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By KIM BELLARD I didn’t write about ChatGPT when it was first introduced a month ago because, well, it seemed like everyone else was. I didn’t play with it to see what it could do.  I didn’t want it to write any poems. I didn’t have any AP tests I wanted it to pass. And, for all you know, I’m not using it to write this. But when The New York Times reports that Google sees ChatGPT as a “Code Red” for its search business, that got my attention. A few months ago I wrote about how Google saw TikTok as an existential threat to its business, estimating that 40% of young people used it for searches. It wa...
Source: The Health Care Blog - December 28, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI ChatGPT Kim Bellard Source Type: blogs

Rescuers Search for Survivors after Brazil Dam Collapse
BRUMADINHO, Brazil (AP) — Firefighters on Monday carefully moved over treacherous mud, sometimes walking, sometimes crawling, in search of survivors or bodies, four days after a dam collapse that buried mine buildings and surrounding neighborhoods with iron ore waste. The confirmed death toll rose to 58, with up to 300 people still missing, authorities said. In an ominous sign, nobody was recovered alive Sunday, a stark difference from the first two days of the disaster, when helicopters were whisking people from the mud. The slow speed of search efforts was due to the treacherous sea of reddish-brown mud that surged out...
Source: JEMS: Journal of Emergency Medical Services News - January 28, 2019 Category: Emergency Medicine Tags: International Major Incidents News Source Type: news

Real-time geotracking and cataloging of mass casualty incident markers in a search and rescue training simulation: Pilot study.
CONCLUSIONS: Panacea generated the COP in real-time compared to a delay with Iron Sights while maintaining the same location precision and marker accuracy. This pilot trial successfully demonstrated the ability to provide real-time actionable intelligence to incident commanders during mass casualty search and rescue missions. Larger field trials are recommended to refine the system and broaden its capabilities. PMID: 31637689 [PubMed - in process]
Source: American Journal of Disaster Medicine - October 24, 2019 Category: International Medicine & Public Health Tags: Am J Disaster Med Source Type: research

Why I Wouldn ’ t Take Google ’ s Depression Test
At the end of August, Google decided to make available directly on its site (through a “knowledge panel”) the ability to take a depression screening quiz. We know a thing or two about online depression screening quizzes, because I put one of the first interactive depression screening quizzes online back in 1996, long before Google even existed. Here’s the thing… Depression screening tests — like the PHQ-9 that Google is now offering on its website — are super helpful tools to give a person a little more insight into the possibility of having a serious mental illness. The problem with Goo...
Source: World of Psychology - September 1, 2017 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: Depression Disorders General Policy and Advocacy Technology depression quiz Depression Test Dr. Google google health search Source Type: blogs

Comparative Biology and the Search for Longevity-Associated Genes
One of the primary goals of the aging research community is to determine exactly how aging progresses from moment to moment at the detailed level of genes and cellular biochemistry. This is a sizable task, not particularly driven by any application in medicine, and will be only incrementally more advanced by the time that rejuvenation therapies based on the SENS model of damage repair are a going concern. The big advantage of the damage repair approach is that it bypasses the need to understand exactly how aging progresses: since the root cause damage is known, it is possible to make progress immediately and quantify the r...
Source: Fight Aging! - March 28, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

In search of antiepileptogenic treatments for post-traumatic epilepsy.
Abstract Post-traumatic epilepsy (PTE) occurs in 20% of individuals with acquired epilepsy, and can impact significantly the quality of life due to the seizures and other functional or cognitive and behavioral outcomes of the traumatic brain injury (TBI) and PTE. There is no available antiepileptogenic or disease modifying treatment for PTE. Animal models of TBI and PTE have been developed, offering useful insights on the value of inflammatory, neurodegenerative pathways, hemorrhages and iron accumulation, calcium channels and other target pathways that could be used for treatment development. Most of the existing...
Source: Neurobiology of Disease - June 21, 2018 Category: Neurology Authors: Saletti PG, Ali I, Casillas-Espinosa PM, Semple BD, Lisgaras C, Moshé SL, Galanopoulou AS Tags: Neurobiol Dis Source Type: research

Scaffold Based Search On The Desferithiocin Archetype.
Abstract Iron overload disorder and diseases where iron mismanagement plays a crucial role requires orally available iron chelators with favourable pharmacokinetic & toxicity profile. Desferrithiocin (DFT), a tridentate and orally available iron chelator has with favourable pharmacokinetic profile but its use has been clinically restricted due to its nephrotoxic potential. The chemical architecture of the DFT has been naturally well optimized for better iron chelation and iron clearance from human biological system. Equally they are also responsible for its toxicity. Hence, subsequent research has been devoted...
Source: Mini Reviews in Medicinal Chemistry - February 28, 2019 Category: Chemistry Authors: Shyam M, Dev A, Sinha BN, Jayaprakash V Tags: Mini Rev Med Chem Source Type: research

In search of the most active MN4 catalyst for the oxygen reduction reaction. The case of perfluorinated Fe phthalocyanine.
J. Mater. Chem. A, 2019, Accepted Manuscript DOI: 10.1039/C9TA09125D, CommunicationGabriel Abarca, Marco Viera, Carolina Aliaga, Jose Marco, Walter Orellana, Jose Zagal, Federico Tasca Iron macrocyclic complexes (MN4) are promising catalysts for replacing platinum (the industrial standard) in electrocatalysis. In particular, FeN4 complexes have been shown to be more active than Pt in alkaline... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - October 17, 2019 Category: Chemistry Authors: Gabriel Abarca Source Type: research

IJERPH, Vol. 16, Pages 4465: Redirecting Research on Fe0 for Environmental Remediation: The Search for Synergy
ctep A survey of the literature on using metallic iron (Fe0) for environmental remediation suggests that the time is ripe to center research on the basic relationship between iron corrosion and contaminant removal. This communication identifies the main problem, which is based on the consideration that contaminant reductive transformation is the cathodic reaction of iron oxidative dissolution. Properly considering the inherent complexities of the Fe0/H2O system will favor an appropriate research design that will enable more efficient and sustainable remediation systems. Successful applications of Fe0/H2O systems requir...
Source: International Journal of Environmental Research and Public Health - November 12, 2019 Category: Environmental Health Authors: Hu Noubactep Tags: Perspective Source Type: research

Fictional patients as literature search examples
Not simulated patients used in exams, but fictional patients as literature search topics.I have used fictional patients for some years.  I looked back to see if I have ever given them names, and can ' t find any evidence of that.  That is good, as perhaps there is a danger the names would not be diverse.  For the medical students who started in 2017, I had this:" Your patient is a five year old with head lice.   Their parent asks if they should use an insecticide lotion to eradicate the lice.   Will this work, and better than the alternatives?  Are there any adver...
Source: Browsing - November 30, 2020 Category: Databases & Libraries Tags: literature searching Source Type: blogs

Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD)
Conclusion: The results show the compounds possess good activity in contrast to the control drug (4HG) and need further in vitro and in vivo validation for possible usage as potential drugs against HIF-PHD2-associated diseases.
Source: Frontiers in Pharmacology - August 21, 2023 Category: Drugs & Pharmacology Source Type: research

In Search of Immune System Differences in Long-Lived Mammals
What are the mechanisms that allow long-lived mammals to be long-lived? It remains to be seen as to whether it will be cost-effective and of sizable benefit to isolate specific genetic differences that can be used as a basis for therapies in humans, but it isn't a terrible idea to conduct the search. Clearly cancer suppression is an interesting topic, and one it might well be possible to build novel therapies based on the study of whales and elephants. Another good place to start is the operation of the immune system. The age-related decline of immune function is clearly important to the onset and progression of age-relate...
Source: Fight Aging! - September 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

IJERPH, Vol. 16, Pages 819: Old and New Threats —Trace Metals and Fluoride Contamination in Soils at Defunct Smithy Sites
IJERPH, Vol. 16, Pages 819: Old and New Threats—Trace Metals and Fluoride Contamination in Soils at Defunct Smithy Sites International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16050819 Authors: Michał Kupiec Paweł Pieńkowski Beata Bosiacka Izabela Gutowska Patrycja Kupnicka Adam Prokopowicz Dariusz Chlubek Irena Baranowska-Bosiacka The aim of this study was to investigate soil contamination with trace elements and fluoride at sites in Szczecin (NW Poland) where economic activity was historically associated with the use of trace metals. As the Polish legislation does ...
Source: International Journal of Environmental Research and Public Health - March 5, 2019 Category: Environmental Health Authors: Micha ł Kupiec Pawe ł Pieńkowski Beata Bosiacka Izabela Gutowska Patrycja Kupnicka Adam Prokopowicz Dariusz Chlubek Irena Baranowska-Bosiacka Tags: Article Source Type: research

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil.
Abstract There are data available in the literature on bioelement concentrations in the serum of various groups of patients; however, very little is known about the serum concentration of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu) in renal transplant patients treated with immunosuppressive drugs, including mycophenolate mofetil (MMF). Monitoring of serum bioelement concentrations in renal transplant recipients is of profound importance, as the proper bioelement levels seem to prolong the normal function of the transplanted organ. Thus, the aim of this current study was to examine and carry out comparativ...
Source: Biological Trace Element Research - February 17, 2020 Category: Biology Authors: Wilk A, Szypulska-Koziarska D, Marchelek-Myśliwiec M, Głazek W, Wiszniewska B Tags: Biol Trace Elem Res Source Type: research

Suicide by intoxication with iron (III) chloride
ConclusionsConsidering the above findings, it was concluded in the forensic report that the death of the woman was caused by the ingestion of iron chloride. The reported case of fatal intoxication is one of the few described in the literature, and its course implies that in the case of initially diagnosed intoxication with corrosive compounds, the possibility of using metal-containing poison should also be considered in the differential diagnosis. In addition to routine toxicological tests performed in fatal cases we also draw attention to the possibility of using specific staining protocols for microscopic specimens.
Source: Forensic Toxicology - May 2, 2021 Category: Forensic Medicine Source Type: research