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Nutrition: Vitamins
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Secretory Production of 7-dehydrocholesterol by Engineered Saccharomyces cerevisiae
CONCLUSION: Selective secretion of different sterol intermediates was characterized in sterol over-produced strain and the extracellular export of 7-DHC developed in present study significantly improved the cell biosynthetic capacity, which offered a novel modification idea for 7-DHC de novo biosynthesis by S. cerevisiae cell factory. This article is protected by copyright. All rights reserved.PMID:37688450 | DOI:10.1002/biot.202300056
Source: Biotechnology Journal - September 9, 2023 Category: Biotechnology Authors: Xia Ke Zi-Hao Pan Hong-Fei Du Yi Shen Ji-Dong Shen Zhi-Qiang Liu Yu-Guo Zheng Source Type: research
Redefine the role of D- α-Tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein, multidrug resistance protein 1, and breast cancer resistance protein mediated cancer multidrug resistance
Eur J Pharm Sci. 2023 Sep 7:106579. doi: 10.1016/j.ejps.2023.106579. Online ahead of print.ABSTRACTCancer drug resistance is an ever-changing problem that most patients need to face in their later stages of treatment, especially the multidrug resistant (MDR) type. The drug efflux transporters, including P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP), play the crucial roles in this sophisticated battle. In recent decades, researchers try to find potential inhibitors to impede the drug efflux function of above transporters. D-α-Tocopheryl polyethylene glycol 1000 su...
Source: European Journal of Pharmaceutical Sciences - September 9, 2023 Category: Drugs & Pharmacology Authors: Jing-Yi Chen Chieh-Ju Sung Ssu-Chi Chen Yi-Ping Hsiang Yung-Chia Hsu Yu-Ning Teng Source Type: research
Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis
Nutrients. 2023 Aug 29;15(17):3775. doi: 10.3390/nu15173775.ABSTRACTAcute leukemia commonly occurs in young children with peak incidence at the age of 2-5 years. However, the etiology is still unclear and many preventable risk factors still deserve to be reviewed. The focus of this systematic review and meta-analysis is to summarize the evidence concerning early life nourishment (breastfeeding, early life diet), neonatal vitamin K administration and the risk of acute leukemia. All epidemiological studies published up to June 2023 and assessing diet-related risk factors for childhood acute leukemia were identified in two el...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Ambroise Kouame Kintossou Jessica Blanco-Lopez Isabel Iguacel Silvia Pisanu Claudia Choma Bettega Almeida Eva Steliarova-Foucher Ciska Sierens Marc J Gunter Elena J Ladas Ronald D Barr Koen Van Herck Zisis Kozlakidis Inge Huybrechts Source Type: research
Adrenomedullin, transcriptionally regulated by vitamin D receptors, alleviates atherosclerosis in mice through suppressing AMPK-mediated endothelial ferroptosis
CONCLUSION: VDR inhibits ox-LDL-induced endothelial dysfunction and ferroptosis by regulating ADM transcription and acting on AMPK signaling pathway. Overexpression of VDR in Apoe-/- mice reduced lipid deposition and plaque area in the thoracic aorta of atherosclerotic mice.PMID:37688783 | DOI:10.1002/tox.23958
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Yanchao Hu Xu Gu Yan Zhang Weidong Ma Lijun Sun Congxia Wang Bincheng Ren Source Type: research
Secretory Production of 7-dehydrocholesterol by Engineered Saccharomyces cerevisiae
CONCLUSION: Selective secretion of different sterol intermediates was characterized in sterol over-produced strain and the extracellular export of 7-DHC developed in present study significantly improved the cell biosynthetic capacity, which offered a novel modification idea for 7-DHC de novo biosynthesis by S. cerevisiae cell factory. This article is protected by copyright. All rights reserved.PMID:37688450 | DOI:10.1002/biot.202300056
Source: Biotechnology Journal - September 9, 2023 Category: Biotechnology Authors: Xia Ke Zi-Hao Pan Hong-Fei Du Yi Shen Ji-Dong Shen Zhi-Qiang Liu Yu-Guo Zheng Source Type: research
Novel Insights into the Molecular Mechanisms of Atherosclerosis
Int J Mol Sci. 2023 Aug 30;24(17):13434. doi: 10.3390/ijms241713434.ABSTRACTAtherosclerosis is one of the most fatal diseases in the world. The associated thickening of the arterial wall and its background and consequences make it a very composite disease entity with many mechanisms that lead to its creation. It is an active process, and scientists from various branches are engaged in research, including molecular biologists, cardiologists, and immunologists. This review summarizes the available information on the pathophysiological implications of atherosclerosis, focusing on endothelium dysfunction, inflammatory factors,...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Armanda Wojtasi ńska Weronika Fr ąk Wiktoria Lisi ńska Natalia Sapeda Ewelina M łynarska Jacek Rysz Beata Franczyk Source Type: research
How vitamins act as novel agents for ameliorating diabetic peripheral neuropathy: A comprehensive overview
Ageing Res Rev. 2023 Sep 7:102064. doi: 10.1016/j.arr.2023.102064. Online ahead of print.ABSTRACTDiabetic peripheral neuropathy (DPN) is a pervasive and incapacitating sequela of diabetes, affecting a significant proportion of those diagnosed with the disease, yet an effective treatment remains elusive. Vitamins have been extensively studied, emerging as a promising target for diagnosing and treating various systemic diseases, but their role in DPN is not known. This review collates and synthesizes knowledge regarding the interplay between vitamins and DPN, drawing on bibliographies from prior studies and relevant articles...
Source: Ageing Research Reviews - September 9, 2023 Category: Genetics & Stem Cells Authors: Kezheng Li Yinuo Chen Jiali Xie Weiwei Cai Chunyang Pang Can Cui Yu Huan Binbin Deng Source Type: research
Redefine the role of D- α-Tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein, multidrug resistance protein 1, and breast cancer resistance protein mediated cancer multidrug resistance
Eur J Pharm Sci. 2023 Sep 7:106579. doi: 10.1016/j.ejps.2023.106579. Online ahead of print.ABSTRACTCancer drug resistance is an ever-changing problem that most patients need to face in their later stages of treatment, especially the multidrug resistant (MDR) type. The drug efflux transporters, including P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP), play the crucial roles in this sophisticated battle. In recent decades, researchers try to find potential inhibitors to impede the drug efflux function of above transporters. D-α-Tocopheryl polyethylene glycol 1000 su...
Source: European Journal of Pharmaceutical Sciences - September 9, 2023 Category: Drugs & Pharmacology Authors: Jing-Yi Chen Chieh-Ju Sung Ssu-Chi Chen Yi-Ping Hsiang Yung-Chia Hsu Yu-Ning Teng Source Type: research
How vitamins act as novel agents for ameliorating diabetic peripheral neuropathy: A comprehensive overview
Ageing Res Rev. 2023 Sep 7;91:102064. doi: 10.1016/j.arr.2023.102064. Online ahead of print.ABSTRACTDiabetic peripheral neuropathy (DPN) is a pervasive and incapacitating sequela of diabetes, affecting a significant proportion of those diagnosed with the disease, yet an effective treatment remains elusive. Vitamins have been extensively studied, emerging as a promising target for diagnosing and treating various systemic diseases, but their role in DPN is not known. This review collates and synthesizes knowledge regarding the interplay between vitamins and DPN, drawing on bibliographies from prior studies and relevant artic...
Source: Ageing Research Reviews - September 9, 2023 Category: Genetics & Stem Cells Authors: Kezheng Li Yinuo Chen Jiali Xie Weiwei Cai Chunyang Pang Can Cui Yu Huan Binbin Deng Source Type: research
Redefine the role of D- α-Tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein, multidrug resistance protein 1, and breast cancer resistance protein mediated cancer multidrug resistance
Eur J Pharm Sci. 2023 Sep 7:106579. doi: 10.1016/j.ejps.2023.106579. Online ahead of print.ABSTRACTCancer drug resistance is an ever-changing problem that most patients need to face in their later stages of treatment, especially the multidrug resistant (MDR) type. The drug efflux transporters, including P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), and breast cancer resistance protein (BCRP), play the crucial roles in this sophisticated battle. In recent decades, researchers try to find potential inhibitors to impede the drug efflux function of above transporters. D-α-Tocopheryl polyethylene glycol 1000 su...
Source: European Journal of Pharmaceutical Sciences - September 9, 2023 Category: Drugs & Pharmacology Authors: Jing-Yi Chen Chieh-Ju Sung Ssu-Chi Chen Yi-Ping Hsiang Yung-Chia Hsu Yu-Ning Teng Source Type: research
Low-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation
Korean J Intern Med. 2023 Sep;38(5):583-594. doi: 10.3904/kjim.2023.035. Epub 2023 Sep 1.ABSTRACTIn the last decade, non-vitamin K antagonist oral anticoagulants (NOACs), a new generation of OACs, were introduced to prevent thromboembolism in patients with atrial fibrillation. Although vitamin K-dependent anticoagulants have long been used as OACs, their inherent disadvantage of considerable bleeding complications has limited their use. NOACs demonstrate similar or superior clinical outcomes to those of warfarin. Although strict dose reduction criteria are recommended for NOACs, low-dose NOACs are frequently utilized, espe...
Source: The Korean Journal of Internal Medicine - September 8, 2023 Category: Internal Medicine Authors: Ki Hong Lee Hyung Wook Park Source Type: research
Role of vitamin D in management of diabetes and unresolved cardiovascular diseases
CONCLUSION: In this review, we present the most recent research on the effects of Vitamin D therapy on various cardiovascular diseases and diabetes, and explain the underlying mechanisms.PMID:37680158 | DOI:10.2174/1573399820666230901151019
Source: Current Diabetes Reviews - September 8, 2023 Category: Endocrinology Authors: Prabhat Kumar Upadhyay Navneet Thakur Vishal Kumar Vishwakarma Ritesh Kumar Srivastav Tarique Mahmood Ansari Source Type: research
Low-dose non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation
Korean J Intern Med. 2023 Sep;38(5):583-594. doi: 10.3904/kjim.2023.035. Epub 2023 Sep 1.ABSTRACTIn the last decade, non-vitamin K antagonist oral anticoagulants (NOACs), a new generation of OACs, were introduced to prevent thromboembolism in patients with atrial fibrillation. Although vitamin K-dependent anticoagulants have long been used as OACs, their inherent disadvantage of considerable bleeding complications has limited their use. NOACs demonstrate similar or superior clinical outcomes to those of warfarin. Although strict dose reduction criteria are recommended for NOACs, low-dose NOACs are frequently utilized, espe...
Source: The Korean Journal of Internal Medicine - September 8, 2023 Category: Internal Medicine Authors: Ki Hong Lee Hyung Wook Park Source Type: research
