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Drug: Metformin
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Total 6409 results found since Jan 2013.
Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea
Chemosphere. 2023 Sep 7:140070. doi: 10.1016/j.chemosphere.2023.140070. Online ahead of print.ABSTRACTThe antidiabetic drug metformin (MET) and its metabolite guanylurea (GUA) have been frequently and ubiquitously detected in surface water. Consequently, there has been a consistent rise in studying the toxicity of MET and GUA in fish over the past decade. Nonetheless, it is noteworthy that no study has assessed the harmful effects both compounds might trigger on fish blood and organs after chronic exposure. Taking into consideration the data above, our research strived to accomplish two primary objectives: Firstly, to asse...
Source: Chemosphere - September 9, 2023 Category: Chemistry Authors: Gustavo Axel Elizalde-Vel ázquez Selene Elizabeth Herrera-V ázquez Leobardo Manuel G ómez-Oliván Sandra Garc ía-Medina Source Type: research
Metformin-suppressed platelet's function in vitro: Possible relation to delayed or failure of platelet-rich fibrin preparation
Toxicol In Vitro. 2023 Sep 4;93:105692. doi: 10.1016/j.tiv.2023.105692. Online ahead of print.ABSTRACTPlatelet-rich fibrin (PRF) is a popular autologous blood-derived biomaterial that is used in regenerative therapy. Owing to its simple preparation without additional factors, the PRF quality directly reflects the characteristics of individual blood samples. Antiplatelet or anticoagulant drugs can hamper the successful preparation of PRF. We recently observed similar phenomena in metformin-taking type-2 diabetics (T2DM). Thus, we hypothesized that metformin interferes with platelet function, thereby suppressing coagulation....
Source: Toxicology in Vitro - September 6, 2023 Category: Toxicology Authors: Takashi Uematsu Hideo Masuki Masayuki Nakamura Hideo Kawabata Yutaka Kitamura Taisuke Watanabe Takao Watanabe Tomoharu Mochizuki Takashi Ushiki Tomoyuki Kawase Source Type: research
Quantitative risk-benefit profiles of oral contraceptives, insulin sensitizers and antiandrogens for women with polycystic ovary syndrome: A model-based meta-analysis
This study aimed to quantitatively evaluate the effects of the aforementioned medications and to compare their risk-benefit profiles. Randomized controlled trials published until 14th March 2022 were searched in PubMed and Embase. A model-based meta-analysis was developed to examine the time-effect profiles of each medication. The maximal percentage change of the effect (Emax) and time to achieve half of Emax (T50) were estimated. Primary outcomes included menstruation, hirsutism score, free androgen index (FAI), body mass index (BMI), insulin sensitivity, and lipid profiles. Overall, 200 studies (9,685 patients and 385 ar...
Source: European Journal of Pharmaceutical Sciences - September 4, 2023 Category: Drugs & Pharmacology Authors: Zhe Tang Jing Guan Jue-Hui Mao Lu Han Juan-Juan Zhang Rui Chen Zheng Jiao Source Type: research
Quantitative risk-benefit profiles of oral contraceptives, insulin sensitizers and antiandrogens for women with polycystic ovary syndrome: a model-based meta-analysis
This study aimed to quantitatively evaluate the effects of the aforementioned medications and to compare their risk-benefit profiles. Randomized controlled trials published until 14th March, 2022 were searched in PubMed and Embase. A model-based meta-analysis was developed to examine the time-effect profiles of each medication. The maximal percentage change of the effect (Emax) and time to achieve half of Emax (T50) were estimated. Primary outcomes included menstruation, hirsutism score, free androgen index (FAI), body mass index (BMI), insulin sensitivity, and lipid profiles. Overall, 200 studies (9,685 patients and 385 a...
Source: European Journal of Pharmaceutical Sciences - September 4, 2023 Category: Drugs & Pharmacology Authors: Zhe Tang Jing Guan Jue-Hui Mao Lu Han Juan-Juan Zhang Rui Chen Zheng Jiao Source Type: research
Metformin and Aspirin: Anticancer effects on A549 and PC3 cancer cells and the mechanisms of action
This study aims to investigate the effect of metformin and aspirin and their combination of them on A549 and PC3 cell lines. Metformin and aspirin were investigated separately and in combination on two cancer cell lines, A549 and PC3. The examined groups include the negative control of untreated cells and the positive control of cisplatin and drugs at concentrations of 15, 10, and 20 μg/ mL to investigate the mechanism of oxidative stress factors (reactive oxygen species, lipid peroxidation, Glutathione (GSH)) and apoptosis (lactate dehydrogenase). The results showed that aspirin, metformin, and their combination could af...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Farzaneh Motafeghi Romina Shahsavari Parham Mortazavi Aysan Babaei Pouria SamadiMojaveri Omid Abed Khojasteh Mohammad Shokrzadeh Source Type: research
Hyperglycaemia aggravates periodontal inflamm-aging by promoting SETDB1-mediated LINE-1 de-repression in macrophages
CONCLUSIONS: The findings of this study show that SETDB1 regulates senescence-like phenotypical switching of macrophages and is a potential candidate for the treatment of diabetes-induced periodontal inflamm-aging.PMID:37661095 | DOI:10.1111/jcpe.13871
Source: Journal of Clinical Periodontology - September 3, 2023 Category: Dentistry Authors: Ziqi Yue Luningxiao Nie Ning Ji Yuezhang Sun Kangjian Zhu Haonan Zou Xiuxiu Song Jiao Chen Qi Wang Source Type: research
Necessity of Different Lignocellulose on Exopolysaccharide Synthesis and Its Hypoglycemic Activity In Vitro of Inonotus obliquus
Appl Biochem Biotechnol. 2023 Sep 2. doi: 10.1007/s12010-023-04716-2. Online ahead of print.ABSTRACTCurrent work proposes elm sawdust, poplar sawdust, pine sawdust, and cotton straw with different lignocellulose compositions and structures as the research objects to investigate the relationship between the hypoglycemic activity of mycelium polysaccharides from Inonotus obliquus and lignocellulose biodegradation. Four kinds of lignocellulosic materials could significantly increase the exopolysaccharide content and α-glucosidase inhibition rate and advance the occurrence time of α-glucosidase inhibition activity. Among all...
Source: Applied Biochemistry and Biotechnology - September 2, 2023 Category: Biochemistry Authors: Xiaohong Lu Yuanyuan Zhao Chunhong Wang Haiyao Zhang Ping Liu Source Type: research
Promising translatable pharmacological interventions for body weight management in individuals with severe mental illness - a narrative review
Expert Opin Pharmacother. 2023 Aug 31. doi: 10.1080/14656566.2023.2254698. Online ahead of print.ABSTRACTINTRODUCTION: Psychotropic medications, especially antipsychotics, have been consistently shown to cause weight gain in individuals with severe mental illness (SMI), a population inherently challenged with poor physical health. Consequently, compared to the general population, this contributes to an increased cardiometabolic burden, including the risk of type 2 diabetes, dyslipidemia, and hypertension. Furthermore, comorbid obesity leads to treatment nonadherence, decreased quality of life, and increased risk of relapse...
Source: Expert Opinion on Pharmacotherapy - September 1, 2023 Category: Drugs & Pharmacology Authors: Riddhita De Femin Prasad Nicolette Stogios Luisa Burin Bj ørn H Ebdrup Filip K Knop Margaret K Hahn Sri Mahavir Agarwal Source Type: research
Long-term oral tribasic copper chloride exposure impedes cognitive function and disrupts mitochondrial metabolism by inhibiting mitophagy in rats
Environ Pollut. 2023 Aug 29:122474. doi: 10.1016/j.envpol.2023.122474. Online ahead of print.ABSTRACTCopper (Cu) is an essential micronutrient element that commonly acted as a feed additive and antimicrobial in agricultural production. Tribasic copper chloride (TBCC) is a relatively new dietary Cu source, and its exposure directly or indirectly affects the safety of animals and ecological environment, thus posing a potential risk to human health. Cu overexposure would produce toxic reactive oxygen species (ROS) that may have toxic effects on the host, but the mechanism of neurotoxicity remains unclear. Herein, to explore t...
Source: Environmental Pollution - August 31, 2023 Category: Environmental Health Authors: Wenlan Yu Xiaoyue Chang Jianzhao Liao Jinwen Quan Siying Liu Ting He Gaolong Zhong Jilei Huang Zhonghua Liu Zhaoxin Tang Source Type: research
Mitophagy-promoting agents and their ability to promote healthy-aging
In conclusion, this article provides an up-to-date source of information about natural and synthetic substances that activate mitophagy and, hopefully, stimulates new hypotheses and studies that promote healthy human aging worldwide.PMID:37650304 | DOI:10.1042/BST20221363
Source: Biochemical Society Transactions - August 31, 2023 Category: Biochemistry Authors: Vijigisha Srivastava Einav Gross Source Type: research
