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Total 25 results found since Jan 2013.

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Investigation on the hesitancy of COVID-19 vaccination among liver transplant recipients: A cross-sectional study in China
CONCLUSION: For liver transplant recipients, COVID-19 vaccine is an important preventive measure. Identifying the factors influencing COVID-19 vaccine hesitancy is therefore critical to developing a promotion plan. Our study shows that more comprehensive vaccine knowledge popularization and relevant medical workers' training can effectively improve the acceptance of COVID-19 vaccine in this population.PMID:36589975 | PMC:PMC9797997 | DOI:10.3389/fpubh.2022.1014942
Source: Pain Physician - January 2, 2023 Category: Anesthesiology Authors: Yixiao Pan Shiming Gong Xinye Zhu Chuqing Xue Yilei Jing Yinghua Sun Yongbing Qian Jianjun Zhang Qiang Xia Source Type: research

Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, September 19th 2022
Conclusion Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life. Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Pneumococcal vaccination coverage among adults newly diagnosed with underlying medical conditions and regional variation in the U.S
CONCLUSION: Pneumococcal vaccination remains low and most adults with underlying conditions are unvaccinated. Insights into factors associated with vaccination, including regional variability, can help to increase pneumococcal vaccination.PMID:35803847 | DOI:10.1016/j.vaccine.2022.06.068
Source: Vaccine - July 8, 2022 Category: Allergy & Immunology Authors: Anna Ostropolets Linda Shoener Dunham Kelly D Johnson Junqing Liu Source Type: research

Optimizing Immunization Strategies in Adult Patients With Chronic Liver Disease and Liver Transplant Recipients
This article summarizes recommendations from the Advisory Committee on Immunization Practices for vaccinations in patients with CLD and liver transplant recipients, and includes a discussion of the influenza, herpes zoster, hepatitis A, hepatitis B, pneumococcal, human papillomavirus, and COVID-19 vaccines.PMID:35505940 | PMC:PMC9053492
Source: Herpes - May 4, 2022 Category: Infectious Diseases Authors: Stacey Rolak Adnan Said Rita German Mary S Hayney Freddy Caldera Source Type: research

Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice. Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Acceptance of SARS-CoV-2 vaccines by liver transplant recipients and candidates
Z Gastroenterol. 2021 Oct 20. doi: 10.1055/a-1649-8568. Online ahead of print.ABSTRACTGuidelines recommend vaccination against SARS-CoV-2 in transplant recipients, candidates, and their household contacts. However, little is known about the acceptance of COVID-19 vaccines in these groups.In March 2021, we surveyed 826 liver transplant recipients, candidates, and their household contacts to determine acceptance rates and factors influencing the acceptance of the COVID-19 vaccine; 341 patients (40%) and 237 household contacts (28%) returned the questionnaire. Ninety percent of patients returning the survey reported they were...
Source: Zeitschrift fur Gastroenterologie - October 20, 2021 Category: Gastroenterology Authors: Philipp A Reuken Stefanie Albers Falk Rauchfuss Pavel Strnad Utz Settmacher Christian Trautwein Andreas Stallmach Tony Bruns Source Type: research

Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases. Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs