cardiovascular, renal, endocrine, gastrointestinal, immune, nervous, and musculoskeletal systems. Also, several cardiovascular, immunological, and neurological disorders have shown differences in prevalence...
Source: Biochemical Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Sofia R Bernstein Caroline Kelleher Raouf A Khalil Source Type: research
Long-running ProMED email service for alerting world to disease outbreaks is in trouble
The first news about the COVID-19 pandemic came not from a government or a scientific publication, but in an email from a disease-alert system called
ProMED
. This fateful missive in December 2019 about a few cases of a mysterious pneumonia in Wuhan, China, is just one example of how physicians and public health experts around the world have used the 30-year-old, free service to share real-time information about local disease outbreaks with tens of thousands of subscribers.
But ProMED is now on life support. Much of its work came to a screeching halt yesterday when 21 of its 38 paid editors and moderators went o...
Source: Science of Aging Knowledge Environment - August 4, 2023 Category: Geriatrics Source Type: research
A bone morphogenetic protein regulates the shell formation of Crassostrea gigas under ocean acidification
Gene. 2023 Aug 2:147687. doi: 10.1016/j.gene.2023.147687. Online ahead of print.ABSTRACTBone morphogenetic proteins (BMPs) are key factors controlling osteoblast differentiation, which have been proved to be involved in the hard tissue formation of marine mollusks. In the present study, a member of BMPs gene (CgBMP7) was identified from Pacific oyster Crassostrea gigas (C. gigas) with the aim to understand its possible role in the regulation of shell formation under ocean acidification (OA) conditions. The open reading frame (ORF) of CgBMP7 was of 1254 bp encoding a polypeptide of 417 amino acids. The deduced amino acid se...
Source: Gene - August 4, 2023 Category: Genetics & Stem Cells Authors: Yuqian Gao Zhaoqun Liu Ting Zhu Xiaoyu Xin Yuhao Jin Lingling Wang Chang Liu Linsheng Song Funding Source Type: research
Artificial intelligence-supported screen reading versus standard double reading in the Mammography Screening with Artificial Intelligence trial (MASAI): a clinical safety analysis of a randomised, controlled, non-inferiority, single-blinded, screening accuracy study
Lancet Oncol. 2023 Aug;24(8):936-944. doi: 10.1016/S1470-2045(23)00298-X.ABSTRACTBACKGROUND: Retrospective studies have shown promising results using artificial intelligence (AI) to improve mammography screening accuracy and reduce screen-reading workload; however, to our knowledge, a randomised trial has not yet been conducted. We aimed to assess the clinical safety of an AI-supported screen-reading protocol compared with standard screen reading by radiologists following mammography.METHODS: In this randomised, controlled, population-based trial, women aged 40-80 years eligible for mammography screening (including general...
Source: Cancer Control - August 4, 2023 Category: Cancer & Oncology Authors: Kristina L ång Viktoria Josefsson Anna-Maria Larsson Stefan Larsson Charlotte H ögberg Hanna Sartor Solveig Hofvind Ingvar Andersson Aldana Rosso Source Type: research
A bone morphogenetic protein regulates the shell formation of Crassostrea gigas under ocean acidification
Gene. 2023 Aug 2:147687. doi: 10.1016/j.gene.2023.147687. Online ahead of print.ABSTRACTBone morphogenetic proteins (BMPs) are key factors controlling osteoblast differentiation, which have been proved to be involved in the hard tissue formation of marine mollusks. In the present study, a member of BMPs gene (CgBMP7) was identified from Pacific oyster Crassostrea gigas (C. gigas) with the aim to understand its possible role in the regulation of shell formation under ocean acidification (OA) conditions. The open reading frame (ORF) of CgBMP7 was of 1254 bp encoding a polypeptide of 417 amino acids. The deduced amino acid se...
Source: Gene - August 4, 2023 Category: Genetics & Stem Cells Authors: Yuqian Gao Zhaoqun Liu Ting Zhu Xiaoyu Xin Yuhao Jin Lingling Wang Chang Liu Linsheng Song Funding Source Type: research
Isolation and survival: The impact of local and MSA isolation on survival among non-Hispanic Black women diagnosed with breast cancer in the United States using a SEER-Medicare cohort
In this study, we examined the relationship between local and Metropolitan Statistical Area (MSA) measures of Black isolation (segregation) and survival among older non-Hispanic (NH) Black women with breast cancer (BC) in the United States. We hypothesized that the influence of local isolation on mortality varies based on MSA isolation-specifically, that high local isolation may be protective in the context of highly segregated MSAs, as ethnic density may offer opportunities for social support and buffer racialized groups from the harmful influences of racism.METHODS: Local and MSA measures of isolation were linked by Cens...
Source: Health and Place - August 2, 2023 Category: Environmental Health Authors: Bethany Canales Purushottam W Laud Sergey Tarima Yuhong Zhou Jean C Bikomeye Emily L McGinley Tina W F Yen Amin Bemanian Kirsten M M Beyer Source Type: research
An unexpected contribution of higher education towards the innovations: the moderate role of green technology
Environ Sci Pollut Res Int. 2023 Aug 1. doi: 10.1007/s11356-023-28655-x. Online ahead of print.ABSTRACTUnderstanding how environmental restrictions affect the relationship between economic stability and unbalanced technical innovation is crucial for optimizing environmental and financial policy frameworks in developing nations to achieve sustainable development goals (SDGs). Understanding the driving effect of green funding on green development is vital for promoting economic transformation and achieving long-term green growth. Green growth is one of the most exciting new strategies for sustained economic expansion. Despit...
Source: Environmental Science and Pollution Research International - August 1, 2023 Category: Environmental Health Authors: Yun Qiu Biao Tang Lian Liu Source Type: research
Eureka Health Launches with $7 Million For Patient-Led Platform To Share and Discover Better Treatments
Thousands of Members in its Long Covid Community; Expands into Metabolic Disease and Autoimmune Disorders
Eureka Health, a new community dedicated to helping chronic disease patients share experiences and discover the latest treatments, launched today to provide hope to people living with chronic diseases. Emerging from stealth with thousands already engaged in its Long Covid group, the AI-powered platform added metabolic disease, autoimmune disorders, ME/CFS, and related conditions. It will expand into other conditions in the coming weeks.
The company also announced that it has raised $7 million in funding. The seed rou...
Source: EMR and HIPAA - July 31, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 23andMe Able Partners Adina Teklu Anne Wojcicki Beren Airstone Bling Capital Bow Capital Cancer Commons Eureka Eureka Health Forward Health Health IT Funding Health IT Fundings Health IT Invest Source Type: blogs
Ponderings on Peer Review: Part 2. Manuscript Critiques
Am J Physiol Regul Integr Comp Physiol. 2023 Jul 31. doi: 10.1152/ajpregu.00112.2023. Online ahead of print.ABSTRACTIn Part 1 of this Perspective, I discussed general principles of scientific peer review in the biomedical sciences aimed at early-stage investigators (i.e., graduate students, postdoctoral fellows, and junior faculty). Here in Part 2, I share my thoughts specifically on the topic of peer review of manuscripts. I begin by defining manuscript peer review and discuss the goals and importance of the concept. I then describe the organizational structure of the process, including the 2 distinct stages involved. Nex...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - July 31, 2023 Category: Physiology Authors: Douglas R Seals Source Type: research
Revealing the concealed: A tribute to Donald L. Morton, MD
Clin Exp Metastasis. 2023 Jul 31. doi: 10.1007/s10585-023-10223-9. Online ahead of print.ABSTRACTDonald L. Morton, MD, epitomized one of America's dream scenarios: a person evolving from the humblest of origins to become an international celebrity in his profession, leading the world in the discipline of surgical oncology. His pioneering accomplishments in various roles have been well documented. Scientists, clinicians, students, and patients benefited from his contributions to the management of malignant diseases, particularly melanoma. His many attributes in pursuing the goal to cure malignant diseases are well known. Br...
Source: Clinical Breast Cancer - July 31, 2023 Category: Cancer & Oncology Authors: S David Nathanson Ian Wood Source Type: research
