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Therapy: Stem Cell Therapy

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Total 3267 results found since Jan 2013.

Over-expression of microRNA-145 elevating autophagy activities via downregulating FRS2 expression
CONCLUSION: The miR-145 acts as a protective factor against chondrocytes by regulating miR-FRS2-autophagy axis. The decrease of miR-145 in articular synovial fluid may turn out to be an important marker for early diagnosis of OA, and modulation of miR-145 may represent a promising therapeutic strategy for OA.PMID:37264620 | DOI:10.2174/1386207326666230602090848
Source: Combinatorial Chemistry and High Throughput Screening - June 2, 2023 Category: Chemistry Authors: Tian Ke Deng Bin Han Xiaodong Zheng Haiyi Lin Tao Zhimeng Wang Zhang Yuanmin Wang Guodong Source Type: research

Successful management of a rare case of gallbladder neuroendocrine carcinoma with tumor thrombi
AbstractA gallbladder neuroendocrine neoplasm (GB ‑NEN) is a bizarre heterogeneous neoplasm arising from neuroendocrine cells, which are present in minimal amounts on the GB mucosa either due to conversion of undifferentiated stem cells, chronic inflammation and resulting in pathological metaplasia or switching of GB adenocarcinoma to neuroendocr ine one. Among all the GB malignancies, GB-NEN accounts for approximately 2.1%. A 41-year-old lady presented with right upper abdomen pain and distension for 2 weeks. Contrast CT showed heterogeneously enhancing wall thickening involving fundus-body of the GB with large exophyt...
Source: International Cancer Conference Journal - May 31, 2023 Category: Cancer & Oncology Source Type: research

Brain stimulation for chronic pain management: a narrative review of analgesic mechanisms and clinical evidence
AbstractChronic pain constitutes one of the most common chronic complaints that people experience. According to the International Association for the Study of Pain, chronic pain is defined as pain that persists or recurs longer than 3 months. Chronic pain has a significant impact on individuals ’ well-being and psychosocial health and the economy of healthcare systems as well. Despite the availability of numerous therapeutic modalities, treatment of chronic pain can be challenging. Only about 30% of individuals with non-cancer chronic pain achieve improvement from standard pharmacologica l treatment. Therefore, numerous ...
Source: Neurosurgical Review - May 29, 2023 Category: Neurosurgery Source Type: research

Investigation of the clinical efficacy of CGF and ozone in the management of alveolar osteitis: a randomized controlled trial
ConclusionsThis study demonstrates that regenerative treatment which modulates angiogenesis, and tissue regeneration by stimulating stem cells, growth factors, and cytokines with CGF  + ozone are more effective than conventional treatment regarding AO.Clinical relevanceUsage of CGF and ozone together provides faster and more satisfactory management of AO.
Source: Clinical Oral Investigations - May 26, 2023 Category: Dentistry Source Type: research

News at a glance: China ’s ethics oversight, ARPA-H’s new science, and $210 million for protein research
PUBLIC HEALTH FDA advisers back maternal RSV shot A vaccine aims to protect infants from respiratory syncytial virus, a leading cause of infant hospitalization. JAMIE KELTER DAVIS/ THE NEW YORK TIMES /REDUX A panel advising the U.S. Food and Drug Administration (FDA) last week recommended that it approve a vaccine given to pregnant people to protect infants from respiratory syncytial virus (RSV), which can cause severe lung infections. The vote was unanimous based on the efficacy of the vaccine, called RSVpreF and branded Abrysvo. Ten members of the panel also...
Source: Science of Aging Knowledge Environment - May 25, 2023 Category: Geriatrics Source Type: research

Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model
CONCLUSION: In summary, we find that MSC treatment has negative effects on the joint in metabolic mild OA. This is an essential finding for the significant group of patients with metabolic OA phenotype, and might help to understand why clinical translation of MSC treatment shows varying therapeutic efficacy thus far. Our results also suggest that MSC-EV-based treatment might be a promising option for these patients, however MSC-EV therapeutic efficacy will need improvement.PMID:37226203 | DOI:10.1186/s13287-023-03368-7
Source: Cell Research - May 24, 2023 Category: Cytology Authors: Kelly Warmink Jaqueline L Rios Suzy Varderidou-Minasian Marta Torres-Torrillas Devin R van Valkengoed Sabine Versteeg Niels Eijkelkamp Harrie Weinans Nicoline M Korthagen Magdalena J Lorenowicz Source Type: research

Endometriosis: Cell Death and Cell Signaling Machinery
Endocrinology. 2023 May 22:bqad057. doi: 10.1210/endocr/bqad057. Online ahead of print.ABSTRACTEndometriosis is an estrogen-dependent disorder defined as the deposition and growth of endometrial tissue outside the uterus, including but not limited to the pelvic peritoneum, rectovaginal septum, and ovaries. Endometriosis is a significant contributor to pelvic pain and subfertility and has been associated with an increased incidence of certain cancers, including ovarian. Appropriate treatment of endometriosis can reduce morbidity, but generally is only used to address symptoms, since no cure currently exists. Multifactorial ...
Source: Endocrinology - May 22, 2023 Category: Endocrinology Authors: Ginearosa Carbone Katherine Nelson Claire Baumgartner Ann M Bode Akimasa Takahashi Ilana Chefetz Source Type: research

Janssen to Highlight Scientific Advances and Commitment to Transform Cancer Care at ASCO and EHA with More than 90 Presentations Showcasing Robust, Differentiated Portfolio and Pipeline in Hematologic Malignancies and Solid Tumors
This study evaluates an investigational combination regimen of IMBRUVICA® (ibrutinib) plus venetoclax (I+V) for newly diagnosed chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL), (Abstracts #7535 and #P617, respectively).Advancing the Science of Solid Tumors Through Precision MedicineJanssen’s continued innovation in solid tumors focuses on advancing precision medicine options for patients with biomarker-driven disease who have limited targeted treatment options and moving patients into earlier lines of therapy when treatments may be more effective. Lung CancerAn oral presentation will report ...
Source: Johnson and Johnson - May 18, 2023 Category: Pharmaceuticals Tags: Innovation Source Type: news

How My Employee Made A Stunning Recovery, And How You Can Too
All the patients we treat at the Sears Institute are special. But today I want to tell you about one who is like family to me… I’m talking about my clinic manager Brandi. If you’ve been to my clinic, you’ve probably met her. She’s a favorite with patients. In all the time I’ve known her, she always had a smile on her face. But Brandi’s smile hid the unbearable pain she endured every moment. Brandi had been in a horrific car accident that caused major damage to her back. Injuries to both her cervical and lumbar spine left her in constant pain. Every move she made was agonizing. It got to the point she coul...
Source: Al Sears, MD Natural Remedies - May 16, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Source Type: news

Fisetin regulates the biological effects of rat nucleus pulposus mesenchymal stem cells under oxidative stress by sirtuin ‐1 pathway
ConclusionsAs a natural compound with little cytotoxicity on NPMSCs, Fis alleviate H2O2-induced apoptosis, inflammation, and ECM degradation by suppressing oxidative stress, this finding may add the theoretical basis for research on new treatment of IDD based on NPMSCs.
Source: Immunity, Inflammation and Disease - May 16, 2023 Category: Allergy & Immunology Authors: Qing Zhou, Chao Zhu, Anwu Xuan, Junyou Zhang, Zhenbiao Zhu, Liang Tang, Dike Ruan Tags: ORIGINAL ARTICLE Source Type: research

Maresin1: A multifunctional regulator in inflammatory bone diseases
Int Immunopharmacol. 2023 May 14;120:110308. doi: 10.1016/j.intimp.2023.110308. Online ahead of print.ABSTRACTInflammation plays a crucial role in the physical response to danger signals, the elimination of toxic stimuli, and the restoration of homeostasis. However, dysregulated inflammatory responses lead to tissue damage, and chronic inflammation can disrupt osteogenic-osteoclastic homeostasis, ultimately leading to bone loss. Maresin1 (MaR1), a member of the specialized pro-resolving mediators (SPMs) family, has been found to possess significant anti-inflammatory, anti-allergic, pro-hemolytic, pro-healing, and pain-reli...
Source: International Immunopharmacology - May 16, 2023 Category: Allergy & Immunology Authors: Zhanwei Zhang Chonghao Ji Daobin Wang Maoshan Wang Xiao She Dawei Song Xin Xu Dongjiao Zhang Source Type: research