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Therapy: Dialysis
Nutrition: Sodium
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Total 466 results found since Jan 2013.
Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
CONCLUSION: Our data suggest a novel electrolyte-based mechanism of immunosuppression in malignant ascites of patients with peritoneal carcinomatosis. We show for the first time that the immunosuppression of NK cytotoxicity in coculture assays is correlated to patient poor survival. Therapeutic application of sodium channel inhibitors may provide new means for restoring immune cell activity in ascites or similar electrolyte imbalanced environments.PMID:37684704 | DOI:10.1186/s13046-023-02798-8
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Antonio Hrvat Mathias Schmidt Bernd Wagner Denise Zwanziger Rainer Kimmig Lothar Volbracht Sven Brandau Nina Mallmann-Gottschalk Source Type: research
Sodium First Approach, to Reset Our Mind for Improving Management of Sodium, Water, Volume and Pressure in Hemodialysis Patients, and to Reduce Cardiovascular Burden and Improve Outcomes
Front Nephrol. 2022 Jul 7;2:935388. doi: 10.3389/fneph.2022.935388. eCollection 2022.ABSTRACTNew physiologic findings related to sodium homeostasis and pathophysiologic associations require a new vision for sodium, fluid and blood pressure management in dialysis-dependent chronic kidney disease patients. The traditional dry weight probing approach that has prevailed for many years must be reviewed in light of these findings and enriched by availability of new tools for monitoring and handling sodium and water imbalances. A comprehensive and integrated approach is needed to improve further cardiac health in hemodialysis (HD...
Source: Atherosclerosis - September 7, 2023 Category: Cardiology Authors: Bernard Canaud Jeroen Kooman Andreas Maierhofer Jochen Raimann Jens Titze Peter Kotanko Source Type: research
Cardiorenal Biomarkers, Canagliflozin, and Outcomes in Diabetic Kidney Disease: The CREDENCE Trial
CONCLUSIONS: Multiple cardiorenal stress biomarkers are strongly prognostic in people with type 2 diabetes and albuminuria. Canagliflozin modestly reduced the longitudinal trajectory of rise in each biomarker. Change in the biomarker level in addition to the baseline level augments the primary outcome prediction.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT02065791.PMID:37603600 | DOI:10.1161/CIRCULATIONAHA.123.065251
Source: Circulation - August 21, 2023 Category: Cardiology Authors: James L Januzzi Reza Mohebi Yuxi Liu Naveed Sattar Hiddo J L Heerspink Eshetu Tefera Muthiah Vaduganathan Javed Butler Yshai Yavin Jingwei Li Carol A Pollock Vlado Perkovic Bruce Neal Michael K Hansen Source Type: research
High osmol gap hyponatremia caused by icodextrin: A case series report
Am J Nephrol. 2023 Aug 14. doi: 10.1159/000533600. Online ahead of print.ABSTRACTRecently hyperosmolar hyponatremia following excessive off-label use of two exchanges of 2L icodextrin daily during peritoneal dialysis (PD) was reported. We encountered a cluster of three cases of PD patients who developed hyperosmolar hyponatremia during on-label use of icodextrin. This appeared to be due to absorption of icodextrin, since, after stopping icodextrin, the serum sodium level and osmol gap returned to normal, while a rechallenge again resulted in hyperosmolar hyponatremia. We excluded higher than usual concentrations of specifi...
Source: American Journal of Nephrology - August 14, 2023 Category: Urology & Nephrology Authors: Caroline W H de Fijter Joanna Stachowska-Pietka Jacek Waniewski Bengt Lindholm Source Type: research
Effects of intravenous sodium thiosulfate on vascular calcification in dialysis patients with end-stage renal disease: a systematic review and meta-analysis
CONCLUSIONS: Intravenous STS may slow down the progression of vascular calcification and ameliorate arterial stiffness in dialysis patients. Reliably defining the efficacy and safety of intravenous STS in attenuating the progression of vascular calcification requires a high-quality trial with a large sample size.PMID:37526956 | DOI:10.5830/CVJA-2023-020
Source: Cardiovascular Journal of Africa - August 1, 2023 Category: Cardiology Authors: Yu-Huan Song AiBing Ning Na Guo Ying Yang Fei Tang Na Zhao Jun Hu Hong Wu Ting Peng Yue-Fei Xiao Guang-Yan Cai Source Type: research
Achieving Good Metabolic Control Without Weight Gain with the Systematic Use of GLP-1-RAs and SGLT-2 Inhibitors in Type 2 Diabetes: A Machine-Learning Projection Using Data from Clinical Practice
Clin Ther. 2023 Jul 12:S0149-2918(23)00201-1. doi: 10.1016/j.clinthera.2023.06.006. Online ahead of print.ABSTRACTPURPOSE: Recently, the 2022 American Diabetes Association and European Association for the Study of Diabetes (ADA-EASD) consensus report stressed the importance of weight control in the management of patients with type 2 diabetes; weight control should be a primary target of therapy. This retrospective analysis evaluated, through an artificial-intelligence (AI) projection of data from the AMD Annals database-a huge collection of most Italian diabetology medical records covering 15 years (2005-2019)-the potentia...
Source: Clinical Therapeutics - July 14, 2023 Category: Drugs & Pharmacology Authors: Carlo Bruno Giorda Antonio Rossi Fabio Baccetti Rita Zilich Francesco Romeo Nreu Besmir Graziano Di Cianni Giacomo Guaita Lelio Morviducci Marco Muselli Alessandro Ozzello Federico Pisani Paola Ponzani Pierluigi Santin Damiano Verda Nicoletta Musacchio Source Type: research
DIALIZE China: A Phase IIIb, Randomized, Placebo-Controlled Study to Reduce Predialysis Hyperkalemia With Sodium Zirconium Cyclosilicate in Chinese Patients
Clin Ther. 2023 Jun 27:S0149-2918(23)00153-4. doi: 10.1016/j.clinthera.2023.04.014. Online ahead of print.ABSTRACTPURPOSE: The DIALIZE China study (Reduce Incidence of Pre-Dialysis Hyperkalaemia With Sodium Zirconium Cyclosilicate in Chinese Subjects) (NCT04217590) evaluated sodium zirconium cyclosilicate (SZC) for the management of hyperkalemia in Chinese patients undergoing hemodialysis.METHODS: In the double-blind, Phase IIIb DIALIZE China study, Chinese adults with kidney failure and predialysis hyperkalemia (predialysis serum potassium [sK+] concentration >5.4 mmol/L after the long interdialytic interval [LIDI] and...
Source: Clinical Therapeutics - June 29, 2023 Category: Drugs & Pharmacology Authors: Zhaohui Ni Renhua Lu Xudong Xu Xueyan Bian Zhihong Zhou Junwei Yang Qun Luo Menghua Chen Chaosheng Chen Xiuli Sun Lei Yu Qiang He Hong Jiang Weijie Yuan Yi Li Rong Zhou Jianqin Wang Xinzhou Zhang Li Zuo Xiangwen Meng Zhiren Chang June Zhao Peter Wessman P Source Type: research
Hemodialysis complications: focus on pruritus and vascular calcifications
Nephrol Ther. 2023 Jun 29;19(S1):6-14. doi: 10.1684/ndt.2023.26.ABSTRACTChronic kidney disease-associated pruritus (CKD-aP) is a frequent complication, with an estimated prevalence of 24-37% in patients treated with hemodialysis. Its pathophysiology is complex and includes four interrelated axes: accumulation of uremic toxins, peripheral neuropathy, an imbalance in the opioid receptors balance, and abnormal activation of immune cells. This symptom which is associated with impaired quality of life is underestimated by caregivers and underreported by patients. Management is not uniformly codified. It includes the use of skin...
Source: Nephrologie and Therapeutique - June 29, 2023 Category: Urology & Nephrology Authors: Antoine Lanot Pablo Urena Source Type: research
DIALIZE China: A Phase IIIb, Randomized, Placebo-Controlled Study to Reduce Predialysis Hyperkalemia With Sodium Zirconium Cyclosilicate in Chinese Patients
Clin Ther. 2023 Jun 27:S0149-2918(23)00153-4. doi: 10.1016/j.clinthera.2023.04.014. Online ahead of print.ABSTRACTPURPOSE: The DIALIZE China study (Reduce Incidence of Pre-Dialysis Hyperkalaemia With Sodium Zirconium Cyclosilicate in Chinese Subjects) (NCT04217590) evaluated sodium zirconium cyclosilicate (SZC) for the management of hyperkalemia in Chinese patients undergoing hemodialysis.METHODS: In the double-blind, Phase IIIb DIALIZE China study, Chinese adults with kidney failure and predialysis hyperkalemia (predialysis serum potassium [sK+] concentration >5.4 mmol/L after the long interdialytic interval [LIDI] and...
Source: Clinical Therapeutics - June 29, 2023 Category: Drugs & Pharmacology Authors: Zhaohui Ni Renhua Lu Xudong Xu Xueyan Bian Zhihong Zhou Junwei Yang Qun Luo Menghua Chen Chaosheng Chen Xiuli Sun Lei Yu Qiang He Hong Jiang Weijie Yuan Yi Li Rong Zhou Jianqin Wang Xinzhou Zhang Li Zuo Xiangwen Meng Zhiren Chang June Zhao Peter Wessman P Source Type: research
Hemodialysis complications: focus on pruritus and vascular calcifications
Nephrol Ther. 2023 Jun 29;19(S1):6-14. doi: 10.1684/ndt.2023.26.ABSTRACTChronic kidney disease-associated pruritus (CKD-aP) is a frequent complication, with an estimated prevalence of 24-37% in patients treated with hemodialysis. Its pathophysiology is complex and includes four interrelated axes: accumulation of uremic toxins, peripheral neuropathy, an imbalance in the opioid receptors balance, and abnormal activation of immune cells. This symptom which is associated with impaired quality of life is underestimated by caregivers and underreported by patients. Management is not uniformly codified. It includes the use of skin...
Source: Nephrologie and Therapeutique - June 29, 2023 Category: Urology & Nephrology Authors: Antoine Lanot Pablo Urena Source Type: research
