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Total 4663 results found since Jan 2013.
Occurrence and risk assessment of pharmaceuticals in hospital wastewater in Costa Rica
Chemosphere. 2023 Aug 5:139746. doi: 10.1016/j.chemosphere.2023.139746. Online ahead of print.ABSTRACTThis work aims to determine the occurrence, hazard and prioritization of pharmaceuticals from hospital wastewater in Costa Rica through the monitoring of 70 compounds and assessing their environmental risk through a hazard quotient approach (HQ). Moreover, the quantification of selected antibiotic resistance genes (ARGs) was conducted for the first time in this matrix in this geographical location. Thirty-four pharmaceuticals were detected, being caffeine, 1,7-dimethylxanthine, acetaminophen, ibuprofen, naproxen, ciproflox...
Source: Chemosphere - August 7, 2023 Category: Chemistry Authors: Carlos E Rodr íguez-Rodríguez Didier Ram írez-Morales Mario Masis-Mora Jos é R Montiel-Mora Claudio Soto-Garita Emanuel Araya-Valverde Juan Carlos Cambronero-Heinrichs Alexandre S ànchez-Melsió Susana Brice ño-Guevara Michael Mendez-Rivera Jos é L Source Type: research
Neutrophils exacerbate acetaminophen-induced liver injury by producing cytotoxic interferon- γ
CONCLUSIONS: Our findings uncover a novel mechanism of neutrophil action in promoting AILI and provide new insights into immune modulation of the disease pathogenesis.PMID:37541108 | DOI:10.1016/j.intimp.2023.110734
Source: International Immunopharmacology - August 4, 2023 Category: Allergy & Immunology Authors: Hao Wu Chunqing Guo Zheng Liu Jinyang Cai Chong Wang Huanfa Yi Arun Sanyal Puneet Puri Huiping Zhou Xiang-Yang Wang Source Type: research
Efficacy of oltipraz in preventing acetaminophen-induced liver injury in mice
In this study, we present OPZ-mediated protection of mice against acetaminophen (APAP)-induced liver injury and discuss its possible contributing factors. Overnight-fasted male CD-1 mice were administered APAP intraperitoneally, and some mice were administered OPZ 16 h before APAP. Hepatotoxicity was assessed by measuring serum alanine aminotransferase leakage and histopathological evaluation. The hepatic mRNA expressions of CYP2E1, glutamate cysteine ligase (GCL), and NAD(P)H:quinone oxidoreductase (NQO1) were measured by real-time reverse-transcription polymerase chain reaction. OPZ protected mice from APAP-induced liver...
Source: Cancer Control - August 3, 2023 Category: Cancer & Oncology Authors: Yasuhiro Masubuchi Kenji Mikami Source Type: research
Schisandrol A, a bioactive constituent from Schisandrae Chinensis Fructus, alleviates drug-induced liver injury by autophagy activation via exosomes
CONCLUSION: Schisandrol A alleviated the symptoms of DILI in mice by inhibiting oxidative stress and inflammation, whereas, it alleviated DILI by activating autophagy in the exosomes.PMID:37531820 | DOI:10.1016/j.bioorg.2023.106751
Source: Bioorganic Chemistry - August 2, 2023 Category: Chemistry Authors: Xiankuan Li Sihan Gong Weishan Chen Ying Zhao Kun Fu Yanchao Zheng Jingzi Chen Source Type: research
Association of Acetaminophen With Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Pharmacologic Considerations and Treatment Options
Cureus. 2023 Jun 28;15(6):e41116. doi: 10.7759/cureus.41116. eCollection 2023 Jun.ABSTRACTAcetaminophen is an extremely common drug with many implications for its analgesic and antipyretic properties. It has a unique mechanism of action and downstream effects that separate it categorically from non-steroidal anti-inflammatory drugs. These differences come with potential adverse effects that range from mild drug reactions to severe life-threatening emergencies. While acetaminophen's toxic liver effects are well known, a lesser-known adverse effect of this drug is its association with the development of Stevens-Johnson syndr...
Source: Pain Physician - July 31, 2023 Category: Anesthesiology Authors: Noah J Spillers Patrick M Luther Norris C Talbot Gianni H Ly Evan M Downs Gabriel Lavespere Denisa Pavlickova Shahab Ahmadzadeh Omar Viswanath Giustino Varrassi Sahar Shekoohi Alan D Kaye Source Type: research
Tangeretin and 4'-demethyltangeretin prevent damage to mouse hepatocytes from oxidative stress by activating the Nrf2-related antioxidant pathway via an epigenetic mechanism
In this study we examined the effects of tangeretin (TAN), a common citrus PMF, and its metabolite 4'-demethyltangeretin (4'-OH-TAN) on activation of the Nrf2 antioxidant system in mouse AML-12 hepatocytes through regulation by epigenetic mechanisms. The ability of TAN and 4'-OH-TAN to inhibit APAP-induced hepatotoxicity was also evaluated. The results showed that TAN and 4'-OH-TAN significantly increased the mRNA and protein levels of Nrf2 and Nrf2-mediated antioxidant and detoxifying enzymes (UGT1A, HO-1, and NQO1) in AML-12 cells. TAN and 4'-OH-TAN also suppressed protein expression of histone deacetylases (HDACs) and D...
Source: Chemico-Biological Interactions - July 30, 2023 Category: Molecular Biology Authors: Zheng-Yuan Su Jen-Chun Chien Yen-Chen Tung Tien-Yuan Wu Jie-An Liao Guor-Jien Wei Source Type: research
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study
CONCLUSION: The results of this study support the significant hepatoprotective effect of SLB nanoliposomes against acetaminophen-induced toxicity depending on the route of administration.PMID:37506470 | DOI:10.1016/j.bbrc.2023.07.045
Source: Cell Research - July 28, 2023 Category: Cytology Authors: Fatemeh Gheybi Alireza Khooei Azam Hoseinian Maham Doagooyan Kebria Houshangi Mahmoud Reza Jaafari Arash Papi Zahra Khoddamipour Amirhossein Sahebkar Seyedeh Hoda Alavizadeh Source Type: research
Protective effect of hot-water and ethanol-aqueous extracts from Anneslea fragrans against acetaminophen-induced acute liver injury in mice
This study provides a new sight that AFW and AFE may have a potential natural resource for the treatment of liver injury.PMID:37506865 | DOI:10.1016/j.fct.2023.113973
Source: Food and Chemical Toxicology - July 28, 2023 Category: Food Science Authors: Yiwen Hu Mengcheng Li Yongpeng Wang Qingwang Xue Xiaodong Luo Afsar Khan Tianrui Zhao Yaping Liu Zhengxuan Wang Yudan Wang Guiguang Cheng Source Type: research
Patient, operative and pain management factors influencing inpatient compared with surgical day care mastectomy procedures at a community hospital
CONCLUSION: We found no significant differences in surgical outcomes between inpatients and those with same-day discharge after mastectomy procedures. These findings add to the growing body of evidence that surgical day care mastectomy procedures are safe in the community setting.PMID:37500104 | DOI:10.1503/cjs.010422
Source: Canadian Journal of Surgery - July 27, 2023 Category: Surgery Authors: Colin Davey Leo Chen Hamish Hwang Source Type: research
