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Low Expression of A3C and PLP2 Indicating a Favorable Prognosis in Human Gliomas
In conclusion, our results not only confirmed A3C played an important role in glioma development, but the A3C IHC test could successfully predict the therapeutic effects and disease prognosis.PMID:37715423 | DOI:10.14715/cmb/2023.69.7.12
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Jong-Shiaw Jin Yu-Ling Tsai Yu-Chan Chang Wen-Chiuan Tsai Source Type: research
Hsa-miR-497-3p impedes the proliferation and invasion of triple-negative breast cancer cells by controlling epithelial-mesenchymal transition through ZEB1 targeting
This study aimed to examine the hsa-miR-497-3p effect and mechanism on the behavior of triple-negative breast cancer (TNBC) cells. We evaluated the expression of Hsa-miR-497-3p in tissue samples obtained from patients diagnosed with TNBC or luminal breast cancer (BrCa), utilizing the quantitative fluorescence polymerase chain reaction (PCR) method. We transfected hsa-miR-497-3p mimics and NC into MDA-MB-231 cells, whilehsa-miR-497-3p inhibitor and NC into TNBC cells, respectively. To examine the impact of hsa-miR-497-3p expression level on TNBC cell proliferation, invasion, and migration, we employed MTT, clone formation, ...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Qian Dong Hu Chen Ying Li Yan Kong Cuizhi Geng Yibing Liu Source Type: research
The relationship between tissue differentiation-inducing non-protein coding RNA expression and tumor size in patients with breast cancer
This study aimed to evaluate the expression level of Tissue Differentiation-Inducing Non-Protein Coding RNA (TINCR) in adjacent tumor and non-tumor tissues of 60 women with invasive ductal breast cancer. The relationship between TINCR expression and the clinical characteristics of patients has also been studied. For this purpose, total RNA was isolated from breast cancer patients' adjacent tumor and non-tumor tissue. RT Prime Script reagent was then used to convert total RNA to cDNA. The qRT-PCR quantified the TINCR expression level and analyzed the results by paired t-test. In addition, ROC curve analysis was used to eval...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Shen Tan Aimin Cui Nan Bai Zicui Zhang Source Type: research
Imaging immune checkpoint networks in cancer tissues with supermultiplexed SERS nanoprobes
Biomaterials. 2023 Sep 12;302:122327. doi: 10.1016/j.biomaterials.2023.122327. Online ahead of print.ABSTRACTCombined immune checkpoint (ICP) inhibitors maximize immune response rates of patients compared to the single-drug treatment strategy in cancer immunotherapy, and prediction of such optimal combinations requires high-throughput imaging techniques and suitable data analysis. In this work, we report a rational strategy for predicting combined drugs of ICP inhibitors based on supermultiplexed surface-enhanced Raman scattering (SERS) imaging and correlation network analysis. To this end, we first built an ultrasensitive...
Source: Biomaterials - September 16, 2023 Category: Materials Science Authors: Jin Li Fugang Liu Xinyuan Bi Jian Ye Source Type: research
Three cases of colon cancer in four generations of the Saudi family, caused by endogamous germline mutations
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):163-171. doi: 10.14715/cmb/2023.69.8.25.ABSTRACTVarious research pieces of evidence have been published in recent years, establishing the increasing prevalence of early colon cancer among young people. In this background, the current study aimed to analyze the reasons behind colon cancer recurrence among endogamous consanguineous cases in four generations of a single Saud family. For this study, the authors conducted the whole-exome sequencing analysis to screen for germline mutations in DNA samples from consanguineous cases within the family. After collecting the colon sam...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Dalal S Alshaya Tahani Mohamed Ibrahim Al-Hazani Mashael Alhumaidi Alotaibi Dalia Mostafa Domiaty Eman Alshehri Maha Abdulla Alwaili Amani Mohammed Alotaibi Areej Saud Jalal Alaa Ali AlQahtani Fatima Abdullah AlQassim Gadah Albasher Wedad Saeed Al-Qahtani Source Type: research
Adjuvant olaparib - High risk early breast cancer with BRCA1 or BRCA2 germline mutation
Bull Cancer. 2023 Sep 14:S0007-4551(23)00340-5. doi: 10.1016/j.bulcan.2023.07.004. Online ahead of print.NO ABSTRACTPMID:37716861 | DOI:10.1016/j.bulcan.2023.07.004
Source: Bulletin du Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Ma ëva Bonneau Audrey Bellesoeur Source Type: research
Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNF α/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells
In this study, supernatant from tumor necrosis factorα (TNFα)-treated human mammary microvascular endothelial cell (HMMEC) promoted cell migration and pseudopod formation in TNBC cells, but these phenomena were disappeared in SC-co-treated HMMEC. TNFα enhanced the expression of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in both HMMEC and human umbilical vein endothelial cell (HUVEC). G-CSF promoted TNBC migration and invasion in vitro, while G-CSF neutralization antibody and SC both inhibited TNBC metastasis in Balb/c mice. SC had no inhibition on the G-CS...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Xiyu Mei Hao Ouyang Hong Zhang Wangya Jia Bin Lu Jingnan Zhang Lili Ji Source Type: research
Interplay Between Estrogen, Kynurenine, and AHR Pathways: An Immunosuppressive Axis with Therapeutic Potential for Breast Cancer Treatment
Biochem Pharmacol. 2023 Sep 14:115804. doi: 10.1016/j.bcp.2023.115804. Online ahead of print.ABSTRACTBreast cancer is one of the most common malignancies among women worldwide. Estrogen exposure via endogenous and exogenous sources during a lifetime, together with environmental exposure to estrogenic compounds, represent the most significant risk factor for breast cancer development. As breast tumors establish, multiple pathways are deregulated. Among them is the aryl hydrocarbon receptor (AHR) signaling pathway. AHR, a ligand-activated transcription factor associated with the metabolism of polycyclic aromatic hydrocarbons...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Jorge Humberto Lim ón Pacheco Guillermo Elizondo Source Type: research
Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNF α/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells
In this study, supernatant from tumor necrosis factorα (TNFα)-treated human mammary microvascular endothelial cell (HMMEC) promoted cell migration and pseudopod formation in TNBC cells, but these phenomena were disappeared in SC-co-treated HMMEC. TNFα enhanced the expression of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in both HMMEC and human umbilical vein endothelial cell (HUVEC). G-CSF promoted TNBC migration and invasion in vitro, while G-CSF neutralization antibody and SC both inhibited TNBC metastasis in Balb/c mice. SC had no inhibition on the G-CS...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Xiyu Mei Hao Ouyang Hong Zhang Wangya Jia Bin Lu Jingnan Zhang Lili Ji Source Type: research
Interplay Between Estrogen, Kynurenine, and AHR Pathways: An Immunosuppressive Axis with Therapeutic Potential for Breast Cancer Treatment
Biochem Pharmacol. 2023 Sep 14:115804. doi: 10.1016/j.bcp.2023.115804. Online ahead of print.ABSTRACTBreast cancer is one of the most common malignancies among women worldwide. Estrogen exposure via endogenous and exogenous sources during a lifetime, together with environmental exposure to estrogenic compounds, represent the most significant risk factor for breast cancer development. As breast tumors establish, multiple pathways are deregulated. Among them is the aryl hydrocarbon receptor (AHR) signaling pathway. AHR, a ligand-activated transcription factor associated with the metabolism of polycyclic aromatic hydrocarbons...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Jorge Humberto Lim ón Pacheco Guillermo Elizondo Source Type: research
A novel self-assembled nanoplatform based on retrofitting poloxamer 188 for triple-negative breast cancer targeting treatment
In this study, a novel self-assembled nanoplatform was developed for active targeting of folate receptor-overexpressing triple-negative breast cancer. This platform, FPP NPs, was prepared by the retrofitted poloxamer 188 derivatives, resulting in nanoparticles with an appropriate size (<100 nm), good stability, and satisfactory biocompatibility. Cellular uptake and in vivo distribution studies showed that the FPP NPs had strong tumor cell uptake and active targeting capabilities. Furthermore, docetaxel (DTX) was loaded into FPP NPs in this research. The resulting DTX/FPP NPs exhibited high drug encapsulation efficiency ...
Source: Chemico-Biological Interactions - September 16, 2023 Category: Molecular Biology Authors: Xueyan Hou Yalin Guan Sisi He Zeqing Wu Jintao Bai Jingjing Xu Jingwen Wang Suyue Xu Huiqing Zhu Yanyan Yin Xue Yang Yongli Shi Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
Novel electrochemical biosensor for breast cancer detection, based on a nanocomposite of carbon nanofiber, metal-organic framework, and magnetic graphene oxide
In this study, we present the newly developed a novel microRNA biosensor based on magnetic rod carbon paste electrodes for breast cancer detection by using a relatively new MOF structure as a substrate. The major goal of manufacturing biosensors, suitable for clinical diagnostics, is to measure very low amount of microRNA 155 in complex environments. Therefore, we used a combination of different materials, including carbon nanofibers, CuBTC-AIA (CuMOF), and Fe@rGO, to improve the electrode surface-to-volume ratio and facilitate the electron transfer process. In this method, 1-pyrenebutyric acid N-hydroxysuccinimide ester w...
Source: Bioelectrochemistry - September 16, 2023 Category: Biochemistry Authors: Emadoddin Amin Sadrabadi Ali Benvidi Mostafa Azimzadeh Leila Asgharnejad Amin Shiralizadeh Dezfuli Patricia Khashayar Source Type: research
The combination of the HDC1 inhibitor SAHA and doxorubicin has synergic efficacy in triple negative breast cancer in vivo
In this study, we investigated the synergistic potential of these two drugs in combination against TNBC. Our results suggested that the combination of these two drugs could enhance the inhibitory effect on cancer cell proliferation, resulting in alterations in cell mitotic phase, and suppression of cancer cell stemness. Moreover, our in vivo study unveiled that when SAHA was combined with DOX, it not only exhibited an inhibitory effect on tumor metastasis but also played a role in regulating the immune microenvironment within tumors. Overall, the combination of DOX and SAHA presents a promising avenue for innovative combin...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Yuheng Pang Runze Shi Liujia Chan Yu Lu Di Zhu Tong Liu Meisi Yan Yuji Wang Wenjing Wang Source Type: research
Additional intraoperative subpectoral plane block vs conventional pain control: A comparison of shoulder movement in patients with mastectomy
CONCLUSIONS: Compared to conventional analgesia, intraoperative pectoral nerve block under direct vision enhances shoulder mobility in forward elevation, external rotation, and arm abduction after mastectomy in breast cancer patients.PMID:37716023 | DOI:10.1016/j.breast.2023.103579
Source: Breast - September 16, 2023 Category: Cancer & Oncology Authors: Sivaporn Pondeenana Chao Saenghirunvattana Patcharin Intarakhao Sorasit Inchan Panuwat Chuemor Atthakorn Jarusriwanna Source Type: research
