Filtered By:
Vaccination: Malaria Vaccine

This page shows you your search results in order of relevance. This is page number 5.

Order by Relevance | Date

Total 1513 results found since Jan 2013.

Genome Editing by CRISPR/Cas9: a Game Change in the Genetic Manipulation of Protists
This article is protected by copyright. All rights reserved
Source: The Journal of Eukaryotic Microbiology - April 30, 2016 Category: Microbiology Authors: Noelia Lander, Miguel A. Chiurillo, Roberto Docampo Tags: Symposium Article Source Type: research

Is Bill Gates a Humanitarian, Villain or Misguided Man?
Conclusion The Bill and Melinda Gates Foundation has donated money to 100 countries and the United States with their stated objective to improve education and world health. Investor Warren Buffet is a primary contributor to the foundation. Some of the foundation’s programs target schools, farmers, and sanitation needs, all worthy causes. One of their primary programs, with significant funding, has included vaccination programs focused on developing countries. These vaccine initiatives have resulted in documented deaths and injuries for thousands of previously healthy children. Are Melinda and Bill Gates simply misguided ...
Source: vactruth.com - July 16, 2016 Category: Allergy & Immunology Authors: Michelle Goldstein Tags: Logical Michelle Goldstein Top Stories Bill and Melinda Gates Foundation truth about vaccines Vaccine Death Source Type: blogs

Lack of plasmodium surface-protein blocks mosquito infection
A previously unknown feature of the malaria parasite development has just been released by an international research team. Their study has shown that, contrary to what has been assumed so far, a Plasmodium surface-protein plays an essential role at a stage of its life cycle that occurs not in the body of the host, but in the guts of the Anopheles mosquito. The finding has consequences for the search for vaccines or drugs that could alleviate the suffering caused by malaria. By 2015, 214 million people were affected by the parasite, especially in Africa.
Source: ScienceDaily Headlines - November 9, 2016 Category: Science Source Type: news

Plasmodium vivax vaccine research - we've only just begun.
Abstract Plasmodium vivax parasites cause the majority of malaria cases outside Africa, and are increasingly being acknowledged as a cause of severe disease. The unique attributes of P. vivax biology, particularly the capacity of the dormant liver stage, the hypnozoite, to maintain blood-stage infections even in the absence of active transmission, make blood-stage vaccines particularly attractive for this species. However, P. vivax vaccine development remains resolutely in first gear, with only a single blood-stage candidate having been evaluated in any depth. Experience with Plasmodium falciparum suggests that a ...
Source: International Journal for Parasitology - November 26, 2016 Category: Parasitology Authors: Tham WH, Beeson JG, Rayner JC Tags: Int J Parasitol Source Type: research

Antimalarial efficacy of low molecular weight chitosan against Plasmodium berghei infection in mice.
CONCLUSION: The results of this study showed that the chitosan has potent antimalarial activity and could be suggested as an alternative antimalarial drug component. PMID: 28035107 [PubMed - in process]
Source: Journal of Vector Borne Diseases - December 31, 2016 Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research

A Systematic Review of the Incidence, Risk Factors and Case Fatality Rates of Invasive Nontyphoidal < i > Salmonella < /i > (iNTS) Disease in Africa (1966 to 2014)
In conclusion, iNTS disease is a substantial cause of community-acquired bacteraemia in Africa. Given the high morbidity and mortality of iNTS disease in Africa, it is important to develop effective prevention and control strategies including vaccination.
Source: PLoS Neglected Tropical Diseases - January 4, 2017 Category: Tropical Medicine Authors: Ifeanyi Valentine Uche Source Type: research

The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development.
Abstract Analysis of our Plamodium falciparum malaria parasite peptides' (1)H-NMR database in the search for H-bonds and π-interactions led us to correlate their presence or absence with a peptide's particular immunological behavior. It was concluded that a 26.5 ± 1.5 Å between positions 1 to 9 of the HLA-DRβ1* interacting region was necessary for proper docking of 20mer-long peptides and these MHC Class II molecules for full-protective immunity. Presence of intramolecular H-bonds or π-interactions leading to righ-handed α-helix or β-turn conformation in this peptide's region induces different immune res...
Source: Biochemical and Biophysical Research communications - January 18, 2017 Category: Biochemistry Authors: Reyes C, Moreno-Vranich A, Patarroyo ME Tags: Biochem Biophys Res Commun Source Type: research

What Experts in Law and Medicine Have to Say About the Cost of Drugs
By ANDY ORAM Pharmaceutical drug costs impinge heavily on consumers’ consciousness, often on a monthly basis, and have become such a stress on the public that they came up repeatedly among both major parties during the U.S. presidential campaign–and remain a bipartisan rallying cry. A good deal of the recent conference named Health Law Year in P/Review, at the Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics at Harvard Law School, covered issues with a bearing on drug costs. It’s interesting to take the academic expertise from that conference–and combine it with a bit of commo...
Source: The Health Care Blog - February 2, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Andy Oram Drug Pricing Pharma Source Type: blogs

Synthesis, antimalarial activity in vitro and docking studies of novel neolignan derivatives
This article is protected by copyright. All rights reserved. Synthesis and docking studies of new neolignan derivatives with antimalarial activity.
Source: Chemical Biology and Drug Design - February 27, 2017 Category: Biology Authors: Gla écia A. N. Pereira, Gisele C. Souza, Lourivaldo S. Santos, Lauro E. S. Barata, Carla C. F. Meneses, Antoniana U. Krettli, Cláudio Tadeu Daniel‐Ribeiro, Cláudio Nahum Alves Tags: Research Article Source Type: research

Synthesis, antimalarial activity in vitro, and docking studies of novel neolignan derivatives
The absence of effective vaccines against malaria and the difficulties associated with controlling mosquito vectors have left chemotherapy as the primary control measure against malaria. However, the emergence and spread of parasite resistance to conventional antimalarial drugs result in a worrisome scenario making the search for new drugs a priority. In the present study, the activities of nine neolignan derivatives were evaluated as follows: (i) against blood forms of chloroquine‐resistant Plasmodium falciparum (clone W2), using the tritiated hypoxanthine incorporation and anti‐HRPII assays; (ii) for cytotoxic activi...
Source: Chemical Biology and Drug Design - April 6, 2017 Category: Biology Authors: Gla écia A. N. Pereira, Gisele C. Souza, Lourivaldo S. Santos, Lauro E. S. Barata, Carla C. F. Meneses, Antoniana U. Krettli, Cláudio Tadeu Daniel‐Ribeiro, Cláudio Nahum Alves Tags: RESEARCH ARTICLE Source Type: research

Why Science is Mistrusted
By, SAURABH JHA MD Recently, the Harvard Chan School of Public Health, in their press release, reported about the effect of surgical checklists in South Carolina. The release was titled, “South Carolina hospitals see major drop in post-surgical deaths with nation’s first proven statewide Surgical Safety Checklist Program.” The Health News Review, for which I review, grades coverage of research in the media. Based on their objective criteria, the Harvard press release would not score highly. The title exudes certainty – “nation’s first proven.” The study, not being a randomized controlled trial (RCT), though s...
Source: The Health Care Blog - April 22, 2017 Category: Consumer Health News Authors: at RogueRad Tags: Uncategorized Source Type: blogs

Chemical Attenuation in the Development of a Whole-Organism Malaria Vaccine Minireviews
Malaria vaccine development has been dominated by the subunit approach; however, many subunit vaccine candidates have had limited efficacy in settings of malaria endemicity. As our search for an efficacious malaria vaccine continues, the development of a whole-organism vaccine is now receiving much scrutiny. One strategy currently being explored in the development of a whole-organism vaccine involves chemical attenuation of the malaria parasite. In vivo and in vitro chemical attenuation of both liver-stage and blood-stage Plasmodium parasites has been investigated. Here, we discuss both approaches of chemical attenuation i...
Source: Infection and Immunity - June 20, 2017 Category: Infectious Diseases Authors: Raja, A. I., Stanisic, D. I., Good, M. F. Tags: Minireviews Source Type: research

Doctors Do Know Best. Exhibit A: The Charlie Gard Case.
By SAURABH JHA, MD For American conservatives, Britain’s NHS is an antiquated Orwellian dystopia. For Brits, even those who don’t love the NHS, American conservatives are better suited to spaghetti westerns, such as Fistful of Dollars, than reality. The twain is unlikely to meet after the recent press surrounding Charlie Gard the infant, now deceased, with a rare, fatal mitochondrial disorder in which mitochondrial DNA is depleted – mitochondrial depletion disorder (MDD). In this condition, the cells lose their power supply and tissues, notably in the brain, die progressively and rapidly. The courts forbade Charlie...
Source: The Health Care Blog - July 31, 2017 Category: Consumer Health News Authors: at RogueRad Tags: OP-ED Patients Source Type: blogs

Philanthropists Join Forces to Fund Africa ’s Cash-Strapped Health Sector
Tristate Heart and Vascular Centre in Nigeria. Credit: Tristate Heart and Vascular CentreBy Pavithra Rao, Africa Renewal*NEW YORK, Sep 28 2017 (IPS)In the 2017 World Happiness Report by Gallup, African countries score poorly. Of the 150 countries on the list, the Central African Republic, Tanzania and Burundi rank as the unhappiest countries in the world. Some of the factors driving unhappiness are the poor state of the continent’s health care systems, the persistence of HIV/AIDS, malaria and tuberculosis, and the growth of lifestyle diseases such as hypertension, heart disease and diabetes.Few African countries make sig...
Source: IPS Inter Press Service - Health - September 28, 2017 Category: International Medicine & Public Health Authors: Pavithra Rao Tags: Development & Aid Featured Global Headlines Health TerraViva United Nations Source Type: news

Quantitative Outcomes of a One Health approach to Study Global Health Challenges
AbstractHaving gained momentum in the last decade, the One Health initiative promotes a holistic approach to address complex global health issues. Before recommending its adoption to stakeholders, however, it is paramount to first compile quantitative evidence of the benefit of such an approach. The aim of this scoping review was to identify and summarize primary research that describes monetary and non-monetary outcomes following adoption of a One Health approach. An extensive literature search yielded a total of 42,167 references, of which 85 were included in the final analysis. The top two biotic health issues address...
Source: EcoHealth - January 12, 2018 Category: Environmental Health Source Type: research