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Specialty: Cytology
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Total 78700 results found since Jan 2013.
CDC42-mediated Wnt signaling facilitates odontogenic differentiation of DPCs during tooth root elongation
CONCLUSIONS: We innovatively revealed that CDC42 was responsible for guiding root elongation in a mesenchyme-specific manner. Furthermore, CDC42-mediated canonical Wnt signaling regulated odontogenic differentiation of DPCs during root formation.PMID:37726858 | PMC:PMC10510226 | DOI:10.1186/s13287-023-03486-2
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Tao Zhou Guoqing Chen Yuchan Xu Shuning Zhang Huilin Tang Tao Qiu Weihua Guo Source Type: research
BATF2 enhances pro-inflammatory cytokine responses in macrophages and improves early host defense against pulmonary < em > Klebsiella pneumoniae < /em > infection
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 19. doi: 10.1152/ajplung.00441.2022. Online ahead of print.ABSTRACTBasic leucine zipper transcription factor ATF-like 2 (BATF2) is a transcription factor that is emerging as an important regulator of the innate immune system. BATF2 is among the top upregulated genes in human alveolar macrophages treated with LPS, but the signaling pathways that induce BATF2 expression in response to Gram-negative stimuli are incompletely understood. In addition, the role of BATF2 in the host response to pulmonary infection with a Gram-negative pathogen like Klebsiella pneumoniae (Kp) is not know...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Rick van der Geest Hern án F Peñaloza Zeyu Xiong Shekina Gonzalez-Ferrer Xiaojing An Huihua Li Hongye Fan Mohammadreza Tabary S Mehdi Nouraie Yanwu Zhao Yingze Zhang Kong Chen Jonathan K Alder William G Bain Janet S Lee Source Type: research
The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: A translational porcine model
In conclusion, we demonstrate a delicate balance between development of pulmonary ischemia-reperfusion injury and right ventricular function during lung transplantation. Furthermore, we provide a physiological basis for potential benefit of extracorporeal life support technology.PMID:37724349 | DOI:10.1152/ajplung.00281.2022
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Michaela Orlitov á Tom Verbelen Anna E Frick Arno Vanstapel Dieter Van Beersel Sofie Ordies Jan Van Slambrouck Janne Kaes Jin Xin Walter Coudyzer Stijn E Verleden Geert M Verleden Bart M Vanaudenaerde Dirk E Van Raemdonck Robin Vos Laurens J Ceulemans Pi Source Type: research
Three-dimensional electrical impedance tomography (EIT) to study regional ventilation/perfusion (V/Q ̇) ratios in anesthetized pigs
This study aimed to develop a 3D method for assessing ventilation/perfusion (V/Q̇) ratios in a pig model of hemodynamic perturbations using electrical impedance tomography (EIT). In order to evaluate the physiological coherence of changes in EIT-derived V/Q̇ ratios, global EIT-derived V/Q̇ mismatches were compared with global gold-standards. The study found regional heterogeneity in the distribution of V/Q̇ ratios in both the ventrodorsal and craniocaudal directions. Although global EIT-derived indices of V/Q̇ mismatch consistently underestimated both low and high V/Q̇ mismatch compared to global gold standards, the ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Shannon Larrabee Sarah Nugen Alejandro Bruhn Ian Porter Symon Stowe Andy Adler Manuel Martin-Flores Joaquin Araos Source Type: research
Establishing an Efficient Electroporation-Based Method to Manipulate Target Gene Expression in the Axolotl Brain
Cell Transplant. 2023 Jan-Dec;32:9636897231200059. doi: 10.1177/09636897231200059.ABSTRACTThe tetrapod salamander species axolotl (Ambystoma mexicanum) is capable of regenerating injured brain. For better understanding the mechanisms of brain regeneration, it is very necessary to establish a rapid and efficient gain-of-function and loss-of-function approaches to study gene function in the axolotl brain. Here, we establish and optimize an electroporation-based method to overexpress or knockout/knockdown target gene in ependymal glial cells (EGCs) in the axolotl telencephalon. By orientating the electrodes, we were able to a...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Sulei Fu Cheng Peng Yan-Yun Zeng Yuanhui Qiu Yanmei Liu Ji-Feng Fei Source Type: research
Research for Cytomegalovirus Mutations Associated With Resistance to Antivirals in Kidney Transplant Receptors
Cell Transplant. 2023 Jan-Dec;32:9636897231195245. doi: 10.1177/09636897231195245.ABSTRACTCytomegalovirus (CMV) mutations associated with antiviral resistance have become a major problem related to high mortality in kidney transplant patients. The aim of the study was to investigate mutations in the CMV genes UL97 and UL54 associated with antiviral resistance. A retrospective observational cohort study was carried out at Hospital Ophir Loyola (HOL), a reference in Kidney Transplantation. A total of 81 patients who underwent kidney transplantation were followed up between 2016 and 2018 were monitored for CMV viral load by p...
Source: Cell Transplantation - September 19, 2023 Category: Cytology Authors: Carla de Castro Sant' Anna Silvia Regina da Cruz Migone Carlos Alberto Machado da Rocha Fernando Augusto Rodrigues Mello J únior Aline Damasceno Seabra Tha ís Brilhante Pontes Jo ão Marildo Rodrigues Salom é Aparecida Soares Viviane de Paiva Rego Joan Source Type: research
CSNK1A1/CK1 α suppresses autoimmunity by restraining the CGAS-STING1 signaling
Autophagy. 2023 Sep 18:1-18. doi: 10.1080/15548627.2023.2256135. Online ahead of print.ABSTRACTSTING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and eliciting innate immunity. Nevertheless, the overactivation or sustained activation of STING1 has been closely associated with the onset of autoimmune disorders. Notably, the majority of these disorders manifest as an upregulated expression of type I interferons and IFN-stimulated genes (ISGs). Hence, strict regulation of STING1 activi...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Mingyu Pan Tongyu Hu Jiao Lyu Yue Yin Jing Sun Quanyi Wang Lingxiao Xu Haiyang Hu Chen Wang Source Type: research
Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development
Cell Mol Neurobiol. 2023 Sep 19. doi: 10.1007/s10571-023-01408-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the primary cause of dementia and is characterized by the death of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of tau protein, and the formation of neurofibrillary tangles within the cells. AD is also associated with other pathologies such as neuroinflammation, dysfunction of synaptic connections and circuits, disorders in mitochondrial function and energy production, epigenetic changes, and abnormalities in the vascular system. Despite extensive research con...
Source: Cellular and Molecular Neurobiology - September 19, 2023 Category: Cytology Authors: Bhavarth P Dave Yesha B Shah Kunal G Maheshwari Kaif A Mansuri Bhadrawati S Prajapati Humzah I Postwala Mehul R Chorawala Source Type: research
Effects of hypoxia in cardiac metabolic remodeling and heart failure
Exp Cell Res. 2023 Sep 17:113763. doi: 10.1016/j.yexcr.2023.113763. Online ahead of print.ABSTRACTAerobic cellular respiration requires oxygen, which is an essential part of cardiomyocyte metabolism. Thus, oxygen is required for the physiologic metabolic activities and development of adult hearts. However, the activities of metabolic pathways associated with hypoxia in cardiomyocytes (CMs) have not been conclusively described. In this review, we discuss the role of hypoxia in the development of the hearts metabolic system, and the metabolic remodeling associated with the hypoxic adult heart. Hypoxia-inducible factors (HIFs...
Source: Experimental Cell Research - September 19, 2023 Category: Cytology Authors: Mingzhou Jiang Xi Fan Yiqing Wang Xiaotian Sun Source Type: research
Phosphotyrosine proteomics in cells synchronized at monopolar cytokinesis reveals EphA2 as functioning in cytokinesis
In this study, we performed a phosphotyrosine proteomic analysis of cells undergoing monopolar cytokinesis synchronized by using the Eg5 inhibitor (+)-S-trityl-l-cysteine (STLC) and the CDK1 inhibitor RO-3306. Phosphotyrosine proteomics gave 362 tyrosine-phosphorylated peptides. Western blot analysis of proteins revealed tyrosine phosphorylation in mitogen-activated protein kinase 14 (MAPK14), vimentin, ephrin type-A receptor 2 (EphA2), and myelin protein zero-like protein 1 (MPZL1) during monopolar cytokinesis. Additionally, we demonstrated that EphA2, a protein with unknown function during cytokinesis, is involved in cyt...
Source: Experimental Cell Research - September 19, 2023 Category: Cytology Authors: Nanami Hasegawa Mayue Hongo Misaki Okada Takahisa Kuga Yuichi Abe Jun Adachi Takeshi Tomonaga Naoto Yamaguchi Yuji Nakayama Source Type: research
Correction
Autophagy. 2023 Sep 19:1. doi: 10.1080/15548627.2023.2260140. Online ahead of print.NO ABSTRACTPMID:37725507 | DOI:10.1080/15548627.2023.2260140
Source: Autophagy - September 19, 2023 Category: Cytology Source Type: research
Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development
Autophagy. 2023 Sep 18. doi: 10.1080/15548627.2023.2259214. Online ahead of print.ABSTRACTColitis-associated colon cancer (CAC) is a distinct form of colorectal cancer that emerges from prolonged colitis in individuals with inflammatory bowel disease (IBD). Chronic inflammation is considered as the most critical contributor to the development and progression of CAC, with the degree and persistence of the inflammatory response being the primary drivers of CAC progression in individuals with IBD. Macroautophagy/autophagy, which is a cellular process that aids in preserving the intestinal mucosal barrier and regulating intest...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Xuanhong Jin Liangkun You Jincheng Qiao Weidong Han Hongming Pan Source Type: research
CSNK1A1/CK1 α suppresses autoimmunity by restraining the CGAS-STING1 signaling
Autophagy. 2023 Sep 18:1-18. doi: 10.1080/15548627.2023.2256135. Online ahead of print.ABSTRACTSTING1 (stimulator of interferon response cGAMP interactor 1) is the quintessential protein in the CGAS-STING1 signaling pathway, crucial for the induction of type I IFN (interferon) production and eliciting innate immunity. Nevertheless, the overactivation or sustained activation of STING1 has been closely associated with the onset of autoimmune disorders. Notably, the majority of these disorders manifest as an upregulated expression of type I interferons and IFN-stimulated genes (ISGs). Hence, strict regulation of STING1 activi...
Source: Autophagy - September 19, 2023 Category: Cytology Authors: Mingyu Pan Tongyu Hu Jiao Lyu Yue Yin Jing Sun Quanyi Wang Lingxiao Xu Haiyang Hu Chen Wang Source Type: research
Evaluation of safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells in pediatric bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
CONCLUSIONS: AT-MSCs could be safely administered to our pediatric cases with BoS post-allo-HSCT. Considering their advanced stage of disease, their sub-optimal functional capacity due to steroid-induced complications, and COVID-19 infection post-treatment, we believe that AT-MSC therapy can have possible efficacy in the management of pediatric BoS. The conduction of further studies with larger sample sizes and more frequent injections is prudent for further optimization of AT-MSC therapy against BoS. Trial registration Iranian Registry of Clinical Trials (IRCT), IRCT20201202049568N2. Registered 22 February 2021, https://e...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Rashin Mohseni Pouya Mahdavi Sharif Maryam Behfar Mohammad Reza Modaresi Rohola Shirzadi Mahta Mardani Leila Jafari Fahimeh Jafari Zeynab Nikfetrat Amir Ali Hamidieh Source Type: research
High-Fat Ketogenic Diets and Ketone Monoester Supplements Differentially Affect Substrate Metabolism during Aerobic Exercise
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00359.2023. Online ahead of print.ABSTRACTChronically adhering to high-fat ketogenic diets or consuming ketone monoester supplements elicits ketosis. Resulting changes in substrate metabolism appear to be drastically different between ketogenic diets and ketone supplements. Consuming a ketogenic diet increases fatty acid oxidation with concomitant decreases in endogenous carbohydrate oxidation. Increased fat oxidation eventually results in an accumulation of circulating ketone bodies, which are metabolites of fatty acids that serve as an alternative source of fue...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Lee M Margolis Stefan M Pasiakos Emily E Howard Source Type: research
