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Specialty: Cytology
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Total 78700 results found since Jan 2013.
Molecular architecture of TMEM63 mechanosensitive ion channels
Cell Calcium. 2023 Sep 11;115:102798. doi: 10.1016/j.ceca.2023.102798. Online ahead of print.NO ABSTRACTPMID:37729772 | DOI:10.1016/j.ceca.2023.102798
Source: Cell Calcium - September 20, 2023 Category: Cytology Authors: Jed T Syrenne Parshuram J Sonawane Swetha E Murthy Source Type: research
Impact of tidal volume strategy at birth on initiating lung injury in preterm lambs
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 20. doi: 10.1152/ajplung.00159.2023. Online ahead of print.ABSTRACTTidal ventilation is essential in supporting the transition to air-breathing at birth, but excessive tidal volume (VT) is an important factor in preterm lung injury. Few studies have assessed the impact of specific VT levels on injury development. Here we used a lamb model of preterm birth to investigate the role of different levels of VT during positive pressure ventilation (PPV) in promoting aeration and initiating early lung injury pathways. VT was delivered as; (i) 7ml/kg throughout (VTstatic), (ii) begun at ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 20, 2023 Category: Cytology Authors: Prue M Pereira-Fantini Kelly R Kenna Monique Fatmous Arun Sett Ellen Douglas Sophia Dahm Magdy Sourial Haoyun Fang David W Greening David G Tingay Source Type: research
Twenty years of research in melanoma therapy-From "nothing works" to cures: A personal account
Pigment Cell Melanoma Res. 2023 Sep 19. doi: 10.1111/pcmr.13133. Online ahead of print.NO ABSTRACTPMID:37726985 | DOI:10.1111/pcmr.13133
Source: Pigment Cell and Melanoma Research - September 20, 2023 Category: Cytology Authors: Meenhard Herlyn Jessie Villanueva Source Type: research
Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling
This study provides a mechanistic understanding of the relationship between the Hippo pathway, polarity, and actomyosin cytoskeleton, and it offers novel insights into how fundamental features of epithelial tissue architecture can serve as inputs into signaling cascades that control tissue growth, patterning, and morphogenesis.PMID:37729921 | DOI:10.1016/j.devcel.2023.08.029
Source: Developmental Cell - September 20, 2023 Category: Cytology Authors: Sherzod A Tokamov Nicki Nouri Ashley Rich Stephan Buiter Michael Glotzer Richard G Fehon Source Type: research
Implementing standardized diversity, equity, and inclusion approaches within scientific communities
Trends Cell Biol. 2023 Sep 18:S0962-8924(23)00170-8. doi: 10.1016/j.tcb.2023.08.006. Online ahead of print.ABSTRACTWithin the global scientific community, there are disparate approaches to diversity, equity, and inclusion (DEI) practices, leading to inequalities that hinder progress. Here, we frame this problem through historical perspectives in the global north and propose a DEI framework adaptable by institutions regardless of location, improving the academic environment for researchers globally.PMID:37730511 | DOI:10.1016/j.tcb.2023.08.006
Source: Trends in Cell Biology - September 20, 2023 Category: Cytology Authors: Aidira D Y Macias Gonzalez Sarah McCallum Jacqueline A De Lora Source Type: research
AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway
In this study, we found that activation of AMPK by AICAR and metformin inhibits foam cell formation via suppression of mTOR in macrophages. Specifically, activation of AMPK indirectly reduced the phosphorylation level of mTOR at Ser2448 and promoted the expression of cholesterol efflux transporters and cholesterol efflux. These inhibitory effects on foam cell formation were counteracted by mTOR activators. Metformin, a more nonspecific AMPK activator than AICAR, appears to inhibit foam cell formation via anti-inflammatory effects in addition to suppression of the mTOR pathway. The results of this study suggest that the dev...
Source: Experimental Cell Research - September 20, 2023 Category: Cytology Authors: Reina Owaki Hiromasa Aoki Kohki Toriuchi Yasumichi Inoue Hidetoshi Hayashi Satoru Takeshita Hiroki Kakita Yasumasa Yamada Mineyoshi Aoyama Source Type: research
A Novel pyroptosis-related signature for predicting prognosis and evaluating tumor immune microenvironment in ovarian cancer
J Ovarian Res. 2023 Sep 20;16(1):196. doi: 10.1186/s13048-023-01275-2.ABSTRACTOvarian cancer (OV) is the most fatal gynecological malignant tumor worldwide, with high recurrence rates and great heterogeneity. Pyroptosis is a newly-acknowledged inflammatory form of cell death with an essential role in cancer progression, though studies focusing on prognostic patterns of pyroptosis in OV are still lacking. Our research filtered 106 potential pyroptosis-related genes (PRGs) among the 6406 differentially expressed genes (DEGs) between the 376 TCGA-OV samples and 180 normal controls. Through the LASSO-Cox analysis, the 6-gene p...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Jiani Yang Chao Wang Yue Zhang Shanshan Cheng Yanna Xu Yu Wang Source Type: research
Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis
CONCLUSION: Our findings imply that dual inhibition of glycolysis and glutaminolysis could be an effective approach for the treatment of RA. It also suggests that targeting more than one metabolic pathway can be a novel treatment approach in non-cancer diseases.PMID:37730663 | DOI:10.1186/s13075-023-03161-0
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Shanzay Ahmed Christopher B Mahony Alyssa Torres Jessica Murillo-Saich Samuel Kemble Martha Cedeno Peter John Attya Bhatti Adam P Croft Monica Guma Source Type: research
singleCellBase: a high-quality manually curated database of cell markers for single cell annotation across multiple species
Biomark Res. 2023 Sep 20;11(1):83. doi: 10.1186/s40364-023-00523-3.ABSTRACTAnnotating cells in the analysis of single-cell RNA-seq (scRNA-seq) data is one of the most challenging tasks that researchers are actively addressing. Manual cell annotation is generally considered the gold standard method, although it is labor intensive and independent of prior knowledge. At present, the relationship between high-quality, known marker genes and cell types is very limited, especially for a variety of species other than humans and mice. The singleCellBase is a manually curated resource of high-quality cell types and gene markers ass...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Fan-Lin Meng Xiao-Ling Huang Wen-Yan Qin Kun-Bang Liu Yan Wang Ming Li Yong-Hong Ren Yan-Ze Li Yi-Min Sun Source Type: research
Barriers and facilitators to implementing advanced HIV disease screening at a secondary referral hospital -Malawi: a convergent parallel study
CONCLUSION: The study has identified major contextual barriers to AHD screening including knowledge gap, poor communication systems and inadequate supporting resources. Improving uptake of AHD screening services would therefore require overcoming the existing barriers by adopting a comprehensive approach in developing barrier-tailored strategies.PMID:37730619 | DOI:10.1186/s12913-023-10009-5
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Brany Mithi Agatha Bula Lester Kapanda Fatsani Ngwalangwa Evanson Z Sambala Source Type: research
Single-nucleus transcriptomic mapping uncovers targets for traumatic brain injury
In this study, we meticulously mapped the transcriptome atlas of murine SVZ and its responses to mTBI at the single-cell level. We observed cell-specific gene expression changes following mTBI and unveiled diverse cell-to-cell interaction networks that influence a wide array of cellular processes. Moreover, we reported novel neurogenesis lineage trajectories and related key transcription factors, which we subsequently validated through loss-of-function experiments. Specifically, we validated the role of Tcf7l1, a cell cycle gene regulator, in promoting neural stem cell differentiation towards the neuronal lineage after mTB...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Qiuyun Yang Lingxuan Zhang Manrui Li Yang Xu Xiaogang Chen Ruixuan Yuan Xiaofeng Ou Min He Miao Liao Lin Zhang Hao Dai Meili Lv Xiaoqi Xie Weibo Liang Xiameng Chen Source Type: research
Time-course transcriptome analysis of a double challenge bleomycin-induced lung fibrosis rat model uncovers ECM homoeostasis-related translationally relevant genes
CONCLUSIONS: The model of lung fibrosis presented in this study lends itself as a valuable tool for preclinical efficacy evaluation of new potential drug candidates. The main finding was the identification of a group of persistently dysregulated genes, mostly related to ECM homoeostasis, which are shared with human IPF.PMID:37730279 | DOI:10.1136/bmjresp-2022-001476
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Martina Bonatti Vanessa Pitozzi Paola Caruso Silvia Pontis Maria Gloria Pittelli Caterina Frati Chiara Mangiaracina Costanza Anna Maria Lagrasta Federico Quaini Simona Cantarella Simone Ottonello Gino Villetti Maurizio Civelli Barbara Montanini Marcello T Source Type: research
New role for the anandamide metabolite prostaglandin F < sub > 2 α < /sub > ethanolamide: Rolling preadipocyte proliferation
J Lipid Res. 2023 Sep 18:100444. doi: 10.1016/j.jlr.2023.100444. Online ahead of print.ABSTRACTWhite adipose tissue regulation is key to metabolic health, yet still perplexing. The chief endocannabinoid anandamide metabolite, prostaglandin F2α ethanolamide (PGF2αEA) inhibits adipogenesis, i.e., the formation of mature adipocytes. We observed that adipocyte progenitor cells-preadipocytes-following treatment with PGF2αEA, yielded larger pellet sizes. Thus, we hypothesized that PGF2αEA might augment preadipocyte proliferation. Cell viability MTT and crystal violet assays, cell counting, and 5-bromo-2'-deoxyuridine (BrdU) ...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Besma Boubertakh Olivier Courtemanche David Marsolais Vincenzo Di Marzo Cristoforo Silvestri Source Type: research
AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway
In this study, we found that activation of AMPK by AICAR and metformin inhibits foam cell formation via suppression of mTOR in macrophages. Specifically, activation of AMPK indirectly reduced the phosphorylation level of mTOR at Ser2448 and promoted the expression of cholesterol efflux transporters and cholesterol efflux. These inhibitory effects on foam cell formation were counteracted by mTOR activators. Metformin, a more nonspecific AMPK activator than AICAR, appears to inhibit foam cell formation via anti-inflammatory effects in addition to suppression of the mTOR pathway. The results of this study suggest that the dev...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Reina Owaki Hiromasa Aoki Kohki Toriuchi Yasumichi Inoue Hidetoshi Hayashi Satoru Takeshita Hiroki Kakita Yasumasa Yamada Mineyoshi Aoyama Source Type: research
Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119595. doi: 10.1016/j.bbamcr.2023.119595. Online ahead of print.ABSTRACTThe nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of hepatocellular carcinoma (HCC). Phosphorylation of p65 is considered as an important mechanism for the positive regulation of NF-κB activity. According to our previous data, p65 can be SUMOylated by small ubiquitin-related modifier 1 (SUMO1) protein, and SUMO1 promotes p65 nuclear import and HCC progression. However, the effect of SUMO1-related p65 SUMOylation on NF-κB transcriptional activity and the relations...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Can Jiang Chunyang Zhang Min Dai Fuyan Wang Sa Xu Dan Han Yanyan Wang Yajie Cao Yanyan Liang Ziyu Zhang Lina Yan Yujun Shen Kewu He Yuxian Shen Jun Liu Source Type: research
