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Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma
Int Rev Cell Mol Biol. 2023;380:149-171. doi: 10.1016/bs.ircmb.2023.04.004. Epub 2023 Jul 21.ABSTRACTCutaneous T-cell lymphoma (CTCL) is a type of cancer that affects skin, and is characterized by abnormal T-cells in the skin. Epigenetic changes have been found to play a significant role in the development and progression of CTCL. Recently, non-coding RNAs (ncRNAs), such as microRNAs and long non-coding RNAs, have been identified as key players in the regulation of gene expression in CTCL. These ncRNAs can alter the expression of genes involved in cell growth, differentiation, and apoptosis, leading to the development and ...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Monaza Adeeb Lubna Therachiyil Safwan Moton Joerg Buddenkotte Majid Ali Alam Shahab Uddin Martin Steinhoff Aamir Ahmad Source Type: research
Effects of blocking CD24 and CD47 'don't eat me' signals in combination with rituximab in mantle-cell lymphoma and chronic lymphocytic leukaemia
J Cell Mol Med. 2023 Aug 31. doi: 10.1111/jcmm.17868. Online ahead of print.ABSTRACTMantle-cell lymphoma (MCL) is a B-cell non-Hodgkin Lymphoma (NHL) with a poor prognosis, at high risk of relapse after conventional treatment. MCL-associated tumour microenvironment (TME) is characterized by M2-like tumour-associated macrophages (TAMs), able to interact with cancer cells, providing tumour survival and resistance to immuno-chemotherapy. Likewise, monocyte-derived nurse-like cells (NLCs) present M2-like profile and provide proliferation signals to chronic lymphocytic leukaemia (CLL), a B-cell malignancy sharing with MCL some ...
Source: J Cell Mol Med - September 1, 2023 Category: Molecular Biology Authors: Andrea Aroldi Mario Mauri Daniele Ramazzotti Matteo Villa Federica Malighetti Valentina Crippa Federica Cocito Chiara Borella Elisa Bossi Carolina Steidl Chiara Scollo Claudia Voena Roberto Chiarle Luca Mologni Rocco Piazza Carlo Gambacorti-Passerini Source Type: research
Expression Changes in Programmed Death Ligand 1 from Precancerous Lesions to Invasive Adenocarcinoma in Subcentimeter Pulmonary Nodules: A Large Study of 2022 Cases in China
CONCLUSIONS: PD-L1 expression was significantly associated with radiological and pathological invasiveness and driver mutation status in subcentimeter pulmonary nodules. The significance of PD-L1 expression in the evolution of early-stage lung adenocarcinoma requires further investigation.PMID:37658270 | DOI:10.1245/s10434-023-14009-x
Source: Ann Oncol - September 1, 2023 Category: Cancer & Oncology Authors: Xiongwen Yang Yi Xiao Hao Hu Zhen-Bin Qiu Yi-Fan Qi Meng-Min Wang Yi-Long Wu Wen-Zhao Zhong Source Type: research
Pirtobrutinib in Covalent BTK-Inhibitor pre-treated relapsed/refractory (R/R) Mantle Cell Lymphoma
Bull Cancer. 2023 Aug 30:S0007-4551(23)00336-3. doi: 10.1016/j.bulcan.2023.07.002. Online ahead of print.NO ABSTRACTPMID:37658026 | DOI:10.1016/j.bulcan.2023.07.002
Source: Bulletin du Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Caroline Fileni Cl émentine Sarkozy Source Type: research
Cost-effectiveness of combination therapy of polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisolone for previously untreated diffuse large B-cell lymphoma in Japan
CONCLUSIONS: This study suggests that Pola + R-CHP is a cost-effective treatment for previously untreated DLBCL in Japan under the public health insurance system.PMID:37656225 | DOI:10.1080/13696998.2023.2254162
Source: Journal of Medical Economics - September 1, 2023 Category: Health Management Authors: Takashi Mizuoka Hiroyuki Sakamaki Shigeo Fuji Shota Saito Tatsunori Murata Shinya Ohno Naoki Inubashiri Tomoha Oshima Kazuhito Yamamoto Source Type: research
Efficacy of single-agent chemotherapy with pegylated liposomal doxorubicin or gemcitabine in a diverse cohort of patients with recalcitrant cutaneous T-cell lymphoma
Br J Dermatol. 2023 Sep 1:ljad311. doi: 10.1093/bjd/ljad311. Online ahead of print.NO ABSTRACTPMID:37655919 | DOI:10.1093/bjd/ljad311
Source: The British Journal of Dermatology - September 1, 2023 Category: Dermatology Authors: David Weiner Andrew Ly Sai Talluru Ananya Munjal Olivia Pierog Richard Ambinder Sima Rozati Source Type: research
T helper type 9 cell response and its role in the neurological clinic of patients with Human T-lymphotropic virus 1
This study aimed to evaluate the expression profiles of PU.1, interferon regulatory factor 4 (IRF-4), and cytokine interleukin-9 (IL-9) during the induction of peripheral immune response and their role in the HTLV-1-infected patients' neurological symptoms. This analytical cross-sectional study was carried out at the Laboratory of Clinical and Epidemiology of Endemic Diseases and the Laboratory of Immunopathology, both from the Tropical Medicine Center at the Federal University of Pará. Assessment of neurological parameters was performed (gait, Expanded Kurtzke Disability State Scale (EDSS) score, upper and lower limb ref...
Source: Immunobiology - September 1, 2023 Category: Allergy & Immunology Authors: Roberto de Sena Rodrigues J únior J éssica Antonia Nunes Gomes George Alberto da Silva Dias Satomi Fujihara Gilberto Toshimitsu Yoshikawa Roberta Vilela Lopes Koyama Rita Catarina Medeiros Sousa Juarez Antonio Sim ões Quaresma Hellen Thais Fuzii Source Type: research
Cost-effectiveness of combination therapy of polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisolone for previously untreated diffuse large B-cell lymphoma in Japan
CONCLUSIONS: This study suggests that Pola + R-CHP is a cost-effective treatment for previously untreated DLBCL in Japan under the public health insurance system.PMID:37656225 | DOI:10.1080/13696998.2023.2254162
Source: Journal of Medical Economics - September 1, 2023 Category: Health Management Authors: Takashi Mizuoka Hiroyuki Sakamaki Shigeo Fuji Shota Saito Tatsunori Murata Shinya Ohno Naoki Inubashiri Tomoha Oshima Kazuhito Yamamoto Source Type: research
T helper type 9 cell response and its role in the neurological clinic of patients with Human T-lymphotropic virus 1
This study aimed to evaluate the expression profiles of PU.1, interferon regulatory factor 4 (IRF-4), and cytokine interleukin-9 (IL-9) during the induction of peripheral immune response and their role in the HTLV-1-infected patients' neurological symptoms. This analytical cross-sectional study was carried out at the Laboratory of Clinical and Epidemiology of Endemic Diseases and the Laboratory of Immunopathology, both from the Tropical Medicine Center at the Federal University of Pará. Assessment of neurological parameters was performed (gait, Expanded Kurtzke Disability State Scale (EDSS) score, upper and lower limb ref...
Source: Immunobiology - September 1, 2023 Category: Allergy & Immunology Authors: Roberto de Sena Rodrigues J únior J éssica Antonia Nunes Gomes George Alberto da Silva Dias Satomi Fujihara Gilberto Toshimitsu Yoshikawa Roberta Vilela Lopes Koyama Rita Catarina Medeiros Sousa Juarez Antonio Sim ões Quaresma Hellen Thais Fuzii Source Type: research
Non-coding RNAs in the epigenetic landscape of cutaneous T-cell lymphoma
Int Rev Cell Mol Biol. 2023;380:149-171. doi: 10.1016/bs.ircmb.2023.04.004. Epub 2023 Jul 21.ABSTRACTCutaneous T-cell lymphoma (CTCL) is a type of cancer that affects skin, and is characterized by abnormal T-cells in the skin. Epigenetic changes have been found to play a significant role in the development and progression of CTCL. Recently, non-coding RNAs (ncRNAs), such as microRNAs and long non-coding RNAs, have been identified as key players in the regulation of gene expression in CTCL. These ncRNAs can alter the expression of genes involved in cell growth, differentiation, and apoptosis, leading to the development and ...
Source: International Review of Cell and Molecular Biology - September 1, 2023 Category: Cytology Authors: Monaza Adeeb Lubna Therachiyil Safwan Moton Joerg Buddenkotte Majid Ali Alam Shahab Uddin Martin Steinhoff Aamir Ahmad Source Type: research
Proteomics-Based Discovery of First-in-Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2)
Angew Chem Int Ed Engl. 2023 Sep 1:e202308292. doi: 10.1002/anie.202308292. Online ahead of print.ABSTRACTChemical probes are essential tools for understanding biological systems and for credentialing potential biomedical targets. Programmed cell death 2 (PDCD2) is a member of the B-cell lymphoma 2 (Bcl-2) family of proteins, which are critical regulators of apoptosis. Here we report the discovery and characterization of 10e, a first-in-class small molecule degrader of PDCD2. We discovered PDCD2 degrader by serendipity using a chemical proteomics approach in contrast to the conventional approach for making bivalent degrade...
Source: Angewandte Chemie - September 1, 2023 Category: Chemistry Authors: Wenzhi Ji Woong Sub Byun Wenchao Lu Xijun Zhu Katherine A Donovan Brendan Dwyer Jianwei Che Linjie Yuan Xianmixinuer Abulaiti Steven M Corsello Eric S Fischer Tinghu Zhang Nathanael Schiander Gray Source Type: research
T helper type 9 cell response and its role in the neurological clinic of patients with Human T-lymphotropic virus 1
This study aimed to evaluate the expression profiles of PU.1, interferon regulatory factor 4 (IRF-4), and cytokine interleukin-9 (IL-9) during the induction of peripheral immune response and their role in the HTLV-1-infected patients' neurological symptoms. This analytical cross-sectional study was carried out at the Laboratory of Clinical and Epidemiology of Endemic Diseases and the Laboratory of Immunopathology, both from the Tropical Medicine Center at the Federal University of Pará. Assessment of neurological parameters was performed (gait, Expanded Kurtzke Disability State Scale (EDSS) score, upper and lower limb ref...
Source: Immunobiology - September 1, 2023 Category: Allergy & Immunology Authors: Roberto de Sena Rodrigues J únior J éssica Antonia Nunes Gomes George Alberto da Silva Dias Satomi Fujihara Gilberto Toshimitsu Yoshikawa Roberta Vilela Lopes Koyama Rita Catarina Medeiros Sousa Juarez Antonio Sim ões Quaresma Hellen Thais Fuzii Source Type: research
Efficacy of single-agent chemotherapy with pegylated liposomal doxorubicin or gemcitabine in a diverse cohort of patients with recalcitrant cutaneous T-cell lymphoma
Br J Dermatol. 2023 Sep 1:ljad311. doi: 10.1093/bjd/ljad311. Online ahead of print.NO ABSTRACTPMID:37655919 | DOI:10.1093/bjd/ljad311
Source: The British Journal of Dermatology - September 1, 2023 Category: Dermatology Authors: David Weiner Andrew Ly Sai Talluru Ananya Munjal Olivia Pierog Richard Ambinder Sima Rozati Source Type: research
Pirtobrutinib in Covalent BTK-Inhibitor pre-treated relapsed/refractory (R/R) Mantle Cell Lymphoma
Bull Cancer. 2023 Aug 30:S0007-4551(23)00336-3. doi: 10.1016/j.bulcan.2023.07.002. Online ahead of print.NO ABSTRACTPMID:37658026 | DOI:10.1016/j.bulcan.2023.07.002
Source: Bulletin du Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Caroline Fileni Cl émentine Sarkozy Source Type: research
Effects of blocking CD24 and CD47 'don't eat me' signals in combination with rituximab in mantle-cell lymphoma and chronic lymphocytic leukaemia
J Cell Mol Med. 2023 Aug 31. doi: 10.1111/jcmm.17868. Online ahead of print.ABSTRACTMantle-cell lymphoma (MCL) is a B-cell non-Hodgkin Lymphoma (NHL) with a poor prognosis, at high risk of relapse after conventional treatment. MCL-associated tumour microenvironment (TME) is characterized by M2-like tumour-associated macrophages (TAMs), able to interact with cancer cells, providing tumour survival and resistance to immuno-chemotherapy. Likewise, monocyte-derived nurse-like cells (NLCs) present M2-like profile and provide proliferation signals to chronic lymphocytic leukaemia (CLL), a B-cell malignancy sharing with MCL some ...
Source: J Cell Mol Med - September 1, 2023 Category: Molecular Biology Authors: Andrea Aroldi Mario Mauri Daniele Ramazzotti Matteo Villa Federica Malighetti Valentina Crippa Federica Cocito Chiara Borella Elisa Bossi Carolina Steidl Chiara Scollo Claudia Voena Roberto Chiarle Luca Mologni Rocco Piazza Carlo Gambacorti-Passerini Source Type: research
