Fight Aging! Newsletter, August 6th 2018
In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging. We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly individuals compared with young healthy controls. This is in line with previous reports describing an increase in FGF21 levels with aging. Levels of β-Klotho, the coreceptor required for cellular responsiveness to FGF21, were increased in subcutaneous adipose tissue from elderly individuals relative to those from young controls, whereas FGF receptor-1 levels were unaltered. Adipose explants from aged and young mice respond similarly to FGF21 "ex vivo". Thus, in contrast to what is observed in obesity and diabetes, high levels of FGF21 in healthy aging are not associated with repressed FGF21-responsiveness machinery in adipose tissue. The lack of evidence for impaired FGF21 responsiveness in adipose tissue establishes a distinction between alterations in the FGF21 endocrine system in aging and chronic metabolic pathologies. Either FGF21 resis...
Authors: Li N, Huang YH Abstract A patient with central venous occlusion at the junction of the superior vena cava and right atrium underwent endovascular revascularization. The leakage of contrast agents was detected during sharp recanalization that was then managed with covered stent deployment. The initial symptom of facial swelling disappeared and the vital signs were stable after treatment. Regrettably, the patient suffered from the clinical features of cardiac tamponade on the third day post-treatment, which was confirmed by computed tomography. Finally, a pericardial effusion was drained, leading to dramatic...
Publication date: Available online 2 July 2020Source: Artificial Intelligence in MedicineAuthor(s): Jacques Bouaud, Sylvia Pelayo, Jean-Baptiste Lamy, Coralie Prebet, Charlotte Ngo, Luis Teixeira, Gilles Guézennec, Brigitte Seroussi
Conclusions: Operative laparoscopy under conscious sedation and local anesthesia appears to be a feasible technique in gynecologic surgery with no adverse patient outcomes. PMID: 32612345 [PubMed - in process]
Conclusion: Upper gastrointestinal pathology is highly common in patients with obesity. There is a significant rate of clinically significant endoscopy findings and all bariatric surgery patients should undergo preoperative endoscopy. PMID: 32612344 [PubMed - in process]
CONCLUSION: recommendations emphasize isolation, proper rest, sleep, nutrition, hydration, medications, and in the more severe cases, oxygen support, monitoring of vital signs, emotional support, and multiprofessional and individualized care. Medications should be used with caution due to a lack of evidence. Future research is needed to analyze the impact of the infection at the beginning of pregnancy and the psychological aspects of pregnant women infected with the virus. PMID: 32609284 [PubMed - in process]
CONCLUSION: it became evident that palliative care in primary health care has been gradually developed, but it is necessary to consider the organization of primary health care and the social policies that support or weaken it, being considered a complex challenge. PMID: 32609270 [PubMed - in process]
CONCLUSION: low-cost, handmade simulators are feasible and effective, resulting in positive learner evaluations. Their availability as open technology allows the dissemination of their use. PMID: 32609265 [PubMed - in process]
Publication date: Available online 3 July 2020Source: International Journal of Africa Nursing SciencesAuthor(s): Oluwaseyi Isaiah Olabisi, Olorunfemi Ola, Adetola Bolaji, Fatimah O. Azeez, Odunola Azeez, Tolulope Esther Olabisi
Publication date: Available online 24 June 2020Source: Saudi Journal of Biological SciencesAuthor(s): Neda M. Bogari, Ashwag Aljohani, Anas Dannoun, Osama Elkhateeb, Masimo Porqueddu, Amr A. Amin, Dema N. Bogari, Mohiuddin M. Taher, Faruk Buba, Reem M. Allam, Mustafa N. Bogari, Francesco Alamanni
Publication date: Available online 3 July 2020Source: Redox BiologyAuthor(s): Jyotirindra Maity, Moonmoon Deb, Carl Greene, Hiranmoy Das
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