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Nutrition: Herbs
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Total 24253 results found since Jan 2013.
Co-administration of Thymoquinone and Propolis in Liposomal Formulations as a Potential Approach for Treatment of Acetic Acid-Induced Ulcerative Colitis: Physiological and Histopathological Analysis
This study is aimed at assessing the potential of liposomal formulations of TQ and Egyptian PP in combination therapy on improving their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects. Clinical, biochemical, and histological evaluations of colonic mucosal damage and inflammation were evaluated. The results exhibited a significant increase in tissue MDA, TNFα, and nitrite levels with activation of caspase-3 in the acetic acid-induced colitis group, which is predominantly downregulated in the treatment groups. The prepared formulations of TQ and PP rev...
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Eman Alaaeldin Hesham Refaat Entesar Ali Saber Neven Makram Aziz Nehad M Reda Abdel-Maqsoud Mohammed Mustafa Abd El Aleem Maha Yehia Kamel Fatma M Mady Source Type: research
Physiological and metabolomic analyses reveal that Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoparticles ameliorate cadmium and arsenic toxicity in Panax notoginseng
This study provides insights into using nanoparticles to improve potential active ingredients of medicinal plants in metal (loid)-contaminated areas.PMID:37726032 | DOI:10.1016/j.envpol.2023.122578
Source: Environmental Pollution - September 19, 2023 Category: Environmental Health Authors: Tianquan Lu Xiaoning Wang Xianliang Cui Jifang Li Jin Xu Peng Xu Jinpeng Wan Source Type: research
Study on the Therapeutic Effect of Coconut Oil Extracts as An Alternative Medicinal Plant in < em > Cryptosporidium < /em > Infected Mice
CONCLUSION: The present study has opened fresh avenues for development of natural therapy like coconut oil extracts, which have a potential therapeutic efficacy against Cryptosporidiosis. That was confirmed by different methodologies, parasitological examination, histopathological examination, and immunohistochemical assays. It paves the way for being a promising anti-parasitic agent for infection eradication. However, further studies are still required to gain more knowledge about different coconut extracts in order to reach the best treatment efficacy.PMID:37724361 | DOI:10.4274/tpd.galenos.2023.22932
Source: Turkish Society for Parasitology - September 19, 2023 Category: Parasitology Authors: Heba M El Naggar Basant O Mohammed Tarek Aboushousha Hagar F Abdelmaksoud Source Type: research
The role of NLRP3 inflammasome in sepsis: A potential therapeutic target
Int Immunopharmacol. 2023 Feb;115:109697. doi: 10.1016/j.intimp.2023.109697. Epub 2023 Jan 20.ABSTRACTSepsis is the host immune imbalance following infection and leads to organ dysfunction, with highly complicated pathophysiology. To date, sepsis still lacks effective therapies with high mortality rates. Recently, numerous studies have highlighted the potential of NLRP3 inflammasome as a therapeutic target during sepsis. NLRP3 inflammasome is a protein complex that could induce the activation of caspase-1 and the following release of pro-inflammatory cytokines such as IL-1β and IL-18. It was demonstrated that NLRP3 inflam...
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Wenfang He Haiyun Dong Chenfang Wu Yanjun Zhong Jinxiu Li Source Type: research
Anti-Cancer Effect of < em > Dorema Ammoniacum Gum < /em > by Targeting Metabolic Reprogramming by Regulating < em > APC, P53, KRAS < /em > Gene Expression in HT-29 Human Colon Cancer Cells
CONCLUSION: This study's results indicate that the dichloromethane solvent of Dorema ammoniacum gum exhibits its antitumor properties by altering the expression of genes involved in HT-29 cells and the consequent change in downstream metabolic reprogramming.PMID:37724146 | PMC:PMC10505474 | DOI:10.52547/rbmb.12.1.127
Source: Mol Biol Cell - September 19, 2023 Category: Molecular Biology Authors: Elham Ghodousi-Dehnavi Mohammad Arjmand Ziba Akbari Mansour Aminzadeh Reza Haji Hosseini Source Type: research
Co-administration of Thymoquinone and Propolis in Liposomal Formulations as a Potential Approach for Treatment of Acetic Acid-Induced Ulcerative Colitis: Physiological and Histopathological Analysis
This study is aimed at assessing the potential of liposomal formulations of TQ and Egyptian PP in combination therapy on improving their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects. Clinical, biochemical, and histological evaluations of colonic mucosal damage and inflammation were evaluated. The results exhibited a significant increase in tissue MDA, TNFα, and nitrite levels with activation of caspase-3 in the acetic acid-induced colitis group, which is predominantly downregulated in the treatment groups. The prepared formulations of TQ and PP rev...
Source: AAPS PharmSciTech - September 19, 2023 Category: Drugs & Pharmacology Authors: Eman Alaaeldin Hesham Refaat Entesar Ali Saber Neven Makram Aziz Nehad M Reda Abdel-Maqsoud Mohammed Mustafa Abd El Aleem Maha Yehia Kamel Fatma M Mady Source Type: research
Identification of quality markers for < em > Cyanotis arachnoidea < /em > and analysis of its physiological mechanism based on chemical pattern recognition, network pharmacology, and experimental validation
In this study, ultra-high-performance liquid chromatography (UHPLC) fingerprint combined with chemical pattern recognition were performed, and four differential components were screened out as quality markers, including 20-Hydroxyecdysone, 3-O-acetyl-20-hydroxyecdysone, Ajugasterone C, and 2-O-acetyl-20-hydroxyecdysone. Network pharmacology analysis revealed 107 therapeutic target genes of Cyanotis arachnoidea in DM treatment, and the key targets were Akt1, TNF, IL-6, MAPK3, and JUN. The hypoglycemic mode of action of Cyanotis arachnoidea may be mediated by tumor necrosis factor (TNF) signaling, cancer, insulin resistance,...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Jingnan Hu Yu Feng Baolin Li Fengxia Wang Qi Qian Wei Tian Liying Niu Xinguo Wang Source Type: research
Phenylethanoid glycosides derived from Cistanche deserticola promote neurological functions and the proliferation of neural stem cells for improving ischemic stroke
This study aims to investigate whether PhGs treatment improves the stroke and its potential mechanisms. Adult male C57BL/6 J mice were administrated PhGs once daily for 7 days after MCAO surgery. The neurological score, and catwalk were evaluated on Day 1, 3 and 7 after ischemic stroke. Furthermore, triphenyl-2,3,5-tetrazoliumchloride (TTC) and hematoxylin-eosin (H&E) staining were used for evaluating the infarct volume and neuronal restoration. The effects of PhGs on NSCs proliferation were investigated in vitro and in vivo. Western blot was used to detect the proteins of Wnt/β-catenin signaling pathway. This study f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 18, 2023 Category: Drugs & Pharmacology Authors: Jingjing Liu Yanyan Wang Qinyuan Li Tao Liu Xu Liu Han Zhang Zhifei Fu Yifan Dai Haiyuan Yang Yu Wang Ying Wang Source Type: research
Exploration of the anti-diabetic potential of hydro-ethanolic leaf extract of Koenigia polystachya L.: an edible wild plant from Northeastern India
CONCLUSIONS: Based on the outcomes of this study, the HELeKP-treated rats have significant free radical scavenging and anti-diabetic potential. Therefore, it can be recommended as a beneficial functional vegetable for consumption.PMID:37723570 | PMC:PMC10506326 | DOI:10.1186/s42826-023-00174-3
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Alokali Kiba Dipankar Saha Bhrigu Kumar Das Source Type: research
Physiological Activities of the King of Bitters (Andrographis paniculata): A Review
Cureus. 2023 Aug 15;15(8):e43515. doi: 10.7759/cureus.43515. eCollection 2023 Aug.ABSTRACTAndrographis paniculata is a versatile tropical plant that is considered to have many essential medicinal properties. Plants can combine an open scope of the natural active compound that carries out significant organic roles and are used as pharmaceuticals. Herbal plants have therapeutic and prophylactic properties, so scientists are concentrating on developing crude drugs to make people's lives easier. Medicinal plants are the primary sources of therapeutic remedies for various ailments. These potential medicinal effects are primaril...
Source: Herpes - September 18, 2023 Category: Infectious Diseases Authors: Sweza Bhaisare Swanand Pathak Vaishnavi V Ajankar Source Type: research
< em > In-vitro < /em > anticancer activity of < em > Rauvolfia tetraphylla < /em > extract on mcf-7 breast cancer cell lines
Bioinformation. 2023 Jan 31;19(1):43-47. doi: 10.6026/97320630019043. eCollection 2023.ABSTRACTThe medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast can...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Abraham Sabu Selvaraj J Gayatridevi R Dilipan E Source Type: research
