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Specialty: Allergy & Immunology

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Total 72221 results found since Jan 2013.

Nrf2 regulates the expression of NOX1 in TNF- α-induced A549 cells
In this study, we analyzed the potential regulatory role of nuclear factor erythroid-2-related factor 2 (Nrf2) on NADPH oxidase 1 (NOX1) in tumor necrosis factor-α (TNF-α)-induced inflammation and oxidative stress in human type II alveolar epithelial cells. In this study, A549 cells were transfected with Nrf2 siRNA and overexpression vectors for 6 h before being induced by TNF-α for 24 h. TNF-α upregulated the expression of NOX1 and Nrf2 in A549 cells. Furthermore, overexpression of Nrf2 could reduce TNF-α-induced NF-κB mRNA and protein expression after transfection with the Nrf2 siRNA vector, and the levels of IL-6,...
Source: Allergologia et Immunopathologia - January 9, 2023 Category: Allergy & Immunology Authors: Weijing Wu Jiamin Zhang Xiaoshan Su Xiaoping Lin Li Zhu Zesen Zhuang Chennan Liu Zhixing Zhu Yiming Zeng Source Type: research

High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease
In conclusion, HUA aggravated CSE-induced cellular ROS levels and led to ROS-dependent mitochondrial dynamics disorder and apoptosis in MLE-12 cells through downregulating PRDX2.PMID:37003188 | DOI:10.1016/j.intimp.2023.110056
Source: International Immunopharmacology - April 1, 2023 Category: Allergy & Immunology Authors: Ya Dong Fei Han Yue Su Bei Sun Wei Zhao Congqing Pan Source Type: research

TLR3 recognition of viral double-stranded RNA in human dental pulp cells is important for the innate immunity
Int Immunopharmacol. 2023 Apr 13;119:110161. doi: 10.1016/j.intimp.2023.110161. Online ahead of print.ABSTRACTDental caries or trauma can expose human dental pulp cells (DPCs) to various oral microorganisms, which play an important role in the development of an innate immune response. In the present study, we examined the expression of Toll-like receptors (TLRs) for sensing microbe-associated molecular patterns in human DPCs. Interestingly, real-time PCR analysis demonstrated that TLR3 is the most highly expressed among 10 different TLRs in human DPCs. Poly(I:C), a representative TLR3 ligand mimicking viral double-stranded...
Source: International Immunopharmacology - April 15, 2023 Category: Allergy & Immunology Authors: Ye-Eun Ha Yoon Ju So Jintaek Im Cheol-Heui Yun Joo-Cheol Park Seung Hyun Han Source Type: research

Equine β-defensin 1 regulates cytokine expression and phagocytosis in S. aureus-infected mouse monocyte macrophages via the Paxillin-FAK-PI3K pathway
In this study, we utilized a PI-3K inhibitor (PKI-402) to treat eBD-1 -treated S. aureus-infected macrophages in vitro. Our results revealed that PKI-402 decreased the expression of eBD-1-promoted TNF-α, IL-6, CXCL10, CD40, RANTES, and p65 mRNA. To further investigate the relationship between eBD-1 and phagocytosis, we examined the expression of paxillin and FcγRIII (CD16 receptor) using western blot and immunofluorescence techniques. Our findings demonstrated that eBD-1 enhanced CD16 and paxillin expression in S. aureus -infected macrophages. Considering the correlation between paxillin expression and focal adhesion kin...
Source: International Immunopharmacology - August 15, 2023 Category: Allergy & Immunology Authors: Le Pei Yongyue Hou Ying Feng Feng Li Hong Su Yuemei Zhang Yue Song Kun Liu Guifang Cao Source Type: research

Ferritin was involved in interleukin-17A enhanced osteogenesis through autophagy activation
In conclusion, IL-17A induced ferritin expression in osteoblasts, which further enhanced osteogenic differentiation via autophagy activation. These findings may provide further insight into the role of IL-17A in osteoblast differentiation and demonstrate ferritin as a potential target in modulating alveolar bone homeostasis.PMID:37713787 | DOI:10.1016/j.intimp.2023.110916
Source: International Immunopharmacology - September 15, 2023 Category: Allergy & Immunology Authors: Wenlin Yuan Yuting Yang Yingming Wei Xufei Yu Jiaqi Bao Jiahui Zhong Zhongxiu Wang Lili Chen Source Type: research

Negatively-regulated necroptosis by autophagy required caspase-6 activation in TNFα-treated murine fibrosarcoma L929 cells.
Abstract Autophagy and necroptosis have been known to be interconnected, while the relationship between autophagy and necroptosis remains unclear. Here, we demonstrated that pan-caspase inhibitor z-VAD-fmk (zVAD) exacerbated TNFα-induced necroptosis and autophagy in murine fibrosarcoma L929 cells. And the RIP-1 inhibitor necrostatin-1 inhibited TNFα+zVAD-induced necroptosis and autophagy. Inhibition of autophagy by 3-methyladenine (3MA) or small interfering RNA (siRNA) against Beclin 1 augmented TNFα-induced necroptosis, while, autophagy inhibition did not influence TNFα+zVAD-induced necroptosis. These results...
Source: International Immunopharmacology - August 10, 2013 Category: Allergy & Immunology Authors: Ye YC, Wang HJ, Chen L, Liu WW, Tashiro SI, Onodera S, Xia MY, Ikejima T Tags: Int Immunopharmacol Source Type: research

Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death.
This study is intended to investigate, the potential applications of RNA interference (RNAi) to block RBBP6 expression, as well as its subsequent effect on cell growth and apoptosis. Our studies indicate that the knockdown of RBBP6 by siRNA modulates p53 gene expression involved in cell death pathways and apoptosis, showing statistically significant gene expression differences. RBBP6 siRNA significantly reduced cell growth compared to the control samples and inhibition of cellular proliferation was observed between 24 and 48h, as shown in the data obtained by real time cell analysis using the xCELLigence system. These resu...
Source: Immunobiology - March 21, 2014 Category: Allergy & Immunology Authors: Moela P, Choene MM, Motadi LR Tags: Immunobiology Source Type: research

Slit2 Exerts Anti‐Inflammatory Actions in Human Placenta and is Decreased with Maternal Obesity
ConclusionThe anti‐inflammatory effects of Slit2 in human placenta is a novel finding, and suggests that inflammatory mediators, which are increased with obesity, downregulates Slit2 to enhance placental inflammation. Given the central role of pro‐inflammatory cytokines in placental nutrient transport, our findings suggest Slit2 may play a role in fetal growth and development.
Source: American Journal of Reproductive Immunology - October 20, 2014 Category: Allergy & Immunology Authors: Ratana Lim, Martha Lappas Tags: Original Article Source Type: research

Effect of β‐glucan on MUC4 and MUC5B expression in human airway epithelial cells
ConclusionThese results demonstrate that in human airway epithelial cells β‐glucan induces MUC4 and MUC5B expression via the TLR4–p38 MAPK–NF‐κB signaling pathway.
Source: International Forum of Allergy and Rhinology - May 1, 2015 Category: Allergy & Immunology Authors: Yong‐Dae Kim, Chang Hoon Bae, Si‐Youn Song, Yoon Seok Choi Tags: ORIGINAL ARTICLE Source Type: research

SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells
Conclusions: In conclusion, our results suggest that SIGIRR plays an important role in the negative regulation of LPS response and tolerance in human bladder epithelial cells, possibly through its impact on TLR-mediated signaling.
Source: BMC Immunology - December 3, 2015 Category: Allergy & Immunology Authors: Dan LiXin ZhangBaiyi Chen Source Type: research

Gallic acid-l-leucine (GAL) conjugate enhances macrophage phagocytosis via inducing leukotriene B4 12-hydroxydehydrogenase (LTB4DH) expression
Publication date: June 2016 Source:Molecular Immunology, Volume 74 Author(s): Yuanyuan Cheng, Hung-Fat Tse, Xuechen Li, Yifan Han, Jianhui Rong Timely clearance of apoptotic cells is an important step in the resolution of ongoing inflammation and the restoration of tissue integrity and function after acute myocardial infarction. Natural products gallic acid and l-leucine are well-documented for anti-inflammatory and anabolic effects. We synthesized gallic acid-l-leucine (GAL) conjugate via direct coupling gallic acid and l-leucine. The aim of the present study was to investigate the effect of GAL conjugate on the ph...
Source: Molecular Immunology - May 1, 2016 Category: Allergy & Immunology Source Type: research

Variable Heavy Chain Domain Derived from a Cell-Penetrating Anti-DNA Monoclonal Antibody for the Intracellular Delivery of Biomolecules.
In this study, we explored the applicability of variable heavy chain (VH) domain as delivery vehicles for mammalian cells. The characteristics of the recombinant VH domain produced from a cell-penetrating monoclonal anti-double stranded DNA antibody 2C10 were analyzed using flow cytometry, confocal microscopy, cell proliferation assay, and cell cycle analysis in various mammalian cell lines. The VH domain penetrated into various cell lines in a time- and dose-dependent manner, although the internalization efficiency varied. The domain was localized in the nuclei as well as the cytoplasm of living cells. It was also interna...
Source: Immunological Investigations - April 8, 2017 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research