Fight Aging! Newsletter, August 6th 2018

In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging. We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly individuals compared with young healthy controls. This is in line with previous reports describing an increase in FGF21 levels with aging. Levels of β-Klotho, the coreceptor required for cellular responsiveness to FGF21, were increased in subcutaneous adipose tissue from elderly individuals relative to those from young controls, whereas FGF receptor-1 levels were unaltered. Adipose explants from aged and young mice respond similarly to FGF21 "ex vivo". Thus, in contrast to what is observed in obesity and diabetes, high levels of FGF21 in healthy aging are not associated with repressed FGF21-responsiveness machinery in adipose tissue. The lack of evidence for impaired FGF21 responsiveness in adipose tissue establishes a distinction between alterations in the FGF21 endocrine system in aging and chronic metabolic pathologies. Either FGF21 resis...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Daria V. Berdnikova RNA is an emerging drug target that opens new perspectives in the treatment of viral and bacterial infections, cancer and a range of so far incurable genetic diseases. Among the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Contributing Correspondent Lizzie Wade joins host Sarah Crespi to discuss fossilized footprints left on a lake shore in North America sometime before the end of Last Glacial Maximum —possibly the earliest evidence for humans on the continent. Read the research. Next, Paolo Cherubini, a senior scientist in the dendrosciences research group at the Swiss Federal Institute for Forest, Snow and Landscape Research, discusses using tree rings to date and authenticate 17th and 18th c entury violins worth millions of dollars. Finally, in this month’s installment of the series of book interviews on race and science, gues...
Source: Science Magazine Podcast - Category: Science Authors: Tags: Scientific Community Source Type: podcasts
Conclusions Analysis of ASC and HOR claims demonstrates significant differences and several common sources of liability. These include improving strategies for thorough screening, preoperative assessment and risk stratifying of patients, incorporating routine dental and airway assessment and documentation, diagnosing and treating perioperative pain adequately, and improving the efficacy of communication between patients and care providers.
Source: Journal of Patient Safety - Category: Health Management Tags: The Health Care Manager Source Type: research
Conclusions Patient safety concerns, speaking up, and withholding voice were frequently reported. With this questionnaire, we present a tool to systematically assess and evaluate important aspects of speaking up in HCOs. This allows for identifying areas for improvement, and because it is a short survey, to monitor changes in speaking up—for example, before and after an improvement project.
Source: Journal of Patient Safety - Category: Health Management Tags: Original Studies Source Type: research
Objectives Insulin charts represent a key component in the inpatient glycemic management process. The aim was to evaluate the quality of structure, documentation, and treatment of diabetic inpatient care to design a new standardized insulin chart for a large university hospital setting. Methods Historically grown blank insulin charts in use at 39 general wards were collected and evaluated for quality structure features. Documentation and treatment quality were evaluated in a consecutive snapshot audit of filled-in charts. The primary end point was the percentage of charts with any medication error. Results ...
Source: Journal of Patient Safety - Category: Health Management Tags: Original Studies Source Type: research
I’ve been interviewing for jobs recently and am realizing how much of private practice pain is just a money making scheme. Comments like “schedule the procedure and medication refills on the same day so they come to get their procedure,” and “3-4 shots a year and a couple urines is not bad revenue” are so common. Tack on sketchy urine labs, churning out patients with scribes, getting paid $$$ by industry and the situation seems even more bleak. my question is - is this unique to pain? On... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Hello all, I I'm finishing my fellowship and was recommended for a job at a clinic. I had a phone interview with them today which went very well. They asked me to come see the facility in person at the end of the interview and had mentioned that they would like me to sign an NDA before seeing the clinic at the end of the interview. I'm very new to this and I'm not sure if this is the norm. My question is, I'm not sure what can be confidential/proprietary in a clinic setting and if I sign... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Conclusions Adults with cerebral palsy or spina bifida have a significantly higher prevalence of common psychological, cardiometabolic, and musculoskeletal morbidity and multimorbidity, as compared with adults without cerebral palsy or spina bifida. Efforts are needed to facilitate the development of improved clinical screening algorithms and early interventions to reduce risk of disease onset/progression in these higher risk populations. To Claim CME Credits Complete the self-assessment activity and evaluation online at CME Objectives Upon completion of this article, t...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: CME Article . 2021 Series . Number 10 Source Type: research
Objective The aim of the study was to assess centrally induced pain processing with pressure pain thresholds bilaterally and remotely in active volleyball and basketball athletes with mild patellar tendinopathy compared with asymptomatic control athletes. Secondary objective was to explore the role of exercise-induced analgesia during a training session in athletes with patellar tendinopathy. Design In this exploratory study, pressure pain thresholds of 21 patellar tendinopathy athletes and 16 age- and sex-matched asymptomatic team members were measured by a blinded assessor bilaterally on the patellar tendon an...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
Conclusion Owing to budget and environmental constraints, the external devices used by individuals with SCI from a developing country are different from those reported in a developed country. The findings provide particular insights into the management of external devices for these individuals of a developing country.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
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