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Chronobiology of mood disorders
ConclusionA preliminary multifaceted model is presented, which will require further development and testing. Future depression research should aim to examine multiple systems concurrently in order to derive a more sophisticated understanding of the underlying neurobiology.
Source: Acta Psychiatrica Scandinavica - August 2, 2013 Category: Psychiatry Authors: G. S. Malhi, S. Kuiper Tags: Clinical Overview Source Type: research

New survey of DNA alterations could aid search for cancer genes
(Dana-Farber Cancer Institute) Scanning the DNA of nearly 5,000 tumor samples, a team led by scientists at Dana-Farber Cancer Institute and the Broad Institute has identified 140 regions of scrambled genetic code believed to contain many undiscovered cancer genes. Mapping of the abnormal regions gives cancer scientists a starting point from which to search for as-yet undiscovered oncogenes and broken tumor-suppressor genes.
Source: EurekAlert! - Medicine and Health - September 27, 2013 Category: Global & Universal Source Type: news

The search for cancer genes could be aided by new survey of DNA alterations
Scanning the DNA of nearly 5,000 tumor samples, a team led by scientists at Dana-Farber Cancer Institute and the Broad Institute has identified 140 regions of scrambled genetic code believed to contain many undiscovered cancer genes. The researchers said the mapping of the abnormal regions gives cancer scientists a starting point from which to search for as-yet undiscovered oncogenes and broken tumor-suppressor genes, which allow cells to divide and grow uncontrollably...
Source: Health News from Medical News Today - October 1, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Imaging and Cerebrospinal Fluid Biomarkers in the Search for Alzheimer's Disease Mechanisms.
Conclusion: Our results indicate a heterogeneous biomarker expression, suggesting diversity of AD pathways in at-risk presymptomatic subjects. © 2013 S. Karger AG, Basel. PMID: 24107601 [PubMed - as supplied by publisher]
Source: Neuro-Degenerative Diseases - October 2, 2013 Category: Neurology Authors: Osorio RS, Pirraglia E, Gumb T, Mantua J, Ayappa I, Williams S, Mosconi L, Glodzik L, de Leon MJ Tags: Neurodegener Dis Source Type: research

Predicting bone scan positivity after biochemical recurrence following radical prostatectomy in both hormone-naive men and patients receiving androgen-deprivation therapy: results from the SEARCH database
& S J Freedland
Source: Prostate Cancer and Prostatic Diseases - January 14, 2014 Category: Urology & Nephrology Authors: D M MoreiraM R CooperbergL E HowardW J AronsonC J KaneM K TerrisC L AmlingM KuchibhatlaS J Freedland Tags: disease-free survival metastasis mortality prostatectomy PSA Source Type: research

Multiatlas segmentation of thoracic and abdominal anatomy with level set-based local search
Segmentation of organs at risk (OARs) remains one of the most time-consuming tasks in radiotherapy treatment planning. Atlas-based segmentation methods using single templates have emerged as a practical approach to automate the process for brain or head and neck anatomy, but pose significant challenges in regions where large interpatient variations are present. We show that significant changes are needed to autosegment thoracic and abdominal datasets by combining multi-atlas deformable registration with a level set-based local search. Segmentation is hierarchical, with a first stage detecting bulk organ location, and a sec...
Source: Journal of Applied Clinical Medical Physics - July 8, 2014 Category: Physics Source Type: research

Improved identification of multiple drugs of abuse and relative metabolites in urine samples using liquid chromatography/triple quadrupole mass spectrometry coupled with a library search.
CONCLUSIONS: The LC/QqQ-MS/MS method is a comprehensive assay in which tMRM and the product ion scan are combined in a single run by using a QqQ mass analyzer to simultaneously quantify amphetamine, ketamine, morphine, and their relative metabolites in urine. The proposed method can be applied in forensic science. Copyright © 2014 John Wiley & Sons, Ltd. PMID: 25156593 [PubMed - in process]
Source: Rapid Communications in Mass Spectrometry : RCM - September 1, 2014 Category: Chemistry Authors: Lin HR, Liao CC, Lin TC Tags: Rapid Commun Mass Spectrom Source Type: research

The search for biomarkers to direct antiangiogenic treatment in epithelial ovarian cancer.
Abstract Antiangiogenic agents have demonstrated improved progression-free survival in women with primary and recurrent epithelial ovarian cancer (EOC). Biomarkers that predict outcomes in patients treated with antiangiogenic agents are being investigated to rationally direct therapy for women most likely to benefit from these agents. Among the most promising plasma-based biomarkers are vascular endothelial growth factor (VEGF)-A, fibroblast growth factor, platelet-derived growth factor, angiopoietin-2, and VEGF receptor-2. While these biomarkers have been correlated with prognosis, they have not been shown to pre...
Source: Gynecologic Oncology - August 29, 2014 Category: Cancer & Oncology Authors: Secord AA, Nixon AB, Hurwitz HI Tags: Gynecol Oncol Source Type: research

Stable statistical representations facilitate visual search.
Observers represent the average properties of object ensembles even when they cannot identify individual elements. To investigate the functional role of ensemble statistics, we examined how modulating statistical stability affects visual search. We varied the mean and/or individual sizes of an array of Gabor patches while observers searched for a tilted target. In “stable” blocks, the mean and/or local sizes of the Gabors were constant over successive displays, whereas in “unstable” baseline blocks they changed from trial to trial. Although there was no relationship between the context and the spatial location of t...
Source: Journal of Experimental Psychology: Human Perception and Performance - July 21, 2014 Category: Psychiatry & Psychology Authors: Corbett, Jennifer E.; Melcher, David Source Type: research

Discovering intrinsic properties of human observers’ visual search and mathematical observers’ scanning
There is a lack of consensus in measuring observer performance in search tasks. To pursue a consensus, we set our goal to obtain metrics that are practical, meaningful, and predictive. We consider a metric practical if it can be implemented to measure human and computer observers’ ...
Source: Journal of the Optical Society of America A - October 21, 2014 Category: Physics Authors: Xin HeFrank SamuelsonRongping ZengBerkman Sahiner Source Type: research

Abstract 283: Biomarker search using gene expression databases in a phase III, controlled clinical trial of postoperative adjuvant chemotherapy for stage III colon cancer (acts-cc): Correlation between gene expression and DNA copy number
Background: The ACTS-CC trial is a randomized, controlled phase III study designed to validate the noninferiority of S-1 to UFT/LV as adjuvant chemotherapy for stage III colon cancer and rectosigmoid cancer. A prospective biomarker search was performed as an auxiliary study of the ACTS-CC trial, using formalin-fixed, paraffin-embedded (FFPE) specimens obtained from 892 patients. The gene expression levels of 5-FU metabolizing enzymes and folate metabolizing enzymes and alterations of genome-wide copy numbers in tumor have been reported (2012 and 2013 Annual Meetings of AACR). In the present study, we performed correlation ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Uetake, H., Ishikawa, T., Ishiguro, M., Matsui, S., Sugihara, K., ACTS-CC Study Group Tags: Clinical Research (Excluding Clinical Trials) Source Type: research

SCN1A Genetic Test for Dravet Syndrome (Severe Myoclonic Epilepsy of Infancy and its Clinical Subtypes) for use in the Diagnosis, Prognosis, Treatment and Management of Dravet Syndrome
Clinical Scenario Test for epilepsy syndromes associated with mutations in the SCN1A gene including the severe infantile onset epilepsies- typical Dravet syndrome (severe myoclonic epilepsy in infancy) and its borderline subtypes. Dravet syndrome typically presents in the first year of life with prolonged febrile and non-febrile, generalised clonic or hemiclonic epileptic seizures in children with no pre-existing developmental problems. Other seizure types including myoclonic, focal and atypical absence seizures appear between the ages of one and four years. The epilepsy is usually refractory to standard anti-epileptic med...
Source: PLOS Currents Evidence on Genomic Tests - April 25, 2013 Category: Genetics & Stem Cells Authors: sustenhouse Source Type: research

Dimethyl fumarate for multiple sclerosis.
CONCLUSIONS: There is moderate-quality evidence to support that dimethyl fumarate at a dose of 240 mg orally three times daily or twice daily reduces both the number of patients with a relapse and the annualised relapse rate over two years of treatment in comparison with placebo. However, the quality of the evidence to support the benefit in reducing the number of patients with disability worsening is low. There is no high-quality data available to evaluate the benefit on MRI outcomes. The common adverse effects such as flushing and gastrointestinal events are mild-to-moderate for most patients. Lymphopenia and leukopenia ...
Source: Cochrane Database of Systematic Reviews - April 22, 2015 Category: Journals (General) Authors: Xu Z, Zhang F, Sun F, Gu K, Dong S, He D Tags: Cochrane Database Syst Rev Source Type: research

Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search
Publication date: 1 February 2016 Source:Food Chemistry, Volume 192 Author(s): Tingting Li , Jingjing Cao , Zhen Li , Xian Wang , Pingli He Broad screening and identification of β-agonists in feed, serum, urine, muscle and liver samples was achieved in a quick and highly sensitive manner using ultra high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) combined with a spectra library search. Solid-phase extraction technology was employed for sample purification and enrichment. After extraction and purification, the samples were analyzed using a Q-Orbitrap hi...
Source: Food Chemistry - July 10, 2015 Category: Food Science Source Type: research

Search for the associated production of the Higgs boson with a top quark pair in multilepton final states with the ATLAS detector
Publication date: 7 October 2015 Source:Physics Letters B, Volume 749 Author(s): ATLAS CollaborationG.AadB.AbbottJ.AbdallahO.AbdinovR.AbenM.AbolinsO.S.AbouZeidH.AbramowiczH.AbreuR.AbreuY.AbulaitiB.S.AcharyaL.AdamczykD.L.AdamsJ.AdelmanS.AdomeitT.AdyeA.A.AffolderT.Agatonovic-JovinJ.A.Aguilar-SaavedraS.P.AhlenF.AhmadovG.AielliH.AkerstedtT.P.A.ÅkessonG.AkimotoA.V.AkimovG.L.AlberghiJ.AlbertS.AlbrandM.J.Alconada VerziniM.AleksaI.N.AleksandrovC.AlexaG.AlexanderT.AlexopoulosM.AlhroobG.AlimontiL.AlioJ.AlisonS.P.AlkireB.M.M.AllbrookeP.P.AllportA.AloisioA.AlonsoF.AlonsoC.AlpigianiA.AltheimerB.Alvarez GonzalezD.Álvarez PiquerasM.G...
Source: Physics Letters B - August 29, 2015 Category: Physics Source Type: research