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Early prediction of growth patterns after pediatric kidney transplantation based on height-related single-nucleotide polymorphisms
CONCLUSIONS: A model with good performance for predicting post-transplant growth patterns in children based on SNPs and clinical variables was constructed and validated using machine learning algorithms. The model is expected to guide clinicians in the management of children after renal transplantation, including the use of growth hormone, glucocorticoid withdrawal, and nutritional supplementation, to alleviate growth retardation in children with ESRD.PMID:37672508 | DOI:10.1097/CM9.0000000000002828
Source: Chinese Medical Journal - September 6, 2023 Category: General Medicine Authors: Yi Feng Yonghua Feng Mingyao Hu Hongen Xu Zhigang Wang Shicheng Xu Yongchuang Yan Chenghao Feng Zhou Li Guiwen Feng Wenjun Shang Source Type: research

Mobile Technology to Monitor and Support Health and Well-Being: Qualitative Study of Perspectives and Design Suggestions From Patients Undergoing Hematopoietic Cell Transplantation
CONCLUSIONS: Participants openly expressed their eagerness to participate in research studies that foster connection and positive relationships with their caregivers as well as with other HCT patients. They emphasized the significance of having access to nutritional support or guidance and highlighted the potential benefits of using mobile technology to enhance these collective efforts.TRIAL REGISTRATION: ClinicalTrials.gov NCT04094844; https://clinicaltrials.gov/study/NCT04094844.INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.2196/19288.PMID:37651172 | DOI:10.2196/49806
Source: Cell Research - August 31, 2023 Category: Cytology Authors: Cinzia Caparso Gwynne Ozkan Maxwell Kluge Humza Salim Aidan Khaghany Amanda Blok Sung Won Choi Source Type: research

Interventions for fatigue in people with kidney failure requiring dialysis
CONCLUSIONS: Exercise, aromatherapy, massage and acupressure may improve fatigue compared to placebo, standard care or no intervention. Pharmacological and other non-pharmacological interventions had uncertain effects on fatigue or fatigue-related outcomes in people receiving dialysis. Future adequately powered, high-quality studies are likely to change the estimated effects of interventions for fatigue and fatigue-related outcomes in people receiving dialysis.PMID:37651553 | DOI:10.1002/14651858.CD013074.pub2
Source: Cochrane Database of Systematic Reviews - August 31, 2023 Category: General Medicine Authors: Patrizia Natale Angela Ju Giovanni Fm Strippoli Jonathan C Craig Valeria M Saglimbene Mark L Unruh Giovanni Stallone Allison Jaure Source Type: research

Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Gut-derived metabolites mediating cognitive development in 5-year-old children: early-life transplant in mice has lasting effects throughout adulthood
Brain Behav Immun. 2023 Aug 7:S0889-1591(23)00232-5. doi: 10.1016/j.bbi.2023.08.009. Online ahead of print.ABSTRACTThe gut microbiota has been causally linked to cognitive development. We aimed to identify metabolites mediating its effect on cognitive development, and foods or nutrients related to most promising metabolites. Faeces from 5-year-old children (DORIAN-PISAC cohort, including 90 general population families with infants, 42/48 females/males, born in 2011-2014) were transplanted (FMT) into C57BL/6 germ-free mice. Children and recipient mice were stratified by cognitive phenotype, or based on protective metabolite...
Source: Brain, Behavior, and Immunity - August 9, 2023 Category: Neurology Authors: Maria Angela Guzzardi Federica La Rosa Federico Granziera Daniele Panetta Mercedes Pardo-Tendero Monica Barone Silvia Turroni Francesco Faita Claudia Kusmic Patrizia Brigidi Daniel Monleon Patricia Iozzo Source Type: research

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Central venous catheter safety in pediatric patients with intestinal failure
Nutr Clin Pract. 2023 Aug 3. doi: 10.1002/ncp.11047. Online ahead of print.ABSTRACTChildren with intestinal failure (IF) require long-term central venous access to provide life-sustaining parenteral nutrition. Mechanical, thrombotic, and infectious complications are potentially life-threatening and may necessitate central venous catheter (CVC) replacement. Repeated central line replacements may lead to a loss of vascular access sites and increases risk for intestinal transplantation. Children with IF face unique challenges for CVC safety given their young age, altered anatomy, and increased risk of thrombosis and infection...
Source: Nutrition in Clinical Practice - August 4, 2023 Category: Nutrition Authors: Rachel Warsco Smith Melissa Pettini Rachel Gulden Danielle Wendel Source Type: research

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