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HBV Infection Is an Intermediate-Risk Disease, Whereas Anaemia Is a Mild-to-Moderate Public Health Problem in Young Ghanaian Adults: A Four-Year Retrospective Analysis of Students' Medical Records
CONCLUSION: Intentional preventative public health campaigns regarding anaemia, HBV, and HCV infection should, respectively, target females and young adult males to increase chances of making real change in behavioural attitudes in these at-risk groups.PMID:37475793 | PMC:PMC10356218 | DOI:10.1155/2023/9318984
Source: Biomed Res - July 21, 2023 Category: Research Authors: Samuel Amoah Andrew Nicholas Yartey Praise Fosu Adjei Margaret Owusu-Akyaw Joseph Boachie David Larbi Simpong Patrick Adu Source Type: research

In search of a vaccine for Plasmodium vivax malaria
Nature, Published online: 28 June 2023; doi:10.1038/d41586-023-02053-2Vaccinologist Arturo Reyes-Sandoval explains how researchers are edging closer to a much-needed vaccine.
Source: Nature AOP - June 28, 2023 Category: Research Authors: Laura Vargas-Parada Source Type: research

Computational Clues of Immunogenic Hotspots in < em > Plasmodium falciparum < /em > Erythrocytic Stage Vaccine Candidate Antigens: In Silico Approach
Biomed Res Int. 2022 Oct 13;2022:5886687. doi: 10.1155/2022/5886687. eCollection 2022.ABSTRACTMalaria is the most pernicious parasitic infection, and Plasmodium falciparum is the most virulent species with substantial morbidity and mortality worldwide. The present in silico investigation was performed to reveal the biophysical characteristics and immunogenic epitopes of the 14 blood-stage proteins of the P. falciparum using comprehensive immunoinformatics approaches. For this aim, various web servers were employed to predict subcellular localization, antigenicity, allergenicity, solubility, physicochemical properties, post...
Source: Biomed Res - October 24, 2022 Category: Research Authors: Mojtaba Azimi-Resketi Saeed Heydaryan Niloufar Kumar Azin Takalou Reza Esmaeelzadeh Dizaji Bahman Noroozi Gorgani Morteza Shams Source Type: research

Efforts Made to Eliminate Drug-Resistant Malaria and Its Challenges
Biomed Res Int. 2021 Aug 30;2021:5539544. doi: 10.1155/2021/5539544. eCollection 2021.ABSTRACTSince 2000, a good deal of progress has been made in malaria control. However, there is still an unacceptably high burden of the disease and numerous challenges limiting advancement towards its elimination and ultimate eradication. Among the challenges is the antimalarial drug resistance, which has been documented for almost all antimalarial drugs in current use. As a result, the malaria research community is working on the modification of existing treatments as well as the discovery and development of new drugs to counter the res...
Source: Biomed Res - September 9, 2021 Category: Research Authors: Wote Amelo Eyasu Makonnen Source Type: research

Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role is t...
Source: Fight Aging! - January 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 12th 2019
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined. Mean nonfasting cholesterol concentration was 72â...
Source: Fight Aging! - August 11, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 28th 2019
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - January 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fresh search for a vaccine against malaria parasite Plasmodium vivax
Hundreds of millions of people each year are infected with Plasmodium vivax, the most widespread form of malaria worldwide. An EU-funded project is tackling the mosquito-borne parasite, leading cutting-edge research efforts to accelerate the development of effective vaccines.
Source: EUROPA - Research Information Centre - April 25, 2018 Category: Research Source Type: news

Fight Aging! Newsletter, April 25th 2016
This study offers one useful data point, as the authors describe a genetic alteration that can boost the supply of new immune cells in old mice. The decline in that supply with age is one of the factors leading to poor immune function - and that means more than just vulnerability to infections, as the immune system is also responsible for destroying potentially cancerous and senescent cells, as well as clearing out forms of damaged proteins and unwanted metabolic waste. Various possibilities for increasing the number of new immune cells already exist in principle, such as regenerating the thymus, or cell therapies in which...
Source: Fight Aging! - April 24, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?
Abstract Malaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable. It is well established that vitamin biosynthetic pathways, such as the vitamin B6 de novo synthesis present in Plasmodium, are excellent drug targets. The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in th...
Source: Biomed Res - February 18, 2014 Category: Research Authors: Kronenberger T, Lindner J, Meissner KA, Zimbres FM, Coronado MA, Sauer FM, Schettert I, Wrenger C Tags: Biomed Res Int Source Type: research