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Total 16 results found since Jan 2013.

New ‐onset retroperitoneal fibrosis following COVID‐19 mRNA vaccination: Coincidental or vaccine‐induced phenomenon?
AbstractThe Pfizer-BioNTech mRNA vaccine is a US Food and Drug Administration-approved coronavirus disease 2019 (COVID-19) vaccine. Although it is reported to be safe and effective, immune dysregulation leading to autoimmunity has become an area of concern. Retroperitoneal fibrosis (RPF) is an immune-mediated fibroinflammatory disease characterized by the deposition of fibrous tissues, primarily around the abdominal aorta and iliac arteries. Herein, we report a case of RPF following Pfizer BioNTech COVID-19 mRNA vaccination. To the best of our knowledge, there have been no published reports on RPF after COVID-19 mRNA vacci...
Source: International Journal of Rheumatic Diseases - February 23, 2023 Category: Rheumatology Authors: Hirut Yadeta Ture, Na Ri Kim, Eon Jeong Nam Tags: CASE REPORT Source Type: research

Uncommon causes of acute appendicitis: foreign bodies in the cecal appendix
Rev Esp Enferm Dig. 2022 Jan 31. doi: 10.17235/reed.2022.8625/2022. Online ahead of print.ABSTRACTA 50-year-old woman with a history of hysterectomy for endometrial cancer in 2015 visited because of abdominal pain for 1 week and fever simultaneous with her third dose of the COVID-19 vaccine. Physical examination revealed a mobile mass in the right iliac fossa, and laboratory testing showed C-reactive protein at 3 mg/dL, with no further changes. Ultrasound results were consistent with an appendiceal inflammatory mass, and a CT scan revealed an appendicolith as likely cause. The patient was subjected to laparoscopy, which fo...
Source: Revista Espanola de Enfermedades Digestivas - January 31, 2022 Category: Gastroenterology Authors: Jose Mar ía Rodríguez Lucas Antonio Jos é Fernández López Francisco Miguel Gonz ález Valverde Mar ía Encarnación Tamayo Rodríguez Antonio Albarrac ín Marín-Blázquez Source Type: research

Cancers, Vol. 13, Pages 3902: Irreversible Electroporation and Nivolumab Combined with Intratumoral Administration of a Toll-like Receptor Ligand, as a Means of In Vivo Vaccination for Metastatic Pancreatic Ductal Adenocarcinoma (PANFIRE-III). A Phase-I Study Protocol
n der Vliet Johanna Wilmink Hester Scheffer Tanja de Gruijl Martijn Group Irreversible electroporation (IRE) is a novel image-guided tumor ablation technique with the ability to generate a window for the establishment of systemic antitumor immunity. IRE transiently alters the tumor’s immunosuppressive microenvironment while simultaneously generating antigen release, thereby instigating an adaptive immune response. Combining IRE with immunotherapeutic drugs, i.e., electroimmunotherapy, has synergistic potential and might induce a durable antitumor response. The primary objective of this study is to assess the ...
Source: Cancers - August 2, 2021 Category: Cancer & Oncology Authors: Bart Geboers Florentine Timmer Alette Ruarus Johanna Pouw Evelien Schouten Joyce Bakker Robbert Puijk Sanne Nieuwenhuizen Madelon Dijkstra M. van den Tol Jan de Vries Daniela Oprea-Lager C. Menke-van der Houven van Oordt Hans van der Vliet Johanna Wilmink Tags: Study Protocol Source Type: research

Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all. Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gro...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 4th 2020
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease. Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus https://www.fightaging.org/archives/2020/04/notes-on-self-experim...
Source: Fight Aging! - May 3, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 6th 2018
In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging. We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly individ...
Source: Fight Aging! - August 5, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Ethics of Keeping Alfie Alive
By SAURABH JHA Of my time arguing with doctors, 30 % is spent convincing British doctors that their American counterparts aren’t idiots, 30 % convincing American doctors that British doctors aren’t idiots, and 40 % convincing both that I’m not an idiot. A British doctor once earnestly asked whether American physicians carry credit card reading machines inside their white coats. Myths about the NHS can be equally comical. British doctors don’t prostate every morning in deference to the NHS, like the citizens of Oceania sang to Big Brother in Orwell’s dystopia. Nor, in their daily rounds, do they calculate opportun...
Source: The Health Care Blog - May 21, 2018 Category: Consumer Health News Authors: at RogueRad Tags: OP-ED Uncategorized AlfieEvans Source Type: blogs

Fight Aging! Newsletter, April 16th 2018
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - April 15, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 8th 2017
This report captures the state of the research community in a nutshell: progress in the sense that ever more scientists are willing to make the treatment of aging the explicit goal of their research, but, unfortunately, there is still a long way to go in improving the nature of that research. It is still near entirely made up of projects that cannot possibly produce a robust and large impact on human life span. The only course of action likely to extend life by decades in the near future is implementation of the SENS vision for rejuvenation therapies - to repair the molecular damage that causes aging. Everything else on th...
Source: Fight Aging! - May 7, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Medical errors: Honesty is the best policy
“It’s a definite that you’re all going to screw up, but it’s not a definite that any of you will learn from that,” declared one of our medical school instructors, years ago. “Cultivate the attitude that allows you to own your mistakes, and then, not repeat them.” How common are medical errors? Medical errors are, frankly, rampant. A recent study used data analysis and extrapolation to estimate that “communication breakdowns, diagnostic errors, poor judgment, and inadequate skill” as well as systems failures in clinical care result in between 200,000 to 400,00 lives lost per year. What this means is that i...
Source: Harvard Health Blog - October 3, 2016 Category: Consumer Health News Authors: Monique Tello, MD, MPH Tags: Health care Managing your health care Safety Source Type: blogs

Complete remission of relapsed cervical cancer through immunochemoradiotherapy: Two case reports and three proposed mechanism
Conclusion We reported two patients with cervical cancer recurrence after conventional therapy. We combined CCRT and ICRT to augment the host cells' immunosurveillance and reach durable response more than 5 years mimic long-term progression-free survival. These two patients showed promising results.
Source: Gynecology and Minimally Invasive Therapy - April 8, 2016 Category: OBGYN Source Type: research

Why I am a Crusader in the Anti-Vaccine, Anti-Drug Movement
Conclusion The doctors gave my daughter drugs they knew would cause her kidneys to stop working. They gave her these drugs in spite of both of us telling them on a day-to-day basis not to give them. The hospital covered it up. The hospital refused to give us the incident report. The hospital refused to give us a copy of the notes from the meeting with the ethics committee. The hospital denied my daughter’s right to make her own decisions. The hospital tried to deny me from being my daughter's advocate. The hospital administrator threatened to charge me with practicing medicine without a license. The CEO refused to talk t...
Source: vactruth.com - September 11, 2015 Category: Allergy & Immunology Authors: Jim O'Kelly Tags: Case Reports on Vaccine Injury Human Jim O'Kelly Top Stories truth about vaccines Vaccine Death Source Type: blogs

It's an epidemic!
OMG! The incidence of thyroid cancer has tripled in the U.S. in the past 30 years, from 3.6 cases/100,000 to 11.6. Is it radioactive fallout? Pesticides? Vaccination? Fluoridation?Nope. It's CT scans. And you can relax. They aren't causing thyroid cancer, they're finding abnormal cells which in the past, nobody would have detected. But, as Brito, Morris and Montori tell us at the linked article (which I don't think you can read but that's okay, I'll tell you what's in it), they aren't actually cancer after all.There are four different kinds of thyroid "cancer," the most common of which is called papillary carcinoma. Guess ...
Source: Stayin' Alive - August 30, 2013 Category: Health Medicine and Bioethics Commentators Source Type: blogs