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Drug: Metformin
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Metformin in type 2 diabetes: Evidence for its beneficial effects on frailty and sarcopenia
Curr Diabetes Rev. 2023 Jul 27. doi: 10.2174/1573399820666230727101141. Online ahead of print.ABSTRACTThis narrative review aimed to discuss the potential interplay among frailty syndrome, sarcopenia and metformin in type 2 diabetes mellitus (T2DM). There is emerging evidence on the potential protective role of metformin on both frailty and sarcopenia. However, results are not always consistent. Thus, further research is needed to provide a definitive answer on any role of metformin in improving frailty and/or sarcopenia in T2DM.PMID:37497698 | DOI:10.2174/1573399820666230727101141
Source: Current Diabetes Reviews - July 27, 2023 Category: Endocrinology Authors: Elisavet E Pyrgioti Nikolaos D Karakousis Petros N Georgakopoulos Nikolaos Papanas Source Type: research
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
Am J Physiol Renal Physiol. 2023 Jul 27. doi: 10.1152/ajprenal.00078.2023. Online ahead of print.ABSTRACTPrepubertal obesity (PPO) is currently an epidemic and is considered a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance and renal injury in obese children are lacking. Recently, we reported that progressive renal injury in Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats was associated with insulin resistance prior to puberty. ...
Source: Am J Physiol Renal P... - July 27, 2023 Category: Urology & Nephrology Authors: Ubong S Ekperikpe Sautan Mandal Stephen J Holt Jacori K Daniels Tyler D Johnson Jonita S Cooper Sarah M Safir Denise C Cornelius Jan M Williams Source Type: research
Clinical Efficacy of Different Doses of Canagliflozin Combined with Metformin in the Treatment of Type 2 Diabetes: Meta-Analysis
CONCLUSION: The meta-analysis demonstrates that high doses of canagliflozin combined with metformin may be potentially effective in patients with T2DM, as evidenced by LS means of HbA1c and FPG, and the above conclusions need to be verified by more high-quality studies.PMID:37499149
Source: Alternative Therapies in Health and Medicine - July 27, 2023 Category: Complementary Medicine Authors: GuangZhi Li Dongmei Zhang Jie Ni Shizhen Wang Source Type: research
Metformin in type 2 diabetes: Evidence for its beneficial effects on frailty and sarcopenia
Curr Diabetes Rev. 2023 Jul 27. doi: 10.2174/1573399820666230727101141. Online ahead of print.ABSTRACTThis narrative review aimed to discuss the potential interplay among frailty syndrome, sarcopenia and metformin in type 2 diabetes mellitus (T2DM). There is emerging evidence on the potential protective role of metformin on both frailty and sarcopenia. However, results are not always consistent. Thus, further research is needed to provide a definitive answer on any role of metformin in improving frailty and/or sarcopenia in T2DM.PMID:37497698 | DOI:10.2174/1573399820666230727101141
Source: Current Diabetes Reviews - July 27, 2023 Category: Endocrinology Authors: Elisavet E Pyrgioti Nikolaos D Karakousis Petros N Georgakopoulos Nikolaos Papanas Source Type: research
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
Am J Physiol Renal Physiol. 2023 Jul 27. doi: 10.1152/ajprenal.00078.2023. Online ahead of print.ABSTRACTPrepubertal obesity (PPO) is currently an epidemic and is considered a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance and renal injury in obese children are lacking. Recently, we reported that progressive renal injury in Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats was associated with insulin resistance prior to puberty. ...
Source: American Journal of Physiology. Renal Physiology - July 27, 2023 Category: Physiology Authors: Ubong S Ekperikpe Sautan Mandal Stephen J Holt Jacori K Daniels Tyler D Johnson Jonita S Cooper Sarah M Safir Denise C Cornelius Jan M Williams Source Type: research
Metformin in type 2 diabetes: Evidence for its beneficial effects on frailty and sarcopenia
Curr Diabetes Rev. 2023 Jul 27. doi: 10.2174/1573399820666230727101141. Online ahead of print.ABSTRACTThis narrative review aimed to discuss the potential interplay among frailty syndrome, sarcopenia and metformin in type 2 diabetes mellitus (T2DM). There is emerging evidence on the potential protective role of metformin on both frailty and sarcopenia. However, results are not always consistent. Thus, further research is needed to provide a definitive answer on any role of metformin in improving frailty and/or sarcopenia in T2DM.PMID:37497698 | DOI:10.2174/1573399820666230727101141
Source: Current Diabetes Reviews - July 27, 2023 Category: Endocrinology Authors: Elisavet E Pyrgioti Nikolaos D Karakousis Petros N Georgakopoulos Nikolaos Papanas Source Type: research
Clinical Efficacy of Different Doses of Canagliflozin Combined with Metformin in the Treatment of Type 2 Diabetes: Meta-Analysis
CONCLUSION: The meta-analysis demonstrates that high doses of canagliflozin combined with metformin may be potentially effective in patients with T2DM, as evidenced by LS means of HbA1c and FPG, and the above conclusions need to be verified by more high-quality studies.PMID:37499149
Source: Alternative Therapies in Health and Medicine - July 27, 2023 Category: Complementary Medicine Authors: GuangZhi Li Dongmei Zhang Jie Ni Shizhen Wang Source Type: research
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
Am J Physiol Renal Physiol. 2023 Jul 27. doi: 10.1152/ajprenal.00078.2023. Online ahead of print.ABSTRACTPrepubertal obesity (PPO) is currently an epidemic and is considered a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance and renal injury in obese children are lacking. Recently, we reported that progressive renal injury in Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats was associated with insulin resistance prior to puberty. ...
Source: American Journal of Physiology. Renal Physiology - July 27, 2023 Category: Physiology Authors: Ubong S Ekperikpe Sautan Mandal Stephen J Holt Jacori K Daniels Tyler D Johnson Jonita S Cooper Sarah M Safir Denise C Cornelius Jan M Williams Source Type: research
Clinical Efficacy of Different Doses of Canagliflozin Combined with Metformin in the Treatment of Type 2 Diabetes: Meta-Analysis
CONCLUSION: The meta-analysis demonstrates that high doses of canagliflozin combined with metformin may be potentially effective in patients with T2DM, as evidenced by LS means of HbA1c and FPG, and the above conclusions need to be verified by more high-quality studies.PMID:37499149
Source: Alternative Therapies in Health and Medicine - July 27, 2023 Category: Complementary Medicine Authors: GuangZhi Li Dongmei Zhang Jie Ni Shizhen Wang Source Type: research
Metformin reduces insulin resistance and attenuates progressive renal injury in prepubertal obese Dahl salt-sensitive rats
Am J Physiol Renal Physiol. 2023 Jul 27. doi: 10.1152/ajprenal.00078.2023. Online ahead of print.ABSTRACTPrepubertal obesity (PPO) is currently an epidemic and is considered a major risk factor for renal injury. Previous studies have demonstrated that insulin resistance contributes to renal injury in obesity, independent of diabetes. However, studies examining the relationship between insulin resistance and renal injury in obese children are lacking. Recently, we reported that progressive renal injury in Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats was associated with insulin resistance prior to puberty. ...
Source: Am J Physiol Renal P... - July 27, 2023 Category: Urology & Nephrology Authors: Ubong S Ekperikpe Sautan Mandal Stephen J Holt Jacori K Daniels Tyler D Johnson Jonita S Cooper Sarah M Safir Denise C Cornelius Jan M Williams Source Type: research
Comparative efficacy and safety profile of once-weekly Semaglutide versus once-daily Sitagliptin as an add-on to metformin in patients with type 2 diabetes: a systematic review and meta-analysis
CONCLUSIONS: In conclusion, the administration of once-weekly Semaglutide exhibited a substantial reduction in HbA1c, average systolic blood pressure (SBP), mean diastolic blood pressure (DBP), body weight, waist circumference, body mass index (BMI), and a rise in pulse rate, as opposed to the once-daily administration of Sitagliptin.PMID:37498865 | DOI:10.1080/07853890.2023.2239830
Source: Annals of Medicine - July 27, 2023 Category: Internal Medicine Authors: Tirath Patel Fnu Nageeta Rohab Sohail Tooba Shaukat Butt Shyamala Ganesan Fnu Madhurita Muhammad Ahmed Mahrukh Zafar Wirda Zafar Muhammad Uzair Zaman Giustino Varrassi Mahima Khatri Satesh Kumar Source Type: research
