Hyperglycaemia aggravates periodontal inflamm-aging by promoting SETDB1-mediated LINE-1 de-repression in macrophages

CONCLUSIONS: The findings of this study show that SETDB1 regulates senescence-like phenotypical switching of macrophages and is a potential candidate for the treatment of diabetes-induced periodontal inflamm-aging.PMID:37661095 | DOI:10.1111/jcpe.13871

Source: Journal of Clinical Periodontology - September 3, 2023 Category: Dentistry Authors: Ziqi Yue Luningxiao Nie Ning Ji Yuezhang Sun Kangjian Zhu Haonan Zou Xiuxiu Song Jiao Chen Qi Wang Source Type: research