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Procedure: Liver Transplant

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Total 13440 results found since Jan 2013.

Review article: the efficacy and safety of daclatasvir in the treatment of chronic hepatitis C virus infection
Conclusion Daclastavir‐containing regimens, with or without PEG‐IFN, have shown promising results in clinical trials, and present an excellent treatment option for those with chronic HCV and for multiple genotypes.
Source: Alimentary Pharmacology and Therapeutics - May 27, 2015 Category: Drugs & Pharmacology Authors: C. Bunchorntavakul, K. R. Reddy Tags: Review Article Source Type: research

Role of Transjugular Intrahepatic Portosystemic Shunts in the Management of Hepatopulmonary Syndrome: A Systemic Literature Review
Conclusions Transjugular intrahepatic portosystemic shunt creation shows promise in the management of HPS. Future prospective studies are warranted.
Source: Journal of Vascular and Interventional Radiology - June 13, 2015 Category: Radiology Source Type: research

A Special Touch: Treatment Considerations for Unique Patient Populations With HCV Genotype 1 Infection.
CONCLUSION: Depending on the population studied, clinicians must consider differences in efficacy outcomes, potential drug interactions, and adverse effects that patients may experience. PMID: 26139639 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - July 2, 2015 Category: Drugs & Pharmacology Authors: Toussaint-Miller KA, Andres J Tags: Ann Pharmacother Source Type: research

Interventions for dialysis patients with hepatitis C virus (HCV) infection.
CONCLUSIONS: Our review demonstrated that in CKD patients on haemodialysis with HCV infection treatment with standard interferon brings about an end of treatment but not a sustained virological response and is relatively well tolerated. PEG interferon is more effective than standard interferon for end of treatment response but not for sustained response; both were equally tolerated. Increasing doses of PEG interferon did not improve responses but high and low doses are equally tolerated. Addition of ribavirin results in more treatment discontinuation. PMID: 26287983 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 19, 2015 Category: Journals (General) Authors: Prabhu RA, Nair S, Pai G, Reddy NP, Suvarna D Tags: Cochrane Database Syst Rev Source Type: research

Increasing Transplant Organ Supply Through Uncontrolled Donation After Cardiac Death
This study would suggest that a publicly accepted approach to uDCD would be to require consent prior to organ preservation, even if this is not legally or ethically required. Should uDCD Protocols Be Pursued In The US? Uncontrolled donation after cardiac death protocols provide an opportunity to expand the organ donor pool, thereby decreasing waiting list time and improving outcomes for potential organ recipients. Given that the waiting list for organ donation has not significantly changed in the past several years, and thousands of people continue to die or have a poor quality of life while awaiting organs, efforts should...
Source: Health Affairs Blog - September 16, 2015 Category: Health Management Authors: Anji Wall and Sunil Geevarghese Tags: Featured Health Professionals Hospitals Organization and Delivery Population Health Bioethics cardiac death health care law next of kin organ donation organ transplants Source Type: blogs

Health-related quality of life measurement in chronic liver disease patients.
CONCLUSIONS: Quality of life instruments are potentially powerful tools for evaluating the functional status, presenting gains of treatment and reflecting patients' ability to return to a normal lifestyle in CLD patients. More attention should be paid by clinicians for integrated use of clinical tests together with HRQOL instruments in liver transplantation for establishing the reference levels of mental, physical, and role-social functioning. PMID: 26424183 [PubMed - in process]
Source: Medicina (Kaunas) - October 2, 2015 Category: Universities & Medical Training Authors: Šumskienė J, Kupčinskas L, Šumskas L Tags: Medicina (Kaunas) Source Type: research

Health-related quality of life measurement in chronic liver disease patients
Conclusions Quality of life instruments are potentially powerful tools for evaluating the functional status, presenting gains of treatment and reflecting patients’ ability to return to a normal lifestyle in CLD patients. More attention should be paid by clinicians for integrated use of clinical tests together with HRQOL instruments in liver transplantation for establishing the reference levels of mental, physical, and role-social functioning.
Source: Medicina - December 12, 2015 Category: Journals (General) Source Type: research

Different behaviour of BK-virus infection in liver transplant recipients.
Abstract Polyomavirus BK (BKV) infects up to 90% of the general population. After primary infection, occurring early during childhood, a state of non-replicative infection is established in the reno-urinary tract, without complications for immunocompetent hosts. In immunocompromised individuals, particularly transplanted patients, asymptomatic BKV viremia and/or viruria can be observed. Renal grafts may also be sources of infection as BKV prefers kidneys rather than other solid organs for transplantation such as the liver. The mechanism behind the higher incidence of BKV infection in kidney transplant patients, co...
Source: World Journal of Gastroenterology : WJG - January 28, 2016 Category: Gastroenterology Authors: Umbro I, Tinti F, Muiesan P, Mitterhofer AP Tags: World J Gastroenterol Source Type: research

Review article: sarcopenia in cirrhosis – aetiology, implications and potential therapeutic interventions
ConclusionSarcopenia in cirrhosis has a complex pathogenesis and simple dietary interventions are insufficient. Improved understanding of the multiple mechanisms involved should allow the development of more effective therapies, which target the specific underlying metabolic derangements.
Source: Alimentary Pharmacology and Therapeutics - February 5, 2016 Category: Drugs & Pharmacology Authors: M. Sinclair, P. J. Gow, M. Grossmann, P. W. Angus Tags: Review Article Source Type: research

Enzyme replacement therapy with laronidase (Aldurazyme(®)) for treating mucopolysaccharidosis type I.
CONCLUSIONS: The current evidence demonstrates that laronidase is effective when compared to placebo in the treatment of mucopolysaccharidosis type I. The included study was comprehensive and of good quality, although there were few participants. The study included all of the key outcome measures we wished to look at. It demonstrated that laronidase is efficacious in relation to reducing biochemical parameters (reduced urine glycosaminoglycan excretion) and improved functional capacity as assessed by forced vital capacity and the six-minute-walk test. In addition glycosaminoglycan storage was reduced as ascertained by a re...
Source: Cochrane Database of Systematic Reviews - March 31, 2016 Category: Journals (General) Authors: Jameson E, Jones S, Remmington T Tags: Cochrane Database Syst Rev Source Type: research

Next Steps Toward Eradication of Hepatitis C in the Era of Direct Acting Antivirals
Conclusions: The eradication of HCV will require significant governmental financial investment for screening, prevention, and treatment of infected patients. Although, we have a long way to eradication of HCV, the next steps could be including proper planning to patient finding, availability of new treatments to all patients and development of HCV prevention strategies such as vaccines.
Source: Hepatitis Monthly - April 17, 2016 Category: Infectious Diseases Source Type: research

Antithymocyte Globulin Induction Therapy in Liver Transplant: Old Drug, New Uses.
CONCLUSIONS: rATG induction therapy may lead to improved renal function and lower rejection rates following liver transplant. The use of this medication can help avoid unwanted adverse effects from other immunosuppression agents. Because of the potential benefits with this induction agent, rATG may have a larger role in induction therapy for liver transplant recipients. PMID: 27147705 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - May 3, 2016 Category: Drugs & Pharmacology Authors: Petite SE, Bollinger JE, Eghtesad B Tags: Ann Pharmacother Source Type: research

Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic Review
Alcoholic hepatitis (AH) occurs in about one‐third of individuals reporting long‐term heavy alcohol use. It is associated with high short‐term mortality, economic burden, and hospital resources utilization. We performed this systematic review to (i) describe clinical characteristics and genomics associated with the risk of AH; (ii) discuss role and limitations of liver biopsy and prognostic scoring systems; (iii) summarize evidence regarding the currently available therapies including liver transplantation; and (iv) outline emerging therapies with areas of unmet need. Literature search was performed for studies publi...
Source: Alcoholism: Clinical and Experimental Research - June 1, 2016 Category: Addiction Authors: Ashwani K. Singal, Sudha Kodali, Lee A. Vucovich, Victor Darley‐Usmar, Thomas D. Schiano Tags: Critical Review Source Type: research

Diagnosis and Treatment of Alcoholic Hepatitis: A Systematic Review.
Abstract Alcoholic hepatitis (AH) occurs in about one-third of individuals reporting long-term heavy alcohol use. It is associated with high short-term mortality, economic burden, and hospital resources utilization. We performed this systematic review to (i) describe clinical characteristics and genomics associated with the risk of AH; (ii) discuss role and limitations of liver biopsy and prognostic scoring systems; (iii) summarize evidence regarding the currently available therapies including liver transplantation; and (iv) outline emerging therapies with areas of unmet need. Literature search was performed for s...
Source: Alcoholism, Clinical and Experimental Research - June 1, 2016 Category: Addiction Authors: Singal AK, Kodali S, Vucovich LA, Darley-Usmar V, Schiano TD Tags: Alcohol Clin Exp Res Source Type: research

Fight Aging! Newsletter, June 6th 2016
This study teaches us that poor wound healing and wrinkling and sagging that occur in aging skin share similar mechanisms." Reduced cell cohesiveness of outgrowths from eccrine sweat glands delays wound closure in elderly skin Human skin heals more slowly in aged vs. young adults, but the mechanism for this delay is unclear. In humans, eccrine sweat glands (ESGs) and hair follicles underlying wounds generate cohesive keratinocyte outgrowths that expand to form the new epidermis. Our results confirm that the outgrowth of cells from ESGs is a major feature of repair in young skin. Strikingly, in aged skin, ...
Source: Fight Aging! - June 5, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs