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Therapy: Neoadjuvant Therapy

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Pediatric Hepatocellular Carcinoma
ConclusionTreatment of pediatric HCC is challenging. Complete surgical resection is essential for the cure. To this end, different neoadjuvant chemotherapy protocols have been designed to convert non-resectable tumors into resectable tumors. For tumors that cannot be resected, liver transplantation for each patient with childhood HCC should be decided individually.
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Rectal cancer: Towards personalized medicine
Cancer Radiother. 2021 Jul 12:S1278-3218(21)00125-6. doi: 10.1016/j.canrad.2021.06.026. Online ahead of print.ABSTRACTThe standard of care for patients with locally advanced rectal cancer has recently changed and is now based on the concept of total neoadjuvant therapy with the association of radiotherapy and systemic chemotherapy before radical surgery. The addition of noeadjuvant systemic chemotherapy before or after radiotherapy during preoperative course significantly decreased the risk of distant metastases and prolonged disease-free survival after surgery. The risk of recurrence varies among patients and the standard...
Source: Cancer Radiotherapie - July 16, 2021 Category: Cancer & Oncology Authors: V Vendrely S Benoist Source Type: research

Bladder preservation in urothelial carcinoma: current trends and future directions
This article explores the bladder sparing alternatives to radical cystectomy and urinary diversion to assist Urologists, Medical Oncologists, and Palliative Care providers in their informed decision making with patients. Recent findings Bladder sparing strategies such as partial cystectomy and trimodality therapy offer long-term cancer outcomes comparable to radical cystectomy in carefully selected patients. Moreover, the toxicity profile in patients, having improved over time, is acceptable, including a low risk of salvage cystectomy. Summary Bladder preservation therapy offers an alternative to radical cyst...
Source: Current Opinion in Supportive and Palliative Care - November 17, 2021 Category: Palliative Care Tags: RENAL AND UROLOGICAL PROBLEMS: Edited by Fred Saad and Andrea Kokorovic Source Type: research

Precision medicine in pancreatic cancer: Patient derived organoid pharmacotyping is a predictive biomarker of clinical treatment response
CONCLUSION: PDOs establishment from tissues obtained from patients previously receiving cytotoxic chemotherapies can be accomplished in a clinically-certified laboratory. Sequencing PDOs following biomass expansion improves clinical sequencing quality. High in-vitro sensitivity to standard-of-care chemotherapeutics predicts good clinical response to systemic chemotherapy in PDAC.PMID:35363262 | DOI:10.1158/1078-0432.CCR-21-4165
Source: Clinical Cancer Research - April 1, 2022 Category: Cancer & Oncology Authors: Toni T Sepp älä Jacquelyn W Zimmerman Reecha Suri Haley Zlomke Gabriel D Ivey Annamaria Szabolcs Christopher R Shubert John L Cameron William R Burns Kelly J Lafaro Jin He Christopher L Wolfgang Ying S Zou Lei Zheng David A Tuveson James R Eshlemann Dav Source Type: research

New Leadership at Brigham and Women's Bolsters Mesothelioma Care
The departure of renowned mesothelioma specialist David Sugarbaker, M.D. from Brigham and Women's Hospital in Boston earlier this year didn't lessen the hospital's commitment. It made that long-standing promise to patients even stronger. Raphael Bueno, M.D., is making sure of that. Bueno, who has replaced Sugarbaker as the chief of the thoracic surgery division, reiterated his pledge recently that Brigham and Women's would remain the country's most prestigious destination for patients with malignant pleural mesothelioma. "It's even better now," Bueno told Asbestos.com. "Patients understand that it’s the whole program ...
Source: Asbestos and Mesothelioma News - June 5, 2014 Category: Environmental Health Authors: Tim Povtak Tags: Treatment & Doctors Source Type: news

Synovial sarcoma in children and adolescents: the European Pediatric Soft Tissue Sarcoma Study Group prospective trial (EpSSG NRSTS 2005)
Conclusion This study demonstrates that collaborative prospective studies on rare pediatric sarcomas are feasible even on a European scale, with excellent treatment compliance. The overall results of treatment were satisfactory, with higher survival rates than those previously published by pediatric groups. Nonetheless, larger, international projects are needed, based on a cooperative effort of pediatric and adult oncologists. Clinical Trials number European Union Drug Regulating Authorities Clinical Trials No. 2005-001139-31.
Source: Annals of Oncology - February 27, 2015 Category: Cancer & Oncology Authors: Ferrari, A., De Salvo, G. L., Brennan, B., van Noesel, M. M., De Paoli, A., Casanova, M., Francotte, N., Kelsey, A., Alaggio, R., Oberlin, O., Carli, M., Ben-Arush, M., Bergeron, C., Merks, J. H. M., Jenney, M., Stevens, M. C., Bisogno, G., Orbach, D. Tags: sarcoma Source Type: research

Colorectal Liver Metastases: A Critical Review of State of the Art
Background: Over 50% of patients with colorectal cancer will develop liver metastases. Only a minority of patients present with technically resectable disease. Around 40% of those undergoing surgical resection are alive five years after their diagnosis compared with less than 1% for those with disseminated disease treated with systemic chemotherapy. Surgical resection remains the only possibility for long-term survival for these patients and great efforts have been made to increase the rates of resection whilst improving long-term outcomes.Summary: This review considers current technical and oncological criteria for resect...
Source: Liver Cancer - November 28, 2016 Category: Cancer & Oncology Source Type: research

Advances in Pediatric Liver Tumors
AbstractPurpose of ReviewHepatoblastoma and hepatocellular carcinoma are rare pediatric tumors. We review the significant advances in hepatoblastoma and pediatric hepatocellular carcinoma prognosis and treatment.Recent FindingsInternational pathologic classification and risk stratification have been extensively reviewed and redefined for hepatoblastoma via international collaborative analyses of an international hepatoblastoma database. International trials have identified patients for whom (1) no adjuvant chemotherapy is indicated, (2) neoadjuvant chemotherapy improves resectability and survival, and (3) intensified thera...
Source: Current Hepatitis Reports - February 12, 2017 Category: Infectious Diseases Source Type: research

Physical activity levels in locally advanced rectal cancer patients following neoadjuvant chemoradiotherapy and an exercise training programme before surgery: a pilot study
ConclusionsPAL variables, daily step count, EE and MET significantly reduced following neoadjuvant CRT in all participants. A 6-week pre-operative in-hospital exercise training programme improved sleep efficiency, sleep duration and lying down time when compared to participants receiving usual care.Trial registrationClinicaltrials.govNCT01325909
Source: Perioperative Medicine - February 15, 2017 Category: Surgery Source Type: research

Febrile neutropenia in adjuvant and neoadjuvant chemotherapy for breast cancer: a retrospective study in routine clinical practice from a single institution
ConclusionThe incidence of FN induced by adjuvant/neoadjuvant chemotherapy in ESBC is higher in routine clinical practice than in clinical trials. AI or inflammatory diseases were significant independent risk factors for FN. Primary prophylaxis in patients at risk (elderly, comorbid patients), especially treated with the FEC regimen, is the keystone of management of this adverse effect. Prevention and management of FN to ensure the patient ’s safety and quality of life are a major issue for both medical oncologists and supportive care physicians.
Source: Supportive Care in Cancer - October 26, 2018 Category: Cancer & Oncology Source Type: research

Laparoscopic bladder-sparing approach in patients with prostatic rhabdomyosarcoma: a case series of two pediatric patients.
Abstract Traditionally, the standard treatment of bladder-prostate rhabdomyosarcoma (BP-RMS) is being implemented to be total cystoprostatectomy and urinary diversion. However, current multimodal treatment approaches emphasize the importance of bladder-sparing surgery.In this case series, it was aimed to indicate the results of the laparoscopic bladder-sparing approach of two pediatric patients with BP RMS. They have admitted to the emergency department due to acute urinary retention (AUR). The tumors located in the prostate causing AUR were detected by Magnetic resonance imaging (MRI) and the pathological diagnos...
Source: Urology Journal - July 21, 2019 Category: Urology & Nephrology Authors: Ozden E, Mercimek MN, Sarikaya S Tags: Urol J Source Type: research

Uveal melanoma : Early detection as the key to successful personalized medicine.
CONCLUSION: The present concept of personalized medicine for UM is restricted to the treatment of the primary tumor. New diagnostic options, such as liquid biopsy and molecular genetic investigations help to acquire a better understanding of the mechanisms involved and provide the foundation for precision medicine in the development of further personalized treatment concepts. PMID: 31820082 [PubMed - as supplied by publisher]
Source: Der Ophthalmologe - December 8, 2019 Category: Opthalmology Authors: Grisanti S, Ranjbar M, Tura A, Heindl LM, Kakkassery V Tags: Ophthalmologe Source Type: research